Developments in diagnosis and antileishmanial drugs

Interdisciplinary Perspectives on Infectious Diseases

Volumn 2012, Issue , 2012, Pages

  Bhargava, Prachi ^a   Singh, Rajni ^a  

^a AMITY UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; ANTILEISHMANIAL AGENT; ANTIMONY DERIVATIVE; CYCLIN DEPENDENT KINASE; DIHYDROFOLATE REDUCTASE; GLUTATHIONE REDUCTASE; GLYCOGEN SYNTHASE KINASE; MEGLUMINE ANTIMONATE; MILTEFOSINE; PAROMOMYCIN; PENTAMIDINE; PENTAVALENT ANTIMONY; SITAMAQUINE; STIBOGLUCONATE SODIUM; SUPEROXIDE DISMUTASE; THIOREDOXIN REDUCTASE; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; AGGLUTINATION TEST; ANEMIA; ANOREXIA; ANTIMICROBIAL ACTIVITY; BLISTER; CARDIOTOXICITY; CREATININE BLOOD LEVEL; CYANOSIS; DIARRHEA; DRUG EFFICACY; DRUG INDUCED HEADACHE; DYSPEPSIA; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHEMA; FOLATE METABOLISM; GEOGRAPHIC DISTRIBUTION; GLYCOSOME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOKALEMIA; HYPOTENSION; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOBLOTTING; INFUSION RELATED REACTION; INSULIN DEPENDENT DIABETES MELLITUS; LATEX AGGLUTINATION TEST; LEISHMANIA BRAZILIENSIS; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA TROPICA; LEISHMANIASIS; MITOCHONDRION; MOLECULAR DIAGNOSIS; NAUSEA; NONHUMAN; OTOTOXICITY; OXIDATIVE STRESS; PAIN; PHASE 4 CLINICAL TRIAL (TOPIC); POLYAMINE SYNTHESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SERODIAGNOSIS; SEROLOGY; SHOCK; SIDE EFFECT; SKIN LEISHMANIASIS; STEROL SYNTHESIS; THROMBOCYTOPENIA; UREMIA; VISCERAL LEISHMANIASIS; VOMITING; WEAKNESS;

EID: 84869070299     PISSN: 1687708X     EISSN: 16877098     Source Type: Journal    
DOI: 10.1155/2012/626838     Document Type: Review

References (120)

1. Pink R., Hudson A., Mouriès M. A., Bendig M., Opportunities and challenges in antiparasitic drug discovery. Nature Reviews Drug Discovery 2005 4 9 727 740 2-s2.0-26044468809 10.1038/nrd1824 (Pubitemid 43090494)
2. Majumder H. K., Das B. B., Ganguly A., DNA topoisomerases of Leishmania: the Potential targets for anti-leishmanial therapy. Advances in Experimental Medicine and Biology 2008 625 103 115 2-s2.0-42949163935 10.1007/978-0-387- 77570-8-9
3. WHO, The world health reportreducing risks, promoting healthy life 2002 Geneva, Switzerland World Health Organization
4. Alvar J., Yactayo S., Bern C., Leishmaniasis and poverty. Trends in Parasitology 2006 22 12 552 557 2-s2.0-33750845322 10.1016/j.pt.2006.09.004 (Pubitemid 44716723)
5. Feasey N., Wansbrough-Jones M., Mabey D. C. W., Solomon A. W., Neglected tropical diseases. British Medical Bulletin 2010 93 1 179 200 2-s2.0-77949388196 10.1093/bmb/ldp046
6. Desjeux P., Leishmaniasis: current situation and new perspectives. Comparative Immunology, Microbiology and Infectious Diseases 2004 27 5 305 318 2-s2.0-3042555141 10.1016/j.cimid.2004.03.004 (Pubitemid 38842803)
7. TDR/WHO, Leishmaniasis. 2012
8. Leishmaniasis Control,. 2007
9. Alvar J., Velez I. D., Bern C., Herrero M., Desjeux P., Cano J., Jannin J., den Boer M., WHO Leishmaniasis Control Team, Leishmaniasis worldwide and global estimates of its incidence. PloS One 7 5 e35671 e356712
10. Herwaldt B. L., Leishmaniasis. The Lancet 1999 354 9185 1191 1199 2-s2.0-0033517487 10.1016/S0140-6736(98)10178-2 (Pubitemid 29460458)
11. Murray H. W., Pépin J., Nutman T. B., Hoffman S. L., Mahmoud A. A. F., Recent advances: tropical medicine. British Medical Journal 2000 320 7233 490 494 2-s2.0-0034685096 (Pubitemid 30173124)
12. Guerin P. J., Olliaro P., Sundar S., Boelaert M., Croft S. L., Desjeux P., Wasunna M. K., Bryceson A. D. M., Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infectious Diseases 2002 2 8 494 501 2-s2.0-0036319712 10.1016/S1473-3099(02)00347-X (Pubitemid 34826855)
13. Berhe N., Wolday D., Hailu A., Abraham Y., Ali A., Gebre-Michael T., Desjeux P., Sönnerborg A., Akuffo H., Britton S., HIV viral load and response to antileishmanial chemotherapy in co-infected patients. AIDS 1999 13 14 1921 1925 2-s2.0-0032710944 10.1097/00002030-199910010-00015 (Pubitemid 29509552)
