메뉴 건너뛰기




Volumn 30, Issue 5, 2012, Pages 1042-1048

Interferon gamma inhibits adipogenesis in vitro and prevents marrow fat infiltration in oophorectomized mice

Author keywords

Adipogenesis; Aging; Interferon gamma; Mesenchymal stem cells; Osteoimmunology; Osteoporosis

Indexed keywords

GAMMA INTERFERON; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84860514967     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1063     Document Type: Article
Times cited : (49)

References (38)
  • 1
    • 77955497814 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of bone remodeling
    • Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem 2010;285:25103-25108.
    • (2010) J Biol Chem , vol.285 , pp. 25103-25108
    • Raggatt, L.J.1    Partridge, N.C.2
  • 3
    • 75049085147 scopus 로고    scopus 로고
    • Osteoimmunology and the effects of the immune system on bone
    • Takayanagi H. Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol 2009;5:667-76.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 667-676
    • Takayanagi, H.1
  • 4
    • 78649447658 scopus 로고    scopus 로고
    • The multiple faces of autoimmune-mediated bone loss
    • Schett G, David J-P. The multiple faces of autoimmune-mediated bone loss. Nat Rev Endocrinol 2010;6:698-706.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 698-706
    • Schett, G.1    David, J.-P.2
  • 5
    • 43149117061 scopus 로고    scopus 로고
    • Relationships between fat and bone
    • DOI 10.1007/s00198-007-0492-z
    • Reid I. Relationships between fat and bone. Osteoporos Int 2008;19: 595-606. (Pubitemid 351642171)
    • (2008) Osteoporosis International , vol.19 , Issue.5 , pp. 595-606
    • Reid, I.R.1
  • 6
    • 79959509369 scopus 로고    scopus 로고
    • Adipokines and the risk of fracture in older adults
    • Barbour KE, Zmuda JM, Boudreau R et al. Adipokines and the risk of fracture in older adults. J Bone Miner Res 2011;26:1568-1576.
    • (2011) J Bone Miner Res , vol.26 , pp. 1568-1576
    • Barbour, K.E.1    Zmuda, J.M.2    Boudreau, R.3
  • 7
    • 68749119383 scopus 로고    scopus 로고
    • Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice
    • Gasparrini M, Rivas D, Elbaz A et al. Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice. Exp Gerontol 2009;44:613-618.
    • (2009) Exp Gerontol , vol.44 , pp. 613-618
    • Gasparrini, M.1    Rivas, D.2    Elbaz, A.3
  • 8
    • 65249093158 scopus 로고    scopus 로고
    • Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis
    • Duque G, Huang DC, Macoritto M et al. Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Stem Cells 2009;27:550-558.
    • (2009) Stem Cells , vol.27 , pp. 550-558
    • Duque, G.1    Huang, D.C.2    Macoritto, M.3
  • 9
    • 79959491400 scopus 로고    scopus 로고
    • Interferon g plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice
    • Duque G, Huang DC, Dion N et al. Interferon g plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice. J Bone Miner Res 2011 26:1472-1483.
    • (2011) J Bone Miner Res , vol.26 , pp. 1472-1483
    • Duque, G.1    Huang, D.C.2    Dion, N.3
  • 10
    • 77954096137 scopus 로고    scopus 로고
    • Osteoclast biology and bone resorption
    • Rosen CJ, Compston JE, Lian JB, eds. 7th ed. Washington: American Society for Bone and Mineral Research
    • Ross FP. Osteoclast biology and bone resorption. In: Rosen CJ, Compston JE, Lian JB, eds. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 7th ed. Washington: American Society for Bone and Mineral Research, 2008:16-22.
    • (2008) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , pp. 16-22
    • Ross, F.P.1
  • 11
    • 36148985603 scopus 로고    scopus 로고
    • Is IFN-γ involved in bone loss or protection? Nothing is simple with cytokines
    • Ferrari Lacraz S, Ferrari S. Is IFN-γ involved in bone loss or protection? Nothing is simple with cytokines. Bonekey Osteovision 2007;4:83-87.
    • (2007) Bonekey Osteovision , vol.4 , pp. 83-87
    • Ferrari Lacraz, S.1    Ferrari, S.2
  • 13
    • 28544442029 scopus 로고    scopus 로고
    • Interplay between interferon and other cytokine systems in bone metabolism
    • Takayanagi H, Sato K, Takaoka A et al. Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev 2005; 208:181-193. (Pubitemid 41746393)
    • (2005) Immunological Reviews , vol.208 , pp. 181-193
    • Takayanagi, H.1    Sato, K.2    Takaoka, A.3    Taniguchi, T.4
