메뉴 건너뛰기




Volumn 1860, Issue 11, 2016, Pages 2416-2427

Interferon-alpha inhibits adipogenesis via regulation of JAK/STAT1 signaling

Author keywords

Adipogenesis; IFN ; JAK; STAT1

Indexed keywords

ALPHA INTERFERON; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIN DEPENDENT KINASE 2; JANUS KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN P21; SMALL INTERFERING RNA; STAT1 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84979243559     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2016.07.009     Document Type: Article
Times cited : (27)

References (49)
  • 1
    • 0031821520 scopus 로고    scopus 로고
    • Understanding adipocyte differentiation
    • [1] Gregoire, F.M., Smas, C.M., Sul, H.S., Understanding adipocyte differentiation. Physiol. Rev. 78 (1998), 783–809.
    • (1998) Physiol. Rev. , vol.78 , pp. 783-809
    • Gregoire, F.M.1    Smas, C.M.2    Sul, H.S.3
  • 2
    • 54749114466 scopus 로고    scopus 로고
    • It's not how fat you are, it's what you do with it that counts
    • [2] Virtue, S., Vidal-Puig, A., It's not how fat you are, it's what you do with it that counts. PLoS Biol. 6 (2008), 1819–1823.
    • (2008) PLoS Biol. , vol.6 , pp. 1819-1823
    • Virtue, S.1    Vidal-Puig, A.2
  • 3
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome—an allostatic perspective
    • [3] Virtue, S., Vidal-Puig, A., Adipose tissue expandability, lipotoxicity and the metabolic syndrome—an allostatic perspective. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1801 (2010), 338–349.
    • (2010) Biochim. Biophys. Acta Mol. Cell Biol. Lipids , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 5
    • 79954459509 scopus 로고    scopus 로고
    • Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis
    • [5] Arner, P., Arner, E., Hammarstedt, A., Smith, U., Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS One 6 (2011), 1–5.
    • (2011) PLoS One , vol.6 , pp. 1-5
    • Arner, P.1    Arner, E.2    Hammarstedt, A.3    Smith, U.4
  • 7
    • 0034537601 scopus 로고    scopus 로고
    • Secretory, endocrine and autocrine/paracrine function of the adipocyte
    • [7] Kim, S., Moustaid-Moussa, N., Secretory, endocrine and autocrine/paracrine function of the adipocyte. J. Nutr. 130 (2000), 3110–3115.
    • (2000) J. Nutr. , vol.130 , pp. 3110-3115
    • Kim, S.1    Moustaid-Moussa, N.2
  • 8
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-α function
    • [8] Uysal, K.T., Wiesbrock, S.M., Marino, M.W., Hotamisligil, G.S., Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389 (1997), 610–614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 9
    • 84873137994 scopus 로고    scopus 로고
    • The Adipose Tissue as an Endocrine Organ, Seminars in Nephrology
    • Elsevier
    • [9] Adamczak, M., Wiecek, A., The Adipose Tissue as an Endocrine Organ, Seminars in Nephrology. 2013, Elsevier, 2–13.
    • (2013) , pp. 2-13
    • Adamczak, M.1    Wiecek, A.2
  • 10
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • [10] Unger, R.H., Lipotoxic diseases. Annu. Rev. Med. 53 (2002), 319–336.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 11
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • [11] Unger, R.H., Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44 (1995), 863–870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 12
    • 33646934768 scopus 로고    scopus 로고
    • Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes
    • [12] Gustafson, B., Smith, U., Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J. Biol. Chem. 281 (2006), 9507–9516.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9507-9516
    • Gustafson, B.1    Smith, U.2
  • 13
    • 84884193931 scopus 로고    scopus 로고
    • Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies
    • [13] McArdle, M.A., Finucane, O.M., Connaughton, R.M., McMorrow, A.M., Roche, H.M., Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front. Endocrinol. (Lausanne) 4 (2013), 1–23.
    • (2013) Front. Endocrinol. (Lausanne) , vol.4 , pp. 1-23
