Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Omar, Hany A ^a,b   Mohamed, Wafaa R ^a   Arab, Hany H ^c   Arafa, El Shaimaa A ^a,d  

^a Beni Suef University   (Egypt)

^b UNIVERSITY OF SHARJAH   (United Arab Emirates)

^c CAIRO UNIVERSITY   (Egypt)

^d TAIF UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CHOLESTEROL; CISPLATIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 10; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; SILYMARIN; STRESS ACTIVATED PROTEIN KINASE; TANGERETIN; TRANSCRIPTION FACTOR NRF2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT; ANTIOXIDANT; FLAVONE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TARGETING; ENZYME INDUCTION; HEPATITIS; HISTOPATHOLOGY; LIVER CELL; LIVER DYSFUNCTION; LIVER FUNCTION TEST; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; ANIMAL; BLOOD; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; LIVER; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHOLESTEROL; CISPLATIN; FLAVONES; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER FUNCTION TESTS; MALE; MALONDIALDEHYDE; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS, WISTAR; SILYMARIN; TRIGLYCERIDES;

EID: 84979895327     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0151649     Document Type: Article

References (73)

1. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene. 2003; 22(47):7265-79. Epub 2003/10/25. doi: 10.1038/sj.onc.1206933 PMID: 14576837.
2. Cui W, Yazlovitskaya EM, Mayo MS, Pelling JC, Persons DL. Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal - regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines. Molecular carcinogenesis. 2000; 29(4):219-28. Epub 2001/02/15. PMID: 11170260.
3. Shi R, Huang Q, Zhu X, Ong YB, Zhao B, Lu J, et al. Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Molecular cancer therapeutics. 2007; 6(4):1338-47. Epub 2007/04/14. doi: 10.1158/1535-7163.MCT-06-0638 PMID: 17431112.
4. Antunes LM, Darin JD, Bianchi MD. Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacological research: the official journal of the Italian Pharmacological Society. 2000; 41(4):405-11. Epub 2000/03/08. doi: 10.1006/phrs.1999.0600 PMID: 10704263.
5. Zicca A, Cafaggi S, Mariggio MA, Vannozzi MO, Ottone M, Bocchini V, et al. Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats. European journal of pharmacology. 2002; 442(3):265-72. Epub 2002/06/18. PMID: 12065080.
6. Atessahin A, Karahan I, Turk G, Gur S, Yilmaz S, Ceribasi AO. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol. 2006; 21(1):42-7. Epub 2005/06/28. doi: 10.1016/j.reprotox.2005.05.003 PMID: 15979841.
7. Tsuruya K, Ninomiya T, Tokumoto M, Hirakawa M, Masutani K, Taniguchi M, et al. Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death. Kidney international. 2003; 63(1):72-82. Epub 2002/12/11. doi: 10.1046/j.1523-1755.2003.00709.x PMID: 12472770.
8. Hong KO, Hwang JK, Park KK, Kim SH. Phosphorylation of c-Jun N-terminal Kinases (JNKs) is involved in the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity. Archives of toxicology. 2005; 79(4):231-6. Epub 2004/11/13. doi: 10.1007/s00204-004-0623-7 PMID: 15536542.
9. Bentli R, Parlakpinar H, Polat A, Samdanci E, Sarihan ME, Sagir M. Molsidomine prevents cisplatin-induced hepatotoxicity. Archives of medical research. 2013; 44(7):521-8. Epub 2013/10/15. doi: 10.1016/j.arcmed.2013.09.013 PMID: 24120390.
10. Lu Y, Cederbaum AI. Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicological sciences: an official journal of the Society of Toxicology. 2006; 89(2):515-23. Epub 2005/10/28. doi: 10.1093/toxsci/kfj031 PMID: 16251482.
11. Pratibha R, Sameer R, Rataboli PV, Bhiwgade DA, Dhume CY. Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats. European journal of pharmacology. 2006; 532(3):290-3. Epub 2006/02/07. doi: 10.1016/j.ejphar.2006.01.007 PMID: 16458885.