  • 14
    • 77956744791 scopus 로고    scopus 로고
    • The immune system and bone
    • Pacifici R. The immune system and bone. Arch Biochem Biophys 2010;503:41-53.
    • (2010) Arch Biochem Biophys , vol.503 , pp. 41-53
    • Pacifici, R.1
  • 15
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-[gamma]
    • Takayanagi H, Ogasawara K, Hida S et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-[gamma]. Nature 2000;408:600-605.
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1    Ogasawara, K.2    Hida, S.3
  • 16
    • 0029047151 scopus 로고
    • Long-term treatment of osteopetrosis with recombinant human interferon gamma
    • Key LL Jr., Rodriguiz RM, Willi SM et al. Long-term treatment of osteopetrosis with recombinant human interferon gamma. N Engl J Med 1995;332:1594-1599.
    • (1995) N Engl J Med , vol.332 , pp. 1594-1599
    • Key Jr., L.L.1    Rodriguiz, R.M.2    Willi, S.M.3
  • 17
    • 79954423688 scopus 로고    scopus 로고
    • IFN-[gamma] directly inhibits TNF-[alpha]-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions
    • Kohara H, Kitaura H, Fujimura Y et al. IFN-[gamma] directly inhibits TNF-[alpha]-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. Immunol Lett 2011;137:53-61.
    • (2011) Immunol Lett , vol.137 , pp. 53-61
    • Kohara, H.1    Kitaura, H.2    Fujimura, Y.3
  • 18
    • 79954636093 scopus 로고    scopus 로고
    • Locally administered interferon-c accelerates lipopolysaccharide-induced osteoclastogenesis independent of immunohistological RANKL upregulation
    • Ayon Haro ER, Ukai T, Yokoyama M et al. Locally administered interferon-c accelerates lipopolysaccharide-induced osteoclastogenesis independent of immunohistological RANKL upregulation. J Periodontal Res 2011;46:361-373.
    • (2011) J Periodontal Res , vol.46 , pp. 361-373
    • Ayon Haro, E.R.1    Ukai, T.2    Yokoyama, M.3
  • 19
    • 47049100977 scopus 로고    scopus 로고
    • Bone and fat connection in aging bone
    • Duque G. Bone and fat connection in aging bone. Curr Opin Rheumatol 2008;20:429-434.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 429-434
    • Duque, G.1
  • 20
    • 31544457103 scopus 로고    scopus 로고
    • Mechanisms of disease: Is osteoporosis the obesity of bone?
    • DOI 10.1038/ncprheum0070, PII N0070
    • Rosen CJ, Bouxsein ML. Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006;2:35-43. (Pubitemid 43153647)
    • (2006) Nature Clinical Practice Rheumatology , vol.2 , Issue.1 , pp. 35-43
    • Rosen, C.J.1    Bouxsein, M.L.2
  • 21
    • 13844257282 scopus 로고    scopus 로고
    • Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways
    • DOI 10.1111/j.1474-9728.2004.00127.x
    • Moerman EJ, Teng K, Lipschitz DA et al. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways. Aging Cell 2004;3:379-389. (Pubitemid 40246708)
    • (2004) Aging Cell , vol.3 , Issue.6 , pp. 379-389
    • Moerman, E.J.1    Teng, K.2    Lipschitz, D.A.3    Lecka-Czernik, B.4
  • 22
    • 38449112480 scopus 로고    scopus 로고
    • Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells
    • DOI 10.1359/jbmr.070701
    • Duque G, Rivas D. Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells. J Bone Miner Res 2007;22:1603-1611. (Pubitemid 351229330)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.10 , pp. 1603-1611
    • Duque, G.1    Rivas, D.2
  • 23
    • 1342265406 scopus 로고    scopus 로고
    • 3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2)
    • DOI 10.1016/j.exger.2003.11.008
    • Duque G, Macoritto M, Kremer R. 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2). Exp Gerontol 2004;39:333-338. (Pubitemid 38264363)
    • (2004) Experimental Gerontology , vol.39 , Issue.3 , pp. 333-338
    • Duque, G.1    Macoritto, M.2    Kremer, R.3
  • 24
    • 34248506892 scopus 로고    scopus 로고
    • Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells
    • DOI 10.1016/j.bone.2006.06.010, PII S8756328206005606
    • Rickard DJ, Wang FL, Rodriguez-Rojas AM et al. Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells. Bone 2006;39:1361-1372. (Pubitemid 44827918)
    • (2006) Bone , vol.39 , Issue.6 , pp. 1361-1372
    • Rickard, D.J.1    Wang, F.-L.2    Rodriguez-Rojas, A.-M.3    Wu, Z.4    Trice, W.J.5    Hoffman, S.J.6    Votta, B.7    Stroup, G.B.8    Kumar, S.9    Nuttall, M.E.10
  • 26
    • 84934443232 scopus 로고    scopus 로고
