Nutrition meets the microbiome: micronutrients and the microbiota

Annals of the New York Academy of Sciences

Volumn 1372, Issue 1, 2016, Pages 53-64

  Biesalski, Hans K ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

bioavailability; malnutrition; microbiome; micronutrients

Indexed keywords

BIOTIN; FOLIC ACID; NICOTINIC ACID; PANTOTHENIC ACID; RETINOL; RIBOFLAVIN; THIAMINE; TRACE ELEMENT; VITAMIN; VITAMIN D; VITAMIN K GROUP;

ARTICLE; BIOAVAILABILITY; COLON MUCOSA; DIARRHEA; ENERGY METABOLISM; HUMAN; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE INFECTION; IRON DEFICIENCY; LARGE INTESTINE; MALNUTRITION; MICROBIOME; NONHUMAN; NUTRITION; RETINOL DEFICIENCY; SMALL INTESTINE; VITAMIN METABOLISM; ZINC DEFICIENCY;

EID: 84978863269     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.13145     Document Type: Article

References (90)

1. Said, H.M. 2013. Recent advances in transport of water soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas. Am. J. Physiol. Gastrointest. Liver Physiol. 305: 601–610.
2. Nicholson, J.K. et al. 2012. Host–gut microbiota metabolic interactions. Science 336: 1262–1267.
3. LeBlanc, J.G., C. Milani, G. Savoy de Giori, et al. 2012. Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr. Opin. Biotech. 24: 1–9.
4. Biesalski, H.K. & P. Grimm. 2005. Pocket Atlas of Nutrition. New York: Thieme.
5. Said, H.M., A. Ortiz, V.S. Subramanian, et al. 2001. Mechanism of thiamine uptake by human colonocytes: studies with cultured colonic epithelial cell line NCM460. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G144–G150.
6. Nabokina, S.M. & H.M. Said. 2012. A high affinity and specific carrier-mediated mechanism for uptake of thiamine pyrophosphate by human colonic epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 303: G389–G395.
7. Champagne, C.P., T.A. Tompkins, N.D. Buckley, et al. 2010. Effect of fermentation by pure and mixed cultures of Streptococcus thermophilus and Lactobacillus helveticus on isoflavone and B-vitamin content of fermented soy beverage. Food Microbiol. 27: 968–972.
8. LeBlanc, J.G. et al. 2011. B-group vitamin production by lactic acid bacteria—current knowledge and potential applications. J. Appl. Microbiol. 111: 1297–1309.
9. Kasper, H. 1970. Vitamin absorption in the colon. Am. J. Proctol. 21: 341–345.
10. Said, H.M., A. Ortiz, M.P. Moyer & N. Yanagawa. 2000. Riboflavin uptake by human derived colonic epithelial NCM460 cells. Am. J. Physiol. Cell Physiol. 278: C270–C276.
11. Fleischman, N.M., D. Das, A. Kumar, et al. 2014. Molecular characterization of novel pyridoxal-5′-phosphate-dependent enzymes from the gut microbiome. Protein Sci. 23: 1060–1076.
12. 6 is required for full motility and virulence in Helicobacter pylori. MBio 1: e00112–10.
13. Pompei, A., L. Cordisco, A. Amaretti, et al. 2007. Folate production by bifidobacteria as a potential probiotic property. Appl. Environ. Microbiol. 73: 179–185.
14. Strozzi, G.P. & L. Mogna. 2008. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J. Clin. Gastroenterol. 42: 179–184.
15. Rong, N., J. Selhub, B.R. Goldin & I.C.H. Rosenberg. 1991. Bacterially synthesized folate in rat large intestine is incorporated into host tissue folyl polyglutamates. J. Nutr. 121: 1955–1959.
16. 12 as a modulator of gut microbial ecology. Cell Metab. 20: 769–778.
17. 12 analogs and compete in the gut. Cell Host Microbe 15: 47–57.
18. Gray, M.J. & J.C. Escalante-Semerena. 2010. A new pathway for the synthesis of α-ribazole-phosphate in Listeria innocua. Mol. Microbiol. 77: 1429–1438.
19. Allen, R.H. & S.P. Stabler. 2008. Identification and quantitation of cobalamin analogues in human feces. Am. J. Clin. Nutr. 87: 1324–1335.