14. Seifert K., Pérez-Victoria F. J., Stettler M., Sánchez-Cañete M. P., Castanys S., Gamarro F., Croft S. L., Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo. International Journal of Antimicrobial Agents 2007 30 3 229 235 2-s2.0-34547337720 10.1016/j.ijantimicag.2007.05.007 (Pubitemid 47135625)
15. Cupolillo E., Brahim L. R., Toaldo C. B., Paes de Oliveira-Neto M., De Brito M. E. F., Falqueto A., Naiff M. D. F., Grimaldi G., Genetic polymorphism and molecular epidemiology of Leishmania (Viannia) braziliensis from different hosts and geographic areas in Brazil. Journal of Clinical Microbiology 2003 41 7 3126 3132 2-s2.0-0037493012 10.1128/JCM.41.7.3126-3132.2003 (Pubitemid 36842310)
16. Dereure J., Rioux J. A., Gallego M., Perieres J., Pratlong F., Mahjour J., Saddiki H., Leishmania tropica in Morocco: infection in dogs. Transactions of the Royal Society of Tropical Medicine and Hygiene 1991 85 5 595 2-s2.0-0026005226
17. Dereure J., Rioux J. A., Khiami A., Pratlong F., Périères J., Martini A., Ecoepidemiology of leishmaniases in Syria. 2Presence, in dogs, of Leishmania infantum Nicolle and Leishmania tropica (Wright) (Kinetoplastida-Trypanonomatidae). Annales de Parasitologie Humaine et Comparee 1991 66 6 252 255 2-s2.0-0026266209
18. Yahia H., Ready P. D., Hamdani A., Testa J. M., Guessous-Idrissi N., Regional genetic differentiation of Phlebotomus sergenti in three Moroccan foci of cutaneous leishmaniasis caused by Leishmania tropica. Parasite 2004 11 2 189 199 2-s2.0-11144350551 (Pubitemid 40021978)
19. Reithinger R., Dujardin J. C., Louzir H., Pirmez C., Alexander B., Brooker S., Cutaneous leishmaniasis. Lancet Infectious Diseases 2007 7 9 581 596 2-s2.0-34548039999 10.1016/S1473-3099(07)70209-8 (Pubitemid 47277438)
20. Bates P. A., Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies. International Journal for Parasitology 2007 37 10 1097 1106 2-s2.0-34447264232 10.1016/j.ijpara.2007.04.003 (Pubitemid 47042030)
21. Rogers M. E., Ilg T., Nikolaev A. V., Ferguson M. A. J., Bates P. A., Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature 2004 430 6998 463 467 2-s2.0-3342875937 10.1038/nature02675 (Pubitemid 38987909)
22. Handman E., Bullen D. V. R., Interaction of Leishmania with the host macrophage. Trends in Parasitology 2002 18 8 332 334 2-s2.0-0036698235 10.1016/S1471-4922(02)02352-8
23. Burchmore R. J. S., Barrett M. P., Life in vacuolesnutrient acquisition by Leishmania amastigotes. International Journal for Parasitology 2001 31 12 1311 1320 2-s2.0-0034825692 10.1016/S0020-7519(01)00259-4 (Pubitemid 32868711)
24. Desjeux P., Leishmaniasis: current situation and new perspectives. Comparative Immunology, Microbiology and Infectious Diseases 2004 27 5 305 318 2-s2.0-3042555141 10.1016/j.cimid.2004.03.004 (Pubitemid 38842803)
25. Collin S. M., Coleman P. G., Ritmeijer K., Davidson R. N., Unseen Kala-azar deaths in south Sudan (1999-2002). Tropical Medicine and International Health 2006 11 4 509 512 2-s2.0-33645325149 10.1111/j.1365-3156.2006.01589.x
26. Singh S. P., Reddy D. C. S., Rai M., Sundar S., Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar, India. Tropical Medicine and International Health 2006 11 6 899 905 2-s2.0-33744898842 10.1111/j.1365-3156.2006.01647.x (Pubitemid 43846450)
27. Jacquet D., Boelaert M., Seaman J., Rijal S., Sundar S., Menten J., Magnus E., Comparative evaluation of freeze-dried and liquid antigens in the direct agglutination test for serodiagnosis of visceral leishmaniasis (ITMA-DAT/VL). Tropical Medicine and International Health 2006 11 12 1777 1784 2-s2.0-33751379061 10.1111/j.1365-3156.2006.01743.x (Pubitemid 44813871)
28. Hotez P. J., Remme J. H. F., Buss P., Alleyne G., Morel C., Breman J. G., Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project. Clinical Infectious Diseases 2004 38 6 871 878 2-s2.0-1642384379 10.1086/382077 (Pubitemid 38387237)
