DHA effects in brain development and function

Nutrients

Volumn 8, Issue 1, 2016, Pages

  Lauritzen, Lotte ^a   Brambilla, Paolo ^b,c   Mazzocchi, Alessandra ^d   Harsløf, Laurine B S ^a   Ciappolino, Valentina ^b   Agostoni, Carlo ^d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b OSPEDALE NIGUARDA CA GRANDA   (Italy)

^c UNIVERSITY OF TEXAS   (United States)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Brain development; Desaturases; Docosahexaenoic acid; Psychiatric disorders

Indexed keywords

ACYL COENZYME A DESATURASE; DOCOSAHEXAENOIC ACID; POLYUNSATURATED FATTY ACID;

ADIPOSE TISSUE; ARTIFICIAL MILK; BRAIN DEVELOPMENT; BRAIN FUNCTION; COGNITION; DIET SUPPLEMENTATION; DIETARY INTAKE; ENZYME POLYMORPHISM; FATTY ACID SYNTHESIS; HUMAN; MEMORY; META ANALYSIS (TOPIC); POSTNATAL DEVELOPMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; BIOSYNTHESIS; BRAIN; MENTAL DISEASE; METABOLISM; PHYSIOLOGY;

BRAIN; COGNITION; DOCOSAHEXAENOIC ACIDS; HUMANS; MENTAL DISORDERS;

EID: 84953911431     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8010006     Document Type: Review

References (115)

1. Vlaardingerbroek, H.; Hornstra, G.; de Koning, T.J.; Smeitink, J.A.; Bakker, H.D.; deKlerk, H.B.;Rubio-Gozalbo, M.E. Essential polyunsaturated fatty acids in plasma and erythrocytes of children with inborn errors of amino acid metabolism. Mol. Genet. Metab. 2006, 88, 159-165.[CrossRef] [PubMed]
2. Abbott, S.K.; Else, P.L.; Atkins, T.A.; Hulbert, A.J. Fatty acid composition of membrane bilayers: Importance of diet polyunsaturated fat balance. Biochim. Biophys. Acta 2012, 1818, 1309-1317.[CrossRef] [PubMed]
3. Neuringer, M.; Connor, W.E.; Lin, D.S.; Barstad, L.; Luck, S. Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc. Natl. Acad. Sci. USA 1986, 83, 4021-4025.[CrossRef] [PubMed]
4. Carrie, I.; Clement, M.; de Javel, D.; Frances, H.; Bourre, J.M. Specific phospholipid fatty acid composition of brain regions in mice: Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. J. Lipid Res. 2000, 41, 465-472.[PubMed]
5. Carver, J.D.; Benford, V.J.; Han, B.; Cantor, A.B. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res. Bull. 2001, 56, 79-85.[CrossRef]
6. Cetin, I.; Alvino, G.; Cardellicchio, M. Long chain fatty acids and dietary fats in fetal nutrition. J. Physiol. 2009, 587, 3441-3451.[CrossRef] [PubMed]
7. Haggarty, P. Effect of placental function on fatty acid requirements during pregnancy. Eur. J. Clin. Nutr. 2004, 58, 1559-1570.[CrossRef] [PubMed]
8. Kuipers, R.S.; Luxwolda, M.F.; Offringa, P.J.; Boersma, E.R.; Dijck-Brouwer, D.A.J.; Muskiet, F.A.J. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. Prostaglandins Leukot. Essent. Fat. Acids 2012, 86, 13-20.[CrossRef] [PubMed]
9. Kuipers, R.S.; Luxwolda, M.F.; Offringa, P.J.; Boersma, E.R.; Dijck-Brouwer, D.A.J.; Muskiet, F.A.J. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. Prostaglandins Leukot. Essent. Fat. Acids 2012, 86, 189-199. [CrossRef] [PubMed]
10. Clandinin, M.T.; Chappell, J.E.; Leong, S.; Heim, T.; Swyer, P.R.; Chance, G.W. Intrauterine fatty acid accretion rates in human brain: Implications for fatty acid requirements. Early Hum. Dev. 1980, 4, 121-129.[CrossRef]
11. Herrera, E. Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development—A review. Placenta 2002, 23, S9-S19.[CrossRef] [PubMed]
