메뉴 건너뛰기




Volumn 110, Issue 8, 2013, Pages 1357-1368

The role of menaquinones (vitamin K2) in human health

Author keywords

Bioavailability; Bone health; CVD; Dietary recommendations; Menaquinones; Vitamin K

Indexed keywords

MENAQUINONE; FARNOQUINONE; PHYTOMENADIONE; VITAMIN;

EID: 84892633509     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114513001013     Document Type: Review
Times cited : (244)

References (107)
  • 1
    • 33745678714 scopus 로고    scopus 로고
    • Vitamin K and the prevention of fractures: Systematic review and meta-analysis of randomized controlled trials
    • Cockayne S, Adamson J, Lanham-New S, et al. (2006) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166, 1256-1261.
    • (2006) Arch Intern Med , vol.166 , pp. 1256-1261
    • Cockayne, S.1    Adamson, J.2    Lanham-New, S.3
  • 2
    • 62749172848 scopus 로고    scopus 로고
    • High dietary menaquinone intake is associated with reduced coronary calcification
    • Beulens JW, Bots ML, Atsma F, et al. (2009) High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 203, 489-493.
    • (2009) Atherosclerosis , vol.203 , pp. 489-493
    • Beulens, J.W.1    Bots, M.L.2    Atsma, F.3
  • 3
    • 7944233489 scopus 로고    scopus 로고
    • Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study
    • Geleijnse JM, Vermeer C, Grobbee DE, et al. (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 134, 3100-3105.
    • (2004) J Nutr , vol.134 , pp. 3100-3105
    • Geleijnse, J.M.1    Vermeer, C.2    Grobbee, D.E.3
  • 4
    • 0442293394 scopus 로고    scopus 로고
    • Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats
    • Spronk HM, Soute BA, Schurgers LJ, et al. (2003) Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res 40, 531-537.
    • (2003) J Vasc Res , vol.40 , pp. 531-537
    • Spronk, H.M.1    Soute, B.A.2    Schurgers, L.J.3
  • 8
    • 77953198478 scopus 로고    scopus 로고
    • Scientific Opinion on principles for deriving and applying Dietary Reference Values
    • EFSA Panel on Dietetic Products, Nutriton and Allergies (NDA) (2010) Scientific Opinion on principles for deriving and applying Dietary Reference Values. EFSA J 8, 1458.
    • (2010) EFSA J , vol.8 , pp. 1458
  • 9
    • 45849118924 scopus 로고    scopus 로고
    • Metabolism and cell biology of vitamin K
    • Shearer MJ & Newman P (2008) Metabolism and cell biology of vitamin K. Thromb Haemost 100, 530-547.
    • (2008) Thromb Haemost , vol.100 , pp. 530-547
    • Shearer, M.J.1    Newman, P.2
  • 10
    • 0019490792 scopus 로고
    • Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implication
    • Collins MD & Jones D (1981) Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implication. Microbiol Rev 45, 316-354.
    • (1981) Microbiol Rev , vol.45 , pp. 316-354
    • Collins, M.D.1    Jones, D.2
  • 11
    • 0031967116 scopus 로고    scopus 로고
    • Dietary intake and adequacy of vitamin K
    • Booth SL & Suttie JW (1998) Dietary intake and adequacy of vitamin K. J Nutr 128, 785-788.
    • (1998) J Nutr , vol.128 , pp. 785-788
    • Booth, S.L.1    Suttie, J.W.2
  • 12
  • 14
    • 84866294287 scopus 로고    scopus 로고
    • Vitamin K oxygenation, glutamate carboxylation, and processivity: Defining the three critical facets of catalysis by the vitamin K-dependent carboxylase
    • Rishavy MA & Berkner KL (2012) Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv Nutr 3, 135-148.
    • (2012) Adv Nutr , vol.3 , pp. 135-148
    • Rishavy, M.A.1    Berkner, K.L.2
  • 15
    • 70349787472 scopus 로고    scopus 로고
    • Vitamin K, an example of triage theory: Is micronutrient inadequacy linked to diseases of aging?
    • McCann JC & Ames BN (2009) Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr 90, 889-907.
    • (2009) Am J Clin Nutr , vol.90 , pp. 889-907
    • McCann, J.C.1    Ames, B.N.2
  • 16
    • 0034445265 scopus 로고    scopus 로고
    • Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations
    • Schurgers LJ & Vermeer C (2000) Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis 30, 298-307.
    • (2000) Haemostasis , vol.30 , pp. 298-307
    • Schurgers, L.J.1    Vermeer, C.2
  • 18
    • 0033991560 scopus 로고    scopus 로고
    • The UK food data-base for vitamin K and why we need it
    • Shearer MJ & Bolton-Smith C (2000) The UK food data-base for vitamin K and why we need it. Food Chem 68, 213-218.
