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Volumn 13, Issue 4, 2016, Pages 1-10

Global strategies are required to cure and eliminate HBV infection

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; ADEFOVIR DIPIVOXIL; ANTIVIRUS AGENT; CIRCULAR DNA; COVALENTLY CLOSED CIRCULAR DNA; ENTECAVIR; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS E ANTIGEN; INTERFERON; LAMIVUDINE; LONAFARNIB; MYRCLUDEX B; NVR 3 778; PEGINTERFERON ALPHA; RECOMBINANT ALPHA INTERFERON; RECOMBINANT INTERLEUKIN 7; SMALL INTERFERING RNA; TENOFOVIR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 84981495379     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2016.7     Document Type: Review
Times cited : (146)

References (114)
  • 1
    • 84857358267 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity
    • Ott, J. J., Stevens, G. A., Groeger, J. & Wiersma, S. T. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 30, 2212-2219 (2012).
    • (2012) Vaccine , vol.30 , pp. 2212-2219
    • Ott, J.J.1    Stevens, G.A.2    Groeger, J.3    Wiersma, S.T.4
  • 2
    • 84940459494 scopus 로고    scopus 로고
    • Towards an HBV cure: State-of-theart and unresolved questions - Report of the ANRS workshop on HBV cure
    • Zeisel, M. B., et al. Towards an HBV cure: state-of-theart and unresolved questions - report of the ANRS workshop on HBV cure. Gut 64, 1314-1326 (2015).
    • (2015) Gut , vol.64 , pp. 1314-1326
    • Zeisel, M.B.1
  • 3
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: A global scientific strategy
    • Deeks, S. G., et al. Towards an HIV cure: a global scientific strategy. Nat. Rev. Immunol. 12, 607-614 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 607-614
    • Deeks, S.G.1
  • 5
    • 84905373172 scopus 로고    scopus 로고
    • Lewin: Guiding us towards a cure for HIV
    • Lo, S. Sharon Lewin: guiding us towards a cure for HIV. Lancet 384, 223 (2014).
    • (2014) Lancet , vol.384 , pp. 223
    • Lo, S.S.1
  • 6
    • 84904439274 scopus 로고    scopus 로고
    • Towards a cure for HIV - Are we making progress?
    • Lewin, S. R., Deeks, S. G. & Barre-Sinoussi, F. Towards a cure for HIV - are we making progress? Lancet 384, 209-211 (2014).
    • (2014) Lancet , vol.384 , pp. 209-211
    • Lewin, S.R.1    Deeks, S.G.2    Barre-Sinoussi, F.3
  • 7
    • 84887343755 scopus 로고    scopus 로고
    • Towards an HIV cure: Science and debate from the International AIDS Society 2013 symposium
    • Purcell, D. F., Elliott, J. H., Ross, A. L. & Frater, J. Towards an HIV cure: science and debate from the International AIDS Society 2013 symposium. Retrovirology 10, 134 (2013).
    • (2013) Retrovirology , vol.10 , pp. 134
    • Purcell, D.F.1    Elliott, J.H.2    Ross, A.L.3    Frater, J.4
  • 8
    • 84863911712 scopus 로고    scopus 로고
    • Public health: Towards a cure for HIV
    • Deeks, S. G. & Barre-Sinoussi, F. Public health: towards a cure for HIV. Nature 487, 293-294 (2012).
    • (2012) Nature , vol.487 , pp. 293-294
    • Deeks, S.G.1    Barre-Sinoussi, F.2
  • 9
    • 78649974978 scopus 로고    scopus 로고
    • Workshop report: Towards a cure: HIV reservoirs and strategies to control them
    • Jefferys, R. J. Workshop report: towards a cure: HIV reservoirs and strategies to control them. J. Int. AIDS Soc. 13 (Suppl. 3), I1 (2010).
    • (2010) J. Int. AIDS Soc. , vol.13 , pp. I1
    • Jefferys, R.J.1
  • 10
    • 84858999539 scopus 로고    scopus 로고
    • Selection of chronic hepatitis B therapy with high barrier to resistance
    • Gish, R., Jia, J. D., Locarnini, S. & Zoulim, F. Selection of chronic hepatitis B therapy with high barrier to resistance. Lancet Infect. Dis. 12, 341-353 (2012).
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 341-353
    • Gish, R.1    Jia, J.D.2    Locarnini, S.3    Zoulim, F.4
  • 11
    • 84856514985 scopus 로고    scopus 로고
    • IFN-a inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • Belloni, L., et al. IFN-a inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J. Clin. Invest. 122, 529-537 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 529-537
    • Belloni, L.1
  • 12
    • 84883746075 scopus 로고    scopus 로고
    • NK cells: A double-edged sword in chronic hepatitis B virus infection
    • Maini, M. K. & Peppa, D. NK cells: a double-edged sword in chronic hepatitis B virus infection. Front. Immunol. 4, 57 (2013).
