Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats

Journal of Biochemistry and Molecular Biology

Volumn 39, Issue 6, 2006, Pages 656-661

  Mansour, Heba Hosny ^a   Hafez, Farouk ^b   Fahmy, Nadia Mohamed ^a  

^a NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Cisplatin; Hepatotoxicity and nitric oxide; Silymarin

Indexed keywords

ANIMALIA;

EID: 33845406305     PISSN: 12258687     EISSN: 12258687     Source Type: Journal    
DOI: 10.5483/bmbrep.2006.39.6.656     Document Type: Article

References (48)

1. Abu Ghadeer, A. R., Ali, S. E., Osman, S. A., Abu Bedair, F. A., Abbady, M. M. and El-Kady, M. R. (2001) Antagonistic role of silymarin against cardiotoxicity and impaired antioxidant induced by adriamycin and/or radiation exposure in albino rats. Pakistan J. Biol. Sci. 4, 604-607.
2. Ahmed, B., Khan, S. A. and Alam, T. (2003) Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1, 4-dioxane ring system. Pharmazie. 58, 173-176.
3. Antunes, G. L. M., Darin, J. D. and Bianchi, M. D. (2000) Protective effects of vitamin C against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacol. Res. 41, 405-411.
4. Borsari, M., Gabbi, C., Ghelfi, F., Grandi, R., Saladini, M., Seven, S. and Borella, F. (2001) Silybin, a new iron-chelating agent. J. Inorg. Biochem. 85, 123-129.
5. Buege, J. A. and Aust, S. D. (1978) Microsomal lipid peroxidation. Methods Enzymol. 52, 302-310.
6. Chavez, E. and Bravo, C. (1988) Silymarin-induced mitochondrial Ca2+ release. Life Sci 43, 975-981.
7. Crocenzi, F. A., Sanchez Pozzi, E. J., Pellegrino, J. M., Rodriguez Garay, E. A., Mottino, A. D. and Roma, M. G. (2003) Preventive effect of silymarin against taurolithocholate-induced cholestasis in the rat. Biochem. Pharmacol. 66, 355-364.
8. Curran, R. D., Ferrari, F. K., Kispert, P. H., Stadler, J., Stuehr, D. J., Simmons, R. L. and Billiar, T. R. (1991) Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. FASEB J. 5, 2085-2092.
9. Dubskaia, T. L. U., Vetoshkina, T. V. and Gol'dberg, V. E. (1994) The mechanisms of the hepatotoxicity of complex platinum compounds. Eksp. Klin. Farmakol. 57, 38-41.
10. Ellman, G L. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys. 17, 214-226.
11. Emerit, J., Beaumont, C. and Trivin, F. (2001) Iron metabolism, free radicls and oxidative injury. Biomed Pharmacother, 55, 333-339.
12. Grau, J. J., Estape, J., Cuchi, M. A., Firvida, J. L., Blanch, J. L. and Ascaso, C. (1996) Calcium supplementation and ototoxicity in patients receiving cisplatin. Er. J. Clin. Pharmacol. 42, 233-235.
13. Hakova, H., Misurova, E. and Kropacova, R. (1996) The effect of silymarin on the concentration and total content of nucleic acids in tissues of continuously irradiated rats. Vet. Med. (Praha) 41, 113-119.
14. Hasegawa, T., Kaneko, F. and Niwa, Y. (1992) Changes in lipid peroxide levels and activity of reactive oxygen scavenging enzymes in skin, serum and liver following UVB irradiation in mice. Life Sci. 50, 1893-1903.
15. Ignarro, L., Buga, G., Wood, K., Byrns, R. E. and Chaudhuri, G. (1987) Endothelium-derived relaxing factor produced and released from artery and veins is nitric oxide. Proc. Nat. Acad. Sci. 84, 9265-9269.
16. Kadikoylu, G., Bolaman, Z., Demir, S., Balkaya, M., Akalin, N. and Enli, Y. (2004) The effects of desferrioxamine on cisplatin-induced lipid peroxidation and the activities of antioxidant enzymes in rat kidneys. Hum Exp Toxicol. 23, 29-34.
17. Kang, J. S., Jeon, Y. J., Park, S. K., Yang, K. H. and Kim, H. M. (2004) Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1 beta and prostaglandin E2 synthesis by silymarin. Biochem. Pharmacol. 67, 175-181.
18. Kim, S. H., Hong, K. O., Chung, W. Y., Hwang, J. K. and Park, K. K. (2004) Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription. Toxicol. Appl. Pharmacol. 196, 346-355.
19. Klukowska, L., Nadulska, A. and Dyba, S. (2001) The influence of cisplatinum and goserelinum on the magnesium and calcium level in rat serum. Ann. Univ. Mariae Curie Sklodowska [Med]. 56, 483-486.
20. Koc, A., Duru, M., Ciralik, H., Akcan, R. and Sogut, S. (2005): Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats. Mol. Cell Biochem. 278, 79-84.
21. Laekeman, G., De Coster, S., De Meyer, K. and Leuven, K. U. (2003) St. Mary's Thistle: an overview. J. Pharm. Belg. 58, 28-31.
22. Lawrence, R. A. and Burk, R. F. (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71, 952-958.
23. Lee, T. Y., Mai, L. M., Wang, G. J., Chiu, J. H., Lin, Y. L. and Lin, H. C. (2003) Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats. J. Pharmacol. Science 91, 202-210.