    • (2000) Food Chem , vol.68 , pp. 213-218
    • Shearer, M.J.1    Bolton-Smith, C.2
  • 19
    • 42249093703 scopus 로고    scopus 로고
    • Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)
    • Nimptsch K, Rohrmann S & Linseisen J (2008) Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr 87, 985-992.
    • (2008) Am J Clin Nutr , vol.87 , pp. 985-992
    • Nimptsch, K.1    Rohrmann, S.2    Linseisen, J.3
  • 20
    • 38549092999 scopus 로고    scopus 로고
    • Vitamin K content of foods and dietary vitamin K intake in Japanese young women
    • Kamao M, Suhara Y, Tsugawa N, et al. (2007) Vitamin K content of foods and dietary vitamin K intake in Japanese young women. J Nutr Sci Vitaminol (Tokyo) 53, 464-470.
    • (2007) J Nutr Sci Vitaminol (Tokyo) , vol.53 , pp. 464-470
    • Kamao, M.1    Suhara, Y.2    Tsugawa, N.3
  • 21
    • 77957150968 scopus 로고    scopus 로고
    • Cheese: An overview
    • 1st vol., 3rd ed., [PF Fox, PLH McSweeney, TM Cogan and TP Guinee, editors]. London: Elsevier Academic Press
    • Fox PF & McSweeney PLH (2004) Cheese: an overview. In Cheese Chemistry, Physics and Microbiology, 1st vol., 3rd ed., pp. 1-18 [PF Fox, PLH McSweeney, TM Cogan and TP Guinee, editors]. London: Elsevier Academic Press.
    • (2004) Cheese Chemistry, Physics and Microbiology , pp. 1-18
    • Fox, P.F.1    McSweeney, P.L.H.2
  • 22
    • 77958198463 scopus 로고    scopus 로고
    • Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes
    • Beulens JW, Van der A D, Grobbee DE, et al. (2010) Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care 33, 1699-1705.
    • (2010) Diabetes Care , vol.33 , pp. 1699-1705
    • Beulens, J.W.1    Van Der A, D.2    Grobbee, D.E.3
  • 23
    • 67650766978 scopus 로고    scopus 로고
    • A high menaquinone intake reduces the incidence of coronary heart disease
    • Gast GC, de Roos NM, Sluijs I, et al. (2009) A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis 19, 504-510.
    • (2009) Nutr Metab Cardiovasc Dis , vol.19 , pp. 504-510
    • Gast, G.C.1    De Roos, N.M.2    Sluijs, I.3
  • 24
    • 33644554490 scopus 로고    scopus 로고
    • Vitamin k contents of meat, dairy, and fast food in the U.S. Diet
    • Elder SJ, Haytowitz DB, Howe J, et al. (2006) Vitamin k contents of meat, dairy, and fast food in the U.S. Diet. J Agric Food Chem 54, 463-467.
    • (2006) J Agric Food Chem , vol.54 , pp. 463-467
    • Elder, S.J.1    Haytowitz, D.B.2    Howe, J.3
  • 25
    • 77957149287 scopus 로고    scopus 로고
    • 2 added for nutritional purpose in foods for particular nutritional uses, food supplements and foods intended for the general population
    • 2 added for nutritional purpose in foods for particular nutritional uses, food supplements and foods intended for the general population. EFSA J 822, 1-31.
    • (2008) EFSA J , vol.822 , pp. 1-31
    • Bresson, J.L.1    Flynn, A.2    Heinonen, M.3
  • 26
    • 0029837810 scopus 로고    scopus 로고
    • Effect of food composition on vitamin K absorption in human volunteers
    • Gijsbers BL, Jie KS & Vermeer C (1996) Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr 76, 223-229.
    • (1996) Br J Nutr , vol.76 , pp. 223-229
    • Gijsbers, B.L.1    Jie, K.S.2    Vermeer, C.3
  • 27
    • 84868634391 scopus 로고    scopus 로고
    • Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women
    • Sato T, Schurgers LJ & Uenishi K (2012) Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J 11, 93.
    • (2012) Nutr J , vol.11 , pp. 93
    • Sato, T.1    Schurgers, L.J.2    Uenishi, K.3
  • 29
    • 0037084981 scopus 로고    scopus 로고
    • Differential lipoprotein transport pathways of K-vitamins in healthy subjects
    • Schurgers LJ & Vermeer C (2002) Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta 1570, 27-32.