    • (2013) Front. Immunol. , vol.4 , pp. 57
    • Maini, M.K.1    Peppa, D.2
  • 13
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • Lucifora, J., et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343, 1221-1228 (2014).
    • (2014) Science , vol.343 , pp. 1221-1228
    • Lucifora, J.1
  • 14
    • 83455179343 scopus 로고    scopus 로고
    • HBV genotypes: Relevance to natural history, pathogenesis and treatment of chronic hepatitis B
    • Kim, B. K., Revill, P. A. & Ahn, S. H. HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B. Antivir. Ther. 16, 1169-1186 (2011).
    • (2011) Antivir. Ther. , vol.16 , pp. 1169-1186
    • Kim, B.K.1    Revill, P.A.2    Ahn, S.H.3
  • 15
    • 84860325201 scopus 로고    scopus 로고
    • New perspectives in the therapy of chronic hepatitis B
    • Lampertico, P. & Liaw, Y. F. New perspectives in the therapy of chronic hepatitis B. Gut 61 (Suppl. 1), i18-i24 (2012).
    • (2012) Gut , vol.61 , pp. i18-i24
    • Lampertico, P.1    Liaw, Y.F.2
  • 16
    • 53549107488 scopus 로고    scopus 로고
    • Meta-analysis: Treatment of hepatitis B infection reduces risk of hepatocellular carcinoma
    • Sung, J. J., Tsoi, K. K., Wong, V. W., Li, K. C. & Chan, H. L. Meta-analysis: treatment of hepatitis B infection reduces risk of hepatocellular carcinoma. Aliment. Pharmacol. Ther. 28, 1067-1077 (2008).
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 1067-1077
    • Sung, J.J.1    Tsoi, K.K.2    Wong, V.W.3    Li, K.C.4    Chan, H.L.5
  • 17
    • 84883212438 scopus 로고    scopus 로고
    • Reduction of hepatitis B surface antigen levels and hepatitis B surface antigen seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy
    • Seto, W. K., et al. Reduction of hepatitis B surface antigen levels and hepatitis B surface antigen seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology 58, 923-931 (2013).
    • (2013) Hepatology , vol.58 , pp. 923-931
    • Seto, W.K.1
  • 18
    • 84922789624 scopus 로고    scopus 로고
    • Kinetics of hepatitis B surface antigen loss in patients with HBeAg-positive chronic hepatitis B treated with tenofovir disoproxil fumarate
    • Marcellin, P., et al. Kinetics of hepatitis B surface antigen loss in patients with HBeAg-positive chronic hepatitis B treated with tenofovir disoproxil fumarate. J. Hepatol. 61, 1228-1237 (2014).
    • (2014) J. Hepatol. , vol.61 , pp. 1228-1237
    • Marcellin, P.1
  • 19
    • 84872169267 scopus 로고    scopus 로고
    • Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy
    • Lai, C. L. & Yuen, M. F. Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy. Hepatology 57, 399-408 (2013).
    • (2013) Hepatology , vol.57 , pp. 399-408
    • Lai, C.L.1    Yuen, M.F.2
  • 20
    • 84938231238 scopus 로고    scopus 로고
    • Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: Limited role for risk scores in Caucasians
    • Arends, P., et al. Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians. Gut 64, 1289-1295 (2015).
    • (2015) Gut , vol.64 , pp. 1289-1295
    • Arends, P.1
  • 21
    • 84879607066 scopus 로고    scopus 로고
    • Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection
    • Hosaka, T., et al. Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection. Hepatology 58, 98-107 (2013).
    • (2013) Hepatology , vol.58 , pp. 98-107
    • Hosaka, T.1
  • 22
    • 84943531655 scopus 로고    scopus 로고
    • Impact of long-term tenofovir disoproxil fumarate on incidence of hepatocellular carcinoma in patients with chronic hepatitis B
    • Kim, W. R., et al. Impact of long-term tenofovir disoproxil fumarate on incidence of hepatocellular carcinoma in patients with chronic hepatitis B. Cancer 121, 3631-3638 (2015).
    • (2015) Cancer , vol.121 , pp. 3631-3638
    • Kim, W.R.1
  • 23
    • 84941190611 scopus 로고    scopus 로고
    • Hepatitis B reactivation in HBsAg-negative/HBcAbpositive patients receiving rituximab for lymphoma: A meta-analysis
    • Mozessohn, L., Chan, K. K., Feld, J. J. & Hicks, L. K. Hepatitis B reactivation in HBsAg-negative/HBcAbpositive patients receiving rituximab for lymphoma: a meta-analysis. J. Viral Hepat. 22, 842-849 (2015).
