Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation

Acta Pharmacologica Sinica

Volumn 27, Issue 4, 2006, Pages 469-476

  Chou, Wen Ying ^a   Lu, Cheng Nan ^a   Lee, Tsung Hsing ^a   Wu, Chia Ling ^a,b   Hung, Kung Sheng ^a   Concejero, Allan M ^a   Jawan, Bruno ^a   Wang, Cheng Haung ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Cyclooxygenase 2; Gelatinase A; Gene therapy; Interleukin 10; Liver cirrhosis; Tissue inhibitor of metalloproteinases

Indexed keywords

CARBON TETRACHLORIDE; INTERLEUKIN 10; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; FIBROGENESIS; GENE THERAPY; GENE TRANSFER; HEALING; LIVER FIBROSIS; LIVER INJURY; MALE; MOUSE; NONHUMAN; SCAR FORMATION;

ACTINS; ANIMALS; COLLAGEN TYPE I; CYCLOOXYGENASE 2; ELECTROPORATION; FIBRONECTINS; GENE THERAPY; GENE TRANSFER TECHNIQUES; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-10; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED ICR; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33645210479     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00304.x     Document Type: Article

References (52)

1. Kershenobich Stalnikowitz D Weissbrod AB. Liver fibrosis and inflammation. A review. Ann Hepatol 2003 2 159 63.
2. Pinzani M Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 2001 21 397 416.
3. 4. Boll Soc Ital Biol Sper 1987 63 273 80.
4. Recknagel RO Glende EA Jr. Dolak JA Waller RL. Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther 1989 43 139 54.
5. Schuppan D Ruehl M Somasundaram R Hahn EG. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 2001 21 351 72.
6. Giannelli G Quaranta V Antonaci S. Tissue remodelling in liver diseases. Histol Histopathol 2003 18 1267 74.
7. Okazaki I Watanabe T Hozawa S Arai M Maruyama K. Molecular mechanism of the reversibility of hepatic fibrosis: with special reference to the role of matrix metalloproteinases. J Gastroenterol Hepatol 2000 15 Suppl D26 32.
8. Desmet VJ Roskams T. Cirrhosis reversal: a duel between dogma and myth. J Hepatol 2004 40 860 7.
9. McCrudden R Iredale JP. Liver fibrosis, the hepatic stellate cell and tissue inhibitors of metalloproteinases. Histol Histopathol 2000 15 1159 68.
10. Arthur MJ. Fibrogenesis II. Metalloproteinases and their inhibi tors in liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2000 279 G245 9.
11. Gressner AM Weiskirchen R Breitkopf K Dooley S. Roles of TGF-β in hepatic fibrosis. Front Biosci 2002 7 d793 807.
12. Tilg H Wilmer A Vogel W Herold M Nolchen B Judmaier G et al. Serum levels of cytokines in chronic liver diseases. Gastroenterology 1992 103 264 74.
13. Asadullah K Sterry W Volk HD. Interleukin-10 therapy: review of a new approach. Pharmacol Rev 2003 55 241 69.
14. Zdanov A. Structural features of the interleukin-10 family of cytokines. Curr Pharm Des 2004 10 3873 84.
15. Nelson DR Lauwers GY Lau JY Davis GL. Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology 2000 118 655 60.
16. Zhang ZL Shen SX Lin B Yu LY Zhu LH Wang WP et al. Intramuscular injection of interleukin-10 plasmid DNA prevented autoimmune diabetes in mice. Acta Pharmacol Sin 2003 24 751 6.
17. Zhang ZL Lin B Yu LY Shen SX Zhu LH Wang WP et al. Gene therapy of experimental autoimmune thyroiditis mice by in vivo administration of plasmid DNA coding for human inter leukin-10. Acta Pharmacol Sin 2003 24 885 90.
18. Lindsay JO Ciesielski CJ Scheinin T Brennan FM Hodgson HJ. Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis. Gut 2003 52 981 7.
19. Andersen SR Lambrecht LJ Swan SK Cutler DL Radwanski E Affrime MB et al. Disposition of recombinant human interleukin-10 in subjects with various degrees of renal function. J Clin Pharmacol 1999 39 1015 20.
20. Meng X Sawamura D Tamai K Hanada K Ishida H Hashimoto I. Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes in hibits contact hypersensitivity at distant areas of the skin. J Clin Invest 1998 101 1462 7.
21. Yao HW Li J Chen JQ Xu SY. Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats. Acta Pharmacol Sin 2004 25 915 20.
22. Molnar MJ Gilbert R Lu Y Liu AB Guo A Larochelle N et al. Factors influencing the efficacy, longevity, and safety of electro-poration-assisted plasmid-based gene transfer into mouse muscles. Mol Ther 2004 10 447 55.
23. Lehr HA Van der Loos CM Teeling P Gown AM. Complete chromogen separation and analysis in double immunohistochemical stains using Photoshop-based image analysis. J Histochem Cytochem 1999 47 119 26.