    • (2002) Biochim Biophys Acta , vol.1570 , pp. 27-32
    • Schurgers, L.J.1    Vermeer, C.2
  • 30
    • 84862110250 scopus 로고    scopus 로고
    • Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats
    • AL Rajaba A, Booth SL, Peterson JW, et al. (2012) Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats. J Nutr 142, 841-845.
    • (2012) J Nutr , vol.142 , pp. 841-845
    • Al Rajaba, A.1    Booth, S.L.2    Peterson, J.W.3
  • 31
    • 0032495584 scopus 로고    scopus 로고
    • Tissue distribution of K-vitamers under different nutritional regimens in the rat
    • Ronden JE, Thijssen HH & Vermeer C (1998) Tissue distribution of K-vitamers under different nutritional regimens in the rat. Biochim Biophys Acta 1379, 16-22.
    • (1998) Biochim Biophys Acta , vol.1379 , pp. 16-22
    • Ronden, J.E.1    Thijssen, H.H.2    Vermeer, C.3
  • 32
    • 0028038107 scopus 로고
    • Vitamin K distribution in rat tissues: Dietary phylloquinone is a source of tissue menaquinone-4
    • Thijssen HH & Drittij-Reijnders MJ (1994) Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. Br J Nutr 72, 415-425.
    • (1994) Br J Nutr , vol.72 , pp. 415-425
    • Thijssen, H.H.1    Drittij-Reijnders, M.J.2
  • 33
    • 67649972845 scopus 로고    scopus 로고
    • Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry
    • Fu X, Peterson JW, Hdeib M, et al. (2009) Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry. Anal Chem 81, 5421-5425.
    • (2009) Anal Chem , vol.81 , pp. 5421-5425
    • Fu, X.1    Peterson, J.W.2    Hdeib, M.3
  • 35
    • 73749085276 scopus 로고    scopus 로고
    • The effect of different meals on the absorption of stable isotope-labelled phylloquinone
    • Jones KS, Bluck LJ, Wang LY, et al. (2009) The effect of different meals on the absorption of stable isotope-labelled phylloquinone. Br J Nutr 102, 1195-1202.
    • (2009) Br J Nutr , vol.102 , pp. 1195-1202
    • Jones, K.S.1    Bluck, L.J.2    Wang, L.Y.3
  • 36
    • 77954762555 scopus 로고    scopus 로고
    • Occurrence, biosynthesis and function of isoprenoid quinones
    • Nowicka B & Kruk J (2010) Occurrence, biosynthesis and function of isoprenoid quinones. Biochim Biophys Acta 1797, 1587-1605.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1587-1605
    • Nowicka, B.1    Kruk, J.2
  • 37
    • 0023118229 scopus 로고
    • Vitamin-K composition of anaerobic gut bacteria
    • Fernandez F & Collins MD (1987) Vitamin-K composition of anaerobic gut bacteria. FEMS Microbiol Lett 63, 175-180.
    • (1987) FEMS Microbiol Lett , vol.63 , pp. 175-180
    • Fernandez, F.1    Collins, M.D.2
  • 38
    • 0030978427 scopus 로고    scopus 로고
    • Intestinal flora and endogenous vitamin synthesis
    • Hill MJ (1997) Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 6, Suppl. 1, S43-S45.
    • (1997) Eur J Cancer Prev , vol.6 , pp. S43-S45
    • Hill, M.J.1
  • 39
    • 0025375895 scopus 로고
    • Dietary modification of potential vitamin K supply from enteric bacterial menaquinones in rats
    • Mathers JC, Fernandez F, Hill MJ, et al. (1990) Dietary modification of potential vitamin K supply from enteric bacterial menaquinones in rats. Br J Nutr 63, 639-652.
    • (1990) Br J Nutr , vol.63 , pp. 639-652
    • Mathers, J.C.1    Fernandez, F.2    Hill, M.J.3
  • 40
    • 0033195169 scopus 로고    scopus 로고
    • Production of menaquinones by lactic acid bacteria
    • Morishita T, Tamura N, Makino T, et al. (1999) Production of menaquinones by lactic acid bacteria. J Dairy Sci 82, 1897-1903.
    • (1999) J Dairy Sci , vol.82 , pp. 1897-1903
    • Morishita, T.1    Tamura, N.2    Makino, T.3
  • 41
    • 34848917113 scopus 로고    scopus 로고
    • Quantitative measurement of tetrahydromenaquinone-9 in cheese fermented by propionibacteria
    • Hojo K, Watanabe R, Mori T, et al. (2007) Quantitative measurement of tetrahydromenaquinone-9 in cheese fermented by propionibacteria. J Dairy Sci 90, 4078-4083.