20. Bauer, E., M. Marz, H. Salem, et al. 2014. Transcriptomic immune response of the cotton stainer Dysdercus fasciatus to experimental elimination of vitamin-supplementing intestinal symbionts. PLoS One 9: e114865.
21. Kjer-Nielsen, L., O. Patel & A.J. Corbett. 2012. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491: 717–725.
22. 12 uptake by the gut commensal bacteria Bacteroides thetaiotaomicron limits the production of the Shiga toxin by enterohemoragic Escherichia coli. Toxins 8: 14.
23. Segal, I., T.L. Ou, A. Demetriou, et al. 1986. Rectal manifestations of pellagra. Int. J. Colorectal Dis. 1: 238–243.
24. Okabe, N., K. Fujita & T. Yao. 1985. Immunological studies on Crohn's disease. III. Defective natural killer activity. J. Clin. Lab. Immunol. 17: 143–146.
25. Okabe, N., K. Urabe, K. Fujita, et al. 1988. Biotin effects in Crohn's disease. Dig. Dis. Sci. 33: 1495–1496.
26. Yadav, P.K., C. Chen & Z. Liu. 2011. Potential role of NK cells in the pathogenesis of inflammatory bowel disease. J. Biomed. Biotechnol. 2011: 348530.
27. 2) in human health. Br. J. Nutr. 110: 1357–1368.
28. McCullough, F.S., C.A. Northrop-Clewes & D.I. Thurnham. 1999. The effect of vitamin A on epithelial integrity. Proc. Nutr. Soc. 58: 289–293.
29. Biesalski, H.K. & D. Nohr. 2003. Importance of vitamin-A for lung function and development. Mol. Aspects Med. 24: 431–440.
30. Napoli, J.L. 2012. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim. Biophys. Acta 1821: 152–167.
31. Grune, T., G. Lietz, A. Palou, et al. 2010. β-carotene is an important vitamin A source for humans. J. Nutr. 140: 2268S–2285S.
32. Mühlhöfer, A., B. Bühler-Ritter, J. Frank, et al. 2003. Carotenoids are decreased in biopsies from colorectal adenomas. Clin. Nutr. 22: 65–70.
33. Cassani, B., E.J. Villablanca & J. De Calisto. 2012. Vitamin A and immune regulation: role of retinoic acid in gut associated dendritic cell education, immune protection and tolerance. Mol. Aspects Med. 33: 63–76.
34. Culligan, E.P., R.D. Sleator, J.R. Marchesi & C. Hill. 2014. Metagenomic identification of a novel salt tolerance gene from human gut microbiome which encodes a membrane protein homology to a brp/blh-family β-carotene 15,15′-monoxygenase. PLoS One 7: e103318.
35. Konieczna, P., R. Ferstl & M. Ziegler. 2013. Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms. PLoS One 8: e62617.
36. Uray, I.P., E. Dmitrovsky & P.H. Brown. 2016. Retinoids and rexinoids in cancer prevention: from laboratory to clinic. Semin. Oncol. 43: 49–64.
37. Cross, H.S., T. Nittke & M. Peterlik. 2009. Modulation of vitamin D synthesis and catabolism in colorectal mucosa: a new target for cancer prevention. Anticancer Res. 29: 3705–3712.
38. Cross, H.S., T. Nittke & E. Kallay. 2011. Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer. Mol. Cell. Endocrinol. 347: 70–79.
39. Yu, S. & M.T. Cantorna. 2008. The vitamin D receptor is required for iNKT cell development. Proc. Natl. Acad. Sci. U.S.A. 105: 5207–5212.
40. 3 of the NOD2/Card15-defensin β2 innate immune pathway defective in Crohn disease. J. Biol. Chem. 285: 2227–2231.
41. Feng, J., S.J. Lee & S. Resta-Lenert. 2005. Effect of probiotic and commensal bacteria on vitamin D-receptor and calcium transport protein expression in intestinal epithelial cells in vitro. Gastroenterology 128: A–47204.
42. Schauber, J., C. Svanholm, S. Termén, et al. 2003. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. Gut 52: 735–741.
43. Termén, S., M. Tollin, E. Rodriguez, et al. 2008. PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells. Mol. Immunol. 45: 3947–3955.
