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Volumn 15, Issue 1, 2016, Pages

The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia

Author keywords

Docosahexaenoic acid; Docosapentaenoic acid; Eicosapentaenoic acid; Hypertriglyceridemia; Omega 3 fatty acids

Indexed keywords

ICOSAPENTAENOIC ACID ETHYL ESTER; OMEGA 3 ACID ETHYL ESTER; OMEGA 3 FATTY ACID; ANTILIPEMIC AGENT; DIACYLGLYCEROL ACYLTRANSFERASE; DOCOSAHEXAENOIC ACID; DRUG COMBINATION; ESTER; ETHYL EICOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84978832830     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-016-0286-4     Document Type: Review
Times cited : (131)

References (97)
  • 1
    • 84984537585 scopus 로고    scopus 로고
    • Trends in elevated triglyceride in adults: United States, 2001-2012
    • Carroll M, Kit B, Lacher D. Trends in elevated triglyceride in adults: United States, 2001-2012. NCHS Data Brief. 2015;198:1-8.
    • (2015) NCHS Data Brief , vol.198 , pp. 1-8
    • Carroll, M.1    Kit, B.2    Lacher, D.3
  • 2
    • 38949171001 scopus 로고    scopus 로고
    • Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial
    • 1:CAS:528:DC%2BD1cXitVWlsb0%3D 18279736
    • Miller M, Cannon CP, Murphy SA, Qin J, Ray KK, Braunwald E. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol. 2008;51:724-30.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 724-730
    • Miller, M.1    Cannon, C.P.2    Murphy, S.A.3    Qin, J.4    Ray, K.K.5    Braunwald, E.6
  • 3
    • 84930025596 scopus 로고    scopus 로고
    • Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins
    • 1:CAS:528:DC%2BC2MXpt1Kqur4%3D 26022813
    • Schwartz GG, Abt M, Bao W, DeMicco D, Kallend D, Miller M, Mundl H, Olsson AG. Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins. J Am Coll Cardiol. 2015;65:2267-75.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 2267-2275
    • Schwartz, G.G.1    Abt, M.2    Bao, W.3    DeMicco, D.4    Kallend, D.5    Miller, M.6    Mundl, H.7    Olsson, A.G.8
  • 4
    • 84925469494 scopus 로고    scopus 로고
    • Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease
    • 1:CAS:528:DC%2BC2cXitFOns7zO 25500239
    • Rosenson RS, Davidson MH, Hirsh BJ, Kathiresan S, Gaudet D. Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease. J Am Coll Cardiol. 2014;64:2525-40.
    • (2014) J Am Coll Cardiol , vol.64 , pp. 2525-2540
    • Rosenson, R.S.1    Davidson, M.H.2    Hirsh, B.J.3    Kathiresan, S.4    Gaudet, D.5
  • 8
    • 84902576469 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • 24239923
    • Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2889-934.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2889-2934
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6    Goldberg, A.C.7    Gordon, D.8    Levy, D.9    Lloyd-Jones, D.M.10
  • 9
    • 84978901996 scopus 로고    scopus 로고
    • AstraZeneca Accessed 24 Nov 2015
    • AstraZeneca. Crestor US prescribing information. Available at: http://www1.astrazeneca-us.com/pi/crestor.pdf. Accessed 24 Nov 2015.
    • Crestor US Prescribing Information
  • 11
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • 1:CAS:528:DC%2BD2sXjtFGlt7c%3D 17368274
    • Guyton JR, Bays HE. Safety considerations with niacin therapy. Am J Cardiol. 2007;99:22c-31c.
    • (2007) Am J Cardiol , vol.99 , pp. 22c-31c
    • Guyton, J.R.1    Bays, H.E.2
  • 13
    • 84941747401 scopus 로고    scopus 로고
    • Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: A review of the literature
    • 1:CAS:528:DC%2BC2MXhtVeisbjE 26296750
    • Ito MK. Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: a review of the literature. Atherosclerosis. 2015;242:647-56.
    • (2015) Atherosclerosis , vol.242 , pp. 647-656
    • Ito, M.K.1
  • 14
    • 84873089854 scopus 로고    scopus 로고
    • GlaxoSmithKline Accessed: 24 Nov 2015
    • GlaxoSmithKline. Lovaza prescribing information. Available at: https://www.gsksource.com/gskprm/htdocs/documents/LOVAZA-PI-PIL.PDF. Accessed: 24 Nov 2015
    • Lovaza Prescribing Information
  • 15
    • 84978902006 scopus 로고    scopus 로고
    • Trygg Pharma Accessed: 24 Nov 2015
    • Trygg Pharma. Omtryg prescribing information. Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/2014/204977s000lbl.pdf. Accessed: 24 Nov 2015
    • Omtryg Prescribing Information
  • 16
    • 84978867217 scopus 로고    scopus 로고
    • Amarin Corporation Accessed: 24 Nov 2015
    • Amarin Corporation. Vascepa prescibing information. Available at: www.vascepa.com/full-prescribing-information.pdf. Accessed: 24 Nov 2015
    • Vascepa Prescibing Information
  • 17
    • 84978836512 scopus 로고    scopus 로고
    • AstraZeneca Accessed: 24 Nov 2015
    • AstraZeneca. Epanova prescribing information. Available at: http://www1.astrazeneca-us.com/pi/epanova.pdf. Accessed: 24 Nov 2015
    • Epanova Prescribing Information
  • 19
    • 0032917836 scopus 로고    scopus 로고
    • Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins
    • 1:CAS:528:DyaK1MXhsVWgtb4%3D 10217357
    • Pownall HJ, Brauchi D, Kilinc C, Osmundsen K, Pao Q, Payton-Ross C, Gotto AJ, Ballantyne CM. Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins. Atherosclerosis. 1999;143:285-97.
