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Volumn 18, Issue 3, 2015, Pages 290-298

Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl4-treated rats

Author keywords

liver fibrosis; oxidative stress; Silymarin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; LACTIC ACID; SILYMARIN; SUNFLOWER OIL; ACTIN; ANTIOXIDANT; PLANT EXTRACT; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84924101723     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2013.0179     Document Type: Article
Times cited : (79)

References (36)
  • 1
    • 84924110964 scopus 로고    scopus 로고
    • Mechanism of liver injury
    • Schiff ER, Sorrell MF, Maddrey WC, eds.). Lippincott Williams & Wilkins, Philadelphia
    • Malhi H, Gores GJ. Mechanism of liver injury. In Schiff's Diseases of the liver, Vol.1. (Schiff ER, Sorrell MF, Maddrey WC, eds.). Lippincott Williams & Wilkins, Philadelphia, 2007, pp. 313-324
    • (2007) Schiff's Diseases of the Liver , vol.1 , pp. 313-324
    • Malhi, H.1    Gores, G.J.2
  • 2
    • 0035966059 scopus 로고    scopus 로고
    • Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway
    • Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem 2001;276:49077-49082
    • (2001) J Biol Chem , vol.276 , pp. 49077-49082
    • Faouzi, S.1    Burckhardt, B.E.2    Hanson, J.C.3    Campe, C.B.4    Schrum, L.W.5    Rippe, R.A.6    Maher, J.J.7
  • 3
    • 0002527906 scopus 로고    scopus 로고
    • Hepatic fibrosis
    • Schiff ER, Sorrell MF, Maddrey WC, eds.). Lippincott Williams & Wilkins, Philadelphia
    • Friedman SL. Hepatic fibrosis. In Schiff's Diseases of the Liver, Vol.1. (Schiff ER, Sorrell MF, Maddrey WC, eds.). Lippincott Williams & Wilkins, Philadelphia, 2007, pp. 395-410
    • (2007) Schiff's Diseases of the Liver , vol.1 , pp. 395-410
    • Friedman, S.L.1
  • 4
    • 84855833416 scopus 로고    scopus 로고
    • Silymarin in the prevention and treatment of liver diseases and primary liver cancer
    • Féher J, Lengyel G. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol 2012;13:210-217
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 210-217
    • Féher, J.1    Lengyel, G.2
  • 5
    • 79957833378 scopus 로고    scopus 로고
    • Silybin and the liver: From basic research to clinical practice
    • Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J gastroenterol 2011;17:2288-2301
    • (2011) World J Gastroenterol , vol.17 , pp. 2288-2301
    • Loguercio, C.1    Festi, D.2
  • 7
    • 80455173913 scopus 로고    scopus 로고
    • Improved antifibrotic effect of a combination of verapamil and silymarin in rat-induced liver fibrosis
    • Shafik AN, Khodeir MM, Gouda NA, Mahmoud ME. Improved antifibrotic effect of a combination of verapamil and silymarin in rat-induced liver fibrosis. Arab J Gastroenterol 2011;12:143-149
    • (2011) Arab J Gastroenterol , vol.12 , pp. 143-149
    • Shafik, A.N.1    Khodeir, M.M.2    Gouda, N.A.3    Mahmoud, M.E.4
  • 8
    • 84859429176 scopus 로고    scopus 로고
    • Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis
    • Chen IS, Chen YC, Chou CH, Chuang RF, Sheen LY, Chiu CH. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. J Sci Food 2012;92:1441-1447
    • (2012) J Sci Food , vol.92 , pp. 1441-1447
    • Chen, I.S.1    Chen, Y.C.2    Chou, C.H.3    Chuang, R.F.4    Sheen, L.Y.5    Chiu, C.H.6
  • 9
    • 18744393745 scopus 로고    scopus 로고
    • Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: Effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid
    • Muriel P, Moreno MG, Hernández Mdel C, Chávez E, Alcantar LK. Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid. Basic Clin Pharmacol Toxicol 2005;96:375-380
    • (2005) Basic Clin Pharmacol Toxicol , vol.96 , pp. 375-380
