Low-cost oral delivery of protein drugs bioencapsulated in plant cells

Plant Biotechnology Journal

Volumn 13, Issue 8, 2015, Pages 1017-1022

  Kwon, Kwang Chul ^a   Daniell, Henry ^a  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Chloroplast; Edible plants; Industrial production; Molecular pharming; Plant made biopharmaceuticals

Indexed keywords

ALPHA GLUCOSIDASE; EPITOPE;

ANIMAL; ANTIBODY PRODUCTION; CHLOROPLAST; GENETICS; GLYCOGEN STORAGE DISEASE TYPE II; HUMAN; METABOLISM; TOBACCO;

ALPHA-GLUCOSIDASES; ANIMALS; ANTIBODY FORMATION; CHLOROPLASTS; EPITOPES; GLYCOGEN STORAGE DISEASE TYPE II; HUMANS; TOBACCO;

EID: 84942197999     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12462     Document Type: Note

References (10)

1. Choi, J., Diao, H., Feng, Z.C., Lau, A., Wang, R., Jevnikar, A.M. and Ma, S. (2014) A fusion protein derived from plants holds promising potential as a new oral therapy for type 2 diabetes. Plant Biotechnol. J. 12, 425-435.
2. Jin, S. and Daniell, H. (2015) Engineered chloroplast genome just got smarter. Trends Plant Sci. doi.10.1016/j.tplants.2015.07.004.
3. Kohli, N., Westerveld, D.R., Ayache, A.C., Verma, A., Shil, P., Prasad, T., Zhu, P., Chan, S.L., Li, Q. and Daniell, H. (2014) Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers. Mol. Ther. 22, 535-546.
4. Kwon, K.C., Nityanandam, R., New, J.S. and Daniell, H. (2013) Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells. Plant Biotechnol. J. 11, 77-86.
5. Shenoy, V., Kwon, K.C., Rathinasabapathy, A., Lin, S., Jin, G., Song, C., Shil, P., Nair, A., Qi, Y., Li, Q., Francis, J., Katovich, M.J., Daniell, H. and Raizada, M.K. (2014) Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension. Hypertension, 64, 1248-1259.
6. Sherman, A., Su, J., Lin, S., Wang, X., Herzog, R.W. and Daniell, H. (2014) Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells. Blood, 124, 1659-1668.
7. Shil, P.K., Kwon, K.C., Zhu, P., Verma, A., Daniell, H. and Li, Q. (2014) Oral delivery of ACE2/Ang-(1-7) bioencapsulated in plant cells protects against experimental uveitis and autoimmune uveoretinitis. Mol. Ther. 22, 2069-2082.
8. Su, J., Zhu, L., Sherman, A., Wang, X., Lin, S., Kamesh, A., Norikane, J.H., Streatfield, S.J., Herzog, R.W. and Daniell, H. (2015a) Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B. Biomaterials, doi:10.1016/j.biomaterials.2015.08.004
9. Su, J., Sherman, A., Doerfler, P.A., Byrne, B.J., Herzog, R.W. and Daniell, H. (2015b) Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice. Plant Biotechnol. J. 13, 1023-1032.
10. Walsh, G. (2014) Biopharmaceutical benchmarks, 2014. Nat. Biotechnol. 32, 992-1000.