29. Bern C., Hightower A. W., Chowdhury R., Ali M., Amann J., Wagatsuma Y., Haque R., Kurkjian K., Vaz L. E., Begum M., Akter T., Cetre-Sossah C. B., Ahluwalia I. B., Dotson E., Secor W. E., Breiman R. F., Maguire J. H., Risk factors for kala-azar in Bangladesh. Emerging Infectious Diseases 2005 11 5 655 662 2-s2.0-20944440741 (Pubitemid 40586387)
30. Collin S., Davidson R., Ritmeijer K., Keus K., Melaku Y., Kipngetich S., Davies C., Conflict and kala-azar: determinants of adverse outcomes of kala-azar among patients in southern Sudan. Clinical Infectious Diseases 2004 38 5 612 619 2-s2.0-1442302894 10.1086/381203 (Pubitemid 38333855)
31. Rey L. C., Martins C. V., Ribeiro H. B., Lima A. A. M., American visceral leishmaniasis (kala-azar) in hospitalized children from an endemic area. Jornal de Pediatria 2005 81 1 73 78 2-s2.0-28344454353 10.2223/1286 (Pubitemid 41717659)
32. Zijlstra E. E., Musa A. M., Khalil E. A. G., El Hassan I. M., El-Hassan A. M., Post-kala-azar dermal leishmaniasis. Lancet Infectious Diseases 2003 3 2 87 98 2-s2.0-0037309309 10.1016/S1473-3099(03)00517-6 (Pubitemid 36164205)
33. Desjeux P. R. V., Post-kala-azar dermal leishmaniasis: facing the challenge of eliminating kala-azar from South Asia. Kala Azar in South Asia: Current Status and Challenges Ahead 2011 Springer Science + Business Media B.V. 111 124
34. Alvar J., Aparicio P., Aseffa A., Den Boer M., Cañavate C., Dedet J. P., Gradoni L., Ter Horst R., López-Vélez R., Moreno J., The relationship between leishmaniasis and AIDS: the second 10 years. Clinical Microbiology Reviews 2008 21 2 334 359 2-s2.0-42349108596 10.1128/CMR.00061-07 (Pubitemid 351555511)
35. Reyburn H., Rowland M., Mohsen M., Khan B., Davies C., The prolonged epidemic of anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: Bringing down the neighbourgood Transactions of the Royal Society of Tropical Medicine and Hygiene 2003 97 2 170 176 2-s2.0-0142061657 10.1016/S0035-9203(03) 90111-8 (Pubitemid 37265628)
36. Goto H., Lindoso J. A. L., Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Review of Anti-Infective Therapy 2010 8 4 419 433 2-s2.0-77950849328 10.1586/eri.10.19
37. Marsden P. D., Lumsden W. H., Trypanosomiasis and leishmaniasis. Practitioner 1971 207 238 181 185 2-s2.0-0015104959
38. Bray R. S., Leishmania. Annual Review of Microbiology 1974 28 189 217
39. Pratt D. M., David J. R., Monoclonal antibodies that distinguish between New World species of Leishmania. Nature 1981 291 5816 581 583 2-s2.0-0019826796 (Pubitemid 11043680)
40. Ryan L., Vexenat A., Marsden P. D., Lainson R., Shaw J. J., The importance of rapid diagnosis of new cases of cutaneous leishmaniasis in pin-pointing the sandfly vector. Transactions of the Royal Society of Tropical Medicine and Hygiene 1990 84 6 786 2-s2.0-0025611428 10.1016/0035-9203(90)90080- X
41. Arnot D. E., Barker D. C., Biochemical identification of cutaneous leishmanias by analysis of kinetoplast DNA. II. Sequence homologies in Leishmania kDNA. Molecular and Biochemical Parasitology 1981 3 1 47 56 2-s2.0-0019570228
42. Miles M. A., Lainson R., Shaw J. J., Povoa M., de Souza A. A., Leishmaniasis in Brazil: XV. Biochemical distinction of Leishmania mexicana amazonensis, L. braziliensis braziliensis and L. braziliensis guyanensis aetiological agents of cutaneous leishmaniasis in the Amazon Basin of Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 1981 75 4 524 529 2-s2.0-0019483770 (Pubitemid 11015392)
43. De Ibarra A. A. L., Howard J. G., Snary D., Monoclonal antibodies to Leishmania tropica major: specificities and antigen location. Parasitology 1982 85 3 523 531 2-s2.0-0020371244 (Pubitemid 13220057)
44. Handman E., Curtis J. M., Leishmania tropica: surface antigens of intracellular and flagellate forms. Experimental Parasitology 1982 54 2 243 249 2-s2.0-0020371717 (Pubitemid 13213114)
45. Wirth D. F., Pratt D. M., Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions. Proceedings of the National Academy of Sciences of the United States of America 1982 79 22 6999 7003 2-s2.0-0344507828 (Pubitemid 13170918)
46. Brainard G. C., Podolin P. L., Near-ultraviolet radiation suppresses pineal melatonin content. Endocrinology 1986 119 5 2201 2205 2-s2.0-0022968957 (Pubitemid 17171403)
