Perspectives on polymeric nanostructures for the therapeutic application of antimicrobial peptides

Nanomedicine

Volumn 11, Issue 13, 2016, Pages 1729-1744

  Sandreschi, Stefania ^a   Piras, Anna Maria ^a   Batoni, Giovanna ^a   Chiellini, Federica ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

antimicrobial peptides; drug delivery; nanostructures; polymers

Indexed keywords

BRILACIDIN; CATHELICIDIN; CSA 13; CZEN 002; DAPTOMYCIN; DEFENSIN; GRAMICIDIN S; HB 107; HB 50; HLF 1 11; IMX 942; ISEGANAN; LTX 109; MERSACIDIN; MX 226; NISALPIN; OFLOXACIN; OMIGANAN; OP 145; OPEBACAN; PAC 113; PEXIGANAN; POLYETHYLENEIMINE; POLYMER; POLYMYXIN B; POLYPEPTIDE ANTIBIOTIC AGENT; POLYSILOXANE; POLYSTYRENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XOMA 629; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; NANOMATERIAL; NANOPARTICLE;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BACTERICIDAL ACTIVITY; BIOLOGICAL ACTIVITY; CATHETER INFECTION; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG SENSITIVITY; ENCAPSULATION; FOOT ULCER; HELICOBACTER INFECTION; HYDROGEL; IMMUNOMODULATION; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEPSIS; TOXICITY; WOUND HEALING; ANIMAL; CHEMISTRY; DRUG DESIGN; DRUG RELEASE; HUMAN; PROCEDURES; SURFACE PROPERTY;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG LIBERATION; HUMANS; NANOPARTICLES; NANOSTRUCTURES; POLYMERS; SURFACE PROPERTIES;

EID: 84978370151     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm-2016-0057     Document Type: Review

References (106)

1. Lin J, Nishino K, Roberts Mc et al. Mechanisms of antibiotic resistance. Front. Microbiol. 6, 34 (2015).
2. Chang H-H, Cohen T, Grad Yh et al. Origin and proliferation of multiple-drug resistance in bacterial pathogens. Microbiol. Mol. Biol. Rev. 79(1), 101-116 (2015).
3. Fauci As, Marston Hd. The perpetual challenge of antimicrobial resistance. JAMA 311(18), 1853-1854 (2014).
4. WHO. Antimicrobial resistance: global report on surveillance 2014. www.who.int
5. Campoccia D, Montanaro L, Arciola CR. A review of the biomaterials technologies for infection-resistant surfaces. Biomaterials 34(34), 8533-8554 (2013).
6. Munoz-Bonilla A, Fernandez-Garcia M. Polymeric materials with antimicrobial activity. Prog. Polym. Sci. 37(2), 281-339 (2012).
7. Siedenbiedel F, Tiller JC. Antimicrobial polymers in solution and on surfaces: overview and functional principles. Polymers 4(1), 46-71 (2012).
8. Kenawy E-R, Salem IA, Abo-Elghit EM et al. New trends in antimicrobial polymers: a state-of-the-art review. Int. J. Chem. Appl. Biol. Sci. 1(6), 95 (2014).
9. Hasan J, Crawford RJ, Ivanova EP. Antibacterial surfaces: the quest for a new generation of biomaterials. Trends Biotechnol. 31(5), 295-304 (2013).
10. Qin X, Li Y, Zhou F et al. Polydimethylsiloxane-polymethacrylate block copolymers tethering quaternary ammonium salt groups for antimicrobial coating. Appl. Surf. Sci. 328, 183-192 (2015).
11. Gao B, Zhang X, Zhu Y. Studies on the preparation and antibacterial properties of quaternized polyethyleneimine. J. Biomater. Sci. Polym. Ed. 18(5), 531-544 (2007).
12. Kelly AM, Kaltenhauser V, Muhlbacher I et al. Poly (2-oxazoline)-derived contact biocides: contributions to the understanding of antimicrobial activity. Macromol. Biosci. 13(1), 116-125 (2013).
13. Park ES, Kim HS, Kim MN et al. Antibacterial activities of polystyrene-block-poly (4-vinyl pyridine) and poly (styrene-random-4-vinyl pyridine). Eur. Polym. J. 40(12), 2819-2822 (2004).
14. Xue Y, Xiao H, Zhang Y. Antimicrobial polymeric materials with quaternary ammonium and phosphonium salts. Int. J. Mol. Sci. 16, 3626-3655 (2015).
15. Baul U, Kuroda K, Vemparala S. Interaction of multiple biomimetic antimicrobial polymers with model bacterial membranes. J. Chem. Phys. 141(8), 084902 (2014).
16. Wei D, Guan Y, Ma Q et al. Condensation between guanidine hydrochloride and diamine/multi-amine and its infuence on the structures and antibacterial activity of oligoguanidines. e-Polymers 12(1), 848-857 (2012).
17. Zhou Z, Wei D, Guan Y et al. Extensive in vitro activity of guanidine hydrochloride polymer analogs against antibiotics-resistant clinically isolated strains. Mater. Sci. Eng. C 31(8), 1836-1843 (2011).
18. Anderson EB, Long TE. Imidazole-and imidazolium-containing polymers for biology and material science applications. Polymer 51(12), 2447-2454 (2010).
19. Punia A, Mancuso A, Banerjee P et al. Nonhemolytic and antibacterial acrylic copolymers with hexamethyleneamine and poly (ethylene glycol) side chains. ACS Macro Lett. 4(4), 426-430 (2015).
20. Wang Y, Tang Y, Zhou Z et al. Membrane perturbation activity of cationic phenylene ethynylene oligomers and polymers: selectivity against model bacterial and mammalian membranes. Langmuir 26(15), 12509-12514 (2010).
21. Lin Y, Liu Q, Cheng L et al. Synthesis and antimicrobial activities of polysiloxane-containing quaternary ammonium salts on bacteria and phytopathogenic fungi. React. Funct. Polym. 85, 36-44 (2014).
22. Vigliotta G, Mella M, Rega D et al. Modulating antimicrobial activity by synthesis: dendritic copolymers based on nonquaternized 2-(dimethylamino) ethyl methacrylate by Cu-mediated ATRP. Biomacromolecules 13(3), 833-841 (2012).
23. Victor R. Poly (2-oxazoline) s as materials for biomedical applications. J. Mater. Sci. Mater. Med. 25(5), 1211-1225 (2014).
24. Lienkamp K, Madkour AE, Tew GN. Antibacterial peptidomimetics: polymeric synthetic mimics of antimicrobial peptides. In: Polymer Composites-Polyolefn Fractionation-Polymeric Peptidomimetics-Collagens. Springer, 141-172 (2013).
25. Lin J, Jiang F, Wen J et al. Fluorinated and un-fuorinated N-halamines as antimicrobial and bioflm-controlling additives for polymers. Polymer 68, 92-100 (2015).
26. Heleno SA, Martins A, Queiroz M et al. Bioactivity of phenolic acