Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

Circulation Research

Volumn 106, Issue 11, 2010, Pages 1743-1752

  Guo, Tao ^a   Cornea, Razvan L ^b   Huke, Sabine ^c   Camors, Emmanuel ^a   Yang, Yi ^a   Picht, Eckard ^a   Fruen, Bradley R ^b   Bers, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Binding properties; Ca sparks; FKBP12; FKBP12.6; Rapamycin; RyR2

Indexed keywords

CALCIUM; CYCLIC AMP; FK 506 BINDING PROTEIN; PROTEIN FKBP12; PROTEIN FKBP12.6; RAPAMYCIN; RYANODINE RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CALCIUM TRANSPORT; CONTROLLED STUDY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HEART MUSCLE CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; RECEPTOR BINDING;

ANIMALS; BLOTTING, WESTERN; CALCIUM SIGNALING; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HEART VENTRICLES; HUMANS; KINETICS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN BINDING; RATS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SIROLIMUS; SWINE; TACROLIMUS BINDING PROTEIN 1A; TACROLIMUS BINDING PROTEINS;

EID: 77953812124     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.219816     Document Type: Article

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