메뉴 건너뛰기




Volumn 2, Issue 8, 2014, Pages 655-666

The polygenic nature of hypertriglyceridaemia: Implications for definition, diagnosis, and management

(25)  Hegele, Robert A a   Ginsberg, Henry N b   Chapman, M John c   Nordestgaard, Børge G d   Kuivenhoven, Jan Albert e   Averna, Maurizio f   Borén, Jan g   Bruckert, Eric c   Catapano, Alberico L h   Descamps, Olivier S i   Hovingh, G Kees j   Humphries, Steve E k   Kovanen, Petri T l   Masana, Luis m   Pajukanta, Päivi n   Parhofer, Klaus G o   Raal, Frederick J p   Ray, Kausik K q   Santos, Raul D r   Stalenhoef, Anton F H s   more..


Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID SEQUESTRANT; FATTY ACID DERIVATIVE; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; NICOTINIC ACID; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

EID: 84906937463     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(13)70191-8     Document Type: Review
Times cited : (484)

References (68)
  • 1
    • 84866146620 scopus 로고    scopus 로고
    • Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline
    • the Endocrine Society
    • Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2012, 97:2969-2989. the Endocrine Society.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2969-2989
    • Berglund, L.1    Brunzell, J.D.2    Goldberg, A.C.3
  • 3
    • 79958148945 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    • the European Atherosclerosis Society Consensus Panel
    • Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011, 32:1345-1361. the European Atherosclerosis Society Consensus Panel.
    • (2011) Eur Heart J , vol.32 , pp. 1345-1361
    • Chapman, M.J.1    Ginsberg, H.N.2    Amarenco, P.3
  • 4
    • 34247471569 scopus 로고    scopus 로고
    • Hypertriglyceridemia: its etiology, effects and treatment
    • Yuan G, Al-Shali KZ, Hegele RA Hypertriglyceridemia: its etiology, effects and treatment. CMAJ 2007, 176:1113-1120.
    • (2007) CMAJ , vol.176 , pp. 1113-1120
    • Yuan, G.1    Al-Shali, K.Z.2    Hegele, R.A.3
  • 5
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in AdultsTreatment of High Blood Cholesterol in Adults
    • Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497. Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in AdultsTreatment of High Blood Cholesterol in Adults.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 6
    • 79960205374 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC), the European Atherosclerosis Society (EAS)the European Atherosclerosis Society (EAS), the ESC Committee for Practice Guidelines 2008-2010 and 2010-2012 Committeesthe ESC Committee for Practice Guidelines 2008-2010 and 2010-2012 Committees
    • Catapano AL, Reiner Z, De Backer G, et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 2011, 217(suppl 1):S1-44. the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC), the European Atherosclerosis Society (EAS)the European Atherosclerosis Society (EAS), the ESC Committee for Practice Guidelines 2008-2010 and 2010-2012 Committeesthe ESC Committee for Practice Guidelines 2008-2010 and 2010-2012 Committees.
    • (2011) Atherosclerosis , vol.217 , Issue.SUPPL. 1
    • Catapano, A.L.1    Reiner, Z.2    De Backer, G.3
  • 7
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • the European Association for Cardiovascular Prevention & Rehabilitation, the ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committeesthe ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees
    • Reiner Z, Catapano AL, De Backer G, et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011, 32:1769-1818. the European Association for Cardiovascular Prevention & Rehabilitation, the ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committeesthe ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees.
    • (2011) Eur Heart J , vol.32 , pp. 1769-1818
    • Reiner, Z.1    Catapano, A.L.2    De Backer, G.3
  • 8
    • 33846637379 scopus 로고    scopus 로고
    • Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262 525 participants in 29 Western prospective studies
    • Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262 525 participants in 29 Western prospective studies. Circulation 2007, 115:450-458.