47. Le Blancq S. M., Peters W., Leishmania in the Old World: 2. Heterogeneity among L. tropica zymodemes. Transactions of the Royal Society of Tropical Medicine and Hygiene 1986 80 1 113 119 2-s2.0-0022438406
48. Travi B. L., Osorio Y., Melby P. C., Chandrasekar B., Arteaga L., Saravia N. G., Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp. Infection and Immunity 2002 70 5 2288 2296 2-s2.0-0036117769 10.1128/IAI.70.5.2288-2296.2002 (Pubitemid 34408367)
49. WHO, Control of the Leishmaniasis. Technical Report 1990 Series 793
50. Mauricio I. L., Stothard J. R., Miles M. A., The strange case of Leishmania chagasi. Parasitology Today 2000 16 5 188 189 2-s2.0-0034191880 10.1016/S0169-4758(00)01637-9 (Pubitemid 30216562)
51. Sharma N. L., Mahajan V. K., Kanga A., Sood A., Katoch V. M., Mauricio I., Singh C. D., Parwan U. C., Sharma V. K., Sharma R. C., Localized cutaneous leishmaniasis due to Leishmania donovani and Leishmania tropica: preliminary findings of the study of 161 new cases from a new endemic focus in Himachal Pradesh, India. American Journal of Tropical Medicine and Hygiene 2005 72 6 819 824 2-s2.0-23844527247 (Pubitemid 41278806)
52. Bañuls A. L., Dujardin J. C., Guerrini F., De Doncker S., Jacquet D., Arevalo J., Noël S., Le Ray D., Tibayrenc M., Is Leishmania (Viannia) peruviana a distinct species? A MLEE/RAPD evolutionary genetics answer. Journal of Eukaryotic Microbiology 2000 47 3 197 207 2-s2.0-0034038127 (Pubitemid 30343213)
53. Fraga J., Montalvo A. M., De Doncker S., Dujardin J. C., Van der Auwera G., Phylogeny of Leishmania species based on the heat-shock protein 70 gene. Infection, Genetics and Evolution 2010 10 2 238 245 2-s2.0-76849102914 10.1016/j.meegid.2009.11.007
54. Murray H. W., Berman J. D., Davies C. R., Saravia N. G., Advances in leishmaniasis. The Lancet 2005 366 9496 1561 1577 2-s2.0-27544475529 10.1016/S0140-6736(05)67629-5 (Pubitemid 41540115)
55. Deborggraeve S., Laurent T., Espinosa D., Van Der Auwera G., Mbuchi M., Wasunna M., El-Safi S., Al-Basheer A. A., Arévalo J., Miranda-Verástegui C., Leclipteux T., Mertens P., Dujardin J. C., Herdewijn P., Büscher P., A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis. Journal of Infectious Diseases 2008 198 10 1565 1572 2-s2.0-54949127159 10.1086/592509
56. Vega-Lopez F., Diagnosis of cutaneous leishmaniasis. Current Opinion in Infectious Diseases 2003 16 97 101 (Pubitemid 36521022)
57. Al-Hucheimi S. N., Sultan B. A., Al-Dhalimi M. A., A comparative study of the diagnosis of Old World cutaneous leishmaniasis in Iraq by polymerase chain reaction and microbiologic and histopathologic methods. International Journal of Dermatology 2009 48 4 404 408 2-s2.0-63249085462 10.1111/j.1365-4632.2009. 03903.x
58. Siddig M., Ghalib H., Shillington D. C., Petersen E. A., Visceral leishmaniasis in the Sudan: comparative parasitological methods of diagnosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 1988 82 1 66 68 2-s2.0-0023838309 (Pubitemid 18056240)
59. Srividya G., Kulshrestha A., Singh R., Salotra P., Diagnosis of visceral leishmaniasis: developments over the last decade. Parasitology Research 2012 110 1065 1078
60. Allahverdiyev A. M., Bagirova M., Uzun S., Alabaz D., Aksaray N., Kocabas E., Koksal F., The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood. American Journal of Tropical Medicine and Hygiene 2005 73 2 276 280 2-s2.0-24644453537 (Pubitemid 41278698)
61. Sreenivas G., Ansari N. A., Singh R., Subba Raju B. V., Bhatheja R., Negi N. S., Salotra P., Diagnosis of visceral leishmaniasis: comparative potential of amastigote antigen, recombinant antigen and PCR. British Journal of Biomedical Science 2002 59 4 218 222 2-s2.0-0038814091 (Pubitemid 38101996)
62. Jacquet D., Boelaert M., Seaman J., Rijal S., Sundar S., Menten J., Magnus E., Comparative evaluation of freeze-dried and liquid antigens in the direct agglutination test for serodiagnosis of visceral leishmaniasis (ITMA-DAT/VL). Tropical Medicine and International Health 2006 11 12 1777 1784 2-s2.0-33751379061 10.1111/j.1365-3156.2006.01743.x (Pubitemid 44813871)