44. Goimbart, A.F. 2009. The vitamin D–antimicrobial peptide pathway and its role in protection against infection. Future Microbiol. 4: 1151.
45. Biesalski, H.K. 2014. Hidden Hunger. Heidelberg: Springer.
46. Keflie, T.S., N. Nölle, C. Lambert, et al. 2015. Vitamin D deficiencies among tuberculosis patients in Africa: a systematic review. Nutrition 31: 1204–1212.
47. Brown, C.C. & R.J. Noelle. 2015. Seeing through the dark: new insights into the immune regulatory functions of vitamin A. Eur. J. Immunol. 45: 1287–1295.
48. Cha, H.R., S. Chang, J. Chang, et al. 2010. Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. J. Immunol. 184: 6799–6806.
49. Somer, A., E. Djunaedi, A.A. Loeden, et al. 1986. Impact of vitamin A supplementation on childhood mortality. Lancet 327: 1169–1173.
50. McDaniel, K.L., K.H. Restori, J.W. Dodds, et al. 2015. Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections. Infect. Immun. 83: 2984–2991.
51. Biesalski, H.K., U. Sobeck & H. Weiser. 2001. Topical application of vitamin A reverses metaplasia of rat vaginal epithelium: a rapid and efficient approach to improve mucosal barrier function. Eur. J. Med. Res. 6: 391–398.
52. Biesalski, H.K. & D. Nohr. 2004. New aspects in vitamin a metabolism: the role of retinyl esters as systemic and local sources for retinol in mucous epithelia. J. Nutr. 134: 3453S–3457S.
53. Sirisinha, S. 2015. The pleiotropic role of vitamin A in regulating mucosal immunity. Asian Pac. J. Allergy Immunol. 33: 71–89.
54. Vaishnava, S., C.L. Behrendt & A.S. Ismail. 2008. Paneth cells directly sense gut commensals and maintain homoeostasis at the intestinal host–microbial interface. Proc. Natl. Acad. Sci. U.S.A. 105: 20858–20863.
55. Koch, M., H.K. Biesalski, E. Stofft, et al. 1990. Crystalloid lysozyme inclusions in Paneth cells of vitamin A deficient rats. Cell. Tissue Res. 260: 625–628.
56. Meyer-Hoffert, U. et al. 2008. Secreted enteric antimicrobial activity localizes to the mucous surface layer. Gut 57: 764–771.
57. Frasca, L. & R. Lande. 2012. Role of defensins and cathelicidin LL37 in auto-immune and auto-inflammatory diseases. Curr. Pharm. Biotechnol. 13: 1882–1897.
58. Mora, J.R., M. Iwata & U.H. Andria. 2008. Vitamin effects on the immune system: vitamins A and D on the center stage. Nature Rev. Immunol. 8: 685–692.
59. Cantorna, M.T., K. McDaniel & S. Bora. 2014. Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. Exp. Biol. Med. 239: 1524–1530.
60. Kong, J., Z. Zhang & M.W. Musch. 2008. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am. J. Physiol. Gastorintest. Liver Physiol. 294: G208–G216.
61. Balamurugan, R., R.R. Mary, S. Chittaranjan, et al. 2010. Low levels of fecal lactobacilli in women with iron-deficiency anaemia in south India. Br. J. Nutr. 104: 931–934.
62. Levrat, M.A., C. Remsey & C. Demigne. 1991. High propionic acid fermentations and mineral accumulation in the cecum of rats adapted to different levels of inulin. J. Nutr. 121: 1730–1737.
63. Ramakrishna, B.S. 2013. Role of the gut microbiota in human nutrition and metabolism. J. Gastroenterol. Hepatol. 28: 9–17.
64. Vahjen, W., R. Pieper & J. Zentek. 2001. Increased dietary zinc oxide changes the bacterial core and enterobacterial composition in the ileum of piglets. J. Anim. Sci. 89: 2430–2439.
65. Pieper, R., W. Vahjen & K. Neumann. 2012. Dose-dependent effects of dietary zinc oxide on bacterial communities and metabolic profiles in the ileum of weaned pigs. J. Anim. Physiol. Anim. Nutr. 96: 825–833.
66. Black, R.E., L.H. Allen, Z. Bhutta, et al. 2008. Maternal and child undernutrition: gloabal and regional exposures and health consequences. Lancet 371: 243–260.
67. IZiNCG. 2006. Improving health of people in need by enhancing zinc nutrition. Accessed April 14, 2016. http://izincg.org.