    • (1999) Atherosclerosis , vol.143 , pp. 285-297
    • Pownall, H.J.1    Brauchi, D.2    Kilinc, C.3    Osmundsen, K.4    Pao, Q.5    Payton-Ross, C.6    Gotto, A.J.7    Ballantyne, C.M.8
  • 20
    • 34548319692 scopus 로고    scopus 로고
    • Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: An 8-week, randomized, double-blind, placebo-controlled study
    • 1:CAS:528:DC%2BD2sXhtVemurjN 17825687
    • Davidson MH, Stein EA, Bays HE, Maki KC, Doyle RT, Shalwitz RA, Ballantyne CM, Ginsberg HN. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther. 2007;29:1354-67.
    • (2007) Clin Ther , vol.29 , pp. 1354-1367
    • Davidson, M.H.1    Stein, E.A.2    Bays, H.E.3    Maki, K.C.4    Doyle, R.T.5    Shalwitz, R.A.6    Ballantyne, C.M.7    Ginsberg, H.N.8
  • 21
    • 84893916503 scopus 로고    scopus 로고
    • Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: The EpanoVa for Lowering Very high triglyceridEs (EVOLVE) trial
    • 24528690
    • Kastelein JJ, Maki KC, Susekov A, Ezhov M, Nordestgaard BG, Machielse BN, Kling D, Davidson MH. Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial. J Clin Lipidol. 2014;8:94-106.
    • (2014) J Clin Lipidol , vol.8 , pp. 94-106
    • Kastelein, J.J.1    Maki, K.C.2    Susekov, A.3    Ezhov, M.4    Nordestgaard, B.G.5    Machielse, B.N.6    Kling, D.7    Davidson, M.H.8
  • 22
    • 84884355278 scopus 로고    scopus 로고
    • A highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk, statin-treated patients with residual hypertriglyceridemia (the ESPRIT trial)
    • 1:CAS:528:DC%2BC3sXhtlKqs7%2FN 23998969
    • Maki KC, Orloff DG, Nicholls SJ, Dunbar RL, Roth EM, Curcio D, Johnson J, Kling D, Davidson MH. A highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk, statin-treated patients with residual hypertriglyceridemia (the ESPRIT trial). Clin Ther. 2013;35:1400-11.
    • (2013) Clin Ther , vol.35 , pp. 1400-1411
    • Maki, K.C.1    Orloff, D.G.2    Nicholls, S.J.3    Dunbar, R.L.4    Roth, E.M.5    Curcio, D.6    Johnson, J.7    Kling, D.8    Davidson, M.H.9
  • 23
    • 80051784104 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial)
    • 1:CAS:528:DC%2BC3MXhtVajtrbF 21683321
    • Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). Am J Cardiol. 2011;108:682-90.
    • (2011) Am J Cardiol , vol.108 , pp. 682-690
    • Bays, H.E.1    Ballantyne, C.M.2    Kastelein, J.J.3    Isaacsohn, J.L.4    Braeckman, R.A.5    Soni, P.N.6
  • 24
    • 84866124338 scopus 로고    scopus 로고
    • Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)
    • 1:CAS:528:DC%2BC38XhtVyktL7E 22819432
    • Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PN. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am J Cardiol. 2012;110:984-92.
    • (2012) Am J Cardiol , vol.110 , pp. 984-992
    • Ballantyne, C.M.1    Bays, H.E.2    Kastelein, J.J.3    Stein, E.4    Isaacsohn, J.L.5    Braeckman, R.A.6    Soni, P.N.7
  • 25
    • 77955833344 scopus 로고    scopus 로고
    • Fish oil for the treatment of cardiovascular disease
    • 20699674 3217043
    • Weitz D, Weintraub H, Fisher E, Schwartzbard AZ. Fish oil for the treatment of cardiovascular disease. Cardiol Rev. 2010;18:258-63.
    • (2010) Cardiol Rev , vol.18 , pp. 258-263
    • Weitz, D.1    Weintraub, H.2    Fisher, E.3    Schwartzbard, A.Z.4
  • 27
    • 79960814823 scopus 로고    scopus 로고
    • Long chain omega-3 dietary supplements: A review of the National Library of Medicine Herbal Supplement Database
    • 1:CAS:528:DC%2BC3MXptlCjs70%3D 21787228
    • Zargar A, Ito MK. Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. Metab Syndr Relat Disord. 2011;9:255-71.
    • (2011) Metab Syndr Relat Disord , vol.9 , pp. 255-271
    • Zargar, A.1    Ito, M.K.2
  • 29
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • Grundy SM, Becker D, Clark LT, Cooper RS, Denke MA, Howard JW, Hunninghake DB, Illingwirth DR, Luepker RV. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
    • Grundy, S.M.1    Becker, D.2    Clark, L.T.3    Cooper, R.S.4    Denke, M.A.5    Howard, J.W.6    Hunninghake, D.B.7    Illingwirth, D.R.8    Luepker, R.V.9
  • 30
  • 32
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes 2014
    • Association AD. Standards of medical care in diabetes 2014. Diabetes Care. 2014;37 Suppl 1:S14-80.
    • (2014) Diabetes Care , vol.37 , pp. S14-S80
    • Association, A.D.1
  • 33
    • 79958148945 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management
    • 1:CAS:528:DC%2BC3MXntF2ht7k%3D 21531743 3105250
    • Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Boren J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 2011;32:1345-61.
    • (2011) Eur Heart J , vol.32 , pp. 1345-1361
    • Chapman, M.J.1    Ginsberg, H.N.2    Amarenco, P.3    Andreotti, F.4    Boren, J.5    Catapano, A.L.6    Descamps, O.S.7    Fisher, E.8    Kovanen, P.T.9    Kuivenhoven, J.A.10
  • 34
    • 79960205374 scopus 로고    scopus 로고
    • ESC/EAS guidelines for the management of dyslipidaemias. The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • 1:CAS:528:DC%2BC3MXptVyrtbo%3D 21882396
    • Catapano AL, Reiner Z, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E, Chapman M, Durrington P, et al. ESC/EAS guidelines for the management of dyslipidaemias. The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis. 2011;217:3-46.
    • (2011) Atherosclerosis , vol.217 , pp. 3-46
    • Catapano, A.L.1    Reiner, Z.2    De Backer, G.3    Graham, I.4    Taskinen, M.R.5    Wiklund, O.6    Agewall, S.7    Alegria, E.8    Chapman, M.9    Durrington, P.10
  • 35
    • 41449110020 scopus 로고    scopus 로고
    • Prescription omega-3 fatty acids and their lipid effects: Physiologic mechanisms of action and clinical implications
    • 1:CAS:528:DC%2BD1cXjtFOisrs%3D 18327998
    • Bays HE, Tighe AP, Sadovsky R, Davidson MH. Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications. Expert Rev Cardiovasc Ther. 2008;6:391-409.
    • (2008) Expert Rev Cardiovasc Ther , vol.6 , pp. 391-409
    • Bays, H.E.1    Tighe, A.P.2    Sadovsky, R.3    Davidson, M.H.4
  • 36
    • 13444309332 scopus 로고    scopus 로고
    • Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids
    • 15473864 1134755
    • Le Jossic-Corcos C, Gonthier C, Zaghini I, Logette E, Shechter I, Bournot P. Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. Biochem J. 2005;385:787-94.
    • (2005) Biochem J , vol.385 , pp. 787-794
    • Le Jossic-Corcos, C.1    Gonthier, C.2    Zaghini, I.3    Logette, E.4    Shechter, I.5    Bournot, P.6
  • 37
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • 1:CAS:528:DyaK1cXjtlKhtbY%3D 9600904 27572
    • Horton JD, Bashmakov Y, Shimomura I, Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci U S A. 1998;95:5987-92.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 38
    • 33746040070 scopus 로고    scopus 로고
    • Why do omega-3 fatty acids lower serum triglycerides?
    • 1:CAS:528:DC%2BD28Xms1yrtb0%3D 16832161
    • Harris WS, Bulchandani D. Why do omega-3 fatty acids lower serum triglycerides? Curr Opin Lipidol. 2006;17:387-93.
    • (2006) Curr Opin Lipidol , vol.17 , pp. 387-393
    • Harris, W.S.1    Bulchandani, D.2
  • 39
    • 0038281520 scopus 로고    scopus 로고
    • Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
    • 12562865
    • Park Y, Harris WS. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res. 2003;44:455-63.
    • (2003) J Lipid Res , vol.44 , pp. 455-463
    • Park, Y.1    Harris, W.S.2
  • 40
    • 0035988357 scopus 로고    scopus 로고
    • Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype
    • 1:CAS:528:DC%2BD38XksFWgs78%3D 12032174
    • Khan S, Minihane AM, Talmud PJ, Wright JW, Murphy MC, Williams CM, Griffin BA. Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. J Lipid Res. 2002;43:979-85.
    • (2002) J Lipid Res , vol.43 , pp. 979-985
    • Khan, S.1    Minihane, A.M.2    Talmud, P.J.3    Wright, J.W.4    Murphy, M.C.5    Williams, C.M.6    Griffin, B.A.7
  • 41
    • 84856179128 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: A review
    • 22264569
    • Jacobson TA, Glickstein SB, Rowe JD, Soni PN. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. J Clin Lipidol. 2012;6:5-18.
    • (2012) J Clin Lipidol , vol.6 , pp. 5-18
    • Jacobson, T.A.1    Glickstein, S.B.2    Rowe, J.D.3    Soni, P.N.4
  • 42
    • 81155139591 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: A systematic review and meta-analysis
    • 1:CAS:528:DC%2BC3MXhsVaht7vN 21975919
    • Wei MY, Jacobson TA. Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep. 2011;13:474-83.
    • (2011) Curr Atheroscler Rep , vol.13 , pp. 474-483
    • Wei, M.Y.1    Jacobson, T.A.2
  • 43
    • 84888286731 scopus 로고    scopus 로고
    • Omega-3 fatty acids: New insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid
    • 1:CAS:528:DC%2BC3sXhslOmtrjN 24184945
    • Davidson MH. Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. Curr Opin Lipidol. 2013;24:467-74.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 467-474
    • Davidson, M.H.1
  • 44
    • 84955333550 scopus 로고    scopus 로고
    • The effect of omega-3 carboxylic acids on apolipoprotein CIII containing lipoproteins in moderate to severe hypertriglyceridemia
    • A16864
    • Morton A, Furtado J, Amerine W, Kling D, Davidson M, Sacks F. The effect of omega-3 carboxylic acids on apolipoprotein CIII containing lipoproteins in moderate to severe hypertriglyceridemia. Circulation. 2014;130 Suppl 1, A16864.
    • (2014) Circulation , vol.130
    • Morton, A.1    Furtado, J.2    Amerine, W.3    Kling, D.4    Davidson, M.5    Sacks, F.6
  • 45
    • 79956014824 scopus 로고    scopus 로고
    • Complexities of plasma apolipoprotein C-III metabolism
    • 1:CAS:528:DC%2BC3MXmslOitr0%3D 21421846 3090227
    • Sacks FM, Zheng C, Cohn JS. Complexities of plasma apolipoprotein C-III metabolism. J Lipid Res. 2011;52:1067-70.
    • (2011) J Lipid Res , vol.52 , pp. 1067-1070
    • Sacks, F.M.1    Zheng, C.2    Cohn, J.S.3
  • 46
    • 84874052886 scopus 로고    scopus 로고
    • Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: Effects on circulating markers of inflammation from the MARINE and ANCHOR studies
    • 1:CAS:528:DC%2BC3sXhsl2ntL%2FE 23325450 3572383
    • Bays HE, Ballantyne CM, Braeckman RA, Stirtan WG, Soni PN. Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies. Am J Cardiovasc Drugs. 2013;13:37-46.
    • (2013) Am J Cardiovasc Drugs , vol.13 , pp. 37-46
    • Bays, H.E.1    Ballantyne, C.M.2    Braeckman, R.A.3    Stirtan, W.G.4    Soni, P.N.5
  • 47
    • 84855358563 scopus 로고    scopus 로고
    • Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization
    • 21459164
    • Milberg P, Frommeyer G, Kleideiter A, Fischer A, Osada N, Breithardt G, Fehr M, Eckardt L. Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. Heart Rhythm. 2011;8:1492-500.
    • (2011) Heart Rhythm , vol.8 , pp. 1492-1500
    • Milberg, P.1    Frommeyer, G.2    Kleideiter, A.3    Fischer, A.4    Osada, N.5    Breithardt, G.6    Fehr, M.7    Eckardt, L.8
  • 49
    • 0036842041 scopus 로고    scopus 로고
    • Eicosapentaenoic acid improves endothelial function in hypertriglyceridemic subjects despite increased lipid oxidizability
    • 12449445
    • Okumura T, Fujioka Y, Morimoto S, Tsuboi S, Masai M, Tsujino T, Ohyanagi M, Iwasaki T. Eicosapentaenoic acid improves endothelial function in hypertriglyceridemic subjects despite increased lipid oxidizability. Am J Med Sci. 2002;324:247-53.
    • (2002) Am J Med Sci , vol.324 , pp. 247-253
    • Okumura, T.1    Fujioka, Y.2    Morimoto, S.3    Tsuboi, S.4    Masai, M.5    Tsujino, T.6    Ohyanagi, M.7    Iwasaki, T.8
  • 51
    • 84879467569 scopus 로고    scopus 로고
    • Beneficial effects of omega-3 fatty acids on low density lipoprotein particle size in patients with type 2 diabetes already under statin therapy
    • 23807924 3689018
    • Lee MW, Park JK, Hong JW, Kim KJ, Shin DY, Ahn CW, Song YD, Cho HK, Park SW, Lee EJ. Beneficial effects of omega-3 fatty acids on low density lipoprotein particle size in patients with type 2 diabetes already under statin therapy. Diabetes Metab J. 2013;37:207-11.
    • (2013) Diabetes Metab J , vol.37 , pp. 207-211
    • Lee, M.W.1    Park, J.K.2    Hong, J.W.3    Kim, K.J.4    Shin, D.Y.5    Ahn, C.W.6    Song, Y.D.7    Cho, H.K.8    Park, S.W.9    Lee, E.J.10
  • 52
    • 79959441185 scopus 로고    scopus 로고
    • Early impact of prescription omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia
    • 1:CAS:528:DC%2BC3MXotlyrsro%3D 21701167
    • Serebruany VL, Miller M, Pokov AN, Lynch D, Jensen JK, Hallen J, Atar D. Early impact of prescription omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia. Cardiology. 2011;118:187-94.
    • (2011) Cardiology , vol.118 , pp. 187-194
    • Serebruany, V.L.1    Miller, M.2    Pokov, A.N.3    Lynch, D.4    Jensen, J.K.5    Hallen, J.6    Atar, D.7
  • 53
    • 0037211979 scopus 로고    scopus 로고
    • Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients
    • 1:CAS:528:DC%2BD38XptlGjsrw%3D 12482554
    • Woodman RJ, Mori TA, Burke V, Puddey IB, Barden A, Watts GF, Beilin LJ. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. Atherosclerosis. 2003;166:85-93.
    • (2003) Atherosclerosis , vol.166 , pp. 85-93
    • Woodman, R.J.1    Mori, T.A.2    Burke, V.3    Puddey, I.B.4    Barden, A.5    Watts, G.F.6    Beilin, L.J.7
  • 54
    • 0032858328 scopus 로고    scopus 로고
    • Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans
    • 1:CAS:528:DyaK1MXlvFGmtbw%3D 10454450
    • Mori TA, Bao DQ, Burke V, Puddey IB, Beilin LJ. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension. 1999;34:253-60.
    • (1999) Hypertension , vol.34 , pp. 253-260
    • Mori, T.A.1    Bao, D.Q.2    Burke, V.3    Puddey, I.B.4    Beilin, L.J.5
  • 55
    • 2442445051 scopus 로고    scopus 로고
    • Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
    • 1:CAS:528:DC%2BD2cXjs1ygsL0%3D 15113713
    • Stark KD, Holub BJ. Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. Am J Clin Nutr. 2004;79:765-73.
    • (2004) Am J Clin Nutr , vol.79 , pp. 765-773
    • Stark, K.D.1    Holub, B.J.2
  • 56
    • 34247105669 scopus 로고    scopus 로고
    • Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women
    • 1:CAS:528:DC%2BD2sXktVSltbk%3D 17374663
    • Theobald HE, Goodall AH, Sattar N, Talbot DC, Chowienczyk PJ, Sanders TA. Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr. 2007;137:973-8.
    • (2007) J Nutr , vol.137 , pp. 973-978
    • Theobald, H.E.1    Goodall, A.H.2    Sattar, N.3    Talbot, D.C.4    Chowienczyk, P.J.5    Sanders, T.A.6
  • 58
    • 4043094921 scopus 로고    scopus 로고
    • Very long chain N-3 fatty acids intake and carotid atherosclerosis: An epidemiological study evaluated by ultrasonography
    • 1:CAS:528:DC%2BD2cXmslers7Y%3D 15306187
    • Hino A, Adachi H, Toyomasu K, Yoshida N, Enomoto M, Hiratsuka A, Hirai Y, Satoh A, Imaizumi T. Very long chain N-3 fatty acids intake and carotid atherosclerosis: an epidemiological study evaluated by ultrasonography. Atherosclerosis. 2004;176:145-9.
    • (2004) Atherosclerosis , vol.176 , pp. 145-149
    • Hino, A.1    Adachi, H.2    Toyomasu, K.3    Yoshida, N.4    Enomoto, M.5    Hiratsuka, A.6    Hirai, Y.7    Satoh, A.8    Imaizumi, T.9
  • 59
    • 77956225520 scopus 로고    scopus 로고
    • Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability
    • 1:CAS:528:DC%2BC3cXhtFams77K 20542512
    • Cawood AL, Ding R, Napper FL, Young RH, Williams JA, Ward MJ, Gudmundsen O, Vige R, Payne SP, Ye S, et al. Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability. Atherosclerosis. 2010;212:252-9.
    • (2010) Atherosclerosis , vol.212 , pp. 252-259
    • Cawood, A.L.1    Ding, R.2    Napper, F.L.3    Young, R.H.4    Williams, J.A.5    Ward, M.J.6    Gudmundsen, O.7    Vige, R.8    Payne, S.P.9    Ye, S.10
  • 60
    • 84906259943 scopus 로고    scopus 로고
    • Triglycerides and cardiovascular disease
    • 1:CAS:528:DC%2BC2cXhtlOrtLnK 25131982
    • Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet. 2014;384:626-35.
    • (2014) Lancet , vol.384 , pp. 626-635
    • Nordestgaard, B.G.1    Varbo, A.2
  • 62
    • 47249110902 scopus 로고    scopus 로고
    • Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction
    • 1:CAS:528:DC%2BD1cXoslyltrw%3D 18614744
    • Sun Q, Ma J, Campos H, Rexrode KM, Albert CM, Mozaffarian D, Hu FB. Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction. Am J Clin Nutr. 2008;88:216-23.
    • (2008) Am J Clin Nutr , vol.88 , pp. 216-223
    • Sun, Q.1    Ma, J.2    Campos, H.3    Rexrode, K.M.4    Albert, C.M.5    Mozaffarian, D.6    Hu, F.B.7
  • 63
    • 80052272215 scopus 로고    scopus 로고
    • Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: An integrated backscatter intravascular ultrasound study
    • 1:CAS:528:DC%2BC3MXhtFeht7zM 21684546
    • Amano T, Matsubara T, Uetani T, Kato M, Kato B, Yoshida T, Harada K, Kumagai S, Kunimura A, Shinbo Y, et al. Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: an integrated backscatter intravascular ultrasound study. Atherosclerosis. 2011;218:110-6.
    • (2011) Atherosclerosis , vol.218 , pp. 110-116
    • Amano, T.1    Matsubara, T.2    Uetani, T.3    Kato, M.4    Kato, B.5    Yoshida, T.6    Harada, K.7    Kumagai, S.8    Kunimura, A.9    Shinbo, Y.10
  • 64
    • 0028177432 scopus 로고
    • Plasma essential fatty acids, cigarette smoking, and dietary antioxidants in peripheral arterial disease. A population-based case-control study
    • 1:STN:280:DyaK2c7mvFWmtg%3D%3D 8123654
    • Leng GC, Horrobin DF, Fowkes FG, Smith FB, Lowe GD, Donnan PT, Ells K. Plasma essential fatty acids, cigarette smoking, and dietary antioxidants in peripheral arterial disease. A population-based case-control study. Arterioscler Thromb. 1994;14:471-8.
    • (1994) Arterioscler Thromb , vol.14 , pp. 471-478
    • Leng, G.C.1    Horrobin, D.F.2    Fowkes, F.G.3    Smith, F.B.4    Lowe, G.D.5    Donnan, P.T.6    Ells, K.7
  • 65
    • 0033668024 scopus 로고    scopus 로고
    • Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation
    • 1:CAS:528:DC%2BD3cXnvVyhsb0%3D 11085354
    • Akiba S, Murata T, Kitatani K, Sato T. Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation. Biol Pharm Bull. 2000;23:1293-7.
    • (2000) Biol Pharm Bull , vol.23 , pp. 1293-1297
    • Akiba, S.1    Murata, T.2    Kitatani, K.3    Sato, T.4
  • 66
    • 33646823117 scopus 로고    scopus 로고
    • Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumor necrosis factor
    • 1:CAS:528:DC%2BD28XltFGjt74%3D 16698313
    • Kishida E, Tajiri M, Masuzawa Y. Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumor necrosis factor. Biochim Biophys Acta. 2006;1761:454-62.
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 454-462
    • Kishida, E.1    Tajiri, M.2    Masuzawa, Y.3
  • 67
    • 0036325388 scopus 로고    scopus 로고
    • Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia
    • 1:CAS:528:DC%2BD38XlvFKiur8%3D 12145148
    • Chan DC, Watts GF, Barrett PH, Beilin LJ, Redgrave TG, Mori TA. Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia. Diabetes. 2002;51:2377-86.
    • (2002) Diabetes , vol.51 , pp. 2377-2386
    • Chan, D.C.1    Watts, G.F.2    Barrett, P.H.3    Beilin, L.J.4    Redgrave, T.G.5    Mori, T.A.6
  • 68
    • 84870302077 scopus 로고    scopus 로고
    • A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: The ECLIPSE (Epanova® compared to Lovaza® in a pharmacokinetic single-dose evaluation) study
    • 23312053
    • Davidson MH, Johnson J, Rooney MW, Kyle ML, Kling DF. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova® compared to Lovaza® in a pharmacokinetic single-dose evaluation) study. J Clin Lipidol. 2012;6:573-84.
    • (2012) J Clin Lipidol , vol.6 , pp. 573-584
    • Davidson, M.H.1    Johnson, J.2    Rooney, M.W.3    Kyle, M.L.4    Kling, D.F.5
  • 69
    • 0027994257 scopus 로고
    • The synthesis of fatty acid ethyl ester by carboxylester lipase
    • 1:CAS:528:DyaK2cXlsFWqu7c%3D 8076651
    • Tsujita T, Okuda H. The synthesis of fatty acid ethyl ester by carboxylester lipase. Eur J Biochem. 1994;224:57-62.
    • (1994) Eur J Biochem , vol.224 , pp. 57-62
    • Tsujita, T.1    Okuda, H.2
  • 70
    • 0036915534 scopus 로고    scopus 로고
    • Carboxyl ester lipase: Structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis
    • 1:CAS:528:DC%2BD38XpslGjsr8%3D 12454261
    • Hui DY, Howles PN. Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis. J Lipid Res. 2002;43:2017-30.
    • (2002) J Lipid Res , vol.43 , pp. 2017-2030
    • Hui, D.Y.1    Howles, P.N.2
  • 71
    • 0029616284 scopus 로고
    • Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats
    • 8541338
    • Ikeda I, Sasaki E, Yasunami H, Nomiyama S, Nakayama M, Sugano M, Imaizumi K, Yazawa K. Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats. Biochim Biophys Acta. 1995;1259:297-304.
    • (1995) Biochim Biophys Acta , vol.1259 , pp. 297-304
    • Ikeda, I.1    Sasaki, E.2    Yasunami, H.3    Nomiyama, S.4    Nakayama, M.5    Sugano, M.6    Imaizumi, K.7    Yazawa, K.8
  • 72
    • 0025331290 scopus 로고
    • [Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers]
    • 1:CAS:528:DyaK3cXlslyisL8%3D 2144420
    • Beckermann B, Beneke M, Seitz I. [Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers]. Arzneimittelforschung. 1990;40:700-4.
    • (1990) Arzneimittelforschung , vol.40 , pp. 700-704
    • Beckermann, B.1    Beneke, M.2    Seitz, I.3
  • 73
    • 33749154105 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review
    • 1:CAS:528:DC%2BD28XhtVajsr3L 16530201
    • Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis. 2006;189:19-30.
    • (2006) Atherosclerosis , vol.189 , pp. 19-30
    • Balk, E.M.1    Lichtenstein, A.H.2    Chung, M.3    Kupelnick, B.4    Chew, P.5    Lau, J.6
  • 74
    • 84978851547 scopus 로고    scopus 로고
    • A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients with Hypertriglyceridemia and on Statin
    • Clinicaltrials.gov. (REDUCE-IT) Accessed: 24 Nov 2015
    • Clinicaltrials.gov. A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event. (REDUCE-IT). Available at: https://clinicaltrials.gov/ct2/show/NCT01492361. Accessed: 24 Nov 2015.
    • The Primary Objective Is to Evaluate the Effect of 4 G/Day AMR101 for Preventing the Occurrence of A First Major Cardiovascular Event
  • 76
    • 84055213533 scopus 로고    scopus 로고
    • Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: Summary report
    • Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents
    • Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics. 2011;128 Suppl 5:S213-56.
    • (2011) Pediatrics , vol.1285 , pp. S213-S256
  • 77
  • 78
    • 0038076490 scopus 로고    scopus 로고
    • Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: Follow up of a randomised controlled trial
    • 1:CAS:528:DC%2BD3sXktlSrt7g%3D 12727766 153849
    • Forsyth JS, Willatts P, Agostoni C, Bissenden J, Casaer P, Boehm G. Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial. BMJ. 2003;326:953.
    • (2003) BMJ , vol.326 , pp. 953
    • Forsyth, J.S.1    Willatts, P.2    Agostoni, C.3    Bissenden, J.4    Casaer, P.5    Boehm, G.6
  • 79
    • 84876672954 scopus 로고    scopus 로고
    • High intake of dietary long-chain omega-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008
    • 1:CAS:528:DC%2BC3sXmtF2rtbg%3D 23460284
    • Skilton MR, Raitakari OT, Celermajer DS. High intake of dietary long-chain omega-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008. Hypertension. 2013;61:972-6.
    • (2013) Hypertension , vol.61 , pp. 972-976
    • Skilton, M.R.1    Raitakari, O.T.2    Celermajer, D.S.3
  • 82
    • 33745063941 scopus 로고    scopus 로고
    • Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters
    • 1:CAS:528:DC%2BD28XntlWgtrw%3D 16809804
    • McKenney JM, Swearingen D, Di SM, Doyle R, Pantaleon C, Kling D, Shalwitz RA. Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters. J Clin Pharmacol. 2006;46:785-91.
    • (2006) J Clin Pharmacol , vol.46 , pp. 785-791
    • McKenney, J.M.1    Swearingen, D.2    Di, S.M.3    Doyle, R.4    Pantaleon, C.5    Kling, D.6    Shalwitz, R.A.7
  • 83
    • 57549108116 scopus 로고    scopus 로고
    • Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults
    • 19006470
    • Di Spirito M, Morelli G, Doyle RT, Johnson J, McKenney J. Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults. Expert Opin Pharmacother. 2008;9:2939-45.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 2939-2945
    • Di Spirito, M.1    Morelli, G.2    Doyle, R.T.3    Johnson, J.4    McKenney, J.5
  • 84
    • 77149180421 scopus 로고    scopus 로고
    • Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia
    • 1:CAS:528:DC%2BC3cXksFGiurw%3D 20104931
    • Kostapanos MS, Milionis HJ, Elisaf MS. Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia. Am J Cardiovasc Drugs. 2010;10:11-28.
    • (2010) Am J Cardiovasc Drugs , vol.10 , pp. 11-28
    • Kostapanos, M.S.1    Milionis, H.J.2    Elisaf, M.S.3
  • 85
    • 0034762548 scopus 로고    scopus 로고
    • An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
    • 1:STN:280:DC%2BD3M3ms1SqtA%3D%3D 11303007 1729738
    • Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA, France M. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart. 2001;85:544-8.
    • (2001) Heart , vol.85 , pp. 544-548
    • Durrington, P.N.1    Bhatnagar, D.2    Mackness, M.I.3    Morgan, J.4    Julier, K.5    Khan, M.A.6    France, M.7
  • 86
    • 75749115919 scopus 로고    scopus 로고
    • Effects of prescription omega-3-acid ethyl esters on non-high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin
    • 1:CAS:528:DC%2BC3cXisFCgtrg%3D 20118387 2813819
    • Bays HE, McKenney J, Maki KC, Doyle RT, Carter RN, Stein E. Effects of prescription omega-3-acid ethyl esters on non-high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin. Mayo Clin Proc. 2010;85:122-8.
    • (2010) Mayo Clin Proc , vol.85 , pp. 122-128
    • Bays, H.E.1    McKenney, J.2    Maki, K.C.3    Doyle, R.T.4    Carter, R.N.5    Stein, E.6
  • 87
    • 33947113384 scopus 로고    scopus 로고
    • Safety considerations with omega-3 fatty acid therapy
    • 1:CAS:528:DC%2BD2sXjtFGltL8%3D 17368277
    • Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007;99:35C-43C.
    • (2007) Am J Cardiol , vol.99 , pp. 35C-43C
    • Bays, H.E.1
  • 88
    • 33947181467 scopus 로고    scopus 로고
    • Expert opinion: Omega-3 fatty acids and bleeding - Cause for concern?
    • 1:CAS:528:DC%2BD2sXjtFGltLw%3D 17368278
    • Harris WS. Expert opinion: omega-3 fatty acids and bleeding - cause for concern? Am J Cardiol. 2007;99:44C-6C.
    • (2007) Am J Cardiol , vol.99 , pp. 44C-46C
    • Harris, W.S.1
  • 89
    • 84978913530 scopus 로고    scopus 로고
    • Multiple-dose administration of a free-fatty acid formulation or EPA/DHA has no effect on the pharmacokinetics or pharmacodynamics of single-dose warfarin
    • Abstract T2284
    • Davidson MH, Marenco T, Honstein A, Johnson J, Kling D. Multiple-dose administration of a free-fatty acid formulation or EPA/DHA has no effect on the pharmacokinetics or pharmacodynamics of single-dose warfarin. In 2012 AAPS Annual Meeting and Exposition. Abstract T2284
    • 2012 AAPS Annual Meeting and Exposition
    • Davidson, M.H.1    Marenco, T.2    Honstein, A.3    Johnson, J.4    Kling, D.5
  • 90
    • 84904059562 scopus 로고    scopus 로고
    • Phase 1 study of the effect of icosapent ethyl on warfarin pharmacokinetic and anticoagulation parameters
    • 1:CAS:528:DC%2BC2cXntFOlurs%3D 24760401
    • Braeckman RA, Stirtan WG, Soni PN. Phase 1 study of the effect of icosapent ethyl on warfarin pharmacokinetic and anticoagulation parameters. Clin Drug Investig. 2014;34:449-56.
    • (2014) Clin Drug Investig , vol.34 , pp. 449-456
    • Braeckman, R.A.1    Stirtan, W.G.2    Soni, P.N.3
  • 91
    • 59549092689 scopus 로고    scopus 로고
    • Complementary and alternative medicine use among adults and children: United States, 2007
    • 19361005
    • Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report. 2008;12:1-23.
    • (2008) Natl Health Stat Report , vol.12 , pp. 1-23
    • Barnes, P.M.1    Bloom, B.2    Nahin, R.L.3
  • 92
    • 0038488757 scopus 로고    scopus 로고
    • Omega-3 oil: fish or pills? No authors listed
    • Omega-3 oil: fish or pills? Consum Rep 2003;68:30-32. No authors listed.
    • (2003) Consum Rep , vol.68 , pp. 30-32
  • 93
    • 84914811260 scopus 로고    scopus 로고
    • Overview of prescription omega-3 fatty acid products for hypertriglyceridemia
    • 25387209
    • Weintraub HS. Overview of prescription omega-3 fatty acid products for hypertriglyceridemia. Postgrad Med. 2014;126:7-18.
    • (2014) Postgrad Med , vol.126 , pp. 7-18
    • Weintraub, H.S.1
  • 94
    • 33750141751 scopus 로고    scopus 로고
    • Fish intake, contaminants, and human health: Evaluating the risks and the benefits
    • 1:CAS:528:DC%2BD28XhtFWmt7%2FF 17047219
    • Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006;296:1885-99.
    • (2006) JAMA , vol.296 , pp. 1885-1899
    • Mozaffarian, D.1    Rimm, E.B.2
  • 95
    • 0037137299 scopus 로고    scopus 로고
    • Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    • 12438303
    • Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106:2747-57.
    • (2002) Circulation , vol.106 , pp. 2747-2757
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 96
    • 0036202812 scopus 로고    scopus 로고
    • Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care
    • 11898942 99405
    • Holub BJ. Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care. CMAJ. 2002;166:608-15.
    • (2002) CMAJ , vol.166 , pp. 608-615
    • Holub, B.J.1


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