    • McArdle, M.A.1    Finucane, O.M.2    Connaughton, R.M.3    McMorrow, A.M.4    Roche, H.M.5
  • 15
    • 84860514967 scopus 로고    scopus 로고
    • Interferon gamma inhibits adipogenesis in vitro and prevents marrow fat infiltration in oophorectomized mice
    • [15] Vidal, C., Bermeo, S., Li, W., Huang, D., Kremer, R., Duque, G., Interferon gamma inhibits adipogenesis in vitro and prevents marrow fat infiltration in oophorectomized mice. Stem Cells 30 (2012), 1042–1048.
    • (2012) Stem Cells , vol.30 , pp. 1042-1048
    • Vidal, C.1    Bermeo, S.2    Li, W.3    Huang, D.4    Kremer, R.5    Duque, G.6
  • 16
    • 84902590290 scopus 로고    scopus 로고
    • Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization
    • 98835.
    • [16] Ying, W., Kanameni, S., Chang, C.-A., Nair, V., Safe, S., Bazer, F.W., Zhou, B., Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization. PLoS One 9 (2014), 1–5, 98835.
    • (2014) PLoS One , vol.9 , pp. 1-5
    • Ying, W.1    Kanameni, S.2    Chang, C.-A.3    Nair, V.4    Safe, S.5    Bazer, F.W.6    Zhou, B.7
  • 17
    • 33646843411 scopus 로고    scopus 로고
    • IFN-α induces apoptosis of adipose tissue cells
    • [17] Birk, R.Z., Rubinstein, M., IFN-α induces apoptosis of adipose tissue cells. Biochem. Biophys. Res. Commun. 345 (2006), 669–674.
    • (2006) Biochem. Biophys. Res. Commun. , vol.345 , pp. 669-674
    • Birk, R.Z.1    Rubinstein, M.2
  • 18
    • 0033795196 scopus 로고    scopus 로고
    • Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
    • [18] Goodbourn, S., Didcock, L., Randall, R., Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J. Gen. Virol. 81 (2000), 2341–2364.
    • (2000) J. Gen. Virol. , vol.81 , pp. 2341-2364
    • Goodbourn, S.1    Didcock, L.2    Randall, R.3
  • 20
    • 0022438854 scopus 로고
    • Interferon treatment of human neoplasia
    • [20] Strander, H., Interferon treatment of human neoplasia. Adv. Cancer Res. 46 (1986), 1–265.
    • (1986) Adv. Cancer Res. , vol.46 , pp. 1-265
    • Strander, H.1
  • 21
    • 84913722302 scopus 로고
    • Antiviral effects of interferon in man
    • [21] Scott, G., Tyrrell, D., Antiviral effects of interferon in man. Interferon 4 (1985), 181–215.
    • (1985) Interferon , vol.4 , pp. 181-215
    • Scott, G.1    Tyrrell, D.2
  • 22
    • 34347272251 scopus 로고    scopus 로고
    • Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use
    • [22] Ferrantini, M., Capone, I., Belardelli, F., Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 89 (2007), 884–893.
    • (2007) Biochimie , vol.89 , pp. 884-893
    • Ferrantini, M.1    Capone, I.2    Belardelli, F.3
  • 23
    • 0024498659 scopus 로고
    • Effect of interferon on glucose tolerance and insulin sensitivity
    • [23] Koivisto, V.A., Pelkonen, R., Cantell, K., Effect of interferon on glucose tolerance and insulin sensitivity. Diabetes 38 (1989), 641–647.
    • (1989) Diabetes , vol.38 , pp. 641-647
    • Koivisto, V.A.1    Pelkonen, R.2    Cantell, K.3
  • 24
    • 14844283411 scopus 로고    scopus 로고
    • Changes in serum lipid concentrations in patients with chronic hepatitis C virus positive hepatitis responsive or non-responsive to interferon therapy
    • [24] Hamamoto, S., Uchida, Y., Wada, T., Moritani, M., Sato, S., Hamamoto, N., Ishihara, S., Watanabe, M., Kinoshita, Y., Changes in serum lipid concentrations in patients with chronic hepatitis C virus positive hepatitis responsive or non-responsive to interferon therapy. J. Gastroenterol. Hepatol. 20 (2005), 204–208.
    • (2005) J. Gastroenterol. Hepatol. , vol.20 , pp. 204-208
    • Hamamoto, S.1    Uchida, Y.2    Wada, T.3    Moritani, M.4    Sato, S.5    Hamamoto, N.6    Ishihara, S.7    Watanabe, M.8    Kinoshita, Y.9
  • 25
    • 0027982085 scopus 로고
    • Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms
    • [25] Doerrler, W., Feingold, K.R., Grunfeld, C., Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms. Cytokine 6 (1994), 478–484.
    • (1994) Cytokine , vol.6 , pp. 478-484
    • Doerrler, W.1    Feingold, K.R.2    Grunfeld, C.3
  • 26
    • 0026733835 scopus 로고
    • Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism
    • [26] Hardardottir, I., Doerrler, W., Feingold, K.R., Grunfeld, C., Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism. Biochem. Biophys. Res. Commun. 186 (1992), 237–243.
    • (1992) Biochem. Biophys. Res. Commun. , vol.186 , pp. 237-243
    • Hardardottir, I.1    Doerrler, W.2    Feingold, K.R.3    Grunfeld, C.4
  • 27
    • 84855508991 scopus 로고    scopus 로고
    • Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice
    • [27] Kim, S.-J., Choi, Y., Choi, Y.-H., Park, T., Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice. J. Nutr. Biochem. 23 (2012), 113–122.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 113-122
    • Kim, S.-J.1    Choi, Y.2    Choi, Y.-H.3    Park, T.4
  • 28
    • 9444219949 scopus 로고    scopus 로고
    • Handbook of Obesity: Etiology and Pathophysiology
    • [28] Ailhaud, G., Hauner, H., Bray, A., Handbook of Obesity: Etiology and Pathophysiology. 2004.
    • (2004)
    • Ailhaud, G.1    Hauner, H.2    Bray, A.3
  • 29
    • 84938872393 scopus 로고    scopus 로고
    • Korean Red Ginseng saponin fraction modulates radiation effects on lipopolysaccharide-stimulated nitric oxide production in RAW264. 7 macrophage cells
    • [29] Lee, Y.J., Han, J.Y., Lee, C.G., Heo, K., Park, S.I., Park, Y.S., Kim, J.S., Yang, K.M., Lee, K.-J., Kim, T.-H., Korean Red Ginseng saponin fraction modulates radiation effects on lipopolysaccharide-stimulated nitric oxide production in RAW264. 7 macrophage cells. J. Ginseng Res. 38 (2014), 208–214.
    • (2014) J. Ginseng Res. , vol.38 , pp. 208-214
    • Lee, Y.J.1    Han, J.Y.2    Lee, C.G.3    Heo, K.4    Park, S.I.5    Park, Y.S.6    Kim, J.S.7    Yang, K.M.8    Lee, K.-J.9    Kim, T.-H.10
  • 30
    • 0034535853 scopus 로고    scopus 로고
    • Adipocyte differentiation and gene expression
    • [30] Ntambi, J.M., Young-Cheul, K., Adipocyte differentiation and gene expression. J. Nutr. 130 (2000), 3122–3126.
    • (2000) J. Nutr. , vol.130 , pp. 3122-3126
    • Ntambi, J.M.1    Young-Cheul, K.2
  • 31
    • 0037422569 scopus 로고    scopus 로고
    • Mitotic clonal expansion: a synchronous process required for adipogenesis
    • [31] Tang, Q.-Q., Otto, T.C., Lane, M.D., Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. 100 (2003), 44–49.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 44-49
    • Tang, Q.-Q.1    Otto, T.C.2    Lane, M.D.3
  • 32
    • 0032553429 scopus 로고    scopus 로고
    • Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-γ in adipocytes
    • [32] Stephens, J.M., Lumpkin, S.J., Fishman, J.B., Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-γ in adipocytes. J. Biol. Chem. 273 (1998), 31408–31416.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31408-31416
    • Stephens, J.M.1    Lumpkin, S.J.2    Fishman, J.B.3
  • 33
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: input and output integration
    • [33] Murray, P.J., The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178 (2007), 2623–2629.
    • (2007) J. Immunol. , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 34
    • 78650150534 scopus 로고    scopus 로고
    • STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest
    • [34] Dimco, G., Knight, R.A., Latchman, D.S., Stephanou, A., STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest. Cell Cycle 9 (2010), 4638–4649.
    • (2010) Cell Cycle , vol.9 , pp. 4638-4649
    • Dimco, G.1    Knight, R.A.2    Latchman, D.S.3    Stephanou, A.4
  • 35
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • [35] Hotamisligil, G.S., Shargill, N.S., Spiegelman, B.M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993), 87–91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 36
    • 0036313033 scopus 로고    scopus 로고
    • Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes nuclear factor-κB activation by TNF-α is obligatory