68. Dhingra, U., G. Hieremath, V.P. Menon, et al. 2009. Zinc deficiency: descriptive epidemiology and morbidity among preschool children in peri-urban population in Delhi, India. J. Health Popul. Nutr. 27: 632–639.
69. Bhutta, Z.A., G.L. Darmstadt, B.S. Hasan & R.A. Haws. 2005. Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence. Pediatrics 115: 519–617.
70. Sturniolo, G.C., V. di Leo, A. Ferronato, et al. 2001. R. Zinc supplementation tightens leaky gut in Crohn's disease. Inflamm. Bowel Dis. 7: 94–98.
71. Crane, J.K., T.M. Naeher, I. Shulgina, et al. 2007. Effect of zinc in enteropathogenic Escherichia coli infection. Infect. Immun. 75: 5974–5984.
72. Starke, I.C., R. Pieper, K. Neumann, et al. 2014. The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets. FEMS Microbiol. Ecol. 87: 416–427.
73. Hojberg, O., N. Canibe, D. Poulsen, et al. 2005. Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned pigs. Appl. Environ. Microbiol. 71: 2267–2277.
74. Reed, S., H. Neuman, S. Moscovich, et al. 2015. Chronic zinc deficiency alters chick gut microbiota composition and function. Nutrients 7: 9768–9784.
75. Christian, P. & C.P. Stewart. 2010. Maternal micronutrient deficiency fetal development and risk of chronic disease. J. Nutr. 140: 437–445.
76. United Nations Subcommitee on Nutrition. 2000. Nutrition policy paper 18. Geneva: ACC/SCN.
77. Biesalski, H.K. 2016. The 1,000-day window and cognitive development. In Malnutrition and the First 1,000 Days of Life: Causes, Consequences, and Solutions. World Review of Nutrition and Dietetics. Vol. 115. H.K. Biesalski & R.E. Black, Eds.: 1–16. Basel: Karger.
78. Eggesbø, M., B. Moen, S. Pedadda, et al. 2011. Development of gut microbiota in infants not exposed to medical interventions. APMIS 119: 17–35.
79. Palmer, C., E.M. Bik, D.B. DiGuilio, et al. 2007. Development of the human infant intestinal microbiota. PLoS Biol. 5: e177.
80. Crider, K.S., T.P. Yang, R.J. Berry, et al. 2012. Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv. Nutr. 3: 21–38.
81. Smith, A.D., Y.I. Kim & H. Refsum. 2008. Is folic acid good for everyone? Am. J. Clin. Nutr. 87: 517–533.
82. Steegers-Theunissen, R.P., S.A. Obermann-Borst, D. Kremer, et al. 2009. Periconceptional maternal folic acid use of 400 μg per day is related to increased methylationof the IGF2 gene in the very young child. PLoS One 4: e7845.
83. Hejimans, B.T., E.W. Tobi, A.D. Stein, et al. 2008. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl. Acad. Sci. U.S.A. 105: 17046–17049.
84. Nagy-Szakal, D., M.C. Ross, S.E. Dowd, et al. 2012. Maternal micronutrients can modify colonic mucosal microbiota matuartation in murien offspring. Gut Microbes 3: 426–433.
85. Uni, Z., G. Zaiger & R. Reifen. 1998. Vitamin A deficiency induces morphometric changes and decreased functionality in chicken small intestine. Br. J. Nutr. 80: 401–407.
86. Ardesia, M., G. Ferlazzo & W. Fries. 2015. Vitamin D and inflammatory bowel disease. Biomed. Res. Int. 2015: 470805.
87. Young, G.P., G.K. Mortimer, G.L. Gopalsamy, et al. 2014. Zinc deficiency in children with environmental enteropathy—development of new strategies: report from an expert workshop. Am. J. Clin. Nutr. 100: 1198–2007.
88. Subramanian, S., S. Huq & T. Yatsunenko. 2014. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 510: 417–421.
89. Smith, M.I., T. Yatsunenko, M.J. Manary, et al. 2013. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science 339: 548–554.
90. Tzioumis, E. & L.S. Adair. 2014. Childhood dual burden of under- and overnutrition in low- and middle-income countries: a critical review. Food Nutr. Bull. 35: 230–243.