    • (2007) Circulation , vol.115 , pp. 450-458
    • Sarwar, N.1    Danesh, J.2    Eiriksdottir, G.3
  • 9
    • 68449103045 scopus 로고    scopus 로고
    • Triglycerides and coronary heart disease: have recent insights yielded conclusive answers?
    • Sarwar N, Sattar N Triglycerides and coronary heart disease: have recent insights yielded conclusive answers?. Curr Opin Lipidol 2009, 20:275-281.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 275-281
    • Sarwar, N.1    Sattar, N.2
  • 10
    • 0020082868 scopus 로고
    • 'Pseudohypertriglyceridemia' caused by hyperglycerolemia due to congenital enzyme deficiency
    • Goussault Y, Turpin E, Neel D, et al. 'Pseudohypertriglyceridemia' caused by hyperglycerolemia due to congenital enzyme deficiency. Clin Chim Acta 1982, 123:269-274.
    • (1982) Clin Chim Acta , vol.123 , pp. 269-274
    • Goussault, Y.1    Turpin, E.2    Neel, D.3
  • 11
    • 79952214780 scopus 로고    scopus 로고
    • Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes: 58 434 individuals from the Copenhagen General Population Study
    • Langsted A, Nordestgaard BG Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes: 58 434 individuals from the Copenhagen General Population Study. Clin Chem 2011, 57:482-489.
    • (2011) Clin Chem , vol.57 , pp. 482-489
    • Langsted, A.1    Nordestgaard, B.G.2
  • 12
    • 0036795589 scopus 로고    scopus 로고
    • Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state
    • Guerin M, Egger P, Soudant C, et al. Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state. J Lipid Res 2002, 43:1652-1660.
    • (2002) J Lipid Res , vol.43 , pp. 1652-1660
    • Guerin, M.1    Egger, P.2    Soudant, C.3
  • 13
    • 34447511196 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007, 298:299-308.
    • (2007) JAMA , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 14
    • 56149115017 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of ischemic stroke in the general population
    • Freiberg JJ, Tybjaerg-Hansen A, Jensen JS, Nordestgaard BG Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA 2008, 300:2142-2152.
    • (2008) JAMA , vol.300 , pp. 2142-2152
    • Freiberg, J.J.1    Tybjaerg-Hansen, A.2    Jensen, J.S.3    Nordestgaard, B.G.4
  • 16
    • 84876175810 scopus 로고    scopus 로고
    • Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction
    • Jørgensen AB, Frikke-Schmidt R, West AS, Grande P, Nordestgaard BG, Tybjærg-Hansen A Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction. Eur Heart J 2013, 34:1826-1833.
    • (2013) Eur Heart J , vol.34 , pp. 1826-1833
    • Jørgensen, A.B.1    Frikke-Schmidt, R.2    West, A.S.3    Grande, P.4    Nordestgaard, B.G.5    Tybjærg-Hansen, A.6
  • 17
    • 65949116169 scopus 로고    scopus 로고
    • Fasting and nonfasting LDL cholesterol: to measure or calculate?
    • Nordestgaard BG, Benn M Fasting and nonfasting LDL cholesterol: to measure or calculate?. Clin Chem 2009, 55:845-847.
    • (2009) Clin Chem , vol.55 , pp. 845-847
    • Nordestgaard, B.G.1    Benn, M.2
  • 18
    • 34447520136 scopus 로고    scopus 로고
    • Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    • Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007, 298:309-316.
    • (2007) JAMA , vol.298 , pp. 309-316
    • Bansal, S.1    Buring, J.E.2    Rifai, N.3    Mora, S.4    Sacks, F.M.5    Ridker, P.M.6
  • 19
    • 0018649439 scopus 로고
    • Atherogenesis: a postprandial phenomenon
    • Zilversmit DB Atherogenesis: a postprandial phenomenon. Circulation 1979, 60:473-485.