12. Bava SV, Puliappadamba VT, Deepti A, Nair A, Karunagaran D, Anto RJ. Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. The Journal of biological chemistry. 2005; 280(8):6301-8. Epub 2004/12/14. doi: 10.1074/jbc.M410647200 PMID: 15590651.
13. Singh RP, Agarwal R. Natural flavonoids targeting deregulated cell cycle progression in cancer cells. Current drug targets. 2006; 7(3):345-54. Epub 2006/03/07. PMID: 16515531.
14. Chen KH, Weng MS, Lin JK. Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochemical pharmacology. 2007; 73(2):215-27. Epub 2006/10/28. doi: 10.1016/j.bcp.2006.09.018 PMID: 17067555.
15. Sak K. Cytotoxicity of dietary flavonoids on different human cancer types. Pharmacognosy reviews. 2014; 8(16):122-46. Epub 2014/08/16. doi: 10.4103/0973-7847.134247 PMID: 25125885; PubMed Central PMCID: PMC4127821.
16. Sundaram R, Shanthi P, Sachdanandam P. Tangeretin, a polymethoxylated flavone, modulates lipid homeostasis and decreases oxidative stress by inhibiting NF-κB activation and proinflammatory cytokines in cardiac tissue of streptozotocin-induced diabetic rats. Journal of Functional Foods. 2015; 16(0):315-33. doi: 10.1016/j.jff.2015.03.024
17. Periyasamy K, Baskaran K, Ilakkia A, Vanitha K, Selvaraj S, Sakthisekaran D. Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats. Cancer Chemother Pharmacol. 2015; 75(2):263-72. Epub 2014/11/29. doi: 10.1007/s00280-014-2629-z PMID: 25431347.
18. Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. Journal of agricultural and food chemistry. 2004; 52(10):2879-86. Epub 2004/05/13. doi: 10.1021/jf035354z PMID: 15137829.
19. Vanhoecke BW, Delporte F, Van Braeckel E, Heyerick A, Depypere HT, Nuytinck M, et al. A safety study of oral tangeretin and xanthohumol administration to laboratory mice. In Vivo. 2005; 19(1):103-7. Epub 2005/03/31. PMID: 15796161.
20. Hirano T, Abe K, Gotoh M, Oka K. Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. British journal of cancer. 1995; 72(6):1380-8. Epub 1995/12/01. PMID: 8519648; PubMed Central PMCID: PMC2034105.
21. Pan MH, Chen WJ, Lin-Shiau SY, Ho CT, Lin JK. Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis. 2002; 23(10):1677-84. Epub 2002/10/12. PMID: 12376477.
22. Walle T, Walle UK. Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. The Journal of pharmacy and pharmacology. 2007; 59(6):857-62. Epub 2007/07/20. doi: 10.1211/jpp.59.6.0012 PMID: 17637178.
23. Arafa el SA, Zhu Q, Barakat BM, Wani G, Zhao Q, El-Mahdy MA, et al. Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. Cancer Res. 2009; 69(23):8910-7. Epub 2009/11/12. doi: 10.1158/0008-5472.CAN-09-1543 PMID: 19903849; PubMed Central PMCID: PMC3319094.
24. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. The American journal of gastroenterology. 1998; 93(2):139-43. Epub 1998/02/19. doi: 10.1111/j.1572-0241.1998.00139.x PMID: 9468229.
25. Naveau S. [Acute alcoholic hepatitis: treatments]. Presse Med. 2001; 30(20):1024-30. Epub 2001/07/04. PMID: 11433695.
26. Laekeman G, De Coster S, De Meyer K. [St. Mary's Thistle: an overview]. Journal de pharmacie de Belgique. 2003; 58(1):28-31. Epub 2003/05/02. PMID: 12722542.
