A safety study of oral tangeretin and xanthohumol administration to laboratory mice

In Vivo

Volumn 19, Issue 1, 2005, Pages 103-108

  Vanhoecke, Barbara W ^a   Delporte, Femke ^a   Van Braeckel, Eva ^a   Heyerick, Arne ^b   Depypere, Herman T ^a   Nuytinck, Margareta ^c   De Keukeleire, Denis ^b   Bracke, Marc E ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Laboratory M Nuytinck   (Belgium)

Author keywords

Flavonoid; Mice; Tangeretin; Xanthohumol

Indexed keywords

ALKALINE PHOSPHATASE; AMYLASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; CALCIUM; CARBOHYDRATE; CHALCONE DERIVATIVE; CHOLESTEROL; CREATINE KINASE; CREATININE; CYANOCOBALAMIN; ESTRADIOL; FLAVONOID; GLUCOSE; HYDROCORTISONE; LACTATE DEHYDROGENASE; LIOTHYRONINE; MAGNESIUM; NITROGEN; PHOSPHORUS; PROGESTERONE; PROTEIN; PROTEIN KINASE; TANGERETIN; THYROXINE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; URIC ACID; XANTHOHUMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; BONE MARROW TOXICITY; CANCER CHEMOTHERAPY; CARBOHYDRATE METABOLISM; CITRUS FRUIT; CONTROLLED STUDY; DOSE RESPONSE; DRUG FATALITY; DRUG MECHANISM; DRUG SAFETY; DRUG STABILITY; DRUG TARGETING; EXOCRINE GLAND; FEMALE; HEMATOLOGICAL PARAMETERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMULUS LUPULUS; IN VIVO STUDY; KIDNEY CORTEX; LEUKOPENIA; LIPID METABOLISM; LIVER TOXICITY; LYMPHOCYTOPENIA; METABOLIC DISORDER; MOUSE; MUSCLE DISEASE; NEPHROTOXICITY; NONHUMAN; OVARY DISEASE; PANCREAS DISEASE; PRENYLATION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; THYROID DISEASE; UREA NITROGEN BLOOD LEVEL;

