SLC13A5 Is a novel transcriptional target of the pregnane x receptor and sensitizes drug-induced steatosis in human liver

Molecular Pharmacology

Volumn 87, Issue 4, 2015, Pages 674-682

  Li, Linhao ^a   Li, Haishan ^a   Garzel, Brandy ^a   Yang, Hui ^a   Sueyoshi, Tatsuya ^b   Li, Qing ^a   Shu, Yan ^a   Zhang, Junran ^c   Hu, Bingfang ^e   Heyward, Scott ^d   Moeller, Timothy ^d   Xie, Wen ^e   Negishi, Masahiko ^b   Wang, Hongbing ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d In Vitro Technologies Inc   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MESSENGER RNA; PREGNANE X RECEPTOR; RIFAMPICIN; SOLUTE CARRIER FAMILY 13 MEMBER 5; UNCLASSIFIED DRUG; COTRANSPORTER; SLC13A5 PROTEIN, HUMAN; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENERGY METABOLISM; FATTY ACID SYNTHESIS; FATTY LIVER; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEPG2 CELL LINE; HUMAN; HUMAN TISSUE; LIPID STORAGE; LIVER CELL; LUCIFERASE ASSAY; METABOLIC DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DNA RESPONSIVE ELEMENT; ENHANCER REGION; GENE SILENCING; GENETICS; LIPID METABOLISM; LIVER; METABOLISM; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALS; ENHANCER ELEMENTS, GENETIC; FATTY LIVER; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIPID METABOLISM; LIVER; MICE, TRANSGENIC; RECEPTORS, STEROID; RESPONSE ELEMENTS; RIFAMPIN; SYMPORTERS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84982150713     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.097287     Document Type: Article

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