Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections

Infection and Immunity

Volumn 83, Issue 7, 2015, Pages 2984-2991

  McDaniel, Kaitlin L ^a   Restori, Katherine H ^b,c   Dodds, Jeffery W ^a   Kennett, Mary J ^a   Ross, A Catharine ^a   Cantornaa, Margherita T ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b MONTREAL GENERAL HOSPITAL   (Canada)

^c RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; RETINOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON; CYTOKINE PRODUCTION; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; HOST; INFLAMMATION; INTESTINE INFECTION; MORTALITY; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; RETINOL DEFICIENCY; SUSCEPTIBLE POPULATION; ANIMAL; ASYMPTOMATIC DISEASE; C57BL MOUSE; CITROBACTER RODENTIUM; COMPLICATION; DISEASE MODEL; DISEASE PREDISPOSITION; ENTEROBACTERIACEAE INFECTION; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOLOGY; SURVIVAL ANALYSIS;

ANIMALS; ASYMPTOMATIC DISEASES; CITROBACTER RODENTIUM; COLON; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ENTEROBACTERIACEAE INFECTIONS; MICE, INBRED C57BL; SURVIVAL ANALYSIS; VITAMIN A DEFICIENCY;

EID: 84931003231     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00201-15     Document Type: Article

References (28)

1. WHO. 2009. Global prevalence of vitamin A deficiency in populations at risk 1995-2005: WHO global database on vitamin A deficiency. World Health Organization, Geneva, Switzerland.
2. West KP, Jr. 2002. Extent of vitamin A deficiency among preschool children and women of reproductive age. J Nutr 132:2857S-2866S.
3. Fawzi WW. 2000. Vitamin A supplementation: implications for morbidity and mortality in children. J Infect Dis 2000:S112-S133. http://dx.doi .org/10.1086/315921.
4. Cantorna MT, Nashold FE, Hayes CE. 1994. In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J Immunol 152:1515-1522.
5. -deficient mice. J Immunol 142:388-393.
6. Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441:231-234. http://dx.doi.org/10.1038/nature04754.
7. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. 2004. Retinoic acid imprints gut-homing specificity on T cells. Immunity 21:527-538. http://dx.doi.org/10.1016/j.immuni.2004.08.011.
8. Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, O'Shea JJ. 2008. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111:1013-1020. http://dx.doi.org/10.1182/blood-2007 -06-096438.
9. Carman JA, Pond L, Nashold F, Wassom DL, Hayes CE. 1992. Immunity to Trichinella spiralis infection in vitamin A-deficient mice. J Exp Med 175:111-120. http://dx.doi.org/10.1084/jem.175.1.111.
10. Ross AC, Stephensen CB. 1996. Vitamin A and retinoids in antiviral responses. FASEB J 10:979-985.
11. Mora JR, Iwata M, von Andrian UH. 2008. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8:685-698. http://dx.doi.org/10.1038/nri2378.
12. Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH. 2013. Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med 210:1117-1124. http://dx.doi.org/10.1084 /jem.20121588.
13. Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF, Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y. 2014. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 343: 432-437. http://dx.doi.org/10.1126/science.1247606.
14. Collins JW, Keeney KM, Crepin VF, Rathinam VA, Fitzgerald KA, Finlay BB, Frankel G. 2014. Citrobacter rodentium: infection, inflammation and the microbiota. Nat Rev Microbiol 12:612-623. http://dx.doi.org /10.1038/nrmicro3315.
15. Bry L, Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172:433-441. http://dx.doi.org/10.4049/jimmunol .172.1.433.
16. Sonnenberg GF, Artis D. 2012. Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity 37: 601-610. http://dx.doi.org/10.1016/j.immuni.2012.10.003.
17. Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles S. 2005. Citrobacter rodentium of mice and man. Cell Microbiol 7:1697-1706. http://dx.doi.org/10.1111/j.1462-5822.2005.00625.x.
18. Smith SM, Levy NS, Hayes CE. 1987. Impaired immunity in vitamin A-deficient mice. J Nutr 117:857-865.
19. Ma Y, Chen Q, Ross AC. 2005. Retinoic acid and polyriboinosinic: polyribocytidylic acid stimulate robust anti-tetanus antibody production while differentially regulating type 1/type 2 cytokines and lymphocyte populations. J Immunol 174:7961-7969. http://dx.doi.org/10.4049 /jimmunol.174.12.7961.
20. Wiles S, Dougan G, Frankel G. 2005. Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract. Cell Microbiol 7:1163-1172. http://dx.doi.org/10 .1111/j.1462-5822.2005.00544.x.
21. Lefrancois L, Lycke N. 2001. Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells. Curr Protoc Immunol Chapter 3:Unit 3.19. http://dx.doi.org/10.1002/0471142735 .im0319s17.
22. Restori KH, McDaniel KL, Wray AE, Cantorna MT, Ross AC. 2014. Streptococcus pneumoniae-induced pneumonia and Citrobacter rodentium- induced gut infection differentially alter vitamin A concentrations in the lung and liver of mice. J Nutr 144:392-398. http://dx.doi.org/10 .3945/jn.113.186569.
23. Basu R, O'Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT. 2012. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity 37:1061-1075. http://dx.doi.org/10.1016/j.immuni.2012.08.024.
24. Meresse B, Malamut G, Cerf-Bensussan N. 2012. Celiac disease: an immunological jigsaw. Immunity 36:907-919. http://dx.doi.org/10.1016 /j.immuni.2012.06.006.
25. Vallance BA, Deng W, Jacobson K, Finlay BB. 2003. Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect Immun 71:3443-3453. http://dx.doi.org/10.1128/IAI.71.6.3443 -3453.2003.
26. Ghosh S, Dai C, Brown K, Rajendiran E, Makarenko S, Baker J, Ma C, Halder S, Montero M, Ionescu VA, Klegeris A, Vallance BA, Gibson DL. 2011. Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression. AmJ Physiol Gastrointest Liver Physiol 301:G39-G49. http://dx .doi.org/10.1152/ajpgi.00509.2010.
27. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ, III, Flier JS, Lowell BB, Fraker DL, Alexander HR. 1997. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 185:171-175. http://dx.doi.org/10.1084/jem .185.1.171.
28. Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, Martens EC, Nunez G. 2012. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336:1325-1329. http://dx.doi .org/10.1126/science.1222195.