    • [36] Ruan, H., Hacohen, N., Golub, T.R., Van Parijs, L., Lodish, H.F., Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes nuclear factor-κB activation by TNF-α is obligatory. Diabetes 51 (2002), 1319–1336.
    • (2002) Diabetes , vol.51 , pp. 1319-1336
    • Ruan, H.1    Hacohen, N.2    Golub, T.R.3    Van Parijs, L.4    Lodish, H.F.5
  • 37
    • 79955611314 scopus 로고    scopus 로고
    • Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
    • [37] Kim, S., Jin, Y., Choi, Y., Park, T., Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochem. Pharmacol. 81 (2011), 1343–1351.
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 1343-1351
    • Kim, S.1    Jin, Y.2    Choi, Y.3    Park, T.4
  • 40
    • 19544384772 scopus 로고    scopus 로고
    • Interference by interferons: Janus faces in vascular proliferative diseases
    • [40] Wessely, R., Interference by interferons: Janus faces in vascular proliferative diseases. Cardiovasc. Res. 66 (2005), 433–443.
    • (2005) Cardiovasc. Res. , vol.66 , pp. 433-443
    • Wessely, R.1
  • 41
    • 0036731485 scopus 로고    scopus 로고
    • Stats: transcriptional control and biological impact
    • [41] Levy, D.E., Darnell, J., Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3 (2002), 651–662.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.2
  • 42
    • 84900006251 scopus 로고    scopus 로고
    • Prostaglandin F2α inhibits adipogenesis via an autocrine-mediated interleukin-11/glycoprotein 130/STAT1-dependent signaling Cascade
    • [42] Annamalai, D., Clipstone, N.A., Prostaglandin F2α inhibits adipogenesis via an autocrine-mediated interleukin-11/glycoprotein 130/STAT1-dependent signaling Cascade. J. Cell. Biochem. 115 (2014), 1308–1321.
    • (2014) J. Cell. Biochem. , vol.115 , pp. 1308-1321
    • Annamalai, D.1    Clipstone, N.A.2
  • 43
    • 10044251947 scopus 로고    scopus 로고
    • Interleukin 11 signaling in 3T3-L1 adipocytes
    • [43] Tenney, R., Stansfield, K., Pekala, P.H., Interleukin 11 signaling in 3T3-L1 adipocytes. J. Cell. Physiol. 202 (2005), 160–166.
    • (2005) J. Cell. Physiol. , vol.202 , pp. 160-166
    • Tenney, R.1    Stansfield, K.2    Pekala, P.H.3
  • 44
    • 70450277113 scopus 로고    scopus 로고
    • Interferon γ attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • [44] McGillicuddy, F.C., Chiquoine, E.H., Hinkle, C.C., Kim, R.J., Shah, R., Roche, H.M., Smyth, E.M., Reilly, M.P., Interferon γ attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J. Biol. Chem. 284 (2009), 31936–31944.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31936-31944
    • McGillicuddy, F.C.1    Chiquoine, E.H.2    Hinkle, C.C.3    Kim, R.J.4    Shah, R.5    Roche, H.M.6    Smyth, E.M.7    Reilly, M.P.8
  • 45
    • 79957663041 scopus 로고    scopus 로고
    • Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes
    • [45] Wada, T., Hoshino, M., Kimura, Y., Ojima, M., Nakano, T., Koya, D., Tsuneki, H., Sasaoka, T., Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 300 (2011), 1112–1123.
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300 , pp. 1112-1123
    • Wada, T.1    Hoshino, M.2    Kimura, Y.3    Ojima, M.4    Nakano, T.5    Koya, D.6    Tsuneki, H.7    Sasaoka, T.8
  • 46
    • 0035929376 scopus 로고    scopus 로고
    • The identification and characterization of a STAT 1 binding site in the PPARγ2 promoter
    • [46] Hogan, J.C., Stephens, J.M., The identification and characterization of a STAT 1 binding site in the PPARγ2 promoter. Biochem. Biophys. Res. Commun. 287 (2001), 484–492.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 484-492
    • Hogan, J.C.1    Stephens, J.M.2
  • 48
    • 84896874273 scopus 로고    scopus 로고
    • Identification of STAT Target Genes in Adipocytes
    • 23092.
    • [48] Zhao, P., Stephens, J.M., Identification of STAT Target Genes in Adipocytes. JAK-STAT, 2, 2013, 1–7, 23092.
    • (2013) JAK-STAT , vol.2 , pp. 1-7
    • Zhao, P.1    Stephens, J.M.2
  • 49


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.