Inhibitors of the cysteine synthase CysM with antibacterial potency against dormant mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 59, Issue 14, 2016, Pages 6848-6859

  Brunner, Katharina ^a   Maric, Selma ^a   Reshma, Rudraraju Srilakshmi ^b   Almqvist, Helena ^a   Seashore Ludlow, Brinton ^a   Gustavsson, Anna Lena ^a   Poyraz, Ömer ^a   Yogeeswari, Perumal ^b   Lundbäck, Thomas ^a   Vallin, Michaela ^a   Sriram, Dharmarajan ^b   Schnell, Robert ^a   Schneider, Gunter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 (3,4 DICHLOROPHENYL)UREIDO]BENZOIC ACID; 3 [3 (4 BROMOPHENYL)UREIDO]BENZOIC ACID; 3 [3 (4 CHLOROPHENYL)UREIDO]BENZOIC ACID; 3 [3 (P TOLYL)UREIDO]BENZOIC ACID; 3 [3 [(1,1' BIPHENYL) 3 YL]UREIDO]BENZOIC ACID; 4 [3 [(1,1' BIPHENYL) 3 YL]UREIDO] 2 HYDROXYBENZOIC ACID; 5 [3 [(1,1' BIPHENYL) 3 YL]UREIDO] 2 HYDROXYBENZOIC ACID; BENZOIC ACID DERIVATIVE; HYDROGEN; ISONIAZID; LYASE INHIBITOR; MOXIFLOXACIN; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UREA DERIVATIVE; ANTIINFECTIVE AGENT; CYSTEINE SYNTHASE; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; BACTERIAL VIABILITY; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; LIGAND BINDING; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE; CYSTEINE SYNTHASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84979947857     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00674     Document Type: Article

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