Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 3, 2016, Pages 829-835

  Sangshetti, Jaiprakash N ^a   Kalam Khan, Firoz A ^a   Kulkarni, Abhishek A ^a   Patil, Rajendra H ^b   Pachpinde, Amol M ^c   Lohar, Kishan S ^d   Shinde, Devanand B ^e  

^a Y B CHAVAN COLLEGE OF PHARMACY   (India)

^b UNIVERSITY OF PUNE   (India)

^c Science and Commerce College   (India)

^d Materials Research Laboratory   (India)

^e SHIVAJI UNIVERSITY   (India)

Author keywords

Antileishmanial; Antioxidant; Ho3+doped CoFe2O4nanoparticles; Indolyl coumarin hybrids; Molecular docking studies

Indexed keywords

ANTILEISHMANIAL AGENT; ANTIOXIDANT; ASCORBIC ACID; BUTYLCRESOL; CHROMENE DERIVATIVE; COUMARIN DERIVATIVE; DIHYDROPTERIDINE REDUCTASE; INDOLE DERIVATIVE; NANOPARTICLE; STIBOGLUCONATE SODIUM; ANTIPROTOZOAL AGENT; COUMARIN; ENZYME INHIBITOR; OXIDOREDUCTASE; PROTOZOAL PROTEIN; PTERIDINE REDUCTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CATALYST; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC50; LEISHMANIA DONOVANI; MOLECULAR DOCKING; NONHUMAN; PHARMACOKINETIC PARAMETERS; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HELA CELL LINE; HUMAN; LEISHMANIA; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ANTIOXIDANTS; ANTIPROTOZOAL AGENTS; BINDING SITES; CELL SURVIVAL; COUMARINS; DRUG DESIGN; ENZYME INHIBITORS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA; MOLECULAR DOCKING SIMULATION; OXIDOREDUCTASES; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84979199736     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.12.085     Document Type: Article

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