    • (2007) J Dairy Sci , vol.90 , pp. 4078-4083
    • Hojo, K.1    Watanabe, R.2    Mori, T.3
  • 42
    • 0026937283 scopus 로고
    • 2) by intestinal bacteria and their role in maintaining coagulation homeostasis
    • 2) by intestinal bacteria and their role in maintaining coagulation homeostasis. Prog Food Nutr Sci 16, 307-343.
    • (1992) Prog Food Nutr Sci , vol.16 , pp. 307-343
    • Conly, J.M.1    Stein, K.2
  • 43
    • 0029133658 scopus 로고
    • The importance of menaquinones in human nutrition
    • Suttie JW (1995) The importance of menaquinones in human nutrition. Annu Rev Nutr 15, 399-417.
    • (1995) Annu Rev Nutr , vol.15 , pp. 399-417
    • Suttie, J.W.1
  • 44
    • 0015304349 scopus 로고
    • Characterization of vitamin K from human liver
    • Duello TJ & Matschiner JT (1972) Characterization of vitamin K from human liver. J Nutr 102, 331-335.
    • (1972) J Nutr , vol.102 , pp. 331-335
    • Duello, T.J.1    Matschiner, J.T.2
  • 45
    • 0025274835 scopus 로고
    • Vitamin K concentrations in the plasma and liver of surgical patients
    • Usui Y, Tanimura H, Nishimura N, et al. (1990) Vitamin K concentrations in the plasma and liver of surgical patients. Am J Clin Nutr 51, 846-852.
    • (1990) Am J Clin Nutr , vol.51 , pp. 846-852
    • Usui, Y.1    Tanimura, H.2    Nishimura, N.3
  • 46
    • 0021154566 scopus 로고
    • The function and metabolism of vitamin K
    • Olson RE (1984) The function and metabolism of vitamin K. Annu Rev Nutr 4, 281-337.
    • (1984) Annu Rev Nutr , vol.4 , pp. 281-337
    • Olson, R.E.1
  • 47
    • 0026533880 scopus 로고
    • Quantitative and qualitative measurements of K vitamins in human intestinal contents
    • Conly JM & Stein K (1992) Quantitative and qualitative measurements of K vitamins in human intestinal contents. Am J Gastroenterol 87, 311-316.
    • (1992) Am J Gastroenterol , vol.87 , pp. 311-316
    • Conly, J.M.1    Stein, K.2
  • 48
    • 0026524478 scopus 로고
    • Colonic absorption of menaquinone-4 and menaquinone-9 in rats
    • Ichihashi T, Takagishi Y, Uchida K, et al. (1992) Colonic absorption of menaquinone-4 and menaquinone-9 in rats. J Nutr 122, 506-512.
    • (1992) J Nutr , vol.122 , pp. 506-512
    • Ichihashi, T.1    Takagishi, Y.2    Uchida, K.3
  • 49
    • 0027337973 scopus 로고
    • 2 status and faecal flora in breast fed and formula fed 1-month-old infants
    • 2 status and faecal flora in breast fed and formula fed 1-month-old infants. Eur J Pediatr 152, 852-855.
    • (1993) Eur J Pediatr , vol.152 , pp. 852-855
    • Fujita, K.1    Kakuya, F.2    Ito, S.3
  • 50
    • 0021262688 scopus 로고
    • Production of menaquinones by intestinal anaerobes
    • Ramotar K, Conly JM, Chubb H, et al. (1984) Production of menaquinones by intestinal anaerobes. J Infect Dis 150, 213-218.
    • (1984) J Infect Dis , vol.150 , pp. 213-218
    • Ramotar, K.1    Conly, J.M.2    Chubb, H.3
  • 51
    • 41249102720 scopus 로고    scopus 로고
    • Determinants of vitamin K status in humans
    • Booth SL & AL Rajaba A (2008) Determinants of vitamin K status in humans. Vitam Horm 78, 1-22.
    • (2008) Vitam Horm , vol.78 , pp. 1-22
    • Booth, S.L.1    Al Rajaba, A.2
  • 53
    • 34447135471 scopus 로고    scopus 로고
    • Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes
    • Harrington DJ, Booth SL, Card DJ, et al. (2007) Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes. J Nutr 137, 1763-1768.
    • (2007) J Nutr , vol.137 , pp. 1763-1768
    • Harrington, D.J.1    Booth, S.L.2    Card, D.J.3
  • 54
    • 84856397114 scopus 로고    scopus 로고
    • Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation
    • Bruge F, Bacchetti T, Principi F, et al. (2011) Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation. Br J Nutr 106, 1058-1062.
