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Volumn 109, Issue 6, 2016, Pages 367-372

Clinical development of cancer therapeutics that target metabolism

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 PYRIDINYL) 1 (4 PYRIDINYL) 2 PROPEN 1 ONE; 6 PHOSPHOFRUCTO 2 KINASE; 6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; AG 120; ANTINEOPLASTIC AGENT; AZD 3965; BIS 2 (5 PHENYLACETAMIDO 1,2,4 THIADIAZOL 2 YL)ETHYL SULFIDE 3; CARBOPLATIN; CB 839; CPI 613; DEOXYGLUCOSE; DICHLOROACETIC ACID; DOCETAXEL; ENASIDENIB; FRUCTOSE 2,6 BISPHOSPHATASE 3; GLUTAMINASE; HEXOKINASE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE INHIBITOR; ISOSORBIDE; LACTATE DEHYDROGENASE; MONOCARBOXYLATE TRANSPORTER 1; PFK 158; UNCLASSIFIED DRUG; TUMOR MARKER;

EID: 84978984470     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcv181     Document Type: Review
Times cited : (29)

References (39)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 43649094992 scopus 로고    scopus 로고
    • Quantitative techniques in 18FDG PET scanning in oncology
    • Castell F, Cook GJ. Quantitative techniques in 18FDG PET scanning in oncology. Br J Cancer 2008; 98:1597-601.
    • (2008) Br J Cancer , vol.98 , pp. 1597-1601
    • Castell, F.1    Cook, G.J.2
  • 4
    • 84863746052 scopus 로고    scopus 로고
    • Marked, homogeneous, and early [18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma
    • McArthur GA, Puzanov I, Amaravadi R, Ribas A, Chapman P, Kim KB, et al. Marked, homogeneous, and early [18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma. J Clin Oncol 2012; 30:1628-34.
    • (2012) J Clin Oncol , vol.30 , pp. 1628-1634
    • McArthur, G.A.1    Puzanov, I.2    Amaravadi, R.3    Ribas, A.4    Chapman, P.5    Kim, K.B.6
  • 5
  • 7
    • 84938153238 scopus 로고    scopus 로고
    • Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance
    • Masui K, Tanaka K, Ikegami S, Villa GR, Yang H, Yong WH, et al. Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance. Proc Natl Acad Sci USA 2015; 112:9406-11.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 9406-9411
    • Masui, K.1    Tanaka, K.2    Ikegami, S.3    Villa, G.R.4    Yang, H.5    Yong, W.H.6
  • 8
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxiainducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    • Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxiainducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007; 27:7381-93.
    • (2007) Mol Cell Biol , vol.27 , pp. 7381-7393
    • Kim, J.W.1    Gao, P.2    Liu, Y.C.3    Semenza, G.L.4    Dang, C.V.5
  • 9
    • 0001422847 scopus 로고
    • Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose
    • Landau BR, Laszlo J, Stengle J, Burk D. Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose. J Natl Cancer Inst 1958; 21:485-94.
    • (1958) J Natl Cancer Inst , vol.21 , pp. 485-494
    • Landau, B.R.1    Laszlo, J.2    Stengle, J.3    Burk, D.4
  • 10
    • 77956627000 scopus 로고    scopus 로고
    • Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
    • Stein M, Lin H, Jeyamohan C, Dvorzhinski D, Gounder M, Bray K, et al. Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. Prostate 2010; 70:1388-94.
    • (2010) Prostate , vol.70 , pp. 1388-1394
    • Stein, M.1    Lin, H.2    Jeyamohan, C.3    Dvorzhinski, D.4    Gounder, M.5    Bray, K.6
  • 11
    • 84874116164 scopus 로고    scopus 로고
    • A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors
    • Raez LE, Papadopoulos K, Ricart AD, Chiorean EG, Dipaola RS, Stein MN, et al. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 2013; 71:523-30.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 523-530
    • Raez, L.E.1    Papadopoulos, K.2    Ricart, A.D.3    Chiorean, E.G.4    Dipaola, R.S.5    Stein, M.N.6
  • 12
    • 84905453325 scopus 로고    scopus 로고
    • 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27
    • Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O'Neal J, et al. 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell Death Dis 2014; 5:e1337
    • (2014) Cell Death Dis , vol.5
    • Yalcin, A.1    Clem, B.F.2    Imbert-Fernandez, Y.3    Ozcan, S.C.4    Peker, S.5    O'Neal, J.6
  • 13
    • 38349183620 scopus 로고    scopus 로고
    • Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
    • Clem B, Telang S, Clem A, Yalcin A, Meier J, Simmons A, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther 2008; 7:110-20.
    • (2008) Mol Cancer Ther , vol.7 , pp. 110-120
    • Clem, B.1    Telang, S.2    Clem, A.3    Yalcin, A.4    Meier, J.5    Simmons, A.6
  • 15
    • 66449103009 scopus 로고    scopus 로고
    • LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
    • Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, et al. LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther 2009; 8:626-35.
    • (2009) Mol Cancer Ther , vol.8 , pp. 626-635
    • Xie, H.1    Valera, V.A.2    Merino, M.J.3    Amato, A.M.4    Signoretti, S.5    Linehan, W.M.6
  • 16
    • 0141569444 scopus 로고    scopus 로고
    • Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
    • Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 2003; 46:4259-64.
    • (2003) J Med Chem , vol.46 , pp. 4259-4264
    • Kitada, S.1    Leone, M.2    Sareth, S.3    Zhai, D.4    Reed, J.C.5    Pellecchia, M.6
  • 17
    • 84874529559 scopus 로고    scopus 로고
    • Phase I study of at-101 (R-(-)-gossypol) in combination with paclitaxel (P) and carboplatin (C) in solid tumors including castrate-resistant prostate cancer (CRPC)
    • Zhao MG Y, Lin H, Harris Addo K, Taber Levinson K, LaRosiliere M, Goodin S, et al. Phase I study of at-101 (R-(-)-gossypol) in combination with paclitaxel (P) and carboplatin (C) in solid tumors including castrate-resistant prostate cancer (CRPC). J Clin Oncol 2011; 29: Abstract 169.
    • (2011) J Clin Oncol , vol.29
    • Zhao, M.G.Y.1    Lin, H.2    Harris Addo, K.3    Taber Levinson, K.4    LaRosiliere, M.5    Goodin, S.6
  • 18
    • 85184968890 scopus 로고    scopus 로고
    • Phase 2 trial of AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head-and-neck squamous cell carcinoma (HNSCC)
    • Sacco A, Nor J, Belile E, Sukari A, Chepeha D, Bradford C, et al. Phase 2 trial of AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head-and-neck squamous cell carcinoma (HNSCC). Int J Rad Oncol 2014; 88: Abstract 199.
    • (2014) Int J Rad Oncol , vol.88
    • Sacco, A.1    Nor, J.2    Belile, E.3    Sukari, A.4    Chepeha, D.5    Bradford, C.6
  • 20
    • 84905096091 scopus 로고    scopus 로고
    • Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy
    • Peppicelli S, Bianchini F, Calorini L. Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy. Cancer Metastasis Rev 2014; 33:823-32.
    • (2014) Cancer Metastasis Rev , vol.33 , pp. 823-832
    • Peppicelli, S.1    Bianchini, F.2    Calorini, L.3
  • 21
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • Doherty JR, Cleveland JL. Targeting lactate metabolism for cancer therapeutics. J Clin Invest 2013; 123:3685-92.
    • (2013) J Clin Invest , vol.123 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 22
    • 84918565034 scopus 로고    scopus 로고
    • Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport
    • Bola BM, Chadwick AL, Michopoulos F, Blount KG, Telfer BA, Williams KJ, et al. Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol Cancer Ther 2014; 13:2805-16.
    • (2014) Mol Cancer Ther , vol.13 , pp. 2805-2816
    • Bola, B.M.1    Chadwick, A.L.2    Michopoulos, F.3    Blount, K.G.4    Telfer, B.A.5    Williams, K.J.6
  • 23
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/H+symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
    • Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, et al. CD147 subunit of lactate/H+symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A 2011; 108:16663-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilc, K.5    Murray, C.M.6