    • (2015) J. Viral Hepat. , vol.22 , pp. 842-849
    • Mozessohn, L.1    Chan, K.K.2    Feld, J.J.3    Hicks, L.K.4
  • 24
    • 84878635506 scopus 로고    scopus 로고
    • Outcomes and risk factors for hepatitis B virus (HBV) reactivation after kidney transplantation in occult HBV carriers
    • Chen, G. D., Gu, J. L., Qiu, J. & Chen, L. Z. Outcomes and risk factors for hepatitis B virus (HBV) reactivation after kidney transplantation in occult HBV carriers. Transpl. Infect. Dis. 15, 300-305 (2013).
    • (2013) Transpl. Infect. Dis. , vol.15 , pp. 300-305
    • Chen, G.D.1    Gu, J.L.2    Qiu, J.3    Chen, L.Z.4
  • 25
    • 84911424291 scopus 로고    scopus 로고
    • Hepatitis B reactivation in patients with previous hepatitis B virus exposure undergoing rituximab-containing chemotherapy for lymphoma: A prospective study
    • Seto, W. K., et al. Hepatitis B reactivation in patients with previous hepatitis B virus exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study. J. Clin. Oncol. 32, 3736-3743 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 3736-3743
    • Seto, W.K.1
  • 26
    • 84942038524 scopus 로고    scopus 로고
    • Monitoring of hepatitis B virus (HBV) DNA and risk of HBV reactivation in B-cell lymphoma: A prospective observational study
    • Kusumoto, S., et al. Monitoring of hepatitis B virus (HBV) DNA and risk of HBV reactivation in B-cell lymphoma: a prospective observational study. Clin. Infect. Dis. 61, 719-729 (2015).
    • (2015) Clin. Infect. Dis. , vol.61 , pp. 719-729
    • Kusumoto, S.1
  • 27
    • 84983726112 scopus 로고    scopus 로고
    • High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load
    • quiz e13-e14
    • Tseng, T. C., et al. High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. Gastroenterology 142, 1140-1149.e3; quiz e13-e14 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1140-1140e3
    • Tseng, T.C.1
  • 28
    • 84911899230 scopus 로고    scopus 로고
    • Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy
    • Lu, H. K., et al. Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. PLoS ONE 9, e113341 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e113341
    • Lu, H.K.1
  • 29
    • 84912122037 scopus 로고    scopus 로고
    • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
    • Elliott, J. H., et al. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLoS Pathog. 10, e1004473 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004473
    • Elliott, J.H.1
  • 30
    • 84920764736 scopus 로고    scopus 로고
    • Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
    • Koniger, C., et al. Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc. Natl Acad. Sci. USA 111, E4244-E4253 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E4244-E4253
    • Koniger, C.1
  • 31
    • 76549181000 scopus 로고
    • A new antigen in leukemia sera
    • Blumberg, B. S., Alter, H. J. & Visnich, S. A new antigen in leukemia sera. JAMA 191, 541-546 (1965).
    • (1965) JAMA , vol.191 , pp. 541-546
    • Blumberg, B.S.1    Alter, H.J.2    Visnich, S.3
  • 32
    • 84902973225 scopus 로고    scopus 로고
    • Strategies to inhibit entry of HBV and HDV into hepatocytes
    • Urban, S., Bartenschlager, R., Kubitz, R. & Zoulim, F. Strategies to inhibit entry of HBV and HDV into hepatocytes. Gastroenterology 147, 48-64 (2014).
    • (2014) Gastroenterology , vol.147 , pp. 48-64
    • Urban, S.1    Bartenschlager, R.2    Kubitz, R.3    Zoulim, F.4
  • 33
    • 84876295707 scopus 로고    scopus 로고
    • The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
    • Volz, T., et al. The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus. J. Hepatol. 58, 861-867 (2013).
    • (2013) J. Hepatol. , vol.58 , pp. 861-867
    • Volz, T.1
  • 34
    • 84899486063 scopus 로고    scopus 로고
    • Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)
    • Watashi, K., et al. Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP). Hepatology 59, 1726-1737 (2014).
    • (2014) Hepatology , vol.59 , pp. 1726-1737
    • Watashi, K.1
  • 35
    • 84949674768 scopus 로고    scopus 로고
    • A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses by targeting sodium taurocholate cotransporting polypeptide
    • Kaneko, M., et al. A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses by targeting sodium taurocholate cotransporting polypeptide. J. Virol. 89, 11945-11953 (2015).
    • (2015) J. Virol. , vol.89 , pp. 11945-11953
    • Kaneko, M.1
  • 36
    • 68049132846 scopus 로고    scopus 로고
    • Control of cccDNA function in hepatitis B virus infection
    • Levrero, M., et al. Control of cccDNA function in hepatitis B virus infection. J. Hepatol. 51, 581-592 (2009).
    • (2009) J. Hepatol. , vol.51 , pp. 581-592
    • Levrero, M.1
  • 37
    • 33644854241 scopus 로고    scopus 로고
    • Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones
    • Pollicino, T., et al. Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology 130, 823-837 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 823-837
    • Pollicino, T.1
  • 38
    • 84875772744 scopus 로고    scopus 로고
    • Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription
    • Benhenda, S., et al. Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription. J. Virol. 87, 4360-4371 (2013).