27. Syed SN, Rizvi W, Kumar A, Khan AA, Moin S, Ahsan A. In vitro antioxidant and in vivo hepatoprotective activity of leave extract of Raphanus sativus in rats using CCL4 model. African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines. 2014; 11(3):102-6. Epub 2014/11/06. PMID: 25371570; PubMed Central PMCID: PMC4202426.
28. Clichici S, Olteanu D, Nagy AL, Oros A, Filip A, Mircea PA. Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl(4)-treated rats. Journal of medicinal food. 2015; 18(3):290-8. Epub 2014/08/19. doi: 10.1089/jmf.2013.0179 PMID: 25133972.
29. Singh D, Arya PV, Sharma A, Dobhal MP, Gupta RS. Modulatory potential of alpha-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats. Journal of ethnopharmacology. 2015; 161:186-93. Epub 2014/12/30. doi: 10.1016/j.jep.2014.12.025 PMID: 25542388.
30. Gopi KS, Reddy AG, Jyothi K, Kumar BA. Acetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats. Toxicology international. 2010; 17(2):64-6. Epub 2010/12/21. doi: 10.4103/0971-6580.72672 PMID: 21170247; PubMed Central PMCID: PMC2997457.
31. Iroanya OO, Adebesin OA, Okpuzor J. Evaluation of the Hepato and Nephron-Protective Effect of a Polyherbal Mixture using Wistar Albino Rats. Journal of clinical and diagnostic research: JCDR. 2014; 8(6):HC15-21. Epub 2014/08/15. doi: 10.7860/JCDR/2014/5875.4501 PMID: 25121002; PubMed Central PMCID: PMC4129255.
32. Pushpavalli G, Veeramani C, Pugalendi KV. Influence of chrysin on hepatic marker enzymes and lipid profile against D-galactosamine-induced hepatotoxicity rats. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2010; 48(6):1654-9. Epub 2010/04/07. doi: 10.1016/j.fct.2010.03.040 PMID: 20362027.
33. Mansour HH, Hafez HF, Fahmy NM. Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats. Journal of biochemistry and molecular biology. 2006; 39(6):656-61. Epub 2006/11/30. PMID: 17129399.
34. Zicca A, Cafaggi S, Mariggio MA, Vannozzi MO, Ottone M, Bocchini V, et al. Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats. Eur J Pharmacol. 2002; 442(3):265-72. Epub 2002/06/18. PMID: 12065080.
35. Arivazhagan L, Sorimuthu Pillai S. Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(alpha)anthracene-induced rat mammary carcinoma. The Journal of nutritional biochemistry. 2014; 25(11):1140-53. Epub 2014/08/26. doi: 10.1016/j.jnutbio.2014.06.007 PMID: 25151216.
36. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957; 28(1):56-63. Epub 1957/07/01. PMID: 13458125.
37. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric oxide: biology and chemistry / official journal of the Nitric Oxide Society. 2001; 5(1):62-71. Epub 2001/02/17. doi: 10.1006/niox.2000.0319 PMID: 11178938.
38. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959; 82(1):70-7. Epub 1959/05/01. PMID: 13650640.
39. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods in enzymology. 1978; 52:302-10. Epub 1978/01/01. PMID: 672633.
40. Arab HH, Salama SA, Omar HA, Arafa el SA, Maghrabi IA. Diosmin Protects against Ethanol-Induced Gastric Injury in Rats: Novel Anti-Ulcer Actions. PloS one. 2015; 10(3):e0122417. Epub 2015/03/31. doi: 10.1371/journal.pone.0122417 PMID: 25821971; PubMed Central PMCID: PMC4378914.
41. Omar HA, Sargeant AM, Weng JR, Wang D, Kulp SK, Patel T, et al. Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. Molecular pharmacology. 2009; 76(5):957-68. doi: 10.1124/mol.109.058180 PMID: 19706731; PubMed Central PMCID: PMC2774988.
42. Sun Y, Yang J, Wang LZ, Sun LR, Dong Q. Crocin attenuates cisplatin-induced liver injury in the mice. Hum Exp Toxicol. 2014; 33(8):855-62. Epub 2013/11/28. doi: 10.1177/0960327113511475 PMID: 24275644.
