Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure

Circulation Research

Volumn 114, Issue 2, 2014, Pages 295-306

  Yang, Yi ^a   Guo, Tao ^a   Oda, Tetsuro ^a   Chakraborty, Asima ^c   Chen, Le ^b   Uchinoumi, Hitoshi ^a   Knowlton, Anne A ^a,b   Fruen, Bradley R ^d   Cornea, Razvan L ^d   Meissner, Gerhard ^c   Bers, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Arrhythmias; Cardiac; Fluorescence resonance energy transfer; Heart failure; Ryanodine receptor calcium release channel

Indexed keywords

CALCIUM ION; CALMODULIN; FK 506 BINDING PROTEIN; RYANODINE RECEPTOR 2; SURAMIN; RYANODINE RECEPTOR; TACROLIMUS BINDING PROTEIN 1B;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; STEADY STATE; ANIMAL; CALCIUM SIGNALING; DISEASE MODEL; GENETICS; HEART ARRHYTHMIA; KINETICS; METABOLISM; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN BINDING; SARCOPLASMIC RETICULUM; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

ARRHYTHMIAS, CARDIAC; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART FAILURE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM SIGNALING; CALMODULIN; DISEASE MODELS, ANIMAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART FAILURE; KINETICS; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RATS; RATS, SPRAGUE-DAWLEY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACROLIMUS BINDING PROTEINS;

EID: 84894214664     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.302857     Document Type: Article

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