Limitations in doxorubicin production from Streptomyces peucetius

Microbiological Research

Volumn 165, Issue 5, 2010, Pages 427-435

  Malla, Sailesh ^a   Prasad Niraula, Narayan ^a   Singh, Bijay ^a   Liou, Kwangkyoung ^a   Kyung Sohng, Jae ^a  

^a SunMoon University   (South Korea)

Author keywords

Biosynthesis; Cytotoxicity; Doxorubicin; Feedback regulation; Product inhibition

Indexed keywords

ANTI-TUMOR ACTIVITIES; CANCER CELL LINES; DOXORUBICIN; FEEDBACK REGULATION; INDUSTRIAL STRAIN; PARENTAL STRAINS; PRODUCT ANALYSIS; PRODUCT INHIBITION;

BIOCHEMISTRY; CELL CULTURE; GENETIC ENGINEERING;

BIOSYNTHESIS;

BACTERIUM; CANCER; DRUG; FEEDBACK MECHANISM; GENETIC ENGINEERING; INHIBITION; TUMOR;

STREPTOMYCES; STREPTOMYCES PEUCETIUS; STREPTOMYCES PEUCETIUS ATCC 27952;

ANTHRACYCLINE; CYTOCHROME P450; DAUNOSAMINE; DOXORUBICIN; HEXOSAMINE; RHODOMYCINONE;

BIOSYNTHESIS; DRUG ANTAGONISM; FEEDBACK SYSTEM; GLYCOSYLATION; METABOLISM; REVIEW; STREPTOMYCES;

ANTHRACYCLINES; BIOSYNTHETIC PATHWAYS; CYTOCHROME P-450 ENZYME SYSTEM; DOXORUBICIN; FEEDBACK, PHYSIOLOGICAL; GLYCOSYLATION; HEXOSAMINES; STREPTOMYCES;

EID: 77954675458     PISSN: 09445013     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micres.2009.11.006     Document Type: Review

References (41)

