CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Journal of Molecular and Cellular Cardiology

Volumn 98, Issue , 2016, Pages 62-72

  Uchinoumi, Hitoshi ^a   Yang, Yi ^a   Oda, Tetsuro ^a,b   Li, Na ^d   Alsina, Katherina M ^d   Puglisi, Jose L ^a   Chen Izu, Ye ^a   Cornea, Razvan L ^c   Wehrens, Xander H T ^d   Bers, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF MINNESOTA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium calmodulin dependent protein kinase II; Calmodulin; Dantrolene; Fluorescence resonance energy transfer; Ryanodine receptor

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; RYANODINE RECEPTOR 2; CALCIUM; CALMODULIN; DANTROLENE; FK 506 BINDING PROTEIN; PROTEIN BINDING; RYANODINE RECEPTOR; TACROLIMUS BINDING PROTEIN 1B;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HEART VENTRICLE TACHYCARDIA; MOUSE; MUSCLE CELL; NONHUMAN; OXIDATION KINETICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RABBIT; ANIMAL; CALCIUM SIGNALING; CARDIAC MUSCLE CELL; CHANNEL GATING; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HEART FAILURE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; PHOSPHORYLATION; RABBITS AND HARES; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; DANTROLENE; DISEASE MODELS, ANIMAL; HEART FAILURE; ION CHANNEL GATING; MICE; MYOCYTES, CARDIAC; PERMEABILITY; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR; TACROLIMUS BINDING PROTEINS;

EID: 84978886079     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.06.007     Document Type: Article

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