IFN-α induces apoptosis of adipose tissue cells

Biochemical and Biophysical Research Communications

Volumn 345, Issue 2, 2006, Pages 669-674

  Birk, Ruth Z ^a   Rubinstein, Menachem ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Adipocytes; Apoptosis; Body weight; Diet induced obesity; IFN

Indexed keywords

ALPHA INTERFERON A-D; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; RECOMBINANT ALPHA INTERFERON;

ADIPOSE TISSUE CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CELL SIZE; CELL STRAIN 3T3; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; IMMUNOMODULATION; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT REDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BODY WEIGHT; DOWN-REGULATION; HUMANS; INTERFERON-ALPHA; MICE; MICE, INBRED C57BL; OBESITY; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 33646843411     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.139     Document Type: Article

References (46)

1. Taniguchi T., and Takaoka A. A weak signal for strong responses: interferon-α/β revisited. Nat. Rev. Mol. Cell. Biol. 2 (2001) 378-386
2. Sangfelt O., Erickson S., Castro J., Heiden T., Einhorn S., and Grander D. Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines. Cell. Growth Differ. 8 (1997) 343-352
3. Otsuki T., Yamada O., and Sakaguchi H. Human myeloma cell apoptosis induced by interferon-α. Br. J. Haematol. 103 (1998) 518-529
4. Sen G.C., Herz R., Davatelis V., and Pestka S. Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids. J. Virol. 50 (1984) 445-450
5. Dai C., and Krantz S.B. Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells. Blood 93 10 (1999) 3309-3316
6. Thyrell L., Erickson S., Zhivotovsky B., Pokrovskaja K., Sangfelt O., Castro J., Einhorn S., and Grander D. Mechanisms of Interferon-alpha induced apoptosis in malignant cells. Oncogene 21 (2002) 1251-1262
7. Thyrell L., Hjortsberg L., Arulampalam V., Panaretakis T., Uhles S., Dagnell M., Zhivotovsky B., Leibiger I., Grander D., and Pokrovskaja K. Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J. Biol. Chem. 279 23 (2004) 24152-24162
8. Uddin S., Lekmine F., Sharma N., Majchrzak B., Mayer I., Young P.R., Bokoch G.M., Fish E.N., and Platanias L.C. The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J. Biol. Chem. 275 (2000) 27634-27640
9. Johansson B.E., Grajower B., and Kilbourne E.D. Infection-permissive immunization with influenza virus neuraminidase prevents weight loss in infected mice. Vaccine 11 (1993) 1037-1039
10. Tanvetyanon T., Stadtmauer E.A., and Kerson L.A. Concurrent administration of interferon alfa-2b and beta-1a. Ann. Pharmacother. 37 (2003) 77-79
11. Kullavanuaya P., Treeprasertsuk S., Thong-Ngam D., Chaermthai K., Gonlachanvit S., and Suwanagool P. The combined treatment of interferon alpha-2a and thymosin alpha 1 for chronic hepatitis C: the 48 weeks end of treatment results. J. Med. Assoc. Thai. 84 Suppl. 1 (2001) S462-S468
12. Chan T.M., Wu P.C., Lau J.Y., Lok A.S., Lai C.L., and Cheng I.K. Interferon treatment for hepatitis C virus infection in patients on haemodialysis. Nephrol. Dial. Transplant. 12 (1997) 1414-1419
13. Gross A., McDonnell J.M., and Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes. Dev. 13 (1999) 1899-1911
14. Espat N.J., Copeland E.M., and Moldawer L.L. Tumor necrosis factor and cachexia: a current perspective. Surg. Oncol. 3 (1994) 255-262
15. Costelli P., Carbo N., Tessitore L., Bagby G.J., Lopes-Soriano F.J., Argiles J.M., and Baccino F.M. Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. J. Clin. Invest. 92 (1993) 2783-2789
16. Strassmann G., Fong M., Kenney J.S., and Jacob C.O. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J. Clin. Invest. 89 (1992) 1681-1684
17. Matthys P., Dijkmans R., Proost P., Van Damme J., Heremans H., Sobis H., and Billiau A. Severe cachexia in mice inoculated with interferon-gamma-producing tumor cells. Int. J. Cancer 49 (1991) 77-782
18. Green H., and Kehinde O. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 7 (1976) 105-113
19. Green H., and Kehinde O. Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line. J. Cell. Physiol. 101 (1979) 169-171
