Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway

Journal of Pharmacological Sciences

Volumn 131, Issue 2, 2016, Pages 77-83

  Wei, Bin ^a   Huang, Qiaoying ^a   Huang, Shunrong ^a   Mai, Wei ^a   Zhong, Xiaogang ^a  

^a PEOPLE'S HOSPITAL OF GUANGXI ZHUANG AUTONOMOUS REGION   (China)

Author keywords

Apoptosis; Autophagy; Gastric cancer; Reactive oxygen species; Trichosanthin

Indexed keywords

ACETYLCYSTEINE; AUTOPHAGY PROTEIN 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MARKER; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 I; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 II; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRICHOSANTHIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; FEMALE; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STOMACH CANCER; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; NUDE MOUSE; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; MICE, INBRED BALB C; MICE, NUDE; NF-KAPPA B; REACTIVE OXYGEN SPECIES; STOMACH NEOPLASMS; TRICHOSANTHIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84978499782     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2016.03.001     Document Type: Article

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