    • (1979) Circulation , vol.60 , pp. 473-485
    • Zilversmit, D.B.1
  • 20
    • 0028903142 scopus 로고
    • Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media
    • Nordestgaard BG, Wootton R, Lewis B Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol 1995, 15:534-542.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 534-542
    • Nordestgaard, B.G.1    Wootton, R.2    Lewis, B.3
  • 21
    • 34249297789 scopus 로고    scopus 로고
    • Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies
    • Norata GD, Grigore L, Raselli S, et al. Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies. Atherosclerosis 2007, 193:321-327.
    • (2007) Atherosclerosis , vol.193 , pp. 321-327
    • Norata, G.D.1    Grigore, L.2    Raselli, S.3
  • 22
    • 0035756399 scopus 로고    scopus 로고
    • A risk factor for atherosclerosis: triglyceride-rich lipoproteins
    • Malloy MJ, Kane JP A risk factor for atherosclerosis: triglyceride-rich lipoproteins. Adv Intern Med 2001, 47:111-136.
    • (2001) Adv Intern Med , vol.47 , pp. 111-136
    • Malloy, M.J.1    Kane, J.P.2
  • 23
    • 0031743318 scopus 로고    scopus 로고
    • Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma
    • Mamo JC, Proctor SD, Smith D Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma. Atherosclerosis 1998, 141(suppl 1):S63-S69.
    • (1998) Atherosclerosis , vol.141 , Issue.SUPPL. 1
    • Mamo, J.C.1    Proctor, S.D.2    Smith, D.3
  • 24
    • 70450081001 scopus 로고    scopus 로고
    • Major lipids, apolipoproteins, and risk of vascular disease
    • the Emerging Risk Factors Collaboration
    • Di Angelantonio E, Sarwar N, Perry P, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 2009, 302:1993-2000. the Emerging Risk Factors Collaboration.
    • (2009) JAMA , vol.302 , pp. 1993-2000
    • Di Angelantonio, E.1    Sarwar, N.2    Perry, P.3
  • 26
    • 77951875017 scopus 로고    scopus 로고
    • Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    • The Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration
    • Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010, 375:1634-1639. The Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration.
    • (2010) Lancet , vol.375 , pp. 1634-1639
  • 27
    • 84887058576 scopus 로고    scopus 로고
    • Common variants associated with plasma triglycerides and risk for coronary artery disease
    • Do R, Willer CJ, Schmidt EM, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013, 45:1345-1352.
    • (2013) Nat Genet , vol.45 , pp. 1345-1352
    • Do, R.1    Willer, C.J.2    Schmidt, E.M.3
  • 28
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
    • Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 2010, 375:1875-1884.
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 29
    • 85048354213 scopus 로고    scopus 로고
    • Combination lipid therapy in type 2 diabetes
    • Sacks FM, Carey VJ, Fruchart JC Combination lipid therapy in type 2 diabetes. N Engl J Med 2010, 363:692-694.
    • (2010) N Engl J Med , vol.363 , pp. 692-694
    • Sacks, F.M.1    Carey, V.J.2    Fruchart, J.C.3
  • 30
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • the AIM-HIGH Investigators
    • Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 2011, 365:2255-2267. the AIM-HIGH Investigators.
    • (2011) N Engl J Med , vol.365 , pp. 2255-2267
    • Boden, W.E.1    Probstfield, J.L.2    Anderson, T.3
  • 31
    • 84866070612 scopus 로고    scopus 로고
    • Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis
    • Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 2012, 308:1024-1033.
    • (2012) JAMA , vol.308 , pp. 1024-1033
    • Rizos, E.C.1    Ntzani, E.E.2    Bika, E.3    Kostapanos, M.S.4    Elisaf, M.S.5
  • 32
    • 0001264511 scopus 로고
    • A system for phenotyping hyperlipoproteinemia
    • Fredrickson DS, Lees RS A system for phenotyping hyperlipoproteinemia. Circulation 1965, 31:321-327.