12. Campbell, F.M.; Gordon, M.J.; Dutta-Roy, A.K. Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids. Life Sci. 1998, 63, 235-240.[CrossRef]
13. Haggarty, P. Fatty acid supply to the human fetus. Annu. Rev. Nutr. 2010, 30, 237-255.[CrossRef] [PubMed]
14. Montes, R.; Chisaguano, A.M.; Castellote, A.I.; Morales, E.; Sunyer, J.; Lopez-Sabater, M.C. Fatty acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. Eur. J. Clin. Nutr. 2013, 67, 658-663.[CrossRef] [PubMed]
15. Agostoni, C.; Galli, C.; Riva, E.; Rise, P.; Colombo, C.; Giovannini, M.; Marangoni, F. Whole blood fatty acid composition at birth: From the maternal compartment to the infant. Clin. Nutr. 2011, 30, 503-505.[CrossRef] [PubMed]
16. Oliveira, O.R.C.; Santana, M.G.; Santos, F.S.; Conceicao, F.D.; Sardinha, F.L.C.; Veiga, G.V.; do Carmo, M.G.T. Composition of fatty acids in the maternal and umbilical cord plasma of adolescent and adult mothers: Relationship with anthropometric parameters of newborn. Lipids Health Dis. 2012, 11, 157.[CrossRef] [PubMed]
17. Gil-Sanchez, A.; Larque, E.; Demmelmair, H.; Acien, M.I.; Faber, F.L.; Parrilla, J.J.; Koletzko, B. Maternal-fetal in vivo transfer of (13C)docosahexaenoic and other fatty acids across the human placenta 12 h after maternal oral intake. Am. J. Clin. Nutr. 2010, 92, 115-122.[CrossRef] [PubMed]
18. Campbell, F.M.; Dutta-Roy, A.K. Plasma-membrane fatty acid binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. FEBS Lett. 1995, 375, 227-230.[CrossRef]
19. Dutta-Roy, A.K. Transfer of long-chain polyunsaturated fatty acids across the human placenta. Prenat. Neonat. Med. 1997, 2, 101-107.
20. Crabtree, J.T.; Gordon, M.J.; Campbell, F.M.; Dutta-Roy, A.K. Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. Mol. Cell. Biochem. 1998, 185, 191-198.[CrossRef] [PubMed]
21. Campbell, F.M.; Clohessy, A.M.; Gordon, M.J.; Page, K.R.; Dutta-Roy, A.K. Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: Role of plasma membrane fatty acid binding protein. J. Lipid Res. 1997, 38, 2558-2568.[PubMed]
22. Allen, K.G.D.; Harris, M.A. The role of n-3 fatty acids in gestation and parturition. Exp. Biol. Med. 2001, 226, 498-506.
23. Cetin, I.; Giovannini, N.; Alvino, G.; Agostoni, C.; Riva, E.; Giovannini, M.; Pardi, G. Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. Pediatr. Res. 2002, 52, 750-755.[CrossRef] [PubMed]
24. Jørgensen, M.H.; Nielsen, P.K.; Michaelsen, K.F.; Lund, P.; Lauritzen, L. The composition of polyunsaturated fatty acids in erythrocytes of lactating mothers and their infants. Mater. Child Nutr. 2006, 2, 29-39.[CrossRef] [PubMed]
25. Koletzko, B.; Schmidt, E.; Bremer, H.J.; Haug, M.; Harzer, G. Effects of dietary long-chain polyunsaturated fatty acids on the essential fatty acid status of premature infants. Eur. J. Pediatr. 1989, 148, 669-675.[CrossRef] [PubMed]
26. Hsieh, A.T.; Brenna, J.T. Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonates. Prostaglandins Leukot. Essent. Fat. Acids 2009, 81, 105-110.[CrossRef] [PubMed]
27. Farquharson, J.; Cockburn, F.; Patrick, W.A.; Jamieson, E.C.; Logan, R.W. Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet 1992, 340, 810-813.[CrossRef]
28. Makrides, M.; Neumann, M.A.; Byard, R.W.; Simmer, K.; Gibson, R.A. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am. J. Clin. Nutr. 1994, 60, 189-194.[PubMed]
29. Harsløf, L.B.S.; Larsen, L.H.; Ritz, C.; Hellgren, L.I.; Michaelsen, K.F.; Vogel, U.; Lauritzen, L. FADS genotype and diet are important determinants of DHA status: A cross-sectional study in Danish infants. Am. J. Clin. Nutr. 2013, 97, 1403-1410.[CrossRef] [PubMed]
30. Lauritzen, L.; Carlson, S.E. Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. Mater. Child Nutr. 2011, 7, 41-58.[CrossRef] [PubMed]
31. Rise, P.; Tragni, E.; Ghezzi, S.; Agostoni, C.; Marangoni, F.; Poli, A.; Catapano, A.L.; Siani, A.; Iacoviello, L.; Galli, C. Different patterns characterize omega-6 and omega-3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. Prostaglandins Leukot. Essent. Fat. Acids 2013, 89, 215-220.[CrossRef] [PubMed]
32. Rahmawaty, S.; Charlton, K.; Lyons-Wall, P.; Meyer, B.J. Dietary intake and food sources of EPA, DPA and DHA in Australian children. Lipids 2013, 48, 869-877.[CrossRef] [PubMed]
33. Wolters, M.; Schlenz, H.; Foraita, R.; Galli, C.; Rise, P.; Moreno, L.A.; Molnar, D.; Russo, P.; Veidebaum, T.; Tornaritis M.; et al. Reference values of whole-blood fatty acids by age and gender from European children aged 3-8 years. Int. J. Obes. 2014, 38, S86-S98.[CrossRef] [PubMed]
34. Crawford, M.A.; Hassam, G.A.; Williams, G.; Whitehouse, W.L. Essential fatty acids and fetal brain growth. Lancet 1976, 1, 452-453.[CrossRef]
35. Sauerwald, T.U.; Hachey, D.L.; Jensen, C.L.; Chen, H.; Anderson, R.E.; Heird, W.C. Intermediates in endogenous synthesis of C22:6 omega-3 and C20:4 omega-6 by term and preterm infants. Pediatr. Res. 1997, 41, 183-187.[CrossRef] [PubMed]
36. Salem, N., Jr.; Wegher, B.; Mena, P.; Uauy, R. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc. Natl. Acad. Sci. USA 1996, 93, 49-54.[CrossRef] [PubMed]
37. Szitanyi, P.; Koletzko, B.; Mydlilova, A.; Demmelmair, H. Metabolism of C-13-labeled linoleic acid in newborn infants during the first week of life. Pediatr. Res. 1999, 45, 669-673.[CrossRef] [PubMed]
38. Uauy, R.D.; Mena, P.; Wegher, B.; Nieto, S.; Salem, N., Jr. Long chain polyunsaturated fatty acid formation in neonates: Effect of gestational age and intrauterine growth. Pediatr. Res. 2000, 47, 127-135.[CrossRef] [PubMed]
39. Carnielli, V.P.; Simonato, M.; Verlato, G.; Luijendijk, I.; de Curtis, M.; Sauer, P.J.; Cogo, P.E. Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids. Am. J. Clin. Nutr. 2007, 86, 1323-1330.[PubMed]
40. Lin, Y.H.; Llanos, A.; Mena, P.; Uauy, R.; Salem, N., Jr.; Pawlosky, R.J. Compartmental analyses of H-2(5)-alpha-linolenic acid and C-13-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6 n-3 in newborn term infants. Am. J. Clin. Nutr. 2010, 92, 284-293.[CrossRef] [PubMed]
41. Xie, L.; Innis, S.M. Genetic Variants of the FADS1 FADS2 gene cluster are associated with altered n-6 and n-3 essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J. Nutr. 2008, 138, 2222-2228.[CrossRef] [PubMed]
42. Koletzko, B.; Lattka, E.; Zeilinger, S.; Illig, T.; Steer, C. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: Findings from the Avon Longitudinal Study of Parents and Children. Am. J. Clin. Nutr. 2011, 93, 211-219.[CrossRef] [PubMed]
43. Schaeffer, L.; Gohlke, H.; Muller, M.; Heid, I.M.; Palmer, L.J.; Kompauer, I.; Demmelmair, H.; Illig, T.; Koletzko, B.; Heinrich, J. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum. Mol. Genet. 2006, 15, 1745-1756.[CrossRef] [PubMed]
44. Mathias, R.A.; Vergara, C.; Gao, L.; Rafaels, N.; Hand, T.; Campbell, M.; Bickel, C.; Ivester, P.; Sergeant, S.; Barnes K.C.; et al. FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. J. Lipid Res. 2010, 51, 2766-2774.[CrossRef] [PubMed]
45. Bokor, S.; Dumont, J.; Spinneker, A.; Gonzalez-Gross, M.; Nova, E.; Widhalm, K.; Moschonis, G.; Stehle, P.; Amouyel, P.; deHenauw, S.; et al. Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. J. Lipid Res. 2010, 51, 2325-2333.[CrossRef] [PubMed]
46. Morales, E.; Bustamante, M.; Gonzalez, J.R.; Guxens, M.; Torrent, M.; Mendez, M.; Garcia-Esteban, R.; Julvez, J.; Forns, J.; Vrijheid, M.; et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrum LCPUFA levels, breastfeeding, and child cognition. PLoS ONE 2011, 6, e17181.[CrossRef] [PubMed]
47. Moltó-Puigmartí, C.; Plat, J.; Mensink, R.P.; Müller, A.; Jansen, E.; Zeegers, M.P.; Thijs, C. FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. Am. J. Clin. Nutr. 2010, 91, 1368-1376.[CrossRef] [PubMed]
48. Lattka, E.; Rzehak, P.; Szabo, E.; Jakobik, V.; Weck, M.; Weyermann, M.; Grallert, H.; Rothenbacher, D.; Heinrich, J.; Brenner, H.; et al. Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation. Am. J. Clin. Nutr. 2011, 93, 382-391. [PubMed]
49. Steer, C.D.; Hibbeln, J.R.; Golding, J.; Smith, G.D. Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: Their associations with two common FADS2 polymorphisms. Hum. Mol. Genet. 2012, 21, 1504-1512. [CrossRef] [PubMed]
50. Lattka, E.; Koletzko, B.; Zeilinger, S.; Hibbeln, J.R.; Klopp, N.; Ring, S.M.; Steer, C.D. Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC). Br. J. Nutr. 2013, 109, 1196-1210. [CrossRef] [PubMed]
51. Jensen, H.A.R.; Harsløf, L.B.S.; Nielsen, M.S.; Christensen, L.B.; Ritz, C.; Michaelsen, K.F.; Vogel, U.; Lauritzen, L. FADS single-nucleotide polymorphisms are associated with behavioral outcomes in children, and the effect varies between genders and is dependent on PPAR genotype. Am. J. Clin. Nutr. 2014, 100, 826-832. [CrossRef] [PubMed]
52. Glaser, C.; Rzehak, P.; Demmelmair, H.; Klopp, N.; Heinrich, J.; Koletzko, B. LISA study group. Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children. PLoS ONE 2011, 6, e21933. [CrossRef] [PubMed]
53. European Food Safety Authority. The Panel on Dietetic Products, Nutrition and Allergies on a request from Mead Johnson Nutritionals. Scientific opinion on DHA and ARA and visual development. EFSA J. 2009, 941, 1-14.[CrossRef]
54. Uauy, R.; Hoffman, D.R.; Mena, P.; Llanos, A.; Birch, E.E. Term infant studies of DHA and ARA supplementation on neurodevelopment: Results of randomized controlled trials. J. Pediatr. 2003, 143, S17-S25.[CrossRef]
55. Simmer, K.; Patole, S.K.; Rao, S.C. Long-chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst. Rev. 2011, 12.[CrossRef]
56. Qawasmi, A.; Landeros-Weisenberger, A.; Leckman, J.F.; Bloch, M.H. Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics 2012, 129, 1141-1149.[CrossRef] [PubMed]
57. Schulzke, S.M.; Patole, S.K.; Simmer, K. Long-chain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst. Rev. 2011, 2.[CrossRef]
58. Delgado-Noguera, M.F.; Calvache, J.A.; Cosp, X.B. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database Syst. Rev. 2010, 12.[CrossRef]
59. Gould, J.F.; Smithers, L.G.; Makrides, M. The effect of maternal omega-3 LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: A systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2013, 97, 531-544.[CrossRef] [PubMed]
60. Makrides, M.; Gibson, R.A.; McPhee, A.J.; Collins, C.T.; Davis, P.G.; Doyle, L.W.; Simmer, K.; Colditz, P.B.; Morris, S.; Smithers, L.G.; et al. Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: A randomized controlled trial. JAMA 2009, 301, 175-178.[CrossRef] [PubMed]
61. Makrides, M.; Gibson, R.A.; McPhee, A.J. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: A randomized controlled trial. JAMA 2010, 304, 1675-1683. [CrossRef] [PubMed]
62. Lauritzen, L.; Jørgensen, M.H.; Olsen, S.F.; Straarup, E.M.; Michaelsen, K.F. Maternal fish oil supplementation in lactation: Effect on developmental outcome in breast-fed infants. Reprod. Nutr. Dev. 2005, 45, 535-547. [CrossRef] [PubMed]
63. Cheatham, C.L.; Nerhammer, A.S.; Asserhøj, M.; Michaelsen, K.F.; Lauritzen, L. Fish oil supplementation during lactation: Effects on cognition and behavior at 7 years of age. Lipids 2011, 46, 637-645.[CrossRef] [PubMed]
64. Asserhøj, M.; Nehammer, S.; Matthiessen, J.; Michaelsen, K.F.; Lauritzen, L. Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. J. Nutr. 2009, 139, 298-304. [CrossRef] [PubMed]
65. Steer, C.D.; Smith, G.D.; Emmett, P.M.; Hibbeln, J.R.; Golding, J. FADS2 polymorphisms modify the effect of breastfeeding on child IQ. PLoS ONE 2010, 5.[CrossRef] [PubMed]
66. Caspi, A.; Williams, B.; Kim-Cohen, J.; Craig, I.W.; Milne, B.J.; Poulton, R.; Schalkwyk, L.C.; Taylor, A.; Werts, H.; Moffitt, T.E. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc. Natl. Acad. Sci. USA 2007, 104, 18860-18865.[CrossRef] [PubMed]
67. Groen-Blokhuis, M.M.; Franic, S.; van Beijsterveldt, C.E.M.; de Geus, E.; Bartels, M.; Davies, G.E.; Ehli, E.A.; Xiao, X.J.; Scheet, P.A.; Althoff, R.; et al. A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2013, 162, 457-465. [CrossRef] [PubMed]
68. Martin, N.W.; Benyamin, B.; Hansell, N.K.; Montgomery, G.W.; Martin, N.G.; Wright, M.J.; Bates, T.C. Cognitive function in adolescence: Testing for interactions between breast-feeding and FADS2 polymorphisms. J. Am. Acad. Child Adolesc. Psychiatry 2011, 50, 55-62. [CrossRef] [PubMed]
69. Steer, C.D.; Lattka, E.; Koletzko, B.; Golding, J.; Hibbeln, J.R. Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am. J. Clin. Nutr. 2013, 98, 1575-1582. [CrossRef] [PubMed]
70. Browning, L.M.; Walker, C.G.; Mander, A.P.; West, A.L.; Madden, J.; Gambell, J.M.; Young, S.; Wang, L.; Jebb, S.A.; Calder, P.C. Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. Am. J. Clin. Nutr. 2012, 96, 748-758. [CrossRef] [PubMed]
71. Drover, J.; Hoffman, D.R.; Castaneda, Y.S.; Morale, S.E.; Birch, E.E. Three randomized controlled trials of early long-chain polyunsaturated fatty acid supplementation on means-end problem solving in 9-month-olds. Child Dev. 2009, 80, 1376-1384.[CrossRef] [PubMed]
72. Hoffman, D.R.; Theuer, R.C.; Castaneda, Y.S.; Wheaton, D.H.; Bosworth, R.G.; O’Connor, A.R.; Morale, S.E.; Wiedemann, L.E.; Birch, E.E. Maturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk. J. Nutr. 2004, 134, 2307-2313.[PubMed]
73. Harbild, H.L.; Harsløf, L.B.S.; Christensen, J.H.; Kannass, K.N.; Lauritzen, L. Fish oil-supplementation from 9 to 12 months of age affects infant attention in a free-play test and is related to change in blood pressure. Prostaglandins Leukot. Essent. Fat. Acids 2013, 89, 327-333. [CrossRef] [PubMed]
74. Parletta, N.; Cooper, P.; Gent, D.N.; Petkov, J.; O’Dea, K. Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: A randomised controlled trial. Prostaglandins Leukot. Essent. Fat. Acids 2013, 89, 71-79. [CrossRef] [PubMed]
75. Baumgartner, J.; Smuts, C.M.; Malan, L.; Kvalsvig, J.; van Stuijvenberg, M.E.; Hurrell, R.F.; Zimmermann, M.B. Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: A randomized, double-blind, placebo-controlled intervention in South Africa. Am. J. Clin. Nutr. 2012, 96, 1327-1338. [CrossRef] [PubMed]
76. McNamara, R.K.; Able, J.; Jandacek, R.; Rider, T.; Tso, P.; Eliassen, J.C.; Alfieri, D.; Weber, W.; Jarvis, K.; DelBello, M.P.; et al. Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: A placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am. J. Clin. Nutr. 2010, 91, 1060-1067. [CrossRef] [PubMed]
77. Sørensen, L.B.; Dyssegaard, C.B.; Damsgaard, C.T.; Petersen, R.A.; Dalskov, S.M.; Hjorth, M.F.; Andersen, R.; Tetens, I.; Ritz, C.; Astrup, A.; et al. The effect of Nordic school meals on concentration and school performance in 8 to 11 year-old children in the OPUS School Meal Study: A cluster-randomized controlled cross-over trial. Br. J. Nutr. 2015, 113, 1280-1291. [CrossRef] [PubMed]
78. Eilander, A.; Hundscheid, D.C.; Osendarp, S.J.; Transler, C.; Zock, P.L. Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: A review of human studies. Prostaglandins Leukot. Essent. Fat. Acids 2007, 76, 189-203. [CrossRef] [PubMed]
79. Osendarp, S.J.M.; Baghurst, K.I.; Bryan, J.; Calvaresi, E.; Hughes, D.; Hussaini, M.; Karyadi, S.J.M.; van Klinken, B.J.W.; van der Knaap, H.C.M.; Lukito, W.; et al. Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. Am. J. Clin. Nutr. 2007, 86, 1082-1093. [PubMed]
80. Kennedy, D.O.; Jackson, P.A.; Elliott, J.M.; Scholey, A.B.; Robertson, B.C.; Greer, J.; Tiplady, B.; Buchanan, T.; Haskell, C.F. Cognitive and mood effects of 8 weeks’ supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years. Nutr. Neurosci. 2009, 12, 48-56. [CrossRef] [PubMed]
81. Kirby, A.; Woodward, A.; Jackson, S.; Wang, Y.; Crawford, M.A. A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8-10 years from a mainstream school population. Res. Dev. Disabil. 2010, 31, 718-730. [CrossRef] [PubMed]
82. Smuts, C.M.; Greeff, J.; Kvalsvig, J.; Zimmermann, M.; Baumgartner, J. Long-chain n-3 polyunsaturated fatty acid supplementation decrease physical activity during class in iron deficient South African school children. Br. J. Nutr. 2015, 113, 212-224. [CrossRef] [PubMed]
83. Rytter, M.J.H.; Andersen, L.B.B.; Houmann, T.; Bilenberg, N.; Hvolby, A.; Mølgaard, C.; Michaelsen, K.F.; Lauritzen, L. Diet in the treatment of ADHD in children-A systematic review of the literature. Nord. J. Psychiatry 2015, 69, 1-18. [CrossRef] [PubMed]
84. Brookes, K.J.; Chen, W.; Xu, X.; Taylor, E.; Asherson, P. Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol. Psychiatry 2006, 60, 1053-1061. [CrossRef] [PubMed]
85. Harsløf, L.B.; Damsgaard, C.; Hellgren, L.; Andersen, A.; Vogel, U.; Lauritzen, L. Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil. Genes Nutr. 2014, 9, 1-11. [CrossRef] [PubMed]
86. Damsgaard, C.T.; Schack-Nielsen, L.; Michaelsen, K.F.; Fruekilde, M.B.; Hels, O.; Lauritzen, L. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants. J. Nutr. 2006, 136, 94-99.[PubMed]
87. Damsbo-Svendsen, S.; Rønsholdt, M.D.; Lauritzen, L. Fish oil-supplementation increases appetite in healthy adults. A randomized controlled cross-over trial. Appetite 2013, 66, 62-66.[CrossRef] [PubMed]
88. Stonehouse, W.; Conlon, C.A.; Podd, J.; Hill, S.R.; Minihane, A.M.; Haskell, C.; Kennedy, D. DHA supplementation improved both memory and reaction time in healthy young adults: A randomized controlled trial. Am. J. Clin. Nutr. 2013, 97, 1134-1143. [CrossRef] [PubMed]
89. Agostoni, C.; Zuccotti, G.V.; Radaelli, G.; Besana, R.; Podesta, A.; Sterpa, A.; Rottoli, A.; Riva, E.; Giovannini, M. Docosahexaenoic acid supplementation and time at achievement of gross motor milestones in healthy infants: A randomized, prospective, double-blind, placebo-controlled trial. Am. J. Clin. Nutr. 2009, 89, 64-70. [CrossRef] [PubMed]
90. Yurko-Mauro, K.; Alexander, D.D.; van Elswyk, M.E. Docosahexaenoic acid and adult memory: A systematic review and meta-analysis. PLoS ONE 2015, 10.[CrossRef]
91. Morris, M.C.; Evans, D.A.; Tangney, C.C.; Bienias, J.L.; Wilson, R.S. Fish consumption and cognitive decline with age in a large community study. Arch. Neurol. 2005, 62, 1849-1853. [CrossRef] [PubMed]
92. Lim, W.S.; Gammack, J.K.; van Niekerk, J.; Dangour, A.D. Omega-3 fatty acid for the prevention of dementia. Cochrane Database Syst. Rev. 2006, 1.[CrossRef]
93. Chiu, C.C.; Su, K.P.; Cheng, T.C.; Liu, H.C.; Chang, C.J.; Dewey, M.E.; Stewart, R.; Huang, S.Y. The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32, 1538-1544. [CrossRef] [PubMed]
94. Yurko-Mauro, K.; McCarthy, D.; Rom, D.; Nelson, E.B.; Ryan, A.S.; Blackwell, A.; Salem, N., Jr.; Stedman, M. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010, 6, 456-464. [CrossRef] [PubMed]
95. Astarita, G.; Jung, K.M.; Berchtold, N.C.; Nguyen, V.Q.; Gillen, D.L.; Head, E.; Cotman, C.W.; Piomelli, D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer’s disease. PLoS ONE 2010, 5, e12538.[CrossRef] [PubMed]
96. Bazan, N.G.; Molina, M.F.; Gordon, W.C. Docosahexaenoic acid Signal lipidomics in nutrition: Significance in aging, neuroinflammation, macular degeneration, Alzheimer’s, and other neurodegenerative diseases. Annu. Rev. Nutr. 2011, 31, 321-351. [CrossRef] [PubMed]
97. De Mel, D.; Suphioglu, C. Fishy business: Effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. Nutrients 2014, 6, 3245-3258. [CrossRef] [PubMed]
98. Labrousse, V.F.; Nadjar, A.; Joffre, C.; Costes, L.; Aubert, A.; Gregoire, S.; Bretillon, L.; Laye, S. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. PLoS ONE 2012, 7, e36861. [CrossRef] [PubMed]
99. Sands, S.A.; Windsor, S.L.; Reid, K.J.; Harris, W.S. The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. Lipids 2005, 40, 343-347. [CrossRef] [PubMed]
100. Hoen, W.P.; Lijmer, J.G.; Duran, M.; Wanders, R.J.; van Beveren, N.J.; de Haan, L. Red blood cell polyunsaturated fatty acids measured in red blood cells and schizophrenia: A meta-analysis. Psychiatry Res. 2013, 207, 1-12. [CrossRef] [PubMed]
101. Peet, M.; Shah, S.; Selvam, K.; Ramchand, C.N. Polyunsaturated fatty acid levels in red cell membranes of unmedicated schizophrenic patients. World J. Biol. Psychiatry 2004, 5, 92-99. [CrossRef] [PubMed]
102. Khan, M.M.; Evans, D.R.; Gunna, V.; Scheffer, R.E.; Parikh, V.V.; Mahadik, S.P. Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics. Schizophr. Res. 2002, 58, 1-10.[CrossRef]
103. Reyazuddin, M.; Azmi, S.A.; Islam, N.; Rizvi, A. Oxidative stress and level of antioxidant enzymes in drug-naive schizophrenics. Indian J. Psychiatry 2014, 56, 344-349. [PubMed]
104. Hashimoto, M.; Maekawa, M.; Katakura, M.; Hamazaki, K.; Matsuoka, Y. Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. J. Pharmacol. Sci. 2014, 124, 294-300. [CrossRef] [PubMed]
105. Amminger, G.P.; Schafer, M.R.; Papageorgiou, K.; Klier, C.M.; Cotton, S.M.; Harrigan, S.M.; Mackinnon, A.; McGorry, P.D.; Berger, G.E. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: A randomized, placebo-controlled trial. Arch. Gen. Psychiatry 2010, 67, 146-154. [CrossRef] [PubMed]
106. Machado-Vieira, R.; Mallinger, A.G. Abnormal function of monoamine oxidase-A in comorbid major depressive disorder and cardiovascular disease: Pathophysiological and therapeutic implications. Mol. Med. Rep. 2012, 6, 915-922. [CrossRef] [PubMed]
107. Weissman, M.M.; Bland, R.C.; Canino, G.J.; Faravelli, C.; Greenwald, S.; Hwu, H.G.; Joyce, P.R.; Karam, E.G.; Lee, C.K.; Lellouch, J.; et al. Cross-national epidemiology of major depression and bipolar disorder. JAMA 1996, 276, 293-299. [CrossRef] [PubMed]
108. Severus, W.E.; Littman, A.B.; Stoll, A.L. Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder. Harv. Rev. Psychiatry 2001, 9, 280-293.[CrossRef] [PubMed]
109. Huang, T.; Zheng, J.; Chen, Y.; Yang, B.; Wahlqvist, M.L.; Li, D. High consumption of omega-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials. Nutrition 2011, 27, 863-867. [CrossRef] [PubMed]
110. Bourre, J.M. Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. J. Nutr. Health Aging 2004, 8, 163-174. [PubMed]
111. Assies, J.; Mocking, R.J.T.; Lok, A.; Ruhé, H.G.; Pouwer, F.; Schene, A.H. Effects of oxidative stress on fatty acid- and one-carbon- metabolism in psychiatric and cardiovascular disease comorbidity. Acta Psychiatr. Scand. 2014, 130, 163-180. [CrossRef] [PubMed]
112. Lin, P.Y.; Huang, S.Y.; Su, K.P. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol. Psychiatry 2010, 68, 140-147. [CrossRef] [PubMed]
113. McNamara, R.K.; Vannest, J.J.; Valentine, J.C. Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology. World J. Psychiatry 2015, 5, 15-34.[PubMed]
114. European Food Safety Authority. The Panel on Dietetic Products, Nutrition and Allergies on a request from Mead Johnson Nutritionals. Scientific Opinion on DHA and ARA and brain development. EFSA J. 2009, 1000, 1-13.[CrossRef]
115. European Food Safety Authority. The Panel on Dietetic Products, Nutrition and Allergies. Scientific Opinion on the substantiation of a health claim related to DHA and contribution to normal brain development pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J. 1924, 12.[CrossRef]