    • (2011) Br J Nutr , vol.106 , pp. 1058-1062
    • Bruge, F.1    Bacchetti, T.2    Principi, F.3
  • 55
    • 27244450442 scopus 로고    scopus 로고
    • Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection
    • Harrington DJ, Soper R, Edwards C, et al. (2005) Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection. J Lipid Res 46, 1053-1060.
    • (2005) J Lipid Res , vol.46 , pp. 1053-1060
    • Harrington, D.J.1    Soper, R.2    Edwards, C.3
  • 56
    • 0026680772 scopus 로고
    • Vitamin K and human nutrition
    • Suttie JW (1992) Vitamin K and human nutrition. J Am Diet Assoc 92, 585-590.
    • (1992) J Am Diet Assoc , vol.92 , pp. 585-590
    • Suttie, J.W.1
  • 57
    • 7244258903 scopus 로고    scopus 로고
    • Effect of vitamin K intake on the stability of oral anticoagulant treatment: Dose-response relationships in healthy subjects
    • Schurgers LJ, Shearer MJ, Hamulyak K, et al. (2004) Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects. Blood 104, 2682-2689.
    • (2004) Blood , vol.104 , pp. 2682-2689
    • Schurgers, L.J.1    Shearer, M.J.2    Hamulyak, K.3
  • 58
    • 0014125907 scopus 로고
    • Dose response and minimal daily requirement for vitamin K in man
    • Frick PG, Riedler G & Brogli H (1967) Dose response and minimal daily requirement for vitamin K in man. J Appl Physiol 23, 387-389.
    • (1967) J Appl Physiol , vol.23 , pp. 387-389
    • Frick, P.G.1    Riedler, G.2    Brogli, H.3
  • 59
    • 0023941998 scopus 로고
    • Vitamin K deficiency from dietary vitamin K restriction in humans
    • Suttie JW, Mummah-Schendel LL, Shah DV, et al. (1988) Vitamin K deficiency from dietary vitamin K restriction in humans. Am J Clin Nutr 47, 475-480.
    • (1988) Am J Clin Nutr , vol.47 , pp. 475-480
    • Suttie, J.W.1    Mummah-Schendel, L.L.2    Shah, D.V.3
  • 60
    • 76549200140 scopus 로고
    • Human sources and absorption of vitamin K in relation to anticoagulation stability
    • Udall JA (1965) Human sources and absorption of vitamin K in relation to anticoagulation stability. JAMA 194, 127-129.
    • (1965) JAMA , vol.194 , pp. 127-129
    • Udall, J.A.1
  • 61
    • 0035186304 scopus 로고    scopus 로고
    • Effects of a hydrogenated form of vitamin K on bone formation and resorption
    • Booth SL, Lichtenstein AH, O'Brien-Morse M, et al. (2001) Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr 74, 783-790.
    • (2001) Am J Clin Nutr , vol.74 , pp. 783-790
    • Booth, S.L.1    Lichtenstein, A.H.2    O'Brien-Morse, M.3
  • 62
    • 0042209876 scopus 로고    scopus 로고
    • Dietary phylloquinone depletion and repletion in older women
    • Booth SL, Martini L, Peterson JW, et al. (2003) Dietary phylloquinone depletion and repletion in older women. J Nutr 133, 2565-2569.
    • (2003) J Nutr , vol.133 , pp. 2565-2569
    • Booth, S.L.1    Martini, L.2    Peterson, J.W.3
  • 63
    • 0026541633 scopus 로고
    • Changes of plasma des-gamma-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K
    • Furukawa M, Nakanishi T, Okuda H, et al. (1992) Changes of plasma des-gamma-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K. Cancer 69, 31-38.
    • (1992) Cancer , vol.69 , pp. 31-38
    • Furukawa, M.1    Nakanishi, T.2    Okuda, H.3
  • 64
    • 77956414295 scopus 로고    scopus 로고
    • 2 supplementation does not influence bone loss in early menopausal women: A randomised double-blind placebo-controlled trial
    • 2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int 21, 1731-1740.
    • (2010) Osteoporos Int , vol.21 , pp. 1731-1740
    • Emaus, N.1    Gjesdal, C.G.2    Almas, B.3
  • 65
    • 0033919825 scopus 로고    scopus 로고
    • 2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals
    • 2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals. J Bone Miner Metab 18, 216-222.
    • (2000) J Bone Miner Metab , vol.18 , pp. 216-222
    • Tsukamoto, Y.1    Ichise, H.2    Kakuda, H.3
  • 66
    • 73749086347 scopus 로고    scopus 로고
    • 2) supplementation on osteocalcin carboxylation in healthy prepubertal children
    • 2) supplementation on osteocalcin carboxylation in healthy prepubertal children. Br J Nutr 102, 1171-1178.
