A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Nature Communications

Volumn 7, Issue , 2016, Pages

  Petit, Anne Elisabeth ^a   Demotte, Nathalie ^a   Scheid, Benoît ^b   Wildmann, Claude ^a   Bigirimana, Rene ^a   Gordon Alonso, Monica ^a   Carrasco, Javier ^c   Valitutti, Salvatore ^d   Godelaine, Daniele ^a   Van Der Bruggen, Pierre ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c Grand Hopital de Charleroi   (Belgium)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GALECTIN 3; GAMMA INTERFERON; GRANZYME B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PERFORIN; TUMOR NECROSIS FACTOR ALPHA; AMINOSUGAR; CYTOKINE; GALECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; N-ACETYLLACTOSAMINE;

CELLS AND CELL COMPONENTS; IMMUNOASSAY; PROTEIN; SECRETION; TUMOR;

ACTIN FILAMENT; ARTICLE; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL SPREADING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM; EXOCYTOSIS; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; INTERNALIZATION; INTRACELLULAR MEMBRANE; LYMPHOCYTE FUNCTION; MICROTUBULE ORGANIZING CENTER; MOLECULAR DOCKING; SECRETORY GRANULE; SIGNAL TRANSDUCTION; TUMOR ASSOCIATED LEUKOCYTE; CELL LINE; METABOLISM; SECRETION (PROCESS);

AMINO SUGARS; CELL ADHESION; CELL LINE; CYTOKINES; GALECTINS; HUMANS; IMMUNOLOGICAL SYNAPSES; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOCYTES, TUMOR-INFILTRATING; RECEPTORS, ANTIGEN, T-CELL;

EID: 84979626000     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12242     Document Type: Article

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