Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

PLoS Pathogens

Volumn 9, Issue 9, 2013, Pages

  Liu, Fei ^a   Campagna, Matthew ^a,b   Qi, Yonghe ^c   Zhao, Xuesen ^a   Guo, Fang ^a   Xu, Chunxiao ^a   Li, Sichen ^d   Li, Wenhui ^c   Block, Timothy M ^a,b   Chang, Jinhong ^a   Guo, Ju Tao ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b HEPATITIS B FOUNDATION   (United States)

^c NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; APICIDIN; CIRCULAR DNA; HEPATITIS B (E) ANTIGEN; HEPATITIS B CORE ANTIGEN; HISTONE DEACETYLASE; HISTONE H3; LAMIVUDINE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA; AVIAN PROTEIN; HISTONE; HISTONE DEACETYLASE INHIBITOR; LYSINE; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA MODIFICATION; DNA TRANSCRIPTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETICS; GENE EXPRESSION; HEPADNAVIRUS; HEPADNAVIRUS INFECTION; HEPATITIS B VIRUS; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MINICHROMOSOME; NONHUMAN; NORTHERN BLOTTING; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; VIRUS REPLICATION; VIRUS TRANSCRIPTION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CHEMISTRY; CHICKEN; DOWN REGULATION; DRUG EFFECTS; DUCK HEPATITIS B VIRUS; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; LIVER CELL; METABOLISM; PROTEIN PROCESSING; VIROLOGY;

ACETYLATION; ANIMALS; AVIAN PROTEINS; CELL LINE; CHICKENS; DNA, CIRCULAR; DNA, VIRAL; DOWN-REGULATION; EPIGENESIS, GENETIC; HEPADNAVIRIDAE INFECTIONS; HEPATITIS B VIRUS, DUCK; HEPATOCYTES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; INTERFERON-ALPHA; LYSINE; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SYNTHESIS INHIBITORS; TRANSCRIPTION, GENETIC;

EID: 84884692876     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003613     Document Type: Article

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