    • Differentiation and characterization of human MSCs
    • Reger RL, Tucker AH, Wolfe MR. Differentiation and characterization of human MSCs. Methods Mol Biol 2008;449:93-107.
    • (2008) Methods Mol Biol , vol.449 , pp. 93-107
    • Reger, R.L.1    Tucker, A.H.2    Wolfe, M.R.3
  • 27
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (RESTV©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (RESTV©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002;30:e36.
    • (2002) Nucleic Acids Res , vol.30
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 28
    • 38749092604 scopus 로고    scopus 로고
    • Inhibition of protein farnesylation arrests adipogenesis and affects PPARgamma expression and activation in differentiating mesenchymal stem cells
    • Rivas D, Akter R, Duque G. Inhibition of protein farnesylation arrests adipogenesis and affects PPARgamma expression and activation in differentiating mesenchymal stem cells. PPAR Res 2007;2007:81654.
    • (2007) PPAR Res , vol.2007 , pp. 81654
    • Rivas, D.1    Akter, R.2    Duque, G.3
  • 29
    • 0036724870 scopus 로고    scopus 로고
    • Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
    • DOI 10.1136/jcp.55.9.693
    • Verma S, Rajaratnam JH, Denton J et al. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 2002;55:693-698. (Pubitemid 34970093)
    • (2002) Journal of Clinical Pathology , vol.55 , Issue.9 , pp. 693-698
    • Verma, S.1    Rajaratnam, J.H.2    Denton, J.3    Hoyland, J.A.4    Byers, R.J.5
  • 30
    • 79952291528 scopus 로고    scopus 로고
    • Interleukins, from 1 to 37, and interferon-[gamma]: Receptors, functions, and roles in diseases
    • Akdis M, Burgler S, Crameri R et al. Interleukins, from 1 to 37, and interferon-[gamma]: Receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011;127:701-721.e1-e70.
    • (2011) J Allergy Clin Immunol , vol.127
    • Akdis, M.1    Burgler, S.2    Crameri, R.3
  • 32
    • 67649867825 scopus 로고    scopus 로고
    • Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells
    • Li B, Shin J, Lee K. Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells. Endocrinology 2009;150:1217-1224.
    • (2009) Endocrinology , vol.150 , pp. 1217-1224
    • Li, B.1    Shin, J.2    Lee, K.3
  • 33
    • 79959445462 scopus 로고    scopus 로고
    • Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis
    • Todoric J, Strobl B, Jais A et al. Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis. Diabetes 2011;60:1668-1676.
    • (2011) Diabetes , vol.60 , pp. 1668-1676
    • Todoric, J.1    Strobl, B.2    Jais, A.3
  • 34
    • 71349086901 scopus 로고    scopus 로고
    • Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    • Elbaz A, Rivas D, Duque G. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology 2009; 10:747-755.
    • (2009) Biogerontology , vol.10 , pp. 747-755
    • Elbaz, A.1    Rivas, D.2    Duque, G.3
  • 35
    • 77955984749 scopus 로고    scopus 로고
    • PPARs in bone: The role in bone cell differentiation and regulation of energy metabolism
    • Lecka-Czernik B. PPARs in bone: The role in bone cell differentiation and regulation of energy metabolism. Curr Osteoporos Rep 2010;8:84-90.
    • (2010) Curr Osteoporos Rep , vol.8 , pp. 84-90
    • Lecka-Czernik, B.1
  • 36
    • 0022354547 scopus 로고
    • Studies of interferon as a regulator of hematopoietic cell proliferation
    • Raefsky EL, Platanias LC, Zoumbos NC et al. Studies of interferon as a regulator of hematopoietic cell proliferation. J Immunol 1985;135: 2507-2512. (Pubitemid 16215841)
    • (1985) Journal of Immunology , vol.135 , Issue.4 , pp. 2507-2512
    • Raefsky, E.L.1    Platanias, L.C.2    Zoumbos, N.C.3    Young, N.S.4
  • 37
    • 67650504733 scopus 로고    scopus 로고
    • Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    • Naveiras O, Nardi V, Wezel PL et al. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 2009;460:259-263.
    • (2009) Nature , vol.460 , pp. 259-263
    • Naveiras, O.1    Nardi, V.2    Wezel, P.L.3
  • 38
    • 77952775569 scopus 로고    scopus 로고
    • Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis
    • Sugimura R, Li L. Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis. J Mol Cell Biol 2010;2:61-62.
    • (2010) J Mol Cell Biol , vol.2 , pp. 61-62
    • Sugimura, R.1    Li, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.