    • (2009) Br J Nutr , vol.102 , pp. 1171-1178
    • Van Summeren, M.J.1    Braam, L.A.2    Lilien, M.R.3
  • 67
    • 77958168617 scopus 로고    scopus 로고
    • Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species
    • Cranenburg EC, Koos R, Schurgers LJ, et al. (2010) Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost 104, 811-822.
    • (2010) Thromb Haemost , vol.104 , pp. 811-822
    • Cranenburg, E.C.1    Koos, R.2    Schurgers, L.J.3
  • 68
    • 84869499148 scopus 로고    scopus 로고
    • The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein
    • Dalmeijer GW, van der Schouw YT, Magdeleyns E, et al. (2012) The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. Atherosclerosis 225, 397-402.
    • (2012) Atherosclerosis , vol.225 , pp. 397-402
    • Dalmeijer, G.W.1    Van Der Schouw, Y.T.2    Magdeleyns, E.3
  • 69
    • 84869492713 scopus 로고    scopus 로고
    • Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects
    • Theuwissen E, Cranenburg EC, Knapen MH, et al. (2012) Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. Br J Nutr 108, 1652-1657.
    • (2012) Br J Nutr , vol.108 , pp. 1652-1657
    • Theuwissen, E.1    Cranenburg, E.C.2    Knapen, M.H.3
  • 70
    • 84855832865 scopus 로고    scopus 로고
    • 2 supplementation on functional vitamin K deficiency in hemodialysis patients: A randomized trial
    • 2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis 59, 186-195.
    • (2012) Am J Kidney Dis , vol.59 , pp. 186-195
    • Westenfeld, R.1    Krueger, T.2    Schlieper, G.3
  • 71
    • 33846186008 scopus 로고    scopus 로고
    • ACCF/AHA clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: A report of the ACCF Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on EBCT) developed in collaboration with the SAIP and the SCCT
    • Greenland P, Bonow RO, Brundage BH, et al. (2007) ACCF/AHA clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 49, 378-402.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 378-402
    • Greenland, P.1    Bonow, R.O.2    Brundage, B.H.3
  • 73
    • 33846958732 scopus 로고    scopus 로고
    • Vitamin K intake and calcifications in breast arteries
    • Maas AH, van der Schouw YT, Beijerinck D, et al. (2007) Vitamin K intake and calcifications in breast arteries. Maturitas 56, 273-279.
    • (2007) Maturitas , vol.56 , pp. 273-279
    • Maas, A.H.1    Van Der Schouw, Y.T.2    Beijerinck, D.3
  • 74
    • 0030770506 scopus 로고    scopus 로고
    • Skeletal functions of vitamin K-dependent proteins: Not just for clotting anymore
    • Booth SL (1997) Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore. Nutr Rev 55, 282-284.
    • (1997) Nutr Rev , vol.55 , pp. 282-284
    • Booth, S.L.1
  • 75
    • 0034055429 scopus 로고    scopus 로고
    • Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women
    • Booth SL, Tucker KL, Chen H, et al. (2000) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71, 1201-1208.
    • (2000) Am J Clin Nutr , vol.71 , pp. 1201-1208
    • Booth, S.L.1    Tucker, K.L.2    Chen, H.3
  • 76
    • 0029861325 scopus 로고    scopus 로고
    • Vitamin K status and bone mass in women with and without aortic atherosclerosis: A population-based study
    • Jie KG, Bots ML, Vermeer C, et al. (1996) Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 59, 352-356.
    • (1996) Calcif Tissue Int , vol.59 , pp. 352-356
    • Jie, K.G.1    Bots, M.L.2    Vermeer, C.3
  • 77
  • 78
    • 0345676495 scopus 로고    scopus 로고
    • Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause
    • Knapen MH, Nieuwenhuijzen Kruseman AC, Wouters RS, et al. (1998) Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 63, 375-379.
    • (1998) Calcif Tissue Int , vol.63 , pp. 375-379
    • Knapen, M.H.1    Nieuwenhuijzen Kruseman, A.C.2    Wouters, R.S.3
  • 79
    • 0033696401 scopus 로고    scopus 로고
    • Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin
    • Luukinen H, Kakonen SM, Pettersson K, et al. (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15, 2473-2478.
    • (2000) J Bone Miner Res , vol.15 , pp. 2473-2478
    • Luukinen, H.1    Kakonen, S.M.2    Pettersson, K.3
  • 80
    • 0033858864 scopus 로고    scopus 로고
    • Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: Effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin
    • Schaafsma A, Muskiet FA, Storm H, et al. (2000) Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. Eur J Clin Nutr 54, 626-631.