24. Medina, J. and Moreno-Otero, R. (2005) Pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs 65, 2445-2461.
25. Mereish, K. A., Bunner, D. L., Regland, D. R. and Creasia, D. A. (1991) Protection against microcystin-L. R. induced hepatotoxicity by silymarin: biochemistry, histopathology and lethality. Pharmacol. Res. 8, 257-277.
26. Minami, M. and Yoshikawa, H. (1979) A simplified assay method of Superoxide dismutase activity for clinical use. Clin. Chim. Acta 92, 337-342.
27. Mira, L., Silva, M. and Manso, C. F. (1994) Scavenging of reactive oxygen species by silibin dihemisuccinate. Biochem. Pharmacol. 48, 753-759.
28. Naveau S. (2001) Acute alcoholic hepatitis treatments. Press Med. 30, 1024-1030.
29. Pratibha, R., Sameer, R., Rataboli, P. V., Bhiwgade, D. A. and Dhume, C. Y. (2006) Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats. Eur. J. Pharmacol. 532, 290-293.
30. Ramadan, L. A., El-Habit, O. H., Arafa, H. and Sayed-Ahmed, M. M. (2001) Effect of cremophor-el on cisplatin-induced organ toxicity in normal rat. J. Egyptian Nat. Cancer Inst. 13, 139-145.
31. Ramadan, L., Roushdy, H. M., Abu Senna, G. M., Amin, N. E. and El-Deshw, O. A. (2002) Radioprotectve effect of silymarin against radiation induced hepatotoxicity. Pharmacol. Res. 45, 447-452.
32. Reitman, S. and Frankel, S. A. (1957) A colourimetric method for the determination of serum oxaloaetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28, 56-63.
33. Rhoden, E. L., Lucas, M. L., Pereira-Lima, L., Rhoden, C. R. and Souto, C. A. (2001) Effects of L-arginine on the kidney levels of malondialdehyde in rats submitted to renal ischaemia-reperfusion. BJU Int. 88, 273-277.
34. Saad, S. Y., Najyar, T. A. and Alashari, M. (2004) Role of non-selective adenosine receptor blockade and phosphodiesterase inhibition in cisplatin-induced nephrogonadal toxicity in rats. Clin. Exp. Pharmacol Physiol. 31, 862-867.
35. Saad, S. Y., Najjar, T. A., Daba, M. H. and Al-Rikabi, A. C. (2002) Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine. Chemotherapy 48, 309-315.
36. Saad, S. Y., Najjar, T. A., Noreddin, A. M. and Al-Rikabi, A. C. (2001) Effects of gemcitabine on cisplatin-induced nephrotoxicity in rats: schedule-dependent study. Pharmacol. Res, 43, 193-198.
37. Sayed-Ahmed, M. M., Khattab, M. M., Gad, M. Z. and Osman, A. M. (2004) Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy. Pharmacol. Toxicol. 89, 140-144.
38. Singh, R. P. and Agarwal, R. (2002) Flavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal. 4, 655-663.
39. Son, K. (1997) Cisplatin-based Interferon gamma gene-therapy of murine ovarian carcinoma. Cancer Gene Ther, 4, 391-396.
40. Son, K. and Kim, Y. M. (1995) In vivo cisplatin-exposed macrophages increase immunostimulant-induced nitric oxide synthesis for tumor synthesis for tumor cell killing. Cancer Res. 55, 5524-5527.
41. Soto, C., Recoba, R., Barron H., Alvarez, C. and Favari, L. (2003) Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 136, 205-212.
42. Valenzuela, A., Monica, A., Soledad, V. and Ricardo, G. (1989) Selectivity of silymarin on the increase of the glutathione content in different tissues of the rats. Planta Med. 55, 420-422.
43. Wang, G., Reed, E. and Li, Q. Q. (2004) Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer. Oncol. Rep. Nov. 12, 955-965.
44. Wink, A. D., Cook, J. A., Christodoulou, D., Krishna, M. C., Pacelli, R., Kim S., DeGraff, W., Gamson, J., Vodovotz, Y., Russo, A. and Mitchell, J. B. (1997) Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin. Nitric Oxide 1, 88-94.
45. Wrenn, H. T. and Feichtmeir, T. V. (1956) The quantitation of albumin based on dye linear binding capacity. Am. J. Clin. Pathol 26, 960-968.
46. Yilmaz, H. R., Sogut, S., Ozyut, B., Ozugurlu, F., Sahin, S., Isik, B., Uz, E. and Ozyurt, H. (2005) The activities of liver adenosine deaminase, xanthine oxidase, catalase, Superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester. Toxicol. Ind. Health 213, 67-73.
47. Zhang, J. and Lindup, W. E. (1996) Cisplatin-induced nephrotoxicity in vitro: increase in cystolic calcium concentration and the inhibition of cystolic and mitochondrial protein kinase C. Toxicol. Lett. 89, 11-17.
48. Zicca, A., Cafaggi, S., Mariggio, M. A., Vannozzi, M. O., Ottone, M., Bocchini, V., Caviglioli, G. and Viale, M. (2004) Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats. Ew. J. Pharmacol. 442, 265-272.