  • 24
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: a new therapeutic target in cancer
    • Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci 2010; 35:427-33.
    • (2010) Trends Biochem Sci , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 25
    • 64749116346 scopus 로고    scopus 로고
    • c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009; 458:762-5.
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6
  • 27
    • 84855453655 scopus 로고    scopus 로고
    • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
    • Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012; 15:110-21.
    • (2012) Cell Metab , vol.15 , pp. 110-121
    • Le, A.1    Lane, A.N.2    Hamaker, M.3    Bose, S.4    Gouw, A.5    Barbi, J.6
  • 29
    • 84880300456 scopus 로고    scopus 로고
    • Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities
    • Cairns RA, Mak TW. Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov 2013; 3:730-41.
    • (2013) Cancer Discov , vol.3 , pp. 730-741
    • Cairns, R.A.1    Mak, T.W.2
  • 30
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013; 340:626-30.
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3    Turcan, S.4    Grommes, C.5    Campos, C.6
  • 32
    • 84979011665 scopus 로고    scopus 로고
    • Targeting isocitrate dehydrogenase-1 (IDH1) and IDH2 mutations. Clinical results in advanced hematologic malignancies
    • de Botton S. Targeting isocitrate dehydrogenase-1 (IDH1) and IDH2 mutations. Clinical results in advanced hematologic malignancies. Ann Oncol 2015; 26: Abstract O11.3.
    • (2015) Ann Oncol , vol.26
    • de Botton, S.1
  • 33
    • 80755133485 scopus 로고    scopus 로고
    • Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
    • Zachar Z, Marecek J, Maturo C, Gupta S, Stuart SD, Howell K, et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl) 2011; 89:1137-48.
    • (2011) J Mol Med (Berl) , vol.89 , pp. 1137-1148
    • Zachar, Z.1    Marecek, J.2    Maturo, C.3    Gupta, S.4    Stuart, S.D.5    Howell, K.6
  • 34
    • 84979004455 scopus 로고    scopus 로고
    • Translational assessment of the efficacy of CPI-613 against pancreatic cancer in animal models versus patients with stage IV disease
    • Retter AS. Translational assessment of the efficacy of CPI-613 against pancreatic cancer in animal models versus patients with stage IV disease. J Clin Oncol 2012; 30:Abstract 3075.
    • (2012) J Clin Oncol , vol.30
    • Retter, A.S.1
  • 35
    • 33846002728 scopus 로고    scopus 로고
    • A mitochondria-K+channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    • Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. A mitochondria-K+channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007; 11:37-51.
    • (2007) Cancer Cell , vol.11 , pp. 37-51
    • Bonnet, S.1    Archer, S.L.2    Allalunis-Turner, J.3    Haromy, A.4    Beaulieu, C.5    Thompson, R.6
  • 36
    • 79958081523 scopus 로고    scopus 로고
    • Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer
    • Robey IF, Martin NK. Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer. BMC Cancer 2011; 11:235
    • (2011) BMC Cancer , vol.11 , pp. 235
    • Robey, I.F.1    Martin, N.K.2
  • 38
  • 39
    • 84979011675 scopus 로고    scopus 로고
    • Phase II study of dichloroacetate (DCA) in combination with chemoradiation (CRT) for unresected, locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN)
    • Powell SF, Spanos WC, Black LJ, Ellison C, Miskimins WK, Puumala SE, et al. Phase II study of dichloroacetate (DCA) in combination with chemoradiation (CRT) for unresected, locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). J Clin Oncol 2015; 33: Abstract e17089.
    • (2015) J Clin Oncol , vol.33
    • Powell, S.F.1    Spanos, W.C.2    Black, L.J.3    Ellison, C.4    Miskimins, W.K.5    Puumala, S.E.6


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