Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Li, Pu ^a   Shi, Jing ^a   He, Qiao ^a   Hu, Qin ^a   Wang, Yun Ying ^a   Zhang, Li Jun ^a   Chan, Wai Ting ^b   Chen, Wei Xian ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PNEUMOLYSIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; WORTMANNIN; ANDROSTANE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; BACTERIAL PROTEIN; BECN1 PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, HUMAN; ONCOPROTEIN; PLY PROTEIN, STREPTOCOCCUS PNEUMONIAE; PRIMER DNA; STREPTOLYSIN; TARGET OF RAPAMYCIN KINASE;

A549 CELL LINE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BACTERIAL CLEARANCE; BACTERIUM MUTANT; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PNEUMOCOCCAL INFECTION; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIAE; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; CELL LINE; CYTOLOGY; EPITHELIUM CELL; GENETICS; LUNG ALVEOLUS; METABOLISM; MUTATION; PATHOGENICITY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANDROSTADIENES; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BACTERIAL PROTEINS; BECLIN-1; BLOTTING, WESTERN; CELL LINE; DNA PRIMERS; EPITHELIAL CELLS; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; POLYMERASE CHAIN REACTION; PULMONARY ALVEOLI; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS; TOR SERINE-THREONINE KINASES;

EID: 84925652601     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122753     Document Type: Article

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