    • (2013) J. Virol. , vol.87 , pp. 4360-4371
    • Benhenda, S.1
  • 39
    • 73949127893 scopus 로고    scopus 로고
    • Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
    • Belloni, L., et al. Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function. Proc. Natl Acad. Sci. USA 106, 19975-19979 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 19975-19979
    • Belloni, L.1
  • 40
    • 84884692876 scopus 로고    scopus 로고
    • Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes
    • Liu, F., et al. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. PLoS Pathog. 9, e1003613 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003613
    • Liu, F.1
  • 41
    • 84947466102 scopus 로고    scopus 로고
    • Mapping of histone modifications in episomal HBV cccDNA uncovers unusual chromatic organization amenable to epigenetic manipulation
    • Topberger, P., et al. Mapping of histone modifications in episomal HBV cccDNA uncovers unusual chromatic organization amenable to epigenetic manipulation. Proc. Natl Acad. Sci. USA 112, E5715-E5724 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.112 , pp. E5715-E5724
    • Topberger, P.1
  • 42
    • 84857053151 scopus 로고    scopus 로고
    • Reasons to consider earlier treatment of chronic HBV infections
    • Zoulim, F. & Mason, W. S. Reasons to consider earlier treatment of chronic HBV infections. Gut 61, 333-336 (2012).
    • (2012) Gut , vol.61 , pp. 333-336
    • Zoulim, F.1    Mason, W.S.2
  • 43
    • 53749103127 scopus 로고    scopus 로고
    • Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle
    • Bourne, C., et al. Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle. J. Virol. 82, 10262-10270 (2008).
    • (2008) J. Virol. , vol.82 , pp. 10262-10270
    • Bourne, C.1
  • 44
    • 84939980734 scopus 로고    scopus 로고
    • HAPS hepatitis B virus (HBV) capsid inhibitors prevent HBC interaction with the viral minichromosome and selected host cells to inhibit transcription and affect cccDNA stability
    • Belloni, L., et al. HAPS hepatitis B virus (HBV) capsid inhibitors prevent HBC interaction with the viral minichromosome and selected host cells to inhibit transcription and affect cccDNA stability. Dig. Liver Dis. 46, e9 (2014).
    • (2014) Dig. Liver Dis. , vol.46 , pp. e9
    • Belloni, L.1
  • 45
    • 0033152857 scopus 로고    scopus 로고
    • The crystal structure of the human hepatitis B virus capsid
    • Wynne, S. A., Crowther, R. A. & Leslie, A. G. The crystal structure of the human hepatitis B virus capsid. Mol. Cell 3, 771-780 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 771-780
    • Wynne, S.A.1    Crowther, R.A.2    Leslie, A.G.3
  • 46
    • 84881478439 scopus 로고    scopus 로고
    • Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure
    • Katen, S. P., Tan, Z., Chirapu, S. R., Finn, M. G. & Zlotnick, A. Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure. Structure 21, 1406-1416 (2013).
    • (2013) Structure , vol.21 , pp. 1406-1416
    • Katen, S.P.1    Tan, Z.2    Chirapu, S.R.3    Finn, M.G.4    Zlotnick, A.5
  • 47
    • 80054867708 scopus 로고    scopus 로고
    • The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication
    • Billioud, G., Pichoud, C., Puerstinger, G., Neyts, J. & Zoulim, F. The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication. Antiviral Res. 92, 271-276 (2011).
    • (2011) Antiviral Res. , vol.92 , pp. 271-276
    • Billioud, G.1    Pichoud, C.2    Puerstinger, G.3    Neyts, J.4    Zoulim, F.5
  • 48
    • 0036721178 scopus 로고    scopus 로고
    • Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro
    • Delaney, W. E. 4th, et al. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrob. Agents Chemother. 46, 3057-3060 (2002).
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3057-3060
    • Delaney, W.E.1
  • 49
    • 0347928672 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids
    • Deres, K., et al. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science 299, 893-896 (2003).
    • (2003) Science , vol.299 , pp. 893-896
    • Deres, K.1
  • 50
    • 0031758695 scopus 로고    scopus 로고
    • Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)β-l-2,3-dideoxy-3-thiacytidine
    • King, R. W., et al. Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)β-l-2,3-dideoxy-3-thiacytidine. Antimicrob. Agents Chemother. 42, 3179-3186 (1998).
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3179-3186
    • King, R.W.1
  • 51
    • 15244357567 scopus 로고    scopus 로고
    • Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death
    • Leupin, O., Bontron, S., Schaeffer, C. & Strubin, M. Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J. Virol. 79, 4238-4245 (2005).
