Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 41569-41575

  Kormendi, Vasilisa ^a   Szyk, Agnieszka ^a   Piszczek, Grzegorz ^b   Roll Mecak, Antonina ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL TRANSFERASE; ACETYL-COA; ACETYLTRANSFERASES; ACTIVE SITE; CATALYTIC CORE; MECHANOSENSATION; MICROTUBULES; MOLECULAR DETERMINANTS; N-TERMINAL DOMAINS; NEURODEGENERATION; NEURONAL POLARITY; PLASTIC REGIONS; POINT MUTATIONS; RESOLUTION STRUCTURE; SUBSTRATE RECOGNITION; THERAPEUTIC POTENTIALS; WILD TYPES;

AC GENERATOR MOTORS; ACETYLATION; OLIGOMERIZATION;

DIMERS;

ACETYL COENZYME A; ACYLTRANSFERASE; ALPHA TUBULIN; HISTONE ACETYLTRANSFERASE GCN5; TUBULIN ACYLTRANSFERASE; UNCLASSIFIED DRUG;

ACETYLATION; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MICROTUBULE; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; OLIGOMERIZATION; PLASTICITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; WILD TYPE;

ACETYL COENZYME A; ACETYLTRANSFERASES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; POINT MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84871287765     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C112.421222     Document Type: Article

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