EID: 16244387343     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K and van Leeuwen PAM: Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74: 418-425, 2001.
2. Brownson DM, Azios NG, Fuqua BK, Dharmawardhane SF and Mabry TJ: Flavonoid effects relevant to cancer. J Nutr 132: 3482S-3489S, 2002.
3. Middleton E Jr, Kandaswami C and Theoharides TC: The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751, 2000.
4. Mojzisova G and Kuchta M: Dietary flavonoids and risk of coronary heart disease. Physiol Res 50: 529-535, 2001.
5. Yang CS, Landau JM, Huang M-T and Newmark HL: Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 21: 381-406, 2001.
6. Frigo DE, Duong BN, Melnik LI, Schief LS, Collins-Burow BM, Pace DK, McLachlan JA and Burow ME: Flavonoid phytochemicals regulate activator protem-1 signal transduction pathways in endometrial and kidney stable cell lines. J Nutr 132: 1848-1853, 2002.
7. Yang EB, Guo YJ, Zhang K, Chen YZ and Mack P: Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives. Biochim Biophys Acta 1550: 144-152, 2001.
8. Le Marchand L: Cancer preventive effects of flavonoids - a review. Biomed Pharmacother 56: 296-301, 2002.
9. Siess M-H, Le Bon A-M, Canivenc-Lavier M-C and Suschetet M: Mechanisms involved in the chemoprevention of flavonoids. Biofactors 12: 193-199, 2000.
10. Wang HK: The therapeutic potential of flavonoids. Expert Opin Investig Drugs 9: 2103-2119, 2000.
11. Lopez-Lazaro M: Flavonoids as anticancer agents: structure-activity relationship study. Curr Med Chem Anti-Canc Agents 2: 691-714, 2002.
12. Bracke ME, Boterberg T, Depypere HT, Stove C, Leclercq G and Mareel MM: The citrus methoxyflavone tangeretin affects human cell-cell interactions. In: Buslig B, Manthey J (eds). Flavonoids in Cell Function, Kluwer Academic/Plenum Publishers, New York, pp. 135-139, 2002.
13. Stevens JF and Page JE: Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 65: 1317-1330, 2004.
14. Boldt S, Weidle UH and Kolch W: The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis 23: 1831-1838, 2002.
15. Osada S and Saji S: New approach to cancer therapy: the application of signal transduction to anti-cancer drug. Curr Med Chem Anti-Canc Agents 3: 119-131, 2003.
16. Hommes DW, Peppelenbosch MP and van Deventer SJH: Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52: 144-151, 2003.
17. Bracke ME, Depypere HT, Boterberg T, Van Marck VL, Vennekens KM, Vanluchene E, Nuytinck M, Serreyn R and Mareel MM: Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. J Natl Cancer Inst 91: 354-359, 1999.
18. Mak NK, Wong-Leung YL, Chan SC, Wen J, Leung KN and Fung MC: Isolation of anti-leukemia compounds from Citrus reticulata. Life Sci 58: 1269-1276, 1996.
19. De Keukeleire J, Ooms G, Heyerick A, Roldan-Ruiz I, Van Bockstaele E and De Keukeleire D: Formation and accumulation of alpha-acids, β-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.). J Agric Food Chem 51: 4436-4441, 2003.
20. Delaney B, Phillips K, Buswell D, Mowry B, Nickels D, Cox D, Wang HB and Manthey J: Immunotoxicity of a standardized citrus polymethoxylated flavone extract. Food Chem Toxicol 39: 1087-1094, 2001.
21. Holden HT, Herberman RB, Santoni A and Nunn ME: Natural cell-mediated cytotoxicity in nude mice. In: Houchens DP, Ovejera AA (eds). Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research, Gustav Fisher, New York, Stuttgart, pp. 81-92, 1978.
22. Amos RJ: Investigation of megaloblastic anaemia. In: Lewis SM, Bain BJ, Bates I (eds). Dacie and Lewis Practical Haematology, Ninth Edition, Churchill Livingstone, London, pp. 129-148, 2001.
23. Tolman KG and Rej R: Liver function. In: Burtis CA, Ashwood ER (eds). Tietz Textbook of Clinical Chemistry, WB Saunders Company, Philadelphia, Third Edition, pp. 1125-1177, 1999.
24. Tietz NW (ed): Clinical Guide to Laboratory Tests, Third Edition, WB Saunders Company, Philadelphia, 1995.
25. McNeely MDD: Pancreatic function. In: Kaplan LA, Pesce AJ (eds). Clinical Chemistry. Theory, Analysis, and Correlation, The CV Mosby Company, St Louis, Missouri, pp. 460-467, 1984.
26. Hartmann AE: Nitrogen metabolites and renal function. In McClatchey KD (ed). Clinical Laboratory Medicine, Williams & Wilkins, Baltimore, pp. 371-385, 1994.
27. Unger RH and Foster DW: Diabetes mellitus. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds). Williams Textbook of Endocrinology, WB Saunders Company, Philadelphia, Ninth Edition, pp. 973-1059, 1998.
28. Kurowska EM and Borradaile NM: Regulation of cholesterol metabolism by citrus juices and their flanonoids. In: Annals of the 23rd IFU Symposium, Havana, Cuba, February 7-13, pp. 340-348, 2000.
29. Stroheker T, Chagnon M-C, Pinnert M-F, Berges R and Canivenc-Lavier M-C: Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. Reprod Toxicol 17: 421-432, 2003.
30. Milligan SR, Kalita JC, Heyerick A, Rong H, De Cooman L and De Keukeleire D: Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 84: 2249-2252, 1999.
31. Hayssen V, van Tienhoven A and van Tienhoven A: Asdell's Patterns of Mammalian Reproduction. A Compendium of Species-Specific Data. Cornell University Press, New York, 1993.
32. Seifer DB and Speroff L (eds): Clinical Gynecologic Endocrinology and Infertility, Second Edition, Lippincott Williams & Wilkins, Philadelphia, 1999.
33. Hennemann G (ed): Thyroid Hormone Metabolism. Marcel Dekker, Inc, New York, 1986.
34. Widmer WW and Montanari AM: The potential for citrus phytochemicals in hypernutritious foods. In: Finley JW, Armstrong DJ, Nagy S, Robinson SF (eds). Hypernutritious Foods, Agscience, Inc, Auburndale, Florida, pp. 75-89, 1996.
35. Stevens JF, Taylor AW, Clawson JE and Deinzer ML: Fate of xanthohumol and related prenylflavonoids from hops to beer. J Agric Food Chem 47: 2421-2428, 1999.
36. Hirano T, Abe K, Gotoh M and Oka K: Citrus flavone tangeretin inhibits leukemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 72 1380-1388, 1995.
37. Ishiwa J, Sato T, Mimaki Y, Sashida Y, Yano M and Ito A: A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. J Rheumatol 27: 20-25, 2000.
38. Mareel M, Berx G, Van Roy F and Bracke M: Cadherin/catenin complex: a target for antiinvasive therapy? J Cell Biochem 61: 524-530, 1996.