    • Muriel, P.1    Moreno, M.G.2    Hernández Mdel, C.3    Chávez, E.4    Alcantar, L.K.5
  • 10
    • 0034859659 scopus 로고    scopus 로고
    • Silymarin: A review of its clinical properties in the management of hepatic disorders
    • Wellington K, Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 2001;15: 465-489
    • (2001) Bio Drugs , vol.15 , pp. 465-489
    • Wellington, K.1    Jarvis, B.2
  • 13
    • 84858081591 scopus 로고    scopus 로고
    • Transient oxidative stress and inflammation after intraperitoneal administration of multiwalled carbon nanotubes functionalized with single strand DNA in rats
    • Clichici S, Biris AR, Tabaran F, Filip A. Transient oxidative stress and inflammation after intraperitoneal administration of multiwalled carbon nanotubes functionalized with single strand DNA in rats. Toxicol Appl Pharmacol 2012;259:281-292
    • (2012) Toxicol Appl Pharmacol , vol.259 , pp. 281-292
    • Clichici, S.1    Biris, A.R.2    Tabaran, F.3    Filip, A.4
  • 14
    • 0017797324 scopus 로고
    • Optimization of methods for aspartate aminotransferase and alanine aminotransferase
    • Bergmeyer HU, Scheibe P, Wahlefeld AW. Optimization of methods for aspartate aminotransferase and alanine aminotransferase. Clin Chem 1978;24:58-73
    • (1978) Clin Chem , vol.24 , pp. 58-73
    • Bergmeyer, H.U.1    Scheibe, P.2    Wahlefeld, A.W.3
  • 15
    • 0014060889 scopus 로고
    • Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-topyruvate assays
    • Krieg AF, Rosenblum LJ, Henry JB. Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-topyruvate assays. Clin Chem 1967;13:196-203
    • (1967) Clin Chem , vol.13 , pp. 196-203
    • Krieg, A.F.1    Rosenblum, L.J.2    Henry, J.B.3
  • 16
  • 17
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 18
    • 0026046598 scopus 로고
    • Improved fluorimetric determination of malondialdehyde
    • Conti M, Moran PC, Levillain P. Improved fluorimetric determination of malondialdehyde. Clin Chem 1991;37:1273-1275
    • (1991) Clin Chem , vol.37 , pp. 1273-1275
    • Conti, M.1    Moran, P.C.2    Levillain, P.3
  • 19
    • 0028239163 scopus 로고
    • Oxidative damage to proteins spectrophotometric method for carbonyl assay
    • Reznick AZ, Packer L. Oxidative damage to proteins spectrophotometric method for carbonyl assay. Meth Enzymol 1994; 233:357-363
    • (1994) Meth Enzymol , vol.233 , pp. 357-363
    • Reznick, A.Z.1    Packer, L.2
  • 20
    • 57149110834 scopus 로고    scopus 로고
    • Glutathione metabolism under high-altitude stress and effect of antioxidant supplementation
    • Vats P, Singh VK, Singh SN, Singh SB. Glutathione metabolism under high-altitude stress and effect of antioxidant supplementation. Aviat Space Environ Med 2008;79:1106-1111
    • (2008) Aviat Space Environ Med , vol.79 , pp. 1106-1111
    • Vats, P.1    Singh, V.K.2    Singh, S.N.3    Singh, S.B.4
  • 23
    • 84884525706 scopus 로고    scopus 로고
    • Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer
    • Su CH, Chen LJ, Liao JF, Cheng JT. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. J Med Food 2013;16:778-784
    • (2013) J Med Food , vol.16 , pp. 778-784
    • Su, C.H.1    Chen, L.J.2    Liao, J.F.3    Cheng, J.T.4
  • 24
    • 36849068081 scopus 로고    scopus 로고
    • Hepatoprotective effect of hygrophila spinosa and cassia occidentalis on carbon tetrachloride induced liver damage in experimental rats
    • Usha K, Hemalatha P. Hepatoprotective effect of hygrophila spinosa and cassia occidentalis on carbon tetrachloride induced liver damage in experimental rats. Indian J Clin Biochem 2007; 22:132-135
    • (2007) Indian J Clin Biochem , vol.22 , pp. 132-135
    • Usha, K.1    Hemalatha, P.2
  • 25
    • 34548385362 scopus 로고    scopus 로고