24. Vergnes L Phan J Strauss M Tafuri S Reue K. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 2003 278 42774 84.
25. Hung KS Lee TH Chou WY Wu CL Cho CL Lu CN et al. Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice. Biochem Biophys Res Commun 2005 336 324 31.
26. Kossakowska AE Edwards DR Lee SS Urbanski LS Stabbler AL Zhang CL et al. Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. Am J Pathol 1998 153 1895 902.
27. Wang CH Chen YJ Lee TH Chen YS Jawan B Hung KS et al. Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice. J Biomed Sci 2004 11 571 8.
28. Wang CH Jawan B Lee TH Hung KS Chou WY Lu CN et al. Single injection of naked plasmid encoding α-melanocyte-stimulating hormone protects against thioacetamide-induced acute liver failure in mice. Biochem Biophys Res Commun 2004 322 153 61.
29. Constandinou C Henderson N Iredale JP. Modeling liver fibro sis in rodents. Methods Mol Med 2005 117 237 50.
30. Rojkind M Greenwel P. Animal models of liver fibrosis. Adv Vet Sci Comp Med 1993 37 333 55.
31. Di Vinicius I Baptista AP Barbosa AA Andrade ZA. Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats. Pathol Res Pract 2005 201 449 56.
32. Pestka S Krause CD Sarkar D Walter MR Shi Y Fisher PB. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 2004 22 929 79.
33. Safadi R Ohta M Alvarez CE Fiel MI Bansal M Mehal WZ et al. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 2004 127 870 82.
34. Reitamo S Remitz A Tamai K Uitto J. Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts. J Clin Invest 1994 94 2489 92.
35. Claria J. Cyclooxygenase-2 biology. Curr Pharm Des 2003 9 2177 90.
36. Planaguma A Claria J Miquel R Lopez-Parra M Titos E Masferrer JL et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. FASEB J 2005 19 1120 2.
37. Mohammed NA Abd El Aleem SA El-Hafiz HA McMahon RF. Distribution of constitutive (COX-1) and inducible (COX-2) cyclooxygenase in postviral human liver cirrhosis: a possible role for COX-2 in the pathogenesis of liver cirrhosis. J Clin Pathol 2004 57 350 4.
38. Sung YK Hwang SY Kim JO Bae HI Kim JC Kim MK. The correlation between cyclooxygenase-2 expression and hepato-cellular carcinogenesis. Mol Cells 2004 17 35 8.
39. Bae SH Jung ES Park YM Kim BS Kim BK Kim DG Ryu WS. Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. Clin Cancer Res 2001 7 1410 8.
40. Berg DJ Zhang J Lauricella DM Moore SA. IL-10 is a central regulator of cyclooxygenase-2 expression and prostaglandin production. J Immunol 2001 166 2674 80.
41. Giron-Gonzalez JA Martinez-Sierra C Rodriguez-Ramos C Rendon P Macias MA Fernandez-Gutierrez C et al. Adhesion molecules as a prognostic marker of liver cirrhosis. Scand J Gastroenterol 2005 40 217 24.
42. Burra P Hubscher SG Shaw J Elias E Adams DH. Is the intercellular adhesion molecule-1/leukocyte function associated antigen 1 pathway of leukocyte adhesion involved in the tissue damage of alcoholic hepatitis Gut 1992 33 268 71.
43. Simeonova PP Gallucci RM Hulderman T Wilson R Kommineni C Rao M et al. The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride. Toxicol Appl Pharmacol 2001 177 112 20.
44. Ip E Farrell G Hall P Robertson G Leclercq I. Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 2004 39 1286 96.
45. Kawachi S Jennings S Panes J Cockrell A Laroux FS Gray L et al. Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice. Am J Physiol Gastrointest Liver Physiol 2000 278 G734 43.
46. Deng J Kohda Y Chiao H Wang Y Hu X Hewitt SM et al. Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int 2001 60 2118 28.
47. Bode W Fernandez-Catalan C Tschesche H Grams F Nagase H Maskos K. Structural properties of matrix metalloproteinases. Cell Mol Life Sci 1999 55 639 52.
48. Wielockx B Lannoy K Shapiro SD Itoh T Itohara S Vandekerckhove J et al. Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy. Nat Med 2001 7 1202 8.
49. Chen TY Hsieh YS Yang CC Wang CP Yang SF Cheng YW et al. Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease. Clin Biochem 2005 38 632 8.
50. Parsons CJ Bradford BU Pan CQ Cheung E Schauer M Knorr A et al. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 2004 40 1106 15.
51. Nie QH Cheng YQ Xie YM Zhou YX Cao YZ. Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis. World J Gastroenterol 2001 7 363 9.
52. Zheng WD Zhang LJ Shi MN Chen ZX Chen YX Huang YH et al. Expression of matrix metalloproteinase-2 and tissue in hibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10. World J Gastroenterol 2005 11 1753 8.