Probing a putative dantrolene-binding site on the cardiac ryanodine receptor

Biochemical Journal

Volumn 387, Issue 3, 2005, Pages 905-909

  Paul Pletzer, Kalanethee ^a   Yamamoto, Takeshi ^b   Ikemoto, Noriaki ^b   Jimenez, Leslie S ^c   Morimoto, Hiromi ^d   Williams, Philip G ^d   Ma, Jianjie ^a   Parness, Jerome ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

3H azidodantrolene; Calcium; Dantrolene; Malignant hyperthermia; Photoaffinity labelling; Ryanodine receptor

Indexed keywords

AMINO ACIDS; CELLS; DRUG PRODUCTS; MUSCULOSKELETAL SYSTEM; PROTEINS; SYNTHESIS (CHEMICAL);

CARDIAC RYANODINE RECEPTOR; DANTROLENE BINDING; PHOTOAFFINITY; SARCOPLASMIC RETICULUM (SR);

CARDIOLOGY;

AMINO ACID; AZIDE; AZIDODANTROLENE; CALCIUM ION; DANTROLENE; EGTAZIC ACID; EPITOPE; HEART RECEPTOR; MONOCLONAL ANTIBODY; RYANODINE RECEPTOR; RYANODINE RECEPTOR 1; RYANODINE RECEPTOR 2; SYNTHETIC PEPTIDE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; CONFORMATION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG TARGETING; HEART FUNCTION; HEART PROTECTION; IMMUNOPRECIPITATION; IN VITRO STUDY; MOLECULAR RECOGNITION; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CALCIUM; DANTROLENE; MUSCLE, SKELETAL; MYOCARDIUM; PROTEIN CONFORMATION; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SWINE;

EID: 18844445706     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041336     Document Type: Article

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