    • (2005) J. Virol. , vol.79 , pp. 4238-4245
    • Leupin, O.1    Bontron, S.2    Schaeffer, C.3    Strubin, M.4
  • 52
    • 84982154746 scopus 로고    scopus 로고
    • Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
    • Decorsiere, A., et al. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature http://dx.doi.org/.10.1038/nature17170 (2016).
    • (2016) Nature
    • Decorsiere, A.1
  • 53
    • 84877026189 scopus 로고    scopus 로고
    • Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection
    • Wooddell, C. I., et al. Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection. Mol. Ther. 21, 973-985 (2013).
    • (2013) Mol. Ther. , vol.21 , pp. 973-985
    • Wooddell, C.I.1
  • 54
    • 84936939671 scopus 로고    scopus 로고
    • Phase II, dose ranging study of ARC-520, a siRNA-based therapeutic, in patients with chronic hepatitis B infection
    • Yuen, M. F., et al. Phase II, dose ranging study of ARC-520, a siRNA-based therapeutic, in patients with chronic hepatitis B infection. Hepatology 60 (Suppl. 1), 1280A (2014).
    • (2014) Hepatology , vol.60 , pp. 1280A
    • Yuen, M.F.1
  • 55
    • 84885023096 scopus 로고    scopus 로고
    • Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases
    • Bloom, K., Ely, A., Mussolino, C., Cathomen, T. & Arbuthnot, P. Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases. Mol. Ther. 21, 1889-1897 (2013).
    • (2013) Mol. Ther. , vol.21 , pp. 1889-1897
    • Bloom, K.1    Ely, A.2    Mussolino, C.3    Cathomen, T.4    Arbuthnot, P.5
  • 56
    • 84927935415 scopus 로고    scopus 로고
    • Targeting hepatitis B virus with CRISPR/Cas9
    • Seeger, C. & Sohn, J. A. Targeting hepatitis B virus with CRISPR/Cas9. Mol. Ther. Nucleic Acids 3, e216 (2014).
    • (2014) Mol. Ther. Nucleic Acids , vol.3 , pp. e216
    • Seeger, C.1    Sohn, J.A.2
  • 57
    • 84907379292 scopus 로고    scopus 로고
    • The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo
    • Lin, S. R., et al. The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo. Mol. Ther. Nucleic Acids 3, e186 (2014).
    • (2014) Mol. Ther. Nucleic Acids , vol.3 , pp. e186
    • Lin, S.R.1
  • 58
    • 84872006797 scopus 로고    scopus 로고
    • Optimal management of chronic hepatitis B patients with treatment failure and antiviral drug resistance
    • Zoulim, F. & Locarnini, S. Optimal management of chronic hepatitis B patients with treatment failure and antiviral drug resistance. Liver Int. 33 (Suppl. 1), 116-124 (2013).
    • (2013) Liver Int. , vol.33 , pp. 116-124
    • Zoulim, F.1    Locarnini, S.2
  • 59
    • 79960124298 scopus 로고    scopus 로고
    • Serum HBsAg decline during long-term potent nucleos(t)ide analogue therapy for chronic hepatitis B and prediction of HBsAg loss
    • Zoutendijk, R., Hansen, B. E., van Vuuren, A. J., Boucher, C. A. & Janssen, H. L. Serum HBsAg decline during long-term potent nucleos(t)ide analogue therapy for chronic hepatitis B and prediction of HBsAg loss. J. Infect. Dis. 204, 415-418 (2011).
    • (2011) J. Infect. Dis. , vol.204 , pp. 415-418
    • Zoutendijk, R.1    Hansen, B.E.2    Van Vuuren, A.J.3    Boucher, C.A.4    Janssen, H.L.5
  • 60
    • 84880939335 scopus 로고    scopus 로고
    • Long-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: Finite treatment duration unlikely
    • Chevaliez, S., Hezode, C., Bahrami, S., Grare, M. & Pawlotsky, J. M. Long-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: finite treatment duration unlikely. J. Hepatol. 58, 676-683 (2013).
    • (2013) J. Hepatol. , vol.58 , pp. 676-683
    • Chevaliez, S.1    Hezode, C.2    Bahrami, S.3    Grare, M.4    Pawlotsky, J.M.5
  • 61
    • 84865487986 scopus 로고    scopus 로고
    • Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir
    • Hadziyannis, S. J., Sevastianos, V., Rapti, I., Vassilopoulos, D. & Hadziyannis, E. Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir. Gastroenterology 143, 629-636.e1 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 629-629e1
    • Hadziyannis, S.J.1    Sevastianos, V.2    Rapti, I.3    Vassilopoulos, D.4    Hadziyannis, E.5
  • 62
    • 2342588229 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis B virus infection
    • Wieland, S., Thimme, R., Purcell, R. H. & Chisari, F. V. Genomic analysis of the host response to hepatitis B virus infection. Proc. Natl Acad. Sci. USA 101, 6669-6674 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6669-6674
    • Wieland, S.1    Thimme, R.2    Purcell, R.H.3    Chisari, F.V.4
  • 63
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro, P., et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 58, 974-982 (2009).