63. Sundar S., Singh R. K., Maurya R., Kumar B., Chhabra A., Singh V., Rai M., Serological diagnosis of Indian visceral leishmaniasis: direct agglutination test versus rK39 strip test. Transactions of the Royal Society of Tropical Medicine and Hygiene 2006 100 6 533 537 2-s2.0-33645867355 10.1016/j.trstmh. 2005.08.018
64. Boelaert M., El-Safi S., Hailu A., Mukhtar M., Rijal S., Sundar S., Wasunna M., Aseffa A., Mbui J., Menten J., Desjeux P., Peeling R. W., Diagnostic tests for kala-azar: a multi-centre study of the freeze-dried DAT, rK39 strip test and KAtex in East Africa and the Indian subcontinent. Transactions of the Royal Society of Tropical Medicine and Hygiene 2008 102 1 32 40 2-s2.0-36549034731 10.1016/j.trstmh.2007.09.003 (Pubitemid 350185837)
65. Kumar R., Pai K., Pathak K., Sundar S., Enzyme-linked immunosorbent assay for recombinant K39 antigen in diagnosis and prognosis of Indian visceral leishmaniasis. Clinical and Diagnostic Laboratory Immunology 2001 8 6 1220 1224 2-s2.0-0034761650 10.1128/CDLI.8.6.1220-1224.2001 (Pubitemid 33035758)
66. Srivastava P., Dayama A., Mehrotra S., Sundar S., Diagnosis of visceral leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 2011 105 1 1 6 2-s2.0-78649692073 10.1016/j.trstmh.2010.09.006
67. Srivastava P., Mehrotra S., Tiwary P., Chakravarty J., Sundar S., Diagnosis of indian visceral leishmaniasis by nucleic acid detection using PCR. PLoS ONE 2011 6 4, article e19304 2-s2.0-79955766597 10.1371/journal.pone. 0019304
68. Maurya R., Singh R. K., Kumar B., Salotra P., Rai M., Sundar S., Evaluation of PCR for diagnosis of Indian kala-azar and assessment of cure. Journal of Clinical Microbiology 2005 43 7 3038 3041 2-s2.0-22144470842 10.1128/JCM.43.7.3038-3041.2005 (Pubitemid 40981299)
69. Kuhls K., Keilonat L., Ochsenreither S., Schaar M., Schweynoch C., Presber W., Schönian G., Multilocus microsatellite typing (MLMT) reveals genetically isolated populations between and within the main endemic regions of visceral leishmaniasis. Microbes and Infection 2007 9 3 334 343 2-s2.0-33847348111 10.1016/j.micinf.2006.12.009 (Pubitemid 46341936)
70. Dey A., Singh S., Genetic heterogeneity among visceral and post-Kala-Azar dermal leishmaniasis strains from eastern India. Infection, Genetics and Evolution 2007 7 2 219 222 2-s2.0-33846611430 10.1016/j.meegid.2006.09.001 (Pubitemid 46172949)
71. Tintaya K. W. Q., Ying X., Dedet J. P., Rijal S., De Bolle X., Dujardin J. C., Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complex. Journal of Infectious Diseases 2004 189 6 1035 1043 2-s2.0-1642263324 10.1086/382049 (Pubitemid 38373096)
72. Mauricio I. L., Stothard J. R., Miles M. A., Leishmania donovani complex: genotyping with the ribosomal internal transcribed spacer and the mini-exon. Parasitology 2004 128 3 263 267 2-s2.0-1842555129 10.1017/S0031182003004578 (Pubitemid 38437958)
73. De Doncker S., Hutse V., Abdellati S., Rijal S., Singh Karki B. M., Decuypere S., Jacquet D., Le Ray D., Boelaert M., Koirala S., Dujardin J. C., A new PCR-ELISA for diagnosis of visceral leishmaniasis in blood of HIV-negative subjects. Transactions of the Royal Society of Tropical Medicine and Hygiene 2005 99 1 25 31 2-s2.0-8744223403 10.1016/j.trstmh.2004.01.015 (Pubitemid 39517033)
74. Khosravi S., Hejazi S. H., Hashemzadeh M., Eslami G., Darani H. Y., Molecular diagnosis of old world leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp. Journal of Vector Borne Diseases 2012 49 1 15 18
75. Zijlstra E. E., Ali M. S., El-Hassan A. M., El-Toum I. A., Satti M., Ghalib H. W., Kager P. A., Kala-azar: a comparative study of parasitological methods and the direct agglutination test in diagnosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 1992 86 5 505 507 2-s2.0-0026700744 10.1016/0035-9203(92)90086-R
