The pleiotropic role of vitamin A in regulating mucosal immunity

Asian Pacific Journal of Allergy and Immunology

Volumn 33, Issue 2, 2015, Pages 71-90

  Sirisinha, Stitaya ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Microbiota; Mucosal immune system; Mucosal immunity; Retinoic acid; Secretory IgA; Vitamin A; Vitamin A deficiency

Indexed keywords

RETINOL; SECRETORY IMMUNOGLOBULIN;

ANIMAL; B LYMPHOCYTE SUBPOPULATION; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE SYSTEM DISEASES; IMMUNOLOGY; INTESTINE; INTESTINE FLORA; METABOLISM; MICROBIOLOGY; MUCOSAL IMMUNITY; NUTRITIONAL STATUS; PHENOTYPE; PROTEIN-ENERGY MALNUTRITION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VITAMIN A DEFICIENCY;

ANIMALS; B-LYMPHOCYTE SUBSETS; GASTROINTESTINAL MICROBIOME; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE SYSTEM DISEASES; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; INTESTINES; NUTRITIONAL STATUS; PHENOTYPE; PROTEIN-ENERGY MALNUTRITION; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 84944882604     PISSN: 0125877X     EISSN: 22288694     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Schaible UE, Kaufmann SHE. Malnutrition and infection: complex mechanisms and global impacts. PloS Med. 2007;4:e115.
2. Nauss KM. Influence of vitamin A status on the immune system. In: Bauernfeind JC, editor. Vitamin A deficiency and its control. New York: Academic Press; 1986. p. 207-43.
3. World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995-2005: WHO Global database on vitamin A deficiency. Geneva: World Health Organization; 2009.
4. Sommer A. Vitamin A deficiency and clinical disease: an historical overview. J Nutr. 2008;138:1835-9.
5. Sirisinha S, Suskind R, Edelman R, Charupatana C, Olson RE. Complement and C3-proactivator levels in children with proteincalorie malnutrition and effect of nutritional treatment. Lancet. 1973;1:1016-20.
6. Edelman R, Suskind, Olson RE, Sirisinha S. Mechanisms of defective cutaneous hypersensitivity in children with protein-calorie malnutrition. Lancet. 1973;1:506-9.
7. Sirisinha S, Suskind R, Edelman R, Asvapaka C, Olson RE. Secretory and serum IgA in children with protein-calorie malnutrition. Pediatrics. 1975; 55:66-70.
8. Udomkesmalee E, Dhanamitta S, Sirisinha S, Charoenkiatkul S, Tuntipopipat S, Banjong O, et al. Effect of vitamin A and zinc supplementation on the nutriture of children in northeast Thailand. Am J Clin Nutr. 1992;56:50-7.
9. Kramer TR, Udomkesmalee E, Dhanamitta S, Sirisinha S, Charoenkiatkul S, Tuntipopipat S, et al. Lymphocyte responsiveness of children supplemented with vitamin A and zinc. Am J Clin Nutr. 1993; 58:566-70.
10. Sirisinha S, Darip MD, Moonkarndi P, Ongsakul M, Lamb AJ. Impaired local immune response in vitamin A-deficient rats. Clin Exp Immunol. 1980;40:127-35.
11. Lamb AJ, Apiwatanaporn P, Olson JA. Induction of rapid, synchronous vitamin A deficiency in the rat. J Nutr. 1974;104:1140-8.
12. Sirisinha S. Impairment of secretory immune system in vitamin A deficiency state. J Sc Soc Thailand.1988;14:161-80.
13. Rojanapo W, Olson JA, Lamb AJ. Biochemical and immunological characterization and the synthesis of rat intestinal glycoproteins following the induction of rapid synchronous vitamin A deficiency. Biochim Biophys Acta. 1980;633:386-99.
14. D’Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011;3:63-103.
15. Villamor E, Fawzi WW. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev. 2005;18:446-64.
16. Mora JR, Iwata M, von Andrian VH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008;8:685-98.
17. Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, et al. Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol. 2015;8:141-51.
