Integrating structural and mutagenesis data to elucidate GPCR ligand binding

Current Opinion in Pharmacology

Volumn 30, Issue , 2016, Pages 51-58

  Munk, Christian ^a   Harpsøe, Kasper ^a   Hauser, Alexander S ^a   Isberg, Vignir ^a   Gloriam, David E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CP 376395; FASIGLIFAM; G PROTEIN COUPLED RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; LIGAND; LY 2119620; MAVOGLURANT; MK 0893; MUSCARINIC M2 RECEPTOR AGONIST; UNCLASSIFIED DRUG; DRUG; PROTEIN BINDING;

ALLOSTERISM; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG RECEPTOR BINDING; HUMAN; LIGAND BINDING; MUTAGENESIS; MUTANT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; REVIEW; SEQUENCE ALIGNMENT; SYSTEMATIC REVIEW; ALLOSTERIC SITE; CHEMISTRY; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; BINDING SITES; DRUG DESIGN; HUMANS; LIGANDS; MUTAGENESIS; PHARMACEUTICAL PREPARATIONS; POINT MUTATION; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84979780638     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2016.07.003     Document Type: Review

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