Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells

Journal of Ethnopharmacology

Volumn 148, Issue 2, 2013, Pages 544-555

  He, Hao ^a   Zang, Ling He ^a   Feng, Yong Sheng ^a   Chen, Li Xia ^a   Kang, Ning ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^c   Qiu, Feng ^a   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Institute for Clinical and Biomedical Sciences   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Physalin A A375 S2 cells Apoptosis Autophagy p53 Noxa

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTINEOPLASTIC AGENT; BECLIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHYSALIN A; PROTEIN NOXA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WITHANOLIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CYTOTOXICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MELANOMA CELL; PHASE CONTRAST MICROSCOPY; RECEPTOR UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MEDICINE, CHINESE TRADITIONAL; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; WITHANOLIDES;

PHYSALIS ALKEKENGI VAR. FRANCHETI;

EID: 84879413727     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.04.051     Document Type: Article

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