    • Hepatic stellate cells and oxidative stress
    • Urtasun R, Nieto N. Hepatic stellate cells and oxidative stress. Rev Esp Enferm Dig 2007;99:223-230
    • (2007) Rev Esp Enferm Dig , vol.99 , pp. 223-230
    • Urtasun, R.1    Nieto, N.2
  • 26
    • 33845642594 scopus 로고    scopus 로고
    • Oxidative-stress and IL-6 mediate the fibrogenic effects of Kupffer cells on stellate cells
    • Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of Kupffer cells on stellate cells. Hepatology 2006;44:1487-1501
    • (2006) Hepatology , vol.44 , pp. 1487-1501
    • Nieto, N.1
  • 28
    • 59649110954 scopus 로고    scopus 로고
    • Non invasive assessment of liver fibrosis
    • Yeshua H, Oren R. Non invasive assessment of liver fibrosis. Ann Transplant 2008;13:5-11
    • (2008) Ann Transplant , vol.13 , pp. 5-11
    • Yeshua, H.1    Oren, R.2
  • 29
    • 80755133394 scopus 로고    scopus 로고
    • Comparison of early treatment with low doses of nilotinib, imatinib and a clinically relevant dose of silymarin in thioacetamide-induced liver fibrosis
    • Shaker ME, Shiha GE, Ibrahim TM. Comparison of early treatment with low doses of nilotinib, imatinib and a clinically relevant dose of silymarin in thioacetamide-induced liver fibrosis. Eur J Pharmacol 2011;670:593-600
    • (2011) Eur J Pharmacol , vol.670 , pp. 593-600
    • Shaker, M.E.1    Shiha, G.E.2    Ibrahim, T.M.3
  • 30
    • 79956057029 scopus 로고    scopus 로고
    • Aminoguanidine potentiates the hepatoprotective effect of silymarin in CCL4 treated rats
    • Ahmed AF, Mahmoud MF, Ouf MA, El-Fathaah EA. Aminoguanidine potentiates the hepatoprotective effect of silymarin in CCL4 treated rats. Ann Hepatol 2011;10:207-215
    • (2011) Ann Hepatol , vol.10 , pp. 207-215
    • Ahmed, A.F.1    Mahmoud, M.F.2    Ouf, M.A.3    El-Fathaah, E.A.4
  • 31
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2006;124:491-504
    • (2006) Indian J Med Res , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 32
    • 13744261157 scopus 로고    scopus 로고
    • Mac the knife? Macrophages-the double-edged sword of hepatic fibrosis
    • Friedman SL. Mac the knife? Macrophages-the double-edged sword of hepatic fibrosis. J Clin Invest 2005;115:29-32
    • (2005) J Clin Invest , vol.115 , pp. 29-32
    • Friedman, S.L.1
  • 34
    • 0036139102 scopus 로고    scopus 로고
    • Stimulation and proliferation of primary rat hepatic stellate cellsy cytochrome P450 2E1-derived reactive oxygen species
    • Nieto N, Friesdman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cellsy cytochrome P450 2E1-derived reactive oxygen species. Hepatology 2002;35: 62-73
    • (2002) Hepatology , vol.35 , pp. 62-73
    • Nieto, N.1    Friesdman, S.L.2    Cederbaum, A.I.3
  • 35
    • 84865176650 scopus 로고    scopus 로고
    • Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: Analysis of isolated hepatic stellate cells
    • Kim M, Yang SG, Kim JM, Lee JW, Kim YS, Lee JI. Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: analysis of isolated hepatic stellate cells. Int J Mol Med 2012;30:473-479
    • (2012) Int J Mol Med , vol.30 , pp. 473-479
    • Kim, M.1    Yang, S.G.2    Kim, J.M.3    Lee, J.W.4    Kim, Y.S.5    Lee, J.I.6
  • 36
    • 0037383495 scopus 로고    scopus 로고
    • A comparison in the progression of liver fibrosis in chronic hepatitisCbetween persistently normal and elevated transaminase
    • Hui CK, Belaye T,Montegrande K,Wright TL: A comparison in the progression of liver fibrosis in chronic hepatitisCbetween persistently normal and elevated transaminase. J Hepatol 2003;38:511-517
    • (2003) J Hepatol , vol.38 , pp. 511-517
    • Hui, C.K.1    Belaye, T.2    Montegrande, K.3    Wright, T.L.4


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