Topical delivery of low-cost protein drug candidates made in chloroplasts for biofilm disruption and uptake by oral epithelial cells

Biomaterials

Volumn 105, Issue , 2016, Pages 156-166

  Liu, Yuan ^a   Kamesh, Aditya C ^a   Xiao, Yuhong ^a   Sun, Victor ^a   Hayes, Michael ^a   Daniell, Henry ^a   Koo, Hyun ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antimicrobial peptide; Dental caries; Drug delivery; Plant biopharmaceuticals; Therapeutic enzymes

Indexed keywords

BACTERIA; BIODEGRADATION; BIOFILMS; BIOMIMETICS; CELLS; COSTS; CYTOLOGY; DRUG DELIVERY; ENZYMES; MICROORGANISMS; PEPTIDES; PLANTS (BOTANY); POLYPEPTIDES;

ANTIMICROBIAL PEPTIDE; BIOPHARMACEUTICALS; CELL-PENETRATING PEPTIDE; DENTAL CARIES; PATHOGENIC BACTERIUM; SECONDARY STRUCTURES; STREPTOCOCCUS MUTANS; THERAPEUTIC ENZYME;

PROTEINS;

CELL PENETRATING PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEGRIN; RETROCYCLIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; PLANT EXTRACT;

ACTINOMYCES NAESLUNDII; ARTICLE; BIOFILM; CHEWING GUM; CHLOROPLAST; CONTROLLED STUDY; DRUG APPROVAL; DRUG COST; DRUG DELIVERY SYSTEM; DRUG FORMULATION; HUMAN; HUMAN CELL; MOUTH MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STREPTOCOCCUS GORDONII; STREPTOCOCCUS MUTANS; SURFACE PROPERTY; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOFILMS; CELL LINE; CELLS, CULTURED; CHLOROPLASTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; MOUTH MUCOSA; PLANT EXTRACTS; TREATMENT OUTCOME;

EID: 84981215918     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.07.042     Document Type: Article

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