FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel

Biophysical Journal

Volumn 101, Issue 9, 2011, Pages 2170-2177

  Guo, Tao ^a   Fruen, Bradley R ^b   Nitu, Florentin R ^b   Nguyen, Trinh D ^b   Yang, Yi ^a   Cornea, Razvan L ^b   Bers, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; FK 506 BINDING PROTEIN; PHOTOPROTEIN; RAPAMYCIN; RYANODINE RECEPTOR; SURAMIN;

ANIMAL; ARTICLE; CELL MEMBRANE PERMEABILITY; CYTOLOGY; DRUG EFFECT; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART MUSCLE; HEART MUSCLE CELL; METABOLISM; PROTEIN BINDING; RAT; SARCOPLASMIC RETICULUM; SWINE;

ANIMALS; CALMODULIN; CELL MEMBRANE PERMEABILITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; LUMINESCENT PROTEINS; MYOCARDIUM; MYOCYTES, CARDIAC; PROTEIN BINDING; RATS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SIROLIMUS; SURAMIN; SUS SCROFA; TACROLIMUS BINDING PROTEINS;

EID: 80455174814     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.09.030     Document Type: Article

References (31)

1. Y.S. Babu, and J.S. Sack W.J. Cook Three-dimensional structure of calmodulin Nature 315 1985 37 40 (Pubitemid 15064895)
2. G. Barbato, and M. Ikura A. Bax Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible Biochemistry 31 1992 5269 5278
3. D. Chin, and A.R. Means Calmodulin: a prototypical calcium sensor Trends Cell Biol. 10 2000 322 328 (Pubitemid 30445239)
4. Y. Saimi, and C. Kung Calmodulin as an ion channel subunit Annu. Rev. Physiol. 64 2002 289 311 (Pubitemid 34259232)
5. D.M. Balshaw, N. Yamaguchi, and G. Meissner Modulation of intracellular calcium-release channels by calmodulin J. Membr. Biol. 185 2002 1 8 (Pubitemid 34074999)
6. D.M. Bers Macromolecular complexes regulating cardiac ryanodine receptor function J. Mol. Cell. Cardiol. 37 2004 417 429 (Pubitemid 38953370)
7. J.T. Lanner, and D.K. Georgiou S.L. Hamilton Ryanodine receptors: structure, expression, molecular details, and function in calcium release Cold Spring Harb. Perspect. Biol. 2 2010 a003996
8. 2+ sensitivity of skeletal and cardiac muscle ryanodine receptors in the presence of calmodulin Am. J. Physiol. Cell Physiol. 279 2000 C724 C733
9. 2+ release channel (ryanodine receptor) Biophys. J. 86 2004 797 804 (Pubitemid 38209525)
10. 2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes Circ. Res. 99 2006 398 406 (Pubitemid 44253696)
11. N. Yamaguchi, and N. Takahashi G. Meissner Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel J. Clin. Invest. 117 2007 1344 1353 (Pubitemid 46718422)
12. 2+ into arrhythmias J. Cardiovasc. Electrophysiol. 13 2002 195 197 (Pubitemid 34211928)
13. 2+-calmodulin targets J. Biol. Chem. 283 2008 31531 31540
14. 2+ in cardiac myocytes Biophys. J. 95 2008 4597 4612
15. 2+ release channel (ryanodine receptor) J. Biol. Chem. 278 2003 23480 23486 (Pubitemid 36830165)
16. G. Meissner, and D.A. Pasek A. Tripathy Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels Proteins 74 2009 207 211
17. T. Wagenknecht, and M. Radermacher S. Fleischer Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor J. Biol. Chem. 272 1997 32463 32471 (Pubitemid 28011931)
18. 2+-calmodulin bind to neighboring locations on the ryanodine receptor J. Biol. Chem. 277 2002 1349 1353 (Pubitemid 34968889)
19. M. Samsó, and W. Feng P.D. Allen Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating PLoS Biol. 7 2009 e85
20. 2+ release channel Proc. Natl. Acad. Sci. USA 106 2009 6128 6133
21. R.L. Cornea, and F.R. Nitu B.R. Fruen Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer J. Biol. Chem. 285 2010 19219 19226
22. T. Guo, and R.L. Cornea D.M. Bers Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks Circ. Res. 106 2010 1743 1752
23. 2+-insensitive mutants of calmodulin Biochemistry 42 2003 2740 2747 (Pubitemid 36330628)
24. R.P. Haugland, and M.T.Z. Spence A. Basey The Handbook: A Guide to Fluorescence Probes and Labeling Technologies 2005 Molecular Probes Eugene, OR
25. X. Wu, and D.M. Bers Free and bound intracellular calmodulin measurements in cardiac myocytes Cell Calcium 41 2007 353 364 (Pubitemid 46277393)
26. D.M. Balshaw, and L. Xu G. Meissner Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor) J. Biol. Chem. 276 2001 20144 20153
27. R.V.L. Papineni, and K.M.S. O'Connell S.L. Hamilton Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1 J. Biol. Chem. 277 2002 49167 49174 (Pubitemid 36014345)
28. M. Klinger, and E. Bofill-Cardona M. Hohenegger Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites Biochem. J. 355 2001 827 833 (Pubitemid 32434102)
29. A.P. Hill, O. Kingston, and R. Sitsapesan Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites Mol. Pharmacol. 65 2004 1258 1268 (Pubitemid 38543496)
30. 2+ leak in heart failure Circ. Res. 97 2005 1314 1322
31. 2+ handling and arrhythmogenesis Circ. Res. 108 2011 871 883