    • (2000) Eur J Clin Nutr , vol.54 , pp. 626-631
    • Schaafsma, A.1    Muskiet, F.A.2    Storm, H.3
  • 81
    • 0034980829 scopus 로고    scopus 로고
    • Carboxylation of osteocalcin may be related to bone quality: A possible mechanism of bone fracture prevention by vitamin K
    • Sugiyama T & Kawai S (2001) Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K. J Bone Miner Metab 19, 146-149.
    • (2001) J Bone Miner Metab , vol.19 , pp. 146-149
    • Sugiyama, T.1    Kawai, S.2
  • 82
    • 0027232105 scopus 로고
    • Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women
    • Szulc P, Chapuy MC, Meunier PJ, et al. (1993) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91, 1769-1774.
    • (1993) J Clin Invest , vol.91 , pp. 1769-1774
    • Szulc, P.1    Chapuy, M.C.2    Meunier, P.J.3
  • 83
    • 0028147029 scopus 로고
    • Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women
    • Szulc P, Arlot M, Chapuy MC, et al. (1994) Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9, 1591-1595.
    • (1994) J Bone Miner Res , vol.9 , pp. 1591-1595
    • Szulc, P.1    Arlot, M.2    Chapuy, M.C.3
  • 84
    • 0029879059 scopus 로고    scopus 로고
    • Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: A three year follow-up study
    • Szulc P, Chapuy MC, Meunier PJ, et al. (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18, 487-488.
    • (1996) Bone , vol.18 , pp. 487-488
    • Szulc, P.1    Chapuy, M.C.2    Meunier, P.J.3
  • 85
    • 0031044021 scopus 로고    scopus 로고
    • Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: The EPIDOS Study
    • Vergnaud P, Garnero P, Meunier PJ, et al. (1997) Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82, 719-724.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 719-724
    • Vergnaud, P.1    Garnero, P.2    Meunier, P.J.3
  • 86
    • 5144230684 scopus 로고    scopus 로고
    • Vitamin K, bone turnover, and bone mass in girls
    • Kalkwarf HJ, Khoury JC, Bean J, et al. (2004) Vitamin K, bone turnover, and bone mass in girls. Am J Clin Nutr 80, 1075-1080.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1075-1080
    • Kalkwarf, H.J.1    Khoury, J.C.2    Bean, J.3
  • 87
    • 33947520767 scopus 로고    scopus 로고
    • Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls
    • O'Connor E, Molgaard C, Michaelsen KF, et al. (2007) Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls. Br J Nutr 97, 661-666.
    • (2007) Br J Nutr , vol.97 , pp. 661-666
    • O'Connor, E.1    Molgaard, C.2    Michaelsen, K.F.3
  • 88
    • 51749087717 scopus 로고    scopus 로고
    • Vitamin K status is associated with childhood bone mineral content
    • van Summeren M, van Coeverden SC, Schurgers LJ, et al. (2008) Vitamin K status is associated with childhood bone mineral content. Br J Nutr 100, 852-858.
    • (2008) Br J Nutr , vol.100 , pp. 852-858
    • Van Summeren, M.1    Van Coeverden, S.C.2    Schurgers, L.J.3
  • 89
    • 33847209546 scopus 로고    scopus 로고
    • Pronounced elevation of undercarboxylated osteocalcin in healthy children
    • van SM, Braam L, Noirt F, et al. (2007) Pronounced elevation of undercarboxylated osteocalcin in healthy children. Pediatr Res 61, 366-370.
    • (2007) Pediatr Res , vol.61 , pp. 366-370
    • Van, S.M.1    Braam, L.2    Noirt, F.3
  • 90
    • 0026409481 scopus 로고
    • Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck
    • Hodges SJ, Pilkington MJ, Stamp TC, et al. (1991) Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. Bone 12, 387-389.
    • (1991) Bone , vol.12 , pp. 387-389
    • Hodges, S.J.1    Pilkington, M.J.2    Stamp, T.C.3
  • 92
    • 0031032118 scopus 로고    scopus 로고
    • Serum vitamin K level and bone mineral density in post-menopausal women
    • Kanai T, Takagi T, Masuhiro K, et al. (1997) Serum vitamin K level and bone mineral density in post-menopausal women. Int J Gynaecol Obstet 56, 25-30.
    • (1997) Int J Gynaecol Obstet , vol.56 , pp. 25-30
    • Kanai, T.1    Takagi, T.2    Masuhiro, K.3
  • 93
    • 0031930708 scopus 로고    scopus 로고
    • Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men
    • Tamatani M, Morimoto S, Nakajima M, et al. (1998) Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men. Metabolism 47, 195-199.