20. Mandrup S., Loftus T.M., MacDougald O.A., Kuhajda F.P., and Lane M.D. Obese gene expression at in vivo levels by fat pads derived from s.c. implanted a preadipocytes. Proc. Natl. Acad. Sci. USA 94 (1997) 4300-4305
21. Rehberg E., Kelder B., Hoal E.G., and Pestka S. Specific molecular activities of recombinant and hybrid leukocyte interferons. J. Biol. Chem. 257 (1982) 11497-11502
22. Rubinsrein S., Familletti P.C., and Pestka S. Convenient assay for interferons. J. Virol. 37 (1981) 755-758
23. Surwit R.S., Feinglos M.N., and Rodin J. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44 (1995) 645-651
24. Gilbert C., Rollet-Labelle E., Caon A.C., and Naccache P.H. Immunoblotting and sequential lysis protocols for the analysis of tyrosine phosphorylation-dependent signaling. J. Immunol. Methods 271 (2002) 185-201
25. Sanceau J., Hiscott J., Delattre O., and Wietzerbin J. IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Oncogene 19 (2000) 3372-3383
26. Minami R., Muta K., Ilseung C., Abe Y., Nishimura J., and Nawata H. Interleukin-6 sensitizes multiple myeloma cell lines for apoptosis induced by interferon-alpha. Exp. Hematol. 28 (2000) 244-255
27. Prins J.B., Walker N.I., Winterford C.M., and Cameron D.P. Apoptosis of human adipocytes in vitro. Biochem. Biophys. Res. Commun. 201 2 (1994) 500-507
28. Lindquist J.M., and Rehnmark S. Ambient temperature regulation of apoptosis in brown adipose tissue. Erk1/2 promotes norepinephrine-dependent cell survival. J. Biol. Chem. 273 46 (1998) 30147-30156
29. Della-Fera M.A., Qian H., and Baile C.A. Adipocyte apoptosis in the regulation of body fat mass by leptin. Diabetes. Obes. Metab. 3 5 (2001) 299-310
30. Prins J.B., Walker N.I., Winterford C.M., and Cameron D.P. Human adipocyte apoptosis occurs in malignancy. Biochem. Biophys. Res. Commun. 205 1 (1994) 625-630
31. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
32. Meier P., Finch A., and Evan G. Apoptosis in development. Nature 407 (2000) 796-801
33. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
34. Kroemer G., and Reed J.C. Mitochondrial control of cell death. Nat. Med. 6 (2000) 513-519
35. Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer. 2 (2002) 489-501
36. Jin W., Wu L., Liang K., Liu B., Lu Y., and Fan Z. Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells. Br. J. Cancer. 89 (2003) 185-191
37. Liang K., Weidong J., Knuefermann C., Schmidt M., Mills G.B., Ang K.K., Milas L., and Fan Z. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol. Cancer. Ther. 2 (2003) 353-360
38. Chakravarti A., Loeffler J.S., and Dyson N.J. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res. 62 (2002) 200-207
39. Dancey J.E. Molecular targeting: PI3 kinase pathway. Ann. Oncol. Suppl. 4 (2004) 233-239
40. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., and Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67 (1998) 227-264
41. Sangfelt O., Osterborg A., Grander D., Anderbring E., Ost A., Mellstedt H., and Einhorn S. Response to interferon therapy in patients with multiple myeloma correlates with expression of the Bcl-2 oncoprotein. Int. J. Cancer 63 (1995) 190-192
42. Chanan-Khan A. Bcl-2 antisense therapy in B-cell malignancies. Blood Rev. 19 (2005) 213-221
43. Feingold K., and Grunfeld C. Role of cytokines in inducing hyperlipidemia. Diabetes 41 (1992) 97-101
44. Hamamoto S., Uchida Y., Wada T., Moritani M., Sato S., Hamamoto N., Ishihara S., Watanabe M., and Kinoshita Y. Changes in serum lipid concentrations in patients with chronic hepatitis c virus positive hepatitis responsive or non-responsive to interferon therapy. J. Gastroenterol. Hepatol. 20 (2005) 204-208
45. Levy Z., Rachmani R., Trestman S., Dvir A., Shaish A., Ravid M., and Harats D. Low-dose interferon-alpha accelerates atherosclerosis in an LDL receptor-deficient mouse model. Eur. J. Intern. Med. 14 (2003) 479-483
46. Minuk G.Y., Weinstein S., and Kaita K.D. Serum cholesterol and low-density lipoprotein cholesterol levels as predictors of response to interferon therapy for chronic hepatitis. Ann. Intern. Med. 132 (2000) 761-762