76. Allahverdiyev A. M., Bagirova M., Uzun S., Alabaz D., Aksaray N., Kocabas E., Koksal F., The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood. American Journal of Tropical Medicine and Hygiene 2005 73 2 276 280 2-s2.0-24644453537 (Pubitemid 41278698)
77. Chappuis F., Rijal S., Soto A., Menten J., Boelaert M., A meta-analysis of the diagnostic performance of the direct agglutination test and rK39 dipstick for visceral leishmaniasis. British Medical Journal 2006 333 7571 723 726 2-s2.0-33749677074 10.1136/bmj.38917.503056.7C (Pubitemid 44555168)
78. Gari-Toussaint M., Leliévre A., Marty P., Le Fichoux Y., Contribution of serological tests to the diagnosis of visceral leishmaniasis in patients infected with the human immunodeficiency virus. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994 88 3 301 302 2-s2.0-0028304542 10.1016/0035-9203(94)90088-4 (Pubitemid 24206447)
79. Schallig H. D. F. H., Schoone G. J., Kroon C. C. M., Hailu A., Chappuis F., Veeken H., Development and application of 'simple' diagnostic tools for visceral leishmaniasis. Medical Microbiology and Immunology 2001 190 1-2 69 71 2-s2.0-0035166124 (Pubitemid 33079362)
80. Sundar S., Singh R. K., Maurya R., Kumar B., Chhabra A., Singh V., Rai M., Serological diagnosis of Indian visceral leishmaniasis: direct agglutination test versus rK39 strip test. Transactions of the Royal Society of Tropical Medicine and Hygiene 2006 100 6 533 537 2-s2.0-33645867355 10.1016/j.trstmh. 2005.08.018
81. Palatnik-de-Sousa C. B., Gomes E. M., Paraguai-de-Souza E., Palatnik M., Luz K., Borojevic R., Leishmania donovani: titration of antibodies to the fucose-mannose ligand as an aid in diagnosis and prognosis of visceral leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 1995 89 4 390 393 2-s2.0-0029121153 10.1016/0035-9203(95)90022-5
82. Kumar R., Pai K., Pathak K., Sundar S., Enzyme-linked immunosorbent assay for recombinant K39 antigen in diagnosis and prognosis of Indian visceral leishmaniasis. Clinical and Diagnostic Laboratory Immunology 2001 8 6 1220 1224 2-s2.0-0034761650 10.1128/CDLI.8.6.1220-1224.2001 (Pubitemid 33035758)
83. Houghton R. L., Petrescu M., Benson D. R., Skeiky Y. A., Scalone A., Badaro R R., Reed S. G., Gradoni L., A cloned antigen (recombinant K39) of Leishmania chagasi diagnostic for visceral leishmaniasis in human immunodeficiency virus type 1 patients and a prognostic indicator for monitoring patients undergoing drug therapy. Journal of Infectious Diseases 1998 177 5 1339 1344 2-s2.0-0031949223 (Pubitemid 28194276)
84. Mohapatra T. M., Singh D. P., Sen M. R., Bharti K., Sundar S., Comparative evaluation of rK9, rK26 and rK39 antigens in the serodiagnosis of Indian visceral leishmaniasis. Journal of Infection in Developing Countries 2010 4 2 114 117 2-s2.0-77950256878
85. Chappuis F., Mueller Y., Nguimfack A., Rwakimari J. B., Couffignal S., Boelaert M., Cavailler P., Loutan L., Piola P., Diagnostic accuracy of two rK39 antigen-based dipsticks and the formol gel test for rapid diagnosis of visceral leishmaniasis in northeastern Uganda. Journal of Clinical Microbiology 2005 43 12 5973 5977 2-s2.0-30744477758 10.1128/JCM.43.12.5973-5977.2005 (Pubitemid 43100646)
86. Chappuis F., Sundar S., Hailu A., Ghalib H., Rijal S., Peeling R. W., Alvar J., Boelaert M., Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nature Reviews Microbiology 2007 5 11 873 882 2-s2.0-35348871028 10.1038/nrmicro1748
87. Pérez-Alvarez M. J., Larreta R., Alonso C., Requena J. M., Characterisation of a monoclonal antibody recognising specifically the HSP70 from Leishmania. Parasitology Research 2001 87 11 907 910 2-s2.0-0034797361 (Pubitemid 32972363)
88. Piarroux R., Gambarelli F., Dumon H., Fontes M., Dunan S., Mary C., Toga B., Quilici M., Comparison of PCR with direct examination of bone marrow aspiration, myeloculture, and serology for diagnosis of visceral leishmaniasis in immunocompromised patients. Journal of Clinical Microbiology 1994 32 3 746 749 2-s2.0-0028012077 (Pubitemid 24062954)