1. Arcamone F, Cassinelli G, Fantini G, Grein A, Orezzi P, Pol C, Spalla C Adriamycin 14-hydroxydaunomycin, a new antitumor antibiotic from Streptomyces peucetius var. caesius. Biotechnol Bioeng 1969, 11(6):1101-1110.
2. Bao W, Sheldon PJ, Wendt-Pienkowski E, Hutchinson CR The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide". J Bacteriol 1999, 181(15):4690-4695.
3. Chen L, Lu Y, Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W. Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Appl Microbiol Biotechnol 2008, 80(2):277-286.
4. Dekleva ML, Titus JA, Strohl WR. Nutrient effects on anthracycline production by Streptomyces peucetius in a defined medium. Can J Microbiol 1985, 31(3):287-294.
5. Dickens ML, Priestley ND, Strohl WR. In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA. J Bacteriol 1997, 179(8):2641-2650.
6. Dykstra KH, Wang HY. Feedback regulation and the intracellular protein profile of Streptomyces griseus in a cycloheximide fermentation. Appl Microbiol Biotechnol 1990, 34(2):191-197.
7. Filippini S, Solinas MM, Breme U, Schluter MB, Gabellini D, Biamonti G, Colombo AL, Garofano L Streptomcyes peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression. Microbiology 1995, 141(4):1007-1016.
8. Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA. Interference by Doxorubicin with DNA Unwinding in MCF-7 Breast Tumor Cells. 1994; 45(4): 649-56.
9. Furuya K, Hutchinson CR. The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis. J Bacteriol 1996, 178(21):6310-6318.
10. Gallo MA, Ward J, Hutchinson CR. The dnrM gene in Streptomyces peucetius contains a naturally-occurring frameshift mutation that is suppressed by another locus outside of the daunorubicin- production gene cluster. Microbiology 1996, 142(pt 2):269-275.
11. Gastaldo L, Marinelli F, Acquarella C, Restelli E, Quarta C. Improvement of the kirromycin fermentation by resin addition. J Ind Microbiol 1996, 16(5):305-308.
12. Grein A. Antitumor anthracyclines produced by Streptomyces peucetius. Adv Appl Microbiol 1987, 32:203-214.
13. Grimm A, Madduri K, Ali A, Hutchinson CR. Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase. Gene 1994, 151:1-10.
14. Hutchinson CR, Colombo AL. Genetic engineering of doxorubicin production in Streptomyces peucetius: a review. J Ind Microbiol Biotechnol 1999, 23(1):647-652.
15. Jiang H, Hutchinson CR. Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius 2006, 157(7):666-674.
16. Lam KS, Veitch JA, Lowe SE, Forenza S. Effect of neutral resins on the production of dynemicins by Micromonospora chersina. J Ind Microbiol 1995, 15(5):453-455.
17. Lee JC, Park HR, Park DJ, Lee HB, Kim YB, Kim CJ. Improved production of teicoplanin using adsorbent resin in fermentations. Lett Appl Microbiol 2003, 37(3):196-200.
18. Lee KM, Lee CK, Choi SU, Park HR, Kitani S, Nihira T, Hwang YI. Cloning and in vivo functional analysis by disruption of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces natalensis. Arch Microbiol 2005, 184(4):249-257.
19. Liu J, Mushegian A. Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci 2003, 12(7):1418-1431.
20. Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR. The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis. J Bacteriol 1998, 180(9):2379-2386.
21. Lomovskaya N, Hong SK, Kim SU, Fonstein L, Furuya K, Hutchinson CR. The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production. J Bacteriol 1996, 178(11):3238-3245.
22. Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR. Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene. J Bacteriol 1999, 181(1):305-318.
23. Lown J.M. Anthracycline and anthraquinone anticancer agents: current status and recent developments. Pharmacol Ther 1993, 60(2):185-214.
24. Madduri K, Hutchinson CR. Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius. J Bacteriol 1995, 177(13):3879-3884.
25. Maharjan S, Oh TJ, Lee HC, Sohng JK. Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439. J Microbiol Biotechnol 2009, 19(2):121-127.
26. Malla S, Niraula NP, Liou K, Sohng JK. Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius. J Biosc Bioeng 2009, 108(2):92-98.
27. Malla S, Niraula NP, Liou K, Sohng JK. Self-resistance mechanism in Streptomyces peucetius: Overexpression of drrA, drrB and drrC for doxorubicin enhancement. Microbiol Res 2009, doi:10.1016/j.micres.2009.04.002.b.
28. Marshall VP, Mcwethy SJ, Sirotti JM, Cialdella JI. The effect of neutral resins on the fermentation production of rubradirin. J Ind Microbiol 1990, 5(5):283-288.
29. Momparler RL, Karon M, Siegel SE, Avila F. Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Cancer Res 1976, 36(8):2891-2895.
30. Otten SL, Gallo MA, Madduri K, Liu X, Hutchinson CR. Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-l-daunosamine. J Bacteriol 1997, 179(13):4446-4450.
31. Otten SL, Ferguson J, Hutchinson CR. Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus. J Bacteriol 1995, 177(5):1216-1224.
32. Otten SL, Liu X, Ferguson J, Hutchinson CR. Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis. J Bacteriol 1995, 177(22):6688-6692.
33. Parajuli N, Viet HT, Ishida K, Tong HT, Lee HC, Liou K, Sohng JK. Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952. Res Microbiol 2005, 156(5-6):707-712.
34. Scotti C, Hutchinson CR. Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis. J Bacteriol 1996, 178(24):7316-7321.
35. Singh B, Lee CB, Sohng JK. Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952. Appl Microbiol Biotechnol 2009, 10.1007/s00253-009-2225-z.
36. Smankski MJ, Peterson RM, Rajski SR, Shen B. Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrob Agents Chemother 2009, 53(4):1299-1304.
37. Stutzman-Engwall KJ, Otten SL, Hutchinson CR. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. J Bacteriol 1992, 174(1):144-154.
38. Tang L, Grimm A, Zhang YX, Hutchinson CR. Purification and characterization of the DNA binding protein, DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. Mol Microbiol 1996, 22(5):801-813.
39. Tsueng G, Lam KS Stabilization effects of resin on the production of potent proteasome inhibitor NPI-0052 during submerged fermentation of Salinispora tropica. J Antibiot (Tokyo) 2007, 60(7):469-472.
40. Walczak RJ, Dickens ML, Priestley ND, Strohl WR. Purification, properties, and characterization of recombinant Streptomyces sp strain C5 DoxA, a cytochrome P450 catalyzing multiple steps in doxorubicin biosynthesis. J Bacteriol 1999, 181(1):298-304.
41. Yang YH, Song E, Kim EJ, Lee K, Kim WS, Park SS, Hahn JS, NdgR Kim BG. an IclR-like regulator involved in amino-acid-dependent growth, quorum sensing, and antibiotic production in Streptomyces coelicolor. Appl Microbiol Biotechnol 2009, 82(3):501-511.