    • (1998) Metabolism , vol.47 , pp. 195-199
    • Tamatani, M.1    Morimoto, S.2    Nakajima, M.3
  • 94
    • 37349032122 scopus 로고    scopus 로고
    • Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women
    • Tsugawa N, Shiraki M, Suhara Y, et al. (2008) Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab 26, 79-85.
    • (2008) J Bone Miner Metab , vol.26 , pp. 79-85
    • Tsugawa, N.1    Shiraki, M.2    Suhara, Y.3
  • 95
    • 2442709997 scopus 로고    scopus 로고
    • Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women
    • Katsuyama H, Ideguchi S, Fukunaga M, et al. (2004) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women. J Nutr Sci Vitaminol (Tokyo) 50, 114-120.
    • (2004) J Nutr Sci Vitaminol (Tokyo) , vol.50 , pp. 114-120
    • Katsuyama, H.1    Ideguchi, S.2    Fukunaga, M.3
  • 96
    • 84859883121 scopus 로고    scopus 로고
    • Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): The Postmenopausal Health Study II
    • Kanellakis S, Moschonis G, Tenta R, et al. (2012) Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. Calcif Tissue Int 90, 251-262.
    • (2012) Calcif Tissue Int , vol.90 , pp. 251-262
    • Kanellakis, S.1    Moschonis, G.2    Tenta, R.3
  • 97
    • 0036613320 scopus 로고    scopus 로고
    • Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women
    • Katsuyama H, Ideguchi S, Fukunaga M, et al. (2002) Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women. J Nutr Sci Vitaminol (Tokyo) 48, 207-215.
    • (2002) J Nutr Sci Vitaminol (Tokyo) , vol.48 , pp. 207-215
    • Katsuyama, H.1    Ideguchi, S.2    Fukunaga, M.3
  • 98
    • 33646413904 scopus 로고    scopus 로고
    • Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study
    • Ikeda Y, Iki M, Morita A, et al. (2006) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. J Nutr 136, 1323-1328.
    • (2006) J Nutr , vol.136 , pp. 1323-1328
    • Ikeda, Y.1    Iki, M.2    Morita, A.3
  • 100
    • 77954362186 scopus 로고    scopus 로고
    • Worldwide status of vitamin D nutrition
    • Lips P (2010) Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol 121, 297-300.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 297-300
    • Lips, P.1
  • 101
    • 80054832428 scopus 로고    scopus 로고
    • 2 and risk of hip fractures: The Hordaland Health Study
    • 2 and risk of hip fractures: The Hordaland Health Study. Bone 49, 990-995.
    • (2011) Bone , vol.49 , pp. 990-995
    • Apalset, E.M.1    Gjesdal, C.G.2    Eide, G.E.3
  • 102
    • 60849090456 scopus 로고    scopus 로고
    • Vitamin K deficiency bleeding (VKDB) in early infancy
    • Shearer MJ (2009) Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev 23, 49-59.
    • (2009) Blood Rev , vol.23 , pp. 49-59
    • Shearer, M.J.1
  • 104
    • 0030738945 scopus 로고    scopus 로고
    • Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains
    • Ronden JE, Groenen-van Dooren MM, Hornstra G, et al. (1997) Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis 132, 61-67.
    • (1997) Atherosclerosis , vol.132 , pp. 61-67
    • Ronden, J.E.1    Groenen-Van Dooren, M.M.2    Hornstra, G.3
  • 105
    • 33751210094 scopus 로고    scopus 로고
    • Thrombin generation, a function test of the haemostatic-thrombotic system
    • Hemker HC, AL Dieri R, De Smeat E, et al. (2006) Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 96, 553-561.
    • (2006) Thromb Haemost , vol.96 , pp. 553-561
    • Hemker, H.C.1    Al Dieri, R.2    De Smeat, E.3
  • 106
    • 83355169610 scopus 로고    scopus 로고
    • The role of dietary vitamin K in the management of oral vitamin K antagonists
    • Holmes MV, Hunt BJ & Shearer MJ (2012) The role of dietary vitamin K in the management of oral vitamin K antagonists. Blood Rev 26, 1-14.
    • (2012) Blood Rev , vol.26 , pp. 1-14
    • Holmes, M.V.1    Hunt, B.J.2    Shearer, M.J.3
  • 107
    • 0035736002 scopus 로고    scopus 로고
    • Efficacy and safety of menatetrenone-4 postmenopausal Thai women
    • Bunyaratavej N, Penkitti P, Kittimanon N, et al. (2001) Efficacy and safety of menatetrenone-4 postmenopausal Thai women. J Med Assoc Thai 84, Suppl. 2, S553-S559.
    • (2001) J Med Assoc Thai , vol.84 , pp. S553-S559
    • Bunyaratavej, N.1    Penkitti, P.2    Kittimanon, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.