Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors

Journal of Biological Chemistry

Volumn 290, Issue 5, 2015, Pages 2870-2878

  Kang, Hye Jin ^a   Wilkins, Angela D ^a   Lichtarge, Olivier ^a   Wensel, Theodore G ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES;

ALLOSTERIC SITE; COMPUTATIONAL APPROACH; COMPUTATIONAL DOCKINGS; EVOLUTIONARY TRACES; LIGAND SPECIFICITY; METABOTROPIC GLUTAMATE RECEPTORS; SEQUENCE VARIATIONS; STRUCTURAL ORIGIN;

LIGANDS;

GLUTAMIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 7; PHOSPHOSERINE; CALCIUM; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HINGE REGION; LIGAND BINDING; RECEPTOR BINDING; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BIOLOGY; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CALCIUM; COMPUTATIONAL BIOLOGY; EVOLUTION, MOLECULAR; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, METABOTROPIC GLUTAMATE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84921915382     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.622233     Document Type: Article

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