Targeting of the Akt-nuclear factor-κB signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma

Molecular Pharmacology

Volumn 76, Issue 5, 2009, Pages 957-968

  Omar, Hany A ^a   Sargeant, Aaron M ^a   Weng, Jing Ru ^b   Wang, Dasheng ^a   Kulp, Samuel K ^a   Patel, Tushar ^a   Chen, Ching Shih ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CHLORO 3 NITROBENZENESULFONYL) 1H INDOL 3 YL METHANOL; 3 INDOLEMETHANOL; ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; OSU A9; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL VIABILITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER METASTASIS; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; THERAPY RESISTANCE; XENOGRAFT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; INDOLES; LIVER NEOPLASMS, EXPERIMENTAL; METHANOL; MICE; MICE, NUDE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70350438403     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.058180     Document Type: Article

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