    • (2009) Gut , vol.58 , pp. 974-982
    • Fisicaro, P.1
  • 64
    • 73149094329 scopus 로고    scopus 로고
    • Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection
    • Hosel, M., et al. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology 50, 1773-1782 (2009).
    • (2009) Hepatology , vol.50 , pp. 1773-1782
    • Hosel, M.1
  • 65
    • 73449093499 scopus 로고    scopus 로고
    • Control of hepatitis B virus replication by innate response of HepaRG cells
    • Lucifora, J., et al. Control of hepatitis B virus replication by innate response of HepaRG cells. Hepatology 51, 63-72 (2010).
    • (2010) Hepatology , vol.51 , pp. 63-72
    • Lucifora, J.1
  • 66
    • 84938366976 scopus 로고    scopus 로고
    • Expression and Functionality of Toll- and RIG-like receptors in HepaRG Cells
    • Luangsay, S., et al. Expression and Functionality of Toll- and RIG-like receptors in HepaRG Cells. J. Hepatol. 63, 1077-1085 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 1077-1085
    • Luangsay, S.1
  • 67
    • 84951107024 scopus 로고    scopus 로고
    • Early inhibition of hepatocyte innate responses by hepatitis B virus
    • Luangsay, S., et al. Early inhibition of hepatocyte innate responses by hepatitis B virus. J. Hepatol. 63, 1314-1322 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 1314-1322
    • Luangsay, S.1
  • 68
    • 80052444371 scopus 로고    scopus 로고
    • The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway
    • Lang, T., et al. The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway. J. Hepatol. 55, 762-769 (2011).
    • (2011) J. Hepatol. , vol.55 , pp. 762-769
    • Lang, T.1
  • 69
    • 33846492518 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
    • Visvanathan, K., et al. Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology 45, 102-110 (2007).
    • (2007) Hepatology , vol.45 , pp. 102-110
    • Visvanathan, K.1
  • 70
    • 80052846666 scopus 로고    scopus 로고
    • The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes
    • Wilson, R., et al. The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes. J. Viral Hepat. 18, e499-e507 (2011).
    • (2011) J. Viral Hepat. , vol.18 , pp. e499-e507
    • Wilson, R.1
  • 71
    • 84906330275 scopus 로고    scopus 로고
    • Down-regulation of IL-18 mediated cell signalling and IFN-gamma expression by the hepatitis B virus e antigen
    • Jegaskanda, S., et al. Down-regulation of IL-18 mediated cell signalling and IFN-gamma expression by the hepatitis B virus e antigen. J. Virol. 88, 10412-10420 (2014).
    • (2014) J. Virol. , vol.88 , pp. 10412-10420
    • Jegaskanda, S.1
  • 72
    • 84874444511 scopus 로고    scopus 로고
    • Impaired Toll-like receptor expression in chronic hepatits B: Implications for pathogenesis and therapy
    • Visvanathan, K., et al. Impaired Toll-like receptor expression in chronic hepatits B: implications for pathogenesis and therapy. Hepatology 38, 138A (2004).
    • (2004) Hepatology , vol.38 , pp. 138A
    • Visvanathan, K.1
  • 73
    • 84952684286 scopus 로고    scopus 로고
    • Interferon-γ and tumor necrosis factor-a produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis
    • Xia, Y., et al. Interferon-γ and tumor necrosis factor-a produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis. Gastroenterology 150, 194-205 (2016).
    • (2016) Gastroenterology , vol.150 , pp. 194-205
    • Xia, Y.1
  • 74
    • 84891640554 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferonstimulated gene induction without detectable serum interferon at low oral doses
    • Fosdick, A., et al. Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferonstimulated gene induction without detectable serum interferon at low oral doses. J. Pharmacol. Exp. Ther. 348, 96-105 (2014).
    • (2014) J. Pharmacol. Exp. Ther. , vol.348 , pp. 96-105
    • Fosdick, A.1
  • 75
    • 84929606985 scopus 로고    scopus 로고
    • Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the woodchuck model of chronic hepatitis B
    • Menne, S., et al. Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the woodchuck model of chronic hepatitis B. J. Hepatol. 62, 1237-1247 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 1237-1247
    • Menne, S.1
  • 76
    • 84910040995 scopus 로고    scopus 로고
    • Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice
    • Wang, Y., et al. Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice. Int. J. Infect. Dis. 29, 31-36 (2014).