    • (1965) Circulation , vol.31 , pp. 321-327
    • Fredrickson, D.S.1    Lees, R.S.2
  • 33
    • 58549109632 scopus 로고    scopus 로고
    • Plasma lipoproteins: genetic influences and clinical implications
    • Hegele RA Plasma lipoproteins: genetic influences and clinical implications. Nat Rev Genet 2009, 10:109-121.
    • (2009) Nat Rev Genet , vol.10 , pp. 109-121
    • Hegele, R.A.1
  • 34
    • 33947679772 scopus 로고    scopus 로고
    • Mechanisms of disease: genetic causes of familial hypercholesterolemia
    • Soutar AK, Naoumova RP Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med 2007, 4:214-225.
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. 214-225
    • Soutar, A.K.1    Naoumova, R.P.2
  • 35
    • 70349983266 scopus 로고    scopus 로고
    • A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
    • Hegele RA, Ban MR, Hsueh N, et al. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia. Hum Mol Genet 2009, 18:4189-4194.
    • (2009) Hum Mol Genet , vol.18 , pp. 4189-4194
    • Hegele, R.A.1    Ban, M.R.2    Hsueh, N.3
  • 36
    • 80051551063 scopus 로고    scopus 로고
    • An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia
    • Johansen CT, Wang J, Lanktree MB, et al. An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia. Arterioscler Thromb Vasc Biol 2011, 31:1916-1926.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1916-1926
    • Johansen, C.T.1    Wang, J.2    Lanktree, M.B.3
  • 38
    • 79960644031 scopus 로고    scopus 로고
    • Genetic bases of hypertriglyceridemic phenotypes
    • Johansen CT, Hegele RA Genetic bases of hypertriglyceridemic phenotypes. Curr Opin Lipidol 2011, 22:247-253.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 247-253
    • Johansen, C.T.1    Hegele, R.A.2
  • 39
    • 84859163245 scopus 로고    scopus 로고
    • Allelic and phenotypic spectrum of plasma triglycerides
    • Johansen CT, Hegele RA Allelic and phenotypic spectrum of plasma triglycerides. Biochim Biophys Acta 2012, 1821:833-842.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 833-842
    • Johansen, C.T.1    Hegele, R.A.2
  • 40
    • 79955583131 scopus 로고    scopus 로고
    • Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol
    • Nordestgaard BG, Freiberg JJ Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol. Curr Vasc Pharmacol 2011, 9:281-286.
    • (2011) Curr Vasc Pharmacol , vol.9 , pp. 281-286
    • Nordestgaard, B.G.1    Freiberg, J.J.2
  • 41
    • 84876167878 scopus 로고    scopus 로고
    • Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
    • Talmud PJ, Shah S, Whittall R, et al. Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study. Lancet 2013, 381:1293-1301.
    • (2013) Lancet , vol.381 , pp. 1293-1301
    • Talmud, P.J.1    Shah, S.2    Whittall, R.3
  • 42
    • 0020049081 scopus 로고
    • Triglyceride and cholesterol metabolism in primary hypertriglyceridemia
    • Beil U, Grundy SM, Crouse JR, Zech L Triglyceride and cholesterol metabolism in primary hypertriglyceridemia. Arteriosclerosis 1982, 2:44-57.
    • (1982) Arteriosclerosis , vol.2 , pp. 44-57
    • Beil, U.1    Grundy, S.M.2    Crouse, J.R.3    Zech, L.4
  • 43
    • 65249109805 scopus 로고    scopus 로고
    • Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review
    • Rahalkar AR, Giffen F, Har B, et al. Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review. Can J Physiol Pharmacol 2009, 87:151-160.
    • (2009) Can J Physiol Pharmacol , vol.87 , pp. 151-160
    • Rahalkar, A.R.1    Giffen, F.2    Har, B.3
  • 44
    • 0024383955 scopus 로고
    • Detection and characterization of the heterozygote state for lipoprotein lipase deficiency
    • Babirak SP, Iverius PH, Fujimoto WY, Brunzell JD Detection and characterization of the heterozygote state for lipoprotein lipase deficiency. Arteriosclerosis 1989, 9:326-334.
