Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

Nature Chemical Biology

Volumn 12, Issue 9, 2016, Pages 748-754

  Miyake, Yasuyuki ^a   Keusch, Jeremy J ^a   Wang, Longlong ^a   Saito, Makoto ^a   Hess, Daniel ^a   Wang, Xiaoning ^b   Melancon, Bruce J ^b   Helquist, Paul ^b   Gut, Heinz ^a   Matthias, Patrick ^a,c  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CD2 ANTIGEN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 10; HISTONE DEACETYLASE 11; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 9; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; NEXTURASTAT A; TRICHOSTATIN A; TRYPTOPHAN; TUBULIN; UNCLASSIFIED DRUG; HDAC6 PROTEIN, HUMAN; HDAC6 PROTEIN, ZEBRAFISH; HISTONE DEACETYLASE; ZEBRAFISH PROTEIN;

ALPHA HELIX; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEACETYLATION; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HISTONE ACETYLATION; HUMAN; IC50; MICROTUBULE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; ZEBRA FISH; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOCATALYSIS; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ACETYLATION; ANIMALS; BIOCATALYSIS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84980324185     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2140     Document Type: Article

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