    • (2014) Int. J. Infect. Dis. , vol.29 , pp. 31-36
    • Wang, Y.1
  • 77
    • 84962625772 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02166047 (2015)
    • (2015)
  • 78
    • 84962666693 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01027065 (2012)
    • (2012)
  • 79
    • 84962776948 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01204762 (2015)
    • (2015)
  • 80
    • 84878233150 scopus 로고    scopus 로고
    • Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection
    • Huang, L. R., et al. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection. Nat. Immunol. 14, 574-583 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 574-583
    • Huang, L.R.1
  • 82
    • 84892853405 scopus 로고    scopus 로고
    • Immune therapeutic strategies in chronic hepatitis B virus infection: Virus or inflammation control?
    • Bertoletti, A. & Gehring, A. J. Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control? PLoS Pathog. 9, e1003784 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003784
    • Bertoletti, A.1    Gehring, A.J.2
  • 83
    • 0025147370 scopus 로고
    • Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
    • Milich, D. R., et al. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc. Natl Acad. Sci. USA 87, 6599-6603 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 6599-6603
    • Milich, D.R.1
  • 84
    • 84925815645 scopus 로고    scopus 로고
    • Trained immunity in newborn infants of HBV-infected mothers
    • Hong, M., et al. Trained immunity in newborn infants of HBV-infected mothers. Nat. Commun. 6, 6588 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6588
    • Hong, M.1
  • 85
    • 84865504614 scopus 로고    scopus 로고
    • Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B
    • Kennedy, P. T., et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B. Gastroenterology 143, 637-645 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 637-645
    • Kennedy, P.T.1
  • 86
    • 77949655584 scopus 로고    scopus 로고
    • The molecular basis of the failed immune response in chronic HBV: Therapeutic implications
    • Maini, M. K. & Schurich, A. The molecular basis of the failed immune response in chronic HBV: therapeutic implications. J. Hepatol. 52, 616-619 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 616-619
    • Maini, M.K.1    Schurich, A.2
  • 87
    • 84930651350 scopus 로고    scopus 로고
    • Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
    • Pallett, L. J., et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat. Med. 21, 591-600 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 591-600
    • Pallett, L.J.1
  • 88
    • 84919773476 scopus 로고    scopus 로고
    • Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: A randomised trial - ANRS HB02 VAC-ADN
    • Fontaine, H., et al. Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial - ANRS HB02 VAC-ADN. Gut 64, 139-147 (2015).
    • (2015) Gut , vol.64 , pp. 139-147
    • Fontaine, H.1
  • 89
    • 84917675883 scopus 로고    scopus 로고
    • Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B
    • Seto, W. K., et al. Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B. Clin. Microbiol. Infect. 20, 1173-1180 (2014).
    • (2014) Clin. Microbiol. Infect. , vol.20 , pp. 1173-1180
    • Seto, W.K.1
  • 90
    • 37249092014 scopus 로고    scopus 로고
    • Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection
    • Wong, D. K., et al. Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection. J. Clin. Microbiol. 45, 3942-3947 (2007).
    • (2007) J. Clin. Microbiol. , vol.45 , pp. 3942-3947
    • Wong, D.K.1
  • 91
    • 84936846131 scopus 로고    scopus 로고
    • Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection
    • Tu, T., et al. Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection. J. Viral Hepat. 22, 737-753 (2015).
    • (2015) J. Viral Hepat. , vol.22 , pp. 737-753
    • Tu, T.1
  • 92
    • 77954991668 scopus 로고    scopus 로고
    • Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection
    • Mason, W. S., Liu, C., Aldrich, C. E., Litwin, S. & Yeh, M. M. Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection. J. Virol. 84, 8308-8315 (2010).
    • (2010) J. Virol. , vol.84 , pp. 8308-8315
    • Mason, W.S.1    Liu, C.2    Aldrich, C.E.3    Litwin, S.4    Yeh, M.M.5
  • 94
    • 0000452973 scopus 로고    scopus 로고
    • Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B
    • Fattovich, G., et al. Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. Gut 46, 420-426 (2000).
    • (2000) Gut , vol.46 , pp. 420-426
    • Fattovich, G.1
  • 96
    • 84945458125 scopus 로고    scopus 로고
    • Optimal management of hepatitis B virus infection - EASL Special Conference
    • Lampertico, P., Maini, M. & Papatheodoridis, G. Optimal management of hepatitis B virus infection - EASL Special Conference. J. Hepatol. 63, 1238-1253 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 1238-1253
    • Lampertico, P.1    Maini, M.2    Papatheodoridis, G.3
  • 97
  • 98
    • 84902091591 scopus 로고    scopus 로고
    • Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta
    • Heidrich, B., et al. Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta. Hepatology 60, 87-97 (2014).
    • (2014) Hepatology , vol.60 , pp. 87-97
    • Heidrich, B.1
  • 99
    • 84947436734 scopus 로고    scopus 로고
    • Can we predict sustained virologic response to interferon a therapy in patients with chronic hepatitis delta virus infection?
    • Scholtes, C., Kumar, R. & Zoulim, F. Can we predict sustained virologic response to interferon a therapy in patients with chronic hepatitis delta virus infection? Clin. Gastroenterol. Hepatol. 13, 2350-2352 (2015).