43. Iseri S, Ercan F, Gedik N, Yuksel M, Alican I. Simvastatin attenuates cisplatin-induced kidney and liver damage in rats. Toxicology. 2007; 230(2-3):256-64. Epub 2007/01/02. doi: 10.1016/j.tox.2006.11.073 PMID: 17196726.
44. Tadagavadi RK, Reeves WB. Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cells. J Immunol. 2010; 185(8):4904-11. Epub 2010/09/17. doi: 10.4049/jimmunol.1000383 PMID: 20844196; PubMed Central PMCID: PMC3169908.
45. Chou WY, Lu CN, Lee TH, Wu CL, Hung KS, Concejero AM, et al. Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation. Acta pharmacologica Sinica. 2006; 27(4):469-76. Epub 2006/03/17. doi: 10.1111/j.1745-7254.2006.00304.x PMID: 16539848.
46. Shaw J, Chen B, Huang WH, Lee AR, Media J, Valeriote FA. The small-molecule TNF-alpha modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo. J Exp Ther Oncol. 2011; 9(2):129-37. Epub 2011/06/28. PMID: 21699020.
47. Rehman MU, Ali N, Rashid S, Jain T, Nafees S, Tahir M, et al. Alleviation of hepatic injury by chrysin in cisplatin administered rats: probable role of oxidative and inflammatory markers. Pharmacological reports: PR. 2014; 66(6):1050-9. Epub 2014/12/03. doi: 10.1016/j.pharep.2014.06.004 PMID: 25443734.
48. Tadagavadi RK, Reeves WB. Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cells. J Immunol. 2010; 185(8):4904-11. Epub 2010/09/17. doi: 10.4049/jimmunol.1000383 PMID: 20844196; PubMed Central PMCID: PMC3169908.
49. Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harbor perspectives in biology. 2009; 1(6):a001651. Epub 2010/05/12. doi: 10.1101/cshperspect.a001651 PMID: 20457564; PubMed Central PMCID: PMC2882124.
50. Koppelman B, Neefjes JJ, de Vries JE, de Waal Malefyt R. Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling. Immunity. 1997; 7(6):861-71. Epub 1998/01/16. PMID: 9430231.
51. Knolle PA, Uhrig A, Hegenbarth S, Loser E, Schmitt E, Gerken G, et al. IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules. Clinical and experimental immunology. 1998; 114(3):427-33. Epub 1998/12/09. PMID: 9844054; PubMed Central PMCID: PMC1905120.
52. Shu Z, Yang B, Zhao H, Xu B, Jiao W, Wang Q, et al. Tangeretin exerts anti-neuroinflammatory effects via NF-kappaB modulation in lipopolysaccharide-stimulated microglial cells. International immunopharmacology. 2014; 19(2):275-82. Epub 2014/01/28. doi: 10.1016/j.intimp.2014.01.011 PMID: 24462494.
53. Louvet A, Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nature reviews Gastroenterology & hepatology. 2015; 12(4):231-42. Epub 2015/03/18. doi: 10.1038/nrgastro.2015.35 PMID: 25782093.
54. Ramos AS, Correia AT, Antunes SC, Goncalves F, Nunes B. Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: detoxification mechanisms, oxidative defence system and peroxidative damage. Environmental toxicology and pharmacology. 2014; 37(3):1221-8. Epub 2014/05/13. doi: 10.1016/j.etap.2014.04.005 PMID: 24816177.
55. Lakshmi A, Subramanian SP. Tangeretin ameliorates oxidative stress in the renal tissues of rats with experimental breast cancer induced by 7,12-dimethylbenz[a]anthracene. Toxicol Lett. 2014; 229(2):333-48. Epub 2014/07/06. doi: 10.1016/j.toxlet.2014.06.845 PMID: 24995432.
56. Lakshmi A, Subramanian S. Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7, 12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats. Biochimie. 2014; 99:96-109. Epub 2013/12/05. doi: 10.1016/j.biochi.2013.11.017 PMID: 24299963.