    • (1989) Arteriosclerosis , vol.9 , pp. 326-334
    • Babirak, S.P.1    Iverius, P.H.2    Fujimoto, W.Y.3    Brunzell, J.D.4
  • 46
    • 0030848547 scopus 로고    scopus 로고
    • Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease
    • Nordestgaard BG, Abildgaard S, Wittrup HH, Steffensen R, Jensen G, Tybjaerg-Hansen A Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease. Circulation 1997, 96:1737-1744.
    • (1997) Circulation , vol.96 , pp. 1737-1744
    • Nordestgaard, B.G.1    Abildgaard, S.2    Wittrup, H.H.3    Steffensen, R.4    Jensen, G.5    Tybjaerg-Hansen, A.6
  • 47
    • 19944431083 scopus 로고    scopus 로고
    • Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia
    • Priore Oliva C, Pisciotta L, Li Volti G, et al. Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia. Arterioscler Thromb Vasc Biol 2005, 25:411-417.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 411-417
    • Priore Oliva, C.1    Pisciotta, L.2    Li Volti, G.3
  • 48
    • 77955070766 scopus 로고    scopus 로고
    • Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    • Johansen CT, Wang J, Lanktree MB, et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 2010, 42:684-687.
    • (2010) Nat Genet , vol.42 , pp. 684-687
    • Johansen, C.T.1    Wang, J.2    Lanktree, M.B.3
  • 49
    • 84860856675 scopus 로고    scopus 로고
    • Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia
    • Johansen CT, Wang J, McIntyre AD, et al. Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. Circ Cardiovasc Genet 2012, 5:66-72.
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 66-72
    • Johansen, C.T.1    Wang, J.2    McIntyre, A.D.3
  • 50
    • 79960110157 scopus 로고    scopus 로고
    • The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
    • Lee JH, Giannikopoulos P, Duncan SA, et al. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 2011, 17:812-815.
    • (2011) Nat Med , vol.17 , pp. 812-815
    • Lee, J.H.1    Giannikopoulos, P.2    Duncan, S.A.3
  • 51
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010, 466:707-713.
    • (2010) Nature , vol.466 , pp. 707-713
    • Teslovich, T.M.1    Musunuru, K.2    Smith, A.V.3
  • 52
    • 84872712625 scopus 로고    scopus 로고
    • 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult
    • Anderson TJ, Grégoire J, Hegele RA, et al. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol 2013, 29:151-167.
    • (2013) Can J Cardiol , vol.29 , pp. 151-167
    • Anderson, T.J.1    Grégoire, J.2    Hegele, R.A.3
  • 53
    • 79959694696 scopus 로고    scopus 로고
    • A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B as markers of cardiovascular risk
    • Sniderman AD, Williams K, Contois JH, et al. A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B as markers of cardiovascular risk. Circ Cardiovasc Qual Outcomes 2011, 4:337-345.
    • (2011) Circ Cardiovasc Qual Outcomes , vol.4 , pp. 337-345
    • Sniderman, A.D.1    Williams, K.2    Contois, J.H.3
  • 54
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • the Cholesterol Treatment Trialists' (CTT) Collaborators
    • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005, 366:1267-1278. the Cholesterol Treatment Trialists' (CTT) Collaborators.
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 55
    • 84864753387 scopus 로고    scopus 로고
    • Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials
    • Morrone D, Weintraub WS, Toth PP, et al. Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials. Atherosclerosis 2012, 223:251-261.
    • (2012) Atherosclerosis , vol.223 , pp. 251-261
    • Morrone, D.1    Weintraub, W.S.2    Toth, P.P.3
  • 56
    • 84859184996 scopus 로고    scopus 로고
    • Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis
    • Boekholdt SM, Arsenault BJ, Mora S, et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 2012, 307:1302-1309.