    • (2015) Clin. Gastroenterol. Hepatol. , vol.13 , pp. 2350-2352
    • Scholtes, C.1    Kumar, R.2    Zoulim, F.3
  • 100
    • 79251490096 scopus 로고    scopus 로고
    • Peginterferon plus adefovir versus either drug alone for hepatitis delta
    • Wedemeyer, H., et al. Peginterferon plus adefovir versus either drug alone for hepatitis delta. N. Engl. J. Med. 364, 322-331 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 322-331
    • Wedemeyer, H.1
  • 101
    • 84922832694 scopus 로고    scopus 로고
    • A proof-of-concept Phase 2a clinical trial with HBV/HDV entry inhibitor Myrcludex B
    • Bogomolov, P., Voronkova, N., Allweiss, L. 3rd & Urban, S. A proof-of-concept Phase 2a clinical trial with HBV/HDV entry inhibitor Myrcludex B. Hepatology 60, 1267A-1290A (2014).
    • (2014) Hepatology , vol.60 , pp. 1267A-1290A
    • Bogomolov, P.1    Voronkova, N.2    Allweiss, L.3    Urban, S.4
  • 102
    • 85047694038 scopus 로고    scopus 로고
    • In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
    • Bordier, B. B., et al. In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. J. Clin. Invest. 112, 407-414 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 407-414
    • Bordier, B.B.1
  • 103
    • 0036785539 scopus 로고    scopus 로고
    • A prenylation inhibitor prevents production of infectious hepatitis delta virus particles
    • Bordier, B. B., et al. A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. J. Virol. 76, 10465-10472 (2002).
    • (2002) J. Virol. , vol.76 , pp. 10465-10472
    • Bordier, B.B.1
  • 104
    • 84942199484 scopus 로고    scopus 로고
    • Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: A proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial
    • Koh, C., et al. Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial. Lancet Infect. Dis. 15, 1167-1174 (2015).
    • (2015) Lancet Infect. Dis. , vol.15 , pp. 1167-1174
    • Koh, C.1
  • 106
    • 79957614798 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
    • Lucifora, J., et al. Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. J. Hepatol. 55, 996-1003 (2011).
    • (2011) J. Hepatol. , vol.55 , pp. 996-1003
    • Lucifora, J.1
  • 107
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle, B., et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126, 1750-1758 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1750-1758
    • Werle-Lapostolle, B.1
  • 108
    • 84880608443 scopus 로고    scopus 로고
    • Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleos(t)ide analogues of different potency
    • Wong, D. K., et al. Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleos(t)ide analogues of different potency. Clin. Gastroenterol. Hepatol. 11, 1004-1010.e1 (2013).
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , pp. 1004-1004e1
    • Wong, D.K.1
  • 109
    • 75149117314 scopus 로고    scopus 로고
    • Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B
    • Fisicaro, P., et al. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology 138, 682-693.e4 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 682-682e4
    • Fisicaro, P.1
  • 110
    • 39549114267 scopus 로고    scopus 로고
    • HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B
    • Fried, M. W., et al. HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology 47, 428-434 (2008).
    • (2008) Hepatology , vol.47 , pp. 428-434
    • Fried, M.W.1
  • 111
    • 84962672943 scopus 로고    scopus 로고
    • Mapping the HBsAg immune phenotype to predict HBsAg loss or decline in chronic hepatitis B in patients receiving nucleot(s)ide analogue therapy
    • Lim, L. Y., et al. Mapping the HBsAg immune phenotype to predict HBsAg loss or decline in chronic hepatitis B in patients receiving nucleot(s)ide analogue therapy. Hepatology 60 (Suppl. 1), 980A (2014).
    • (2014) Hepatology , vol.60 , pp. 980A
    • Lim, L.Y.1
  • 112
    • 84871814966 scopus 로고    scopus 로고
    • Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis
    • Ganes, E. J., et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N. Engl. J. Med. 368, 34-44 (2013).
    • (2013) C. N. Engl. J. Med. , vol.368 , pp. 34-44
    • Ganes, E.J.1
  • 113
    • 84928889426 scopus 로고    scopus 로고
    • The immune tolerant phase of chronic HBV infection: New perspectives on an old concept
    • Bertoletti, A. & Kennedy, P. T. The immune tolerant phase of chronic HBV infection: new perspectives on an old concept. Cell. Mol. Immunol. 12, 258-263 (2015).
    • (2015) Cell. Mol. Immunol. , vol.12 , pp. 258-263
    • Bertoletti, A.1    Kennedy, P.T.2
  • 114
    • 84898936752 scopus 로고    scopus 로고
    • Hepatic immune regulation and its involvement in viral hepatitis infection
    • Knolle, P. A. & Thimme, R. Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology 146, 1193-1207 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1193-1207
    • Knolle, P.A.1    Thimme, R.2


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