18. Klebanoff CA, Spencer SP, Torabi-Parizi P, Grainger JR, Roychoudhuri R, Ji Y, et al. Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med. 2013;210:1961-76.
19. Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, et al. Retinoic acid regulates development of a gut homing precursor for intestinal dendritic cells. Mucosal Immunol. 2013;6:847-56.
20. Rudraraju R, Jones BG, Surman SL, Sealy RE, Thomas PG, Hurwitz JL. Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A. PLoS ONE. 2014;9:e86554.
21. McDermott MR, Mark DA, Befus AD, Baliga BS, Suskind RM, Bienenstock J. Impaired intestinal localization of mesenteric lymphoblasts associated with vitamin A deficiency and proteincalorie malnutrition. Immunology. 1982;45:1-5.
22. Kaufman DR, De Calisto J, Simmons NL, Cruz AN, Villablanca EJ, Mora JR, et al. Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity. J Immunol. 2011;187:1877-83
23. Strober W. Vitamin A rewrites the ABCs of oral tolerance. Mucosal Immunol. 2008;1:92-5.
24. Ross AC, Chen Q, Ma Y. Vitamin A and retinoic acid in the regulation of B-cell development and antibody production. Vitam Horm. 2011;86:103-6.
25. Hall JA, Grainger JR, Spencer SP, Belkaid Y. The role of retinoic acid in tolerance and immunity. Immunity. 2011;35:13-22.
26. Raverdeau M, Mills KHG. Modulation of T cell and innate immune responses by retinoic acid. J Immunol. 2014;192:2953-8.
27. Cha H-R, Chang S-Y, Chang J-H, Kim J-O, Yang J-Y, Kim C-H, et al. Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. J Immunol. 2010; 184:6799-8606.
28. Amos B, Lotan D, Lotan R. Increased fucosylation of highmolecular-weight glycoproteins accompanies retinoic acid-induced differentiation of F-9 embryonal carcinoma cells. Int J Cancer. 1990;46:86-94.
29. Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol. 2014;14:667-85.
30. Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14:141-53.
31. Spencer SP, Belkaid Y. Dietary and commensal derived nutrients: shaping mucosal and systemic immunity. Curr Opin Immunol. 2012;24:379-84.
32. Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, et al. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. 2014;345;1254009.
33. Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, et al. Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature. 2014;514:638-41.
34. Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, et al. Epithelial IL-22RA-mediated fucosylation promotes intestine colonization resistance to an opportunistic pathogen. Cell Host Microbe. 2014;16:504-16.
35. Geissmann F, Revy P, Brousse N, Lepelletier Y, Folli C, Durandy A, et al. Retinoids regulate survival and antigen presentation by immature dendritic cells. J Exp Med. 2003;198:623-34.
36. Cassani B, Villablanca EJ, De Calisto J, Wang S, Mora JR. Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance. Mol Aspects Med. 2012;33:63-76.
37. Ongsakul M, Sirisinha S, Lamb AJ. Impaired blood clearance of bacteria and phagocytic activity in vitamin A-deficient rats. Proc Soc Exp Biol Med. 1985;178:204-8.
38. Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, et al. Retinoic acid expression associates with enhanced IL-22 production by γδT cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med. 2013;210:1117-24.
39. Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace WW, et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity. 2010;33:71-83.
40. Iwata M, Ishima Y, Kagechika H. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol. 2003;15:1017-25.
41. Iwata M, Hirakiyama A, Ishima Y, Kagechika H, Kato C, Song SY. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21:527-38.
42. Mora JR, Iwata M, Eksteen B, Song SY, Junt T, Senman B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006;314:1157-60.
43. Beijer MR, Kraal G, den Haan JMM. Vitamin A and dendritic cell differentiation. Immunology. 2013; 142:39-45.
44. Pino-Lagos K, Benson MJ, Noelle RJ. Retinoic acid in the immune system. Ann N Y Acad Sc. 2008;1143:170-87.
45. Liu X, Li Y, Wang Y, Wang Q, Li X, Bi Y, et al. Gestational vitamin A deficiency reduces the intestinal immune response by decreasing the number of immune cells in rat offspring. Nutrition. 2014;30:350-7.
46. Seo G-Y, Jang Y-S, Kim H-A, Lee M-R, Park M-H, Park S-K, et al. Retinoic acid, acting as a highly specific IgA isotype switch factor, cooperates with TGF-β1 to enhance the overall IgA response. J Leuk Biol. 2013;94:325-35.
47. Bjersing JL, Telemo E, Dahlgren U, Hanson LA. Loss of ileal IgA+ plasma cells and of CD+ lymphocytes in ileal Peyer’s patches of vitamin A deficient rats. Clin Exp Immunol. 2002;130:404-8.
48. Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, et al. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol. 2015;16:286-289.
49. Stephensen CB, Moldoveanu Z, Gangopadhyay NN. Vitamin A deficiency diminishes the salivary IgA response and enhances the serum IgG response to influenza A virus infection in BALB/c mice. J Nutr. 1996;126:94-102.
50. Wiedermann U, Hanson LA, Holmgren J, Kahu H, Dahlgren UI. Impaired mucosal antibody response to cholera toxin in vitamin A deficient rats immunized with oral cholera vaccine. Infect Immun. 1993;61:3952-7.
51. Puengtomwatanakul S, Sirisinha S. Impaired biliary secretion of immunoglobulin A in vitamin A deficient rats. Proc Soc Exp Biol Med. 1986;182:437-42.
52. Gangopadhyay NN, Moldoveanu Z, Stephensen CB. Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice. J Nutr. 1996;126:2960-7.
53. Walker JA, Barlow JL, McKenzie ANJ. Innate lymphoid cells— how did we miss them? Nat Rev Immunol. 2013;13:75-87
54. McKenzie ANJ, Spits H, Ebert G. Innate lymphoid cells in inflammation and immunity. Immunity. 2014;41:366-74.
55. Kim CH. Host and microbial factors in regulation of T cells in the intestine. Front Immunol. 2013;4:141.
56. Kiss EA, Vonarbourq C, Kopfmann S, Hobeika E, Finke D, Esser C, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 2011;334:61-5.
57. Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015;519:242-6.
58. Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science. 2014;343:432-37.
59. Allen JE, Maizels RM. Diversity and dialogue in immunity to helminthes. Nat Rev Immunol. 2011;11:375-88.
60. van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature. 2014;508:123-7.
61. Kabat AM, Srinivasam N, Maloy KJ. Modulation of immune development and function by intestinal microbiota. Trends Immunol. 2014;35:507-17.
62. Brown EM, Sadarangani M, Finlay BB. The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol. 2013;14:660-7.
63. Kaiko GE, Stappenbeck TS. Host-microbe interactions shaping the gastrointestinal environment. Trends Immunol. 2014;35:538-48.
64. Thaiss CA, Levy M, Suez J, Elenov E. The interplay between the innate immune system and the microbiota. Cur Op Immunol. 2014;26:41-8.
65. Brestoff JR, Artis D. Commensal bacteria at the interface of host metabolism and the immune response. Nat Immunol. 2013;14:676-84.
66. Maslowski K, Mackay CR. Diet, gut microbiota and immune responses. Nat Immunol. 2011;12:5-9.
67. Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, et al. Host-gut microbiota metabolic interactions. Science. 2012;336:1262-7.
68. Jain N, Walker WA. Diet and host-microbial crosstalk in postnatal intestinal immune homeostasis. Nat Rev Gastroenterol Hepatol. 2015;12:14-25.
69. Ubeda C, Palmer EG. Securing the border: lymphotoxin, IL-23 and IL-22 keep out the bad guys and ‘fatten’ the homeland. Nat Immunol. 2012;13:940-1.