Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase

Journal of Medicinal Chemistry

Volumn 59, Issue 6, 2016, Pages 2567-2578

  Pieroni, Marco ^a   Annunziato, Giannamaria ^a   Beato, Claudia ^a   Wouters, Randy ^a,d   Benoni, Roberto ^a   Campanini, Barbara ^a   Pertinhez, Thelma A ^a,e   Bettati, Stefano ^a,b   Mozzarelli, Andrea ^a,b,c   Costantino, Gabriele ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^c CNR Consiglio Nazionale delle Ricerche   (Italy)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e S MARIA NUOVA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CHLOROBENZYL) 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; 1 (4 METHYLBENZYL) 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; 1 BENZYL 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; 1 ETHYL 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; CYCLOPROPANE DERIVATIVE; ENZYME INHIBITOR; TRANS 1 (4 CHLOROBENZYL) 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; TRANS 1 (4 METHYLBENZYL) 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; TRANS 1 BENZYL 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; TRANS 1 ETHYL 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; TRANS 1 PHENETHYL 2 PHENYLCYCLOPROPANECARBOXYLIC ACID; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CARBOXYLIC ACID; CYSTEINE SYNTHASE; ISOENZYME; PROTEIN BINDING; PYRIDOXAL 5 PHOSPHATE;

ARTICLE; BINDING SITE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVE SITE; HYDROGEN BOND; NONHUMAN; RACEMIC MIXTURE; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; ANTIBIOTIC RESISTANCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CARBOXYLIC ACIDS; CYCLOPROPANES; CYSTEINE SYNTHASE; DRUG RESISTANCE, BACTERIAL; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN BINDING; PYRIDOXAL PHOSPHATE; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84962159613     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01775     Document Type: Article

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