89. De Doncker S., Hutse V., Abdellati S., Rijal S., Singh Karki B. M., Decuypere S., Jacquet D., Le Ray D., Boelaert M., Koirala S., Dujardin J. C., A new PCR-ELISA for diagnosis of visceral leishmaniasis in blood of HIV-negative subjects. Transactions of the Royal Society of Tropical Medicine and Hygiene 2005 99 1 25 31 2-s2.0-8744223403 10.1016/j.trstmh.2004.01.015 (Pubitemid 39517033)
90. Singh R. K., Pandey H. P., Sundar S., Visceral leishmaniasis (kala-azar): challenges ahead. Indian Journal of Medical Research 2006 123 3 331 344 2-s2.0-33745218506 (Pubitemid 43905573)
91. Jha T. K., Evaluation of diamidine compound (pentamidine isethionate) in the treatment of resistant cases of kala-azar occurring in North Bihar, India. Transactions of the Royal Society of Tropical Medicine and Hygiene 1983 77 2 167 170 2-s2.0-0020605193 (Pubitemid 13052564)
92. Jha S. N., Singh N. K., Jha T. K., Changing response to diamidine compounds in cases of kala-azar unresponsive to antimonial. The Journal of the Association of Physicians of India 1991 39 4 314 316 2-s2.0-0026146449
93. Sundar S., Treatment of visceral leishmaniasis. Medical Microbiology and Immunology 2001 190 1-2 89 92 2-s2.0-0035162724 (Pubitemid 33079367)
94. Croft S. L., Yardley V., Chemotherapy of leishmaniasis. Current Pharmaceutical Design 2002 8 4 319 342 2-s2.0-0036240055 10.2174/ 1381612023396258 (Pubitemid 34460464)
95. Jhingran A., Chawla B., Saxena S., Barrett M. P., Madhubala R., Paromomycin: uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology 2009 164 2 111 117 2-s2.0-59649112802 10.1016/j.molbiopara.2008.12.007
96. Singh N., Kumar M., Singh R. K., Leishmaniasis: current status of available drugs and new potential drug targets. Asian Pacific Journal of Tropical Medicine 2012 5 6 485 497
97. Rochette A., Raymond F., Ubeda J. M., Smith M., Messier N., Boisvert S., Rigault P., Corbeil J., Ouellette M., Papadopoulou B., Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. BMC Genomics 2008 9 255 281 2-s2.0-47249134311 10.1186/1471-2164-9-255 (Pubitemid 351984856)
98. Krieger S., Schwarz W., Arlyanayagam M. R., Fairlamb A. H., Krauth-Siegel R. L., Clayton C., Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Molecular Microbiology 2000 35 3 542 552 2-s2.0-0033977079 10.1046/j.1365-2958.2000.01721.x (Pubitemid 30085272)
99. Castro-Pinto D. B., Genestra M., Menezes G. B., Waghabi M., Gonçalves A., De Nigris Del Cistia C., Sant'Anna C. M. R., Leon L. L., Mendonça-Lima L., Cloning and expression of trypanothione reductase from a New World Leishmania species. Archives of Microbiology 2008 189 4 375 384 2-s2.0-43349083951 10.1007/s00203-007-0328-4
100. Rodrigues R. F., Castro-Pinto D., Echevarria A., dos Reis C. M., Del Cistia C. N., Santanna C. M., teixeira F., Castro H., Canto-Cavalheiro M., Leon A L. L., Investigation of trypanothione reductase inhibitory activity by 1, 3, 4- thiadiazolium-2-aminide derivatives and molecular docking studies. Bioorganic & Medicinal Chemistry 2012 20 5 1760 1766
101. Ascenzi P., Bocedi A., Visca P., Antonini G., Gradoni L., Catalytic properties of cysteine proteinases from Trypanosoma cruzi and Leishmania infantum: a pre-steady-state and steady-state study. Biochemical and Biophysical Research Communications 2003 309 3 659 665 2-s2.0-0041328861 10.1016/j.bbrc.2003.08.015 (Pubitemid 37083302)
102. Lorente S. O., Gómez R., Jiménez C., Cammerer S., Yardley V., De Luca-Fradley K., Croft S. L., Ruiz Perez L. M., Urbina J., Pacanowska D. G., Gilbert I. H., Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. Bioorganic and Medicinal Chemistry 2005 13 10 3519 3529 2-s2.0-20244386998 10.1016/j.bmc.2005.02.060 (Pubitemid 40545807)
103. Bhargava P., Kumar K., Chaudhaery S. S., Saxena A. K., Roy U., Cloning, overexpression and characterization of Leishmania donovani squalene synthase. FEMS Microbiology Letters 2010 311 1 82 92 2-s2.0-77956401283 10.1111/j.1574-6968.2010.02071.x
104. Urbina J. A., Concepcion J. L., Rangel S., Visbal G., Lira R., Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana. Molecular and Biochemical Parasitology 2002 125 1-2 35 45 2-s2.0-0036860240 (Pubitemid 35449244)