57. Martins NM, Santos NA, Curti C, Bianchi ML, Santos AC. Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver. Journal of applied toxicology: JAT. 2008; 28(3):337-44. Epub 2007/07/03. doi: 10.1002/jat.1284 PMID: 17604343.
58. Wang K. Molecular mechanisms of hepatic apoptosis. Cell death & disease. 2014; 5:e996. Epub 2014/01/18. doi: 10.1038/cddis.2013.499 PMID: 24434519; PubMed Central PMCID: PMC4040708.
59. Sohn JH, Han KL, Kim JH, Rukayadi Y, Hwang JK. Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biological & pharmaceutical bulletin. 2008; 31(2):273-7. Epub 2008/02/02. PMID: 18239286.
60. Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell research. 2005; 15(1):11-8. Epub 2005/02/03. doi: 10.1038/sj.cr.7290257 PMID: 15686620.
61. Malik S, Suchal K, Gamad N, Dinda AK, Arya DS, Bhatia J. Telmisartan ameliorates cisplatin-induced nephrotoxicity by inhibiting MAPK mediated inflammation and apoptosis. European journal of pharmacology. 2015; 748:54-60. doi: 10.1016/j.ejphar.2014.12.008 PMID: 25510231.
62. Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004; 23(16):2838-49. doi: 10.1038/sj.onc.1207556 PMID: 15077147.
63. Indran IR, Tufo G, Pervaiz S, Brenner C. Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. Biochimica et biophysica acta. 2011; 1807(6):735-45. doi: 10.1016/j.bbabio.2011.03.010 PMID: 21453675.
64. Ramesh G, Reeves WB. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. American journal of physiology Renal physiology. 2005; 289(1):F166-74. doi: 10.1152/ajprenal.00401.2004 PMID: 15701814.
65. Francescato HDC, Costa RS, Júnior FB, Coimbra TM. Effect of JNK inhibition on cisplatin-induced renal damage. Nephrology Dialysis Transplantation. 2007; 22(8):2138-48. doi: 10.1093/ndt/gfm144
66. Helmy MM, Helmy MW, Abd Allah DM, Abo Zaid AM, Mohy El-Din MM. Selective ETA receptor blockade protects against cisplatin-induced acute renal failure in male rats. European journal of pharmacology. 2014; 730:133-9. doi: 10.1016/j.ejphar.2014.03.002 PMID: 24632086
67. Bubici C, Papa S, Dean K, Franzoso G. Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene. 2006; 25(51):6731-48. Epub 2006/10/31. doi: 10.1038/sj.onc.1209936 PMID: 17072325.
68. Nakagawa H, Maeda S. Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPK. Pathology research international. 2012; 2012:172894. Epub 2012/06/06. doi: 10.1155/2012/172894 PMID: 22666632; PubMed Central PMCID: PMC3361329.
69. Luo J, Tsuji T, Yasuda H, Sun Y, Fujigaki Y, Hishida A. The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association. 2008; 23(7):2198-205. doi: 10.1093/ndt/gfn090 PMID: 18385389.
70. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001; 410(6824):37-40. doi: 10.1038/35065000 PMID: 11242034.
71. Parlakpinar H, Sahna E, Ozer MK, Ozugurlu F, Vardi N, Acet A. Physiological and pharmacological concentrations of melatonin protect against cisplatin-induced acute renal injury. Journal of pineal research. 2002; 33(3):161-6. PMID: 12220331.
72. Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. Journal of cellular and molecular medicine. 2004; 8(4):445-54. PMID: 15601573.
73. Hayakawa K, Meng Y, Hiramatsu N, Kasai A, Yao J, Kitamura M. Spontaneous activation of the NFkappaB signaling pathway in isolated normal glomeruli. American journal of physiology Renal physiology. 2006; 291(6):F1169-76. doi: 10.1152/ajprenal.00513.2005 PMID: 16705144.