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Volumn 242, Issue 2, 2015, Pages 647-656

Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: A review of the literature

Author keywords

Fibrates; Hypertriglyceridemia; Long chain omega 3 fatty acids; Niacin; Statins; Triglycerides

Indexed keywords

CREATININE; FIBRIC ACID DERIVATIVE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LIVER ENZYME; LONG CHAIN FATTY ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; OMEGA 3 FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; TRIACYLGLYCEROL;

EID: 84941747401     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.06.012     Document Type: Review
Times cited : (54)

References (102)
  • 1
    • 84866732882 scopus 로고    scopus 로고
    • Treatment options for the management of hypertriglyceridemia: strategies based on the best-available evidence
    • Maki K.C., Bays H.E., Dicklin M.R. Treatment options for the management of hypertriglyceridemia: strategies based on the best-available evidence. J. Clin. Lipidol. 2012, 6:413-426.
    • (2012) J. Clin. Lipidol. , vol.6 , pp. 413-426
    • Maki, K.C.1    Bays, H.E.2    Dicklin, M.R.3
  • 2
    • 61849163580 scopus 로고    scopus 로고
    • EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries
    • Kotseva K., Wood D., De Backer G., et al. EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. Eur. J. Cardiovasc. Prev. Rehabil. 2009, 16:121-137.
    • (2009) Eur. J. Cardiovasc. Prev. Rehabil. , vol.16 , pp. 121-137
    • Kotseva, K.1    Wood, D.2    De Backer, G.3
  • 3
    • 85027956925 scopus 로고    scopus 로고
    • Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association
    • Miller M., Stone N.J., Ballantyne C., et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 2011, 123:2292-2333.
    • (2011) Circulation , vol.123 , pp. 2292-2333
    • Miller, M.1    Stone, N.J.2    Ballantyne, C.3
  • 4
    • 79960205374 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Catapano A.L., Reiner Z., De Backer G., et al. ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 2011, 217:3-46.
    • (2011) Atherosclerosis , vol.217 , pp. 3-46
    • Catapano, A.L.1    Reiner, Z.2    De Backer, G.3
  • 5
    • 79958148945 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    • Chapman M.J., Ginsberg H.N., Amarenco P., et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur. Heart J. 2011, 32:1345-1361.
    • (2011) Eur. Heart J. , vol.32 , pp. 1345-1361
    • Chapman, M.J.1    Ginsberg, H.N.2    Amarenco, P.3
  • 6
    • 84866146620 scopus 로고    scopus 로고
    • Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline
    • Berglund L., Brunzell J.D., Goldberg A.C., et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2012, 97:2969-2989.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 2969-2989
    • Berglund, L.1    Brunzell, J.D.2    Goldberg, A.C.3
  • 7
    • 84860144206 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists' guidelines for management of dyslipidemia and prevention of atherosclerosis
    • Jellinger P.S., Smith D.A., Mehta A.E., et al. American Association of Clinical Endocrinologists' guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocr. Pract. 2012, 18(Suppl. 1):1-78.
    • (2012) Endocr. Pract. , vol.18 , pp. 1-78
    • Jellinger, P.S.1    Smith, D.A.2    Mehta, A.E.3
  • 8
    • 84906937463 scopus 로고    scopus 로고
    • The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management
    • Hegele R.A., Ginsberg H.N., Chapman M.J., et al. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014, 2:655-666.
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , pp. 655-666
    • Hegele, R.A.1    Ginsberg, H.N.2    Chapman, M.J.3
  • 9
    • 84908397421 scopus 로고    scopus 로고
    • National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1-executive summary
    • Jacobson T.A., Ito M.K., Maki K.C., et al. National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1-executive summary. J. Clin. Lipidol. 2014, 8:473-488.
    • (2014) J. Clin. Lipidol. , vol.8 , pp. 473-488
    • Jacobson, T.A.1    Ito, M.K.2    Maki, K.C.3
  • 10
    • 0037126526 scopus 로고    scopus 로고
    • Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002, 106:3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 11
    • 34447511196 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • Nordestgaard B.G., Benn M., Schnohr P., et al. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007, 298:299-308.
    • (2007) JAMA , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3
  • 12
    • 84872675457 scopus 로고    scopus 로고
    • Remnant cholesterol as a causal risk factor for ischemic heart disease
    • Varbo A., Benn M., Tybjaerg-Hansen A., et al. Remnant cholesterol as a causal risk factor for ischemic heart disease. J. Am. Coll. Cardiol. 2013, 61:427-436.
    • (2013) J. Am. Coll. Cardiol. , vol.61 , pp. 427-436
    • Varbo, A.1    Benn, M.2    Tybjaerg-Hansen, A.3
  • 13
    • 0015698060 scopus 로고
    • The interaction of familial and secondary causes of hypertriglyceridemia: role in pancreatitis
    • Brunzell J.D., Schrott H.G. The interaction of familial and secondary causes of hypertriglyceridemia: role in pancreatitis. Trans. Assoc. Am. Physicians 1973, 86:245-254.
    • (1973) Trans. Assoc. Am. Physicians , vol.86 , pp. 245-254
    • Brunzell, J.D.1    Schrott, H.G.2
  • 14
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18:499-502.
    • (1972) Clin. Chem. , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 15
    • 84897481560 scopus 로고    scopus 로고
    • Novel unbiased equations to calculate triglyceride-rich lipoprotein cholesterol from routine non-fasting lipids
    • Hermans M.P., Ahn S.A., Rousseau M.F. Novel unbiased equations to calculate triglyceride-rich lipoprotein cholesterol from routine non-fasting lipids. Cardiovasc. Diabetol. 2014, 13:56.
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 56
    • Hermans, M.P.1    Ahn, S.A.2    Rousseau, M.F.3
  • 16
    • 38949171001 scopus 로고    scopus 로고
    • Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial
    • Miller M., Cannon C.P., Murphy S.A., et al. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J. Am. Coll. Cardiol. 2008, 51:724-730.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 724-730
    • Miller, M.1    Cannon, C.P.2    Murphy, S.A.3
  • 17
    • 0028903142 scopus 로고
    • Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media
    • Nordestgaard B.G., Wootton R., Lewis B. Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler. Thromb. Vasc. Biol. 1995, 15:534-542.
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , pp. 534-542
    • Nordestgaard, B.G.1    Wootton, R.2    Lewis, B.3
  • 18
    • 0030937821 scopus 로고    scopus 로고
    • The role of triglyceride-rich lipoprotein families in the progression of atherosclerotic lesions as determined by sequential coronary angiography from a controlled clinical trial
    • Alaupovic P., Mack W.J., Knight-Gibson C., et al. The role of triglyceride-rich lipoprotein families in the progression of atherosclerotic lesions as determined by sequential coronary angiography from a controlled clinical trial. Arterioscler. Thromb. Vasc. Biol. 1997, 17:715-722.
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 715-722
    • Alaupovic, P.1    Mack, W.J.2    Knight-Gibson, C.3
  • 19
    • 34548166870 scopus 로고    scopus 로고
    • Remnant-like lipoprotein particles impair endothelial function: direct and indirect effects on nitric oxide synthase
    • Zheng X.Y., Liu L. Remnant-like lipoprotein particles impair endothelial function: direct and indirect effects on nitric oxide synthase. J. Lipid Res. 2007, 48:1673-1680.
    • (2007) J. Lipid Res. , vol.48 , pp. 1673-1680
    • Zheng, X.Y.1    Liu, L.2
  • 20
    • 64749100482 scopus 로고    scopus 로고
    • Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation
    • Wang L., Gill R., Pedersen T.L., et al. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation. J. Lipid Res. 2009, 50:204-213.
    • (2009) J. Lipid Res. , vol.50 , pp. 204-213
    • Wang, L.1    Gill, R.2    Pedersen, T.L.3
  • 21
    • 33847010885 scopus 로고    scopus 로고
    • Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha
    • Ting H.J., Stice J.P., Schaff U.Y., et al. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ. Res. 2007, 100:381-390.
    • (2007) Circ. Res. , vol.100 , pp. 381-390
    • Ting, H.J.1    Stice, J.P.2    Schaff, U.Y.3
  • 22
    • 0037109169 scopus 로고    scopus 로고
    • New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism
    • Ginsberg H.N. New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism. Circulation 2002, 106:2137-2142.
    • (2002) Circulation , vol.106 , pp. 2137-2142
    • Ginsberg, H.N.1
  • 23
    • 84865338549 scopus 로고    scopus 로고
    • Lipid-modifying therapies and risk of pancreatitis: a meta-analysis
    • Preiss D., Tikkanen M.J., Welsh P., et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA 2012, 308:804-811.
    • (2012) JAMA , vol.308 , pp. 804-811
    • Preiss, D.1    Tikkanen, M.J.2    Welsh, P.3
  • 24
    • 3042570661 scopus 로고    scopus 로고
    • Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials
    • Edwards J.E., Moore R.A. Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials. BMC Fam. Pract. 2003, 4:18.
    • (2003) BMC Fam. Pract. , vol.4 , pp. 18
    • Edwards, J.E.1    Moore, R.A.2
  • 25
  • 26
    • 0023232216 scopus 로고
    • Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick M.H., Elo O., Haapa K., et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 1987, 317:1237-1245.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 27
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins H.B., Robins S.J., Collins D., et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 1999, 341:410-418.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 28
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. The Bezafibrate Infarction Prevention (BIP) study
    • The BIP Study Group. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. The Bezafibrate Infarction Prevention (BIP) study. Circulation 2000, 102:21-27.
    • (2000) Circulation , vol.102 , pp. 21-27
  • 29
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    • Keech A., Simes R.J., Barter P., et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005, 366:1849-1861.
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3
  • 30
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials
    • Birjmohun R.S., Hutten B.A., Kastelein J.J., et al. Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials. J. Am. Coll. Cardiol. 2005, 45:185-197.
    • (2005) J. Am. Coll. Cardiol. , vol.45 , pp. 185-197
    • Birjmohun, R.S.1    Hutten, B.A.2    Kastelein, J.J.3
  • 31
    • 58249086417 scopus 로고    scopus 로고
    • Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk
    • Robinson J.G., Wang S., Smith B.J., et al. Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. J. Am. Coll. Cardiol. 2009, 53:316-322.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 316-322
    • Robinson, J.G.1    Wang, S.2    Smith, B.J.3
  • 32
    • 33744985842 scopus 로고    scopus 로고
    • Effects of fenofibrate on atherogenic dyslipidemia in hypertriglyceridemic subjects
    • Davidson M.H., Bays H.E., Stein E., et al. Effects of fenofibrate on atherogenic dyslipidemia in hypertriglyceridemic subjects. Clin. Cardiol. 2006, 29:268-273.
    • (2006) Clin. Cardiol. , vol.29 , pp. 268-273
    • Davidson, M.H.1    Bays, H.E.2    Stein, E.3
  • 33
    • 56849101891 scopus 로고    scopus 로고
    • Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing
    • Farnier M. Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing. Vasc. Health Risk Manag. 2008, 4:991-1000.
    • (2008) Vasc. Health Risk Manag. , vol.4 , pp. 991-1000
    • Farnier, M.1
  • 34
    • 31144439939 scopus 로고    scopus 로고
    • Low-density lipoprotein size and cardiovascular risk assessment
    • Rizzo M., Berneis K. Low-density lipoprotein size and cardiovascular risk assessment. QJM 2006, 99:1-14.
    • (2006) QJM , vol.99 , pp. 1-14
    • Rizzo, M.1    Berneis, K.2
  • 36
    • 84855557895 scopus 로고    scopus 로고
    • Treatment of hypertriglyceridemia with fibric acid derivatives: impact on lipid subfractions and translation into a reduction in cardiovascular events
    • McCullough P.A., Ahmed A.B., Zughaib M.T., et al. Treatment of hypertriglyceridemia with fibric acid derivatives: impact on lipid subfractions and translation into a reduction in cardiovascular events. Rev. Cardiovasc. Med. 2011, 12:173-185.
    • (2011) Rev. Cardiovasc. Med. , vol.12 , pp. 173-185
    • McCullough, P.A.1    Ahmed, A.B.2    Zughaib, M.T.3
  • 37
    • 0032506273 scopus 로고    scopus 로고
    • Mechanism of action of fibrates on lipid and lipoprotein metabolism
    • Staels B., Dallongeville J., Auwerx J., et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998, 98:2088-2093.
    • (1998) Circulation , vol.98 , pp. 2088-2093
    • Staels, B.1    Dallongeville, J.2    Auwerx, J.3
  • 39
    • 84875303002 scopus 로고    scopus 로고
    • Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches
    • Nikolic D., Katsiki N., Montalto G., et al. Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches. Nutrients 2013, 5:928-948.
    • (2013) Nutrients , vol.5 , pp. 928-948
    • Nikolic, D.1    Katsiki, N.2    Montalto, G.3
  • 40
    • 84899656061 scopus 로고    scopus 로고
    • Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study
    • Hoogeveen R.C., Gaubatz J.W., Sun W., et al. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study. Arterioscler. Thromb. Vasc. Biol. 2014, 34:1069-1077.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 1069-1077
    • Hoogeveen, R.C.1    Gaubatz, J.W.2    Sun, W.3
  • 41
    • 33645741889 scopus 로고    scopus 로고
    • Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    • Otvos J.D., Collins D., Freedman D.S., et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation 2006, 113:1556-1563.
    • (2006) Circulation , vol.113 , pp. 1556-1563
    • Otvos, J.D.1    Collins, D.2    Freedman, D.S.3
  • 42
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
    • Jun M., Foote C., Lv J., et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 2010, 375:1875-1884.
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 43
    • 0026597808 scopus 로고
    • Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment
    • Manninen V., Tenkanen L., Koskinen P., et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation 1992, 85:37-45.
    • (1992) Circulation , vol.85 , pp. 37-45
    • Manninen, V.1    Tenkanen, L.2    Koskinen, P.3
  • 44
    • 64749095070 scopus 로고    scopus 로고
    • Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    • Scott R., O'Brien R., Fulcher G., et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 2009, 32:493-498.
    • (2009) Diabetes Care , vol.32 , pp. 493-498
    • Scott, R.1    O'Brien, R.2    Fulcher, G.3
  • 45
    • 79960700766 scopus 로고    scopus 로고
    • Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis
    • Lee M., Saver J.L., Towfighi A., et al. Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis. Atherosclerosis 2011, 217:492-498.
    • (2011) Atherosclerosis , vol.217 , pp. 492-498
    • Lee, M.1    Saver, J.L.2    Towfighi, A.3
  • 46
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • Ginsberg H.N., Elam M.B., Lovato L.C., et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N. Engl. J. Med. 2010, 362:1563-1574.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3
  • 47
    • 0032530770 scopus 로고    scopus 로고
    • Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia
    • Guyton J.R., Goldberg A.C., Kreisberg R.A., et al. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am. J. Cardiol. 1998, 82:737-743.
    • (1998) Am. J. Cardiol. , vol.82 , pp. 737-743
    • Guyton, J.R.1    Goldberg, A.C.2    Kreisberg, R.A.3
  • 48
    • 0034644442 scopus 로고    scopus 로고
    • Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Arterial Disease Multiple Intervention Trial
    • Elam M.B., Hunninghake D.B., Davis K.B., et al. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Arterial Disease Multiple Intervention Trial. JAMA 2000, 284:1263-1270.
    • (2000) JAMA , vol.284 , pp. 1263-1270
    • Elam, M.B.1    Hunninghake, D.B.2    Davis, K.B.3
  • 49
    • 78649888517 scopus 로고    scopus 로고
    • Lipoprotein(a) as a cardiovascular risk factor: current status
    • Nordestgaard B.G., Chapman M.J., Ray K., et al. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur. Heart J. 2010, 31:2844-2853.
    • (2010) Eur. Heart J. , vol.31 , pp. 2844-2853
    • Nordestgaard, B.G.1    Chapman, M.J.2    Ray, K.3
  • 50
    • 0038201868 scopus 로고    scopus 로고
    • Effects of extended-release niacin on lipoprotein subclass distribution
    • Morgan J.M., Capuzzi D.M., Baksh R.I., et al. Effects of extended-release niacin on lipoprotein subclass distribution. Am. J. Cardiol. 2003, 91:1432-1436.
    • (2003) Am. J. Cardiol. , vol.91 , pp. 1432-1436
    • Morgan, J.M.1    Capuzzi, D.M.2    Baksh, R.I.3
  • 51
    • 84864270750 scopus 로고    scopus 로고
    • Extended-release niacin/laropiprant effects on lipoprotein subfractions in patients with type 2 diabetes mellitus
    • Bays H., Giezek H., McKenney J.M., et al. Extended-release niacin/laropiprant effects on lipoprotein subfractions in patients with type 2 diabetes mellitus. Metab. Syndr. Relat. Disord. 2012, 10:260-266.
    • (2012) Metab. Syndr. Relat. Disord. , vol.10 , pp. 260-266
    • Bays, H.1    Giezek, H.2    McKenney, J.M.3
  • 52
    • 84898748566 scopus 로고    scopus 로고
    • High-density lipoprotein particle subclass heterogeneity and incident coronary heart disease
    • Akinkuolie A.O., Paynter N.P., Padmanabhan L., et al. High-density lipoprotein particle subclass heterogeneity and incident coronary heart disease. Circ. Cardiovasc. Qual. Outcomes 2014, 7:55-63.
    • (2014) Circ. Cardiovasc. Qual. Outcomes , vol.7 , pp. 55-63
    • Akinkuolie, A.O.1    Paynter, N.P.2    Padmanabhan, L.3
  • 53
    • 77952397461 scopus 로고    scopus 로고
    • Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
    • Bruckert E., Labreuche J., Amarenco P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis 2010, 210:353-361.
    • (2010) Atherosclerosis , vol.210 , pp. 353-361
    • Bruckert, E.1    Labreuche, J.2    Amarenco, P.3
  • 54
    • 84872679028 scopus 로고    scopus 로고
    • The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression
    • Lavigne P.M., Karas R.H. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression. J. Am. Coll. Cardiol. 2013, 61:440-446.
    • (2013) J. Am. Coll. Cardiol. , vol.61 , pp. 440-446
    • Lavigne, P.M.1    Karas, R.H.2
  • 55
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
    • Canner P.L., Berge K.G., Wenger N.K., et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J. Am. Coll. Cardiol. 1986, 8:1245-1255.
    • (1986) J. Am. Coll. Cardiol. , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 56
    • 0015593704 scopus 로고
    • The coronary drug project. Design, methods, and baseline results
    • The coronary drug project. Design, methods, and baseline results. Circulation 1973, 47:I1-I50. The Coronary Drug Project Research Group.
    • (1973) Circulation , vol.47 , pp. I1-I50
  • 57
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • HPS2-THRIVE Collaborative Group. HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur. Heart J. 2013, 34:1279-1291.
    • (2013) Eur. Heart J. , vol.34 , pp. 1279-1291
  • 58
    • 84904252744 scopus 로고    scopus 로고
    • Effects of extended-release niacin with laropiprant in high-risk patients
    • Landray M.J., Haynes R., Hopewell J.C., et al. Effects of extended-release niacin with laropiprant in high-risk patients. N. Engl. J. Med. 2014, 371:203-212.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 203-212
    • Landray, M.J.1    Haynes, R.2    Hopewell, J.C.3
  • 59
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • Boden W.E., Probstfield J.L., Anderson T., et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N. Engl. J. Med. 2011, 365:2255-2267.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2255-2267
    • Boden, W.E.1    Probstfield, J.L.2    Anderson, T.3
  • 60
    • 0030974010 scopus 로고    scopus 로고
    • N-3 fatty acids and serum lipoproteins: human studies
    • Harris W.S. n-3 fatty acids and serum lipoproteins: human studies. Am. J. Clin. Nutr. 1997, 65:1645S-1654S.
    • (1997) Am. J. Clin. Nutr. , vol.65 , pp. 1645S-1654S
    • Harris, W.S.1
  • 61
    • 84893916503 scopus 로고    scopus 로고
    • Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial
    • Kastelein J.J., Maki K.C., Susekov A., et al. Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial. J. Clin. Lipidol. 2014, 8:94-106.
    • (2014) J. Clin. Lipidol. , vol.8 , pp. 94-106
    • Kastelein, J.J.1    Maki, K.C.2    Susekov, A.3
  • 62
    • 80051784104 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label extension [MARINE] trial)
    • Bays H.E., Ballantyne C.M., Kastelein J.J., et al. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label extension [MARINE] trial). Am. J. Cardiol. 2011, 108:682-690.
    • (2011) Am. J. Cardiol. , vol.108 , pp. 682-690
    • Bays, H.E.1    Ballantyne, C.M.2    Kastelein, J.J.3
  • 63
    • 84914811260 scopus 로고    scopus 로고
    • Overview of prescription omega-3 fatty acid products for hypertriglyceridemia
    • Weintraub H.S. Overview of prescription omega-3 fatty acid products for hypertriglyceridemia. Postgrad. Med. 2014, 126:7-18.
    • (2014) Postgrad. Med. , vol.126 , pp. 7-18
    • Weintraub, H.S.1
  • 64
    • 33749154105 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
    • Balk E.M., Lichtenstein A.H., Chung M., et al. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 2006, 189:19-30.
    • (2006) Atherosclerosis , vol.189 , pp. 19-30
    • Balk, E.M.1    Lichtenstein, A.H.2    Chung, M.3
  • 65
    • 0035698484 scopus 로고    scopus 로고
    • The effect of n-3 fatty acids on low density lipoprotein subfractions
    • Griffin B.A. The effect of n-3 fatty acids on low density lipoprotein subfractions. Lipids 2001, 36(Suppl. l):S91-S97.
    • (2001) Lipids , vol.36 , pp. S91-S97
    • Griffin, B.A.1
  • 66
    • 84879467569 scopus 로고    scopus 로고
    • Beneficial effects of Omega-3 fatty acids on low density lipoprotein particle size in patients with type 2 diabetes already under statin therapy
    • Lee M.W., Park J.K., Hong J.W., et al. Beneficial effects of Omega-3 fatty acids on low density lipoprotein particle size in patients with type 2 diabetes already under statin therapy. Diabetes Metab. J. 2013, 37:207-211.
    • (2013) Diabetes Metab. J. , vol.37 , pp. 207-211
    • Lee, M.W.1    Park, J.K.2    Hong, J.W.3
  • 67
    • 84861567223 scopus 로고    scopus 로고
    • Lipoprotein subfractions and dietary intake of n-3 fatty acid: the Genetics of Coronary Artery Disease in Alaska Natives study
    • Annuzzi G., Rivellese A.A., Wang H., et al. Lipoprotein subfractions and dietary intake of n-3 fatty acid: the Genetics of Coronary Artery Disease in Alaska Natives study. Am. J. Clin. Nutr. 2012, 95:1315-1322.
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 1315-1322
    • Annuzzi, G.1    Rivellese, A.A.2    Wang, H.3
  • 68
    • 84941736641 scopus 로고    scopus 로고
    • Amarin Corporation plc Vascepa Prescibing Information 2014, Available from:. http://www.vascepa.com/full-prescribing-information.pdf.
    • (2014) Vascepa Prescibing Information
  • 69
    • 84941740756 scopus 로고    scopus 로고
    • GlaxoSmithKline plc Lovaza Prescribing Information 2014, Available from:. https://www.gsksource.com/gskprm/htdocs/documents/LOVAZA-PI-PIL.PDF.
    • (2014) Lovaza Prescribing Information
  • 70
    • 84941745323 scopus 로고    scopus 로고
    • AstraZeneca Epanova Prescribing Information 2014, Available from:. http://www1.astrazeneca-us.com/pi/epanova.pdf.
    • (2014) Epanova Prescribing Information
  • 72
    • 77955833344 scopus 로고    scopus 로고
    • Fish oil for the treatment of cardiovascular disease
    • Weitz D., Weintraub H., Fisher E., et al. Fish oil for the treatment of cardiovascular disease. Cardiol. Rev. 2010, 18:258-263.
    • (2010) Cardiol. Rev. , vol.18 , pp. 258-263
    • Weitz, D.1    Weintraub, H.2    Fisher, E.3
  • 73
    • 84923088118 scopus 로고    scopus 로고
    • Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA
    • Albert B.B., Derraik J.G., Cameron-Smith D., et al. Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA. Sci. Rep. 2015, 5:7928.
    • (2015) Sci. Rep. , vol.5 , pp. 7928
    • Albert, B.B.1    Derraik, J.G.2    Cameron-Smith, D.3
  • 74
    • 79960814823 scopus 로고    scopus 로고
    • Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database
    • Zargar A., Ito M.K. Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. Metab. Syndr. Relat. Disord. 2011, 9:255-271.
    • (2011) Metab. Syndr. Relat. Disord. , vol.9 , pp. 255-271
    • Zargar, A.1    Ito, M.K.2
  • 75
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico
    • GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999, 354:447-455.
    • (1999) Lancet , vol.354 , pp. 447-455
  • 76
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    • Yokoyama M., Origasa H., Matsuzaki M., et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007, 369:1090-1098.
    • (2007) Lancet , vol.369 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 77
    • 78549233384 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular events after myocardial infarction
    • Kromhout D., Giltay E.J., Geleijnse J.M. n-3 fatty acids and cardiovascular events after myocardial infarction. N. Engl. J. Med. 2010, 363:2015-2026.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2015-2026
    • Kromhout, D.1    Giltay, E.J.2    Geleijnse, J.M.3
  • 78
    • 78650169331 scopus 로고    scopus 로고
    • OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction
    • Rauch B., Schiele R., Schneider S., et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation 2010, 122:2152-2159.
    • (2010) Circulation , vol.122 , pp. 2152-2159
    • Rauch, B.1    Schiele, R.2    Schneider, S.3
  • 79
    • 84877624255 scopus 로고    scopus 로고
    • N-3 fatty acids in patients with multiple cardiovascular risk factors
    • Roncaglioni M.C., Tombesi M., Avanzini F., et al. n-3 fatty acids in patients with multiple cardiovascular risk factors. N. Engl. J. Med. 2013, 368:1800-1808.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1800-1808
    • Roncaglioni, M.C.1    Tombesi, M.2    Avanzini, F.3
  • 80
    • 84873667731 scopus 로고    scopus 로고
    • Omega 3 fatty acids and cardiovascular outcomes: systematic review and meta-analysis
    • Kotwal S., Jun M., Sullivan D., et al. Omega 3 fatty acids and cardiovascular outcomes: systematic review and meta-analysis. Circ. Cardiovasc. Qual. Outcomes 2012, 5:808-818.
    • (2012) Circ. Cardiovasc. Qual. Outcomes , vol.5 , pp. 808-818
    • Kotwal, S.1    Jun, M.2    Sullivan, D.3
  • 81
    • 84866070612 scopus 로고    scopus 로고
    • Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis
    • Rizos E.C., Ntzani E.E., Bika E., et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 2012, 308:1024-1033.
    • (2012) JAMA , vol.308 , pp. 1024-1033
    • Rizos, E.C.1    Ntzani, E.E.2    Bika, E.3
  • 85
    • 0034887738 scopus 로고    scopus 로고
    • Lipid-lowering drugs and risk of myopathy: a population-based follow-up study
    • Gaist D., Rodriguez L.A., Huerta C., et al. Lipid-lowering drugs and risk of myopathy: a population-based follow-up study. Epidemiology 2001, 12:565-569.
    • (2001) Epidemiology , vol.12 , pp. 565-569
    • Gaist, D.1    Rodriguez, L.A.2    Huerta, C.3
  • 86
    • 9644252909 scopus 로고    scopus 로고
    • Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs
    • Graham D.J., Staffa J.A., Shatin D., et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA 2004, 292:2585-2590.
    • (2004) JAMA , vol.292 , pp. 2585-2590
    • Graham, D.J.1    Staffa, J.A.2    Shatin, D.3
  • 87
    • 3042623891 scopus 로고    scopus 로고
    • Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy
    • Chang J.T., Staffa J.A., Parks M., et al. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. Pharmacoepidemiol. Drug Saf. 2004, 13:417-426.
    • (2004) Pharmacoepidemiol. Drug Saf. , vol.13 , pp. 417-426
    • Chang, J.T.1    Staffa, J.A.2    Parks, M.3
  • 88
    • 37449001912 scopus 로고    scopus 로고
    • Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use
    • Holoshitz N., Alsheikh-Ali A.A., Karas R.H. Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use. Am. J. Cardiol. 2008, 101:95-97.
    • (2008) Am. J. Cardiol. , vol.101 , pp. 95-97
    • Holoshitz, N.1    Alsheikh-Ali, A.A.2    Karas, R.H.3
  • 89
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • Kyrklund C., Backman J.T., Neuvonen M., et al. Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin. Pharmacol. Ther. 2003, 73:538-544.
    • (2003) Clin. Pharmacol. Ther. , vol.73 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3
  • 90
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • Guyton J.R., Bays H.E. Safety considerations with niacin therapy. Am. J. Cardiol. 2007, 99:22C-31C.
    • (2007) Am. J. Cardiol. , vol.99 , pp. 22C-31C
    • Guyton, J.R.1    Bays, H.E.2
  • 91
    • 84875540714 scopus 로고    scopus 로고
    • Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose
    • Sazonov V., Maccubbin D., Sisk C.M., et al. Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose. Int. J. Clin. Pract. 2013, 67:297-302.
    • (2013) Int. J. Clin. Pract. , vol.67 , pp. 297-302
    • Sazonov, V.1    Maccubbin, D.2    Sisk, C.M.3
  • 92
    • 34548319692 scopus 로고    scopus 로고
    • Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study
    • Davidson M.H., Stein E.A., Bays H.E., et al. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin. Ther. 2007, 29:1354-1367.
    • (2007) Clin. Ther. , vol.29 , pp. 1354-1367
    • Davidson, M.H.1    Stein, E.A.2    Bays, H.E.3
  • 93
    • 84866124338 scopus 로고    scopus 로고
    • Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)
    • Ballantyne C.M., Bays H.E., Kastelein J.J., et al. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am. J. Cardiol. 2012, 110:984-992.
    • (2012) Am. J. Cardiol. , vol.110 , pp. 984-992
    • Ballantyne, C.M.1    Bays, H.E.2    Kastelein, J.J.3
  • 94
    • 33747120160 scopus 로고    scopus 로고
    • N-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    • Wang C., Harris W.S., Chung M., et al. n-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am. J. Clin. Nutr. 2006, 84:5-17.
    • (2006) Am. J. Clin. Nutr. , vol.84 , pp. 5-17
    • Wang, C.1    Harris, W.S.2    Chung, M.3
  • 95
    • 77953012291 scopus 로고    scopus 로고
    • Omega-3 fatty acids in high-risk cardiovascular patients: a meta-analysis of randomized controlled trials
    • Filion K.B., El Khoury F., Bielinski M., et al. Omega-3 fatty acids in high-risk cardiovascular patients: a meta-analysis of randomized controlled trials. BMC Cardiovasc. Disord. 2010, 10:24.
    • (2010) BMC Cardiovasc. Disord. , vol.10 , pp. 24
    • Filion, K.B.1    El Khoury, F.2    Bielinski, M.3
  • 96
    • 0031425356 scopus 로고    scopus 로고
    • Safety and efficacy of Omacor in severe hypertriglyceridemia
    • Harris W.S., Ginsberg H.N., Arunakul N., et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J. Cardiovasc. Risk 1997, 4:385-391.
    • (1997) J. Cardiovasc. Risk , vol.4 , pp. 385-391
    • Harris, W.S.1    Ginsberg, H.N.2    Arunakul, N.3
  • 97
    • 33745063941 scopus 로고    scopus 로고
    • Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters
    • McKenney J.M., Swearingen D., Di Spirito M., et al. Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters. J. Clin. Pharmacol. 2006, 46:785-791.
    • (2006) J. Clin. Pharmacol. , vol.46 , pp. 785-791
    • McKenney, J.M.1    Swearingen, D.2    Di Spirito, M.3
  • 98
    • 57549108116 scopus 로고    scopus 로고
    • Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults
    • Di Spirito M., Morelli G., Doyle R.T., et al. Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults. Expert Opin. Pharmacother. 2008, 9:2939-2945.
    • (2008) Expert Opin. Pharmacother. , vol.9 , pp. 2939-2945
    • Di Spirito, M.1    Morelli, G.2    Doyle, R.T.3
  • 99
    • 77149180421 scopus 로고    scopus 로고
    • Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia
    • Kostapanos M.S., Milionis H.J., Elisaf M.S. Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia. Am. J. Cardiovasc. Drugs 2010, 10:11-28.
    • (2010) Am. J. Cardiovasc. Drugs , vol.10 , pp. 11-28
    • Kostapanos, M.S.1    Milionis, H.J.2    Elisaf, M.S.3
  • 100
    • 81155139591 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis
    • Wei M.Y., Jacobson T.A. Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr. Atheroscler. Rep. 2011, 13:474-483.
    • (2011) Curr. Atheroscler. Rep. , vol.13 , pp. 474-483
    • Wei, M.Y.1    Jacobson, T.A.2
  • 101
    • 84856179128 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review
    • Jacobson T.A., Glickstein S.B., Rowe J.D., et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. J. Clin. Lipidol. 2012, 6:5-18.
    • (2012) J. Clin. Lipidol. , vol.6 , pp. 5-18
    • Jacobson, T.A.1    Glickstein, S.B.2    Rowe, J.D.3
  • 102
    • 84902576469 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines
    • Stone N.J., Robinson J.G., Lichtenstein A.H., et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J. Am. Coll. Cardiol. 2014, 63:2889-2934.
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2889-2934
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3


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