Pyridoxal-phosphate dependent mycobacterial cysteine synthases: Structure, mechanism and potential as drug targets

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 9, 2015, Pages 1175-1183

  Schnell, Robert ^a   Sriram, Dharmarajan ^b   Schneider, Gunter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Abbreviations OAS O acetyl serine; OPS O phosphoserine; PLP pyridoxal 5 phosphate,APS, adenosine 5 phosphosulfate, SAR, structure activity relationships.

Indexed keywords

BACTERIAL ENZYME; CYSK1 ENZYME; CYSK2 ENZYME; CYSM ENZYME; CYSTEINE SYNTHASE; PHOSPHOSERINE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CYSTEINE;

ARTICLE; BACTERIAL GENOME; BIOSYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; PHYSIOLOGY;

BACILLI (CLASS); MYCOBACTERIUM TUBERCULOSIS;

ANTI-BACTERIAL AGENTS; CYSTEINE; CYSTEINE SYNTHASE; HUMANS; MYCOBACTERIUM TUBERCULOSIS; PYRIDOXAL PHOSPHATE;

EID: 84937639072     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.11.010     Document Type: Review

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