    • (2012) JAMA , vol.307 , pp. 1302-1309
    • Boekholdt, S.M.1    Arsenault, B.J.2    Mora, S.3
  • 58
    • 84870501784 scopus 로고    scopus 로고
    • University of Oxford Clinical Trial Service Unit, Epidemiological Studies UnitEpidemiological Studies Unit, (accessed Nov 28, 2013).
    • HPS2-THRIVE University of Oxford Clinical Trial Service Unit, Epidemiological Studies UnitEpidemiological Studies Unit, (accessed Nov 28, 2013). http://www.ctsu.ox.ac.uk/research/mega-trials/hps2-thrive.
    • HPS2-THRIVE
  • 59
    • 77952525229 scopus 로고    scopus 로고
    • Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial
    • the Triple Study Group
    • Huijgen R, Abbink EJ, Bruckert E, et al. Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial. Clin Ther 2010, 32:615-625. the Triple Study Group.
    • (2010) Clin Ther , vol.32 , pp. 615-625
    • Huijgen, R.1    Abbink, E.J.2    Bruckert, E.3
  • 60
    • 84868470681 scopus 로고    scopus 로고
    • Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
    • the LifeLines Cohort Study
    • Asselbergs FW, Guo Y, van Iperen EP, et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet 2012, 91:823-838. the LifeLines Cohort Study.
    • (2012) Am J Hum Genet , vol.91 , pp. 823-838
    • Asselbergs, F.W.1    Guo, Y.2    van Iperen, E.P.3
  • 61
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012, 148:1293-1307.
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1    Mias, G.I.2    Li-Pook-Than, J.3
  • 62
    • 84866518216 scopus 로고    scopus 로고
    • An anatomically comprehensive atlas of the adult human brain transcriptome
    • Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 2012, 489:391-399.
    • (2012) Nature , vol.489 , pp. 391-399
    • Hawrylycz, M.J.1    Lein, E.S.2    Guillozet-Bongaarts, A.L.3
  • 63
    • 77952571307 scopus 로고    scopus 로고
    • Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency
    • Gaudet D, de Wal J, Tremblay K, et al. Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency. Atheroscler Suppl 2010, 11:55-60.
    • (2010) Atheroscler Suppl , vol.11 , pp. 55-60
    • Gaudet, D.1    de Wal, J.2    Tremblay, K.3
  • 64
    • 57549090220 scopus 로고    scopus 로고
    • Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients
    • Stroes ES, Nierman MC, Meulenberg JJ, et al. Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients. Arterioscler Thromb Vasc Biol 2008, 28:2303-2304.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2303-2304
    • Stroes, E.S.1    Nierman, M.C.2    Meulenberg, J.J.3
  • 65
    • 84871945617 scopus 로고    scopus 로고
    • Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
    • the Phase 3 HoFH Lomitapide Study investigators
    • Cuchel M, Meagher EA, du Toit Theron H, et al. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 2013, 381:40-46. the Phase 3 HoFH Lomitapide Study investigators.
    • (2013) Lancet , vol.381 , pp. 40-46
    • Cuchel, M.1    Meagher, E.A.2    du Toit Theron, H.3
  • 66
    • 77949485460 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
    • Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet 2010, 375:998-1006.
    • (2010) Lancet , vol.375 , pp. 998-1006
    • Raal, F.J.1    Santos, R.D.2    Blom, D.J.3
  • 67
    • 58149262866 scopus 로고    scopus 로고
    • A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    • Pollin TI, Damcott CM, Shen H, et al. A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science 2008, 322:1702-1705.
    • (2008) Science , vol.322 , pp. 1702-1705
    • Pollin, T.I.1    Damcott, C.M.2    Shen, H.3
  • 68
    • 78649755576 scopus 로고    scopus 로고
    • Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia
    • Musunuru K, Pirruccello JP, Do R, et al. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med 2010, 363:2220-2227.
    • (2010) N Engl J Med , vol.363 , pp. 2220-2227
    • Musunuru, K.1    Pirruccello, J.P.2    Do, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.