105. Jiménez-Jiménez C., Carrero-Lérida J., Sealey-Cardona M., Ruiz-Pérez L. M., Urbina J. A., González- Pacanowska D., Δ24 (25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme. Molecular and Biochemical Parasitology 2008 160 1 52 59 2-s2.0-43949122198 10.1016/j.molbiopara.2008.03.010 (Pubitemid 351699264)
106. Roberts C. W., McLeod R., Rice D. W., Ginger M., Chance M. L., Goad L. J., Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa. Molecular and Biochemical Parasitology 2003 126 2 129 142 2-s2.0-0037327813 10.1016/S0166-6851(02)00280-3 (Pubitemid 36255612)
107. Heby O., Persson L., Madhubala R., Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. Amino Acids 2007 33 2 359 366 2-s2.0-34547654456 10.1007/s00726-007-0537-9 (Pubitemid 47222983)
108. Iniesta V., Gómez-Nieto L. C., Corraliza I., The inhibition of arginase by N ω -hydroxy-L-arginine controls the growth of Leishmania inside macrophages. Journal of Experimental Medicine 2001 193 6 777 783 2-s2.0-0035911231 10.1084/jem.193.6.777 (Pubitemid 32524470)
109. Balana-Fouce R., Calvo-Álvarez E., Álvarez-Velilla R., Prada C. F., Pérez-Pertejo Y., Reguera R. M., Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis. Molecular and Biochemical Parasitology 2012 181 2 85 93
110. Bakker B. M., Mensonides F. I. C., Teusink B., Van Hoek P., Michels P. A. M., Westerhoff H. V., Compartmentation protects trypanosomes from the dangerous design of glycolysis. Proceedings of the National Academy of Sciences of the United States of America 2000 97 5 2087 2092 2-s2.0-0034102066 10.1073/pnas.030539197 (Pubitemid 30134026)
111. Michels P. A. M., Hannaert V., Bringaud F., Metabolic aspects of glycosomes in Trypanosomatidaenew data and views. Parasitology Today 2000 16 11 482 489 2-s2.0-0034333236 10.1016/S0169-4758(00)01810-X
112. Hassan P., Fergusson D., Grant K. M., Mottram J. C., The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. Molecular and Biochemical Parasitology 2001 113 2 189 198 2-s2.0-0035815349 10.1016/S0166-6851(01)00220-1 (Pubitemid 32274292)
113. Grant K. M., Dunion M. H., Yardley V., Skaltsounis A. L., Marko D., Eisenbrand G., Croft S. L., Meijer L., Mottram J. C., Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. Antimicrobial Agents and Chemotherapy 2004 48 8 3033 3042 2-s2.0-3342936476 10.1128/AAC.48.8.3033-3042.2004 (Pubitemid 38989172)
114. Xingi E., Smirlis D., Myrianthopoulos V., Magiatis P., Grant K. M., Meijer L., Mikros E., Skaltsounis A. L., Soteriadou K., 6-Br-5methylindirubin- 3′oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis. International Journal for Parasitology 2009 39 12 1289 1303 2-s2.0-68249107643 10.1016/j.ijpara.2009. 04.005
115. Liang P. H., Anderson K. S., Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase. Biochemistry 1998 37 35 12195 12205 2-s2.0-0032167808 10.1021/bi9803168 (Pubitemid 28411305)
116. Senkovich O., Schormann N., Chattopadhyay D., Structures of dihydrofolate reductase-thymidylate synthase of trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate. Acta Crystallographica Section D 2009 65 7 704 716 2-s2.0-68149165443 10.1107/S090744490901230X
117. Zuccotto F., Martin A. C. R., Laskowski R. A., Thornton J. M., Gilbert I. H., Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania. Journal of Computer-Aided Molecular Design 1998 12 3 241 257 2-s2.0-0032059055 (Pubitemid 128510954)
118. Kuntz I. D., Structure-based strategies for drug design and discovery. Science 1992 257 5073 1078 1082 2-s2.0-0026730489
119. Veras P. S. T., Brodskyn C. I., Balestieri F. M. P., De Freitas L. A. R., Ramos A. P. S., Queiroz A. R. P., Barral A., Beverley S. M., Barral-Netto M., A dhfr-ts- Leishmania major Knockout Mutant Cross-protects against Leishmania amazonensis. Memorias do Instituto Oswaldo Cruz 1999 94 4 491 496 2-s2.0-0033159171 (Pubitemid 129572523)
120. Fonseca-Silva F., Inacio J. D. F., Canto-Cavalheiro M. M., Almeida-Amaral E. E., Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis. PLoS ONE 2011 6 2, article e14666 2-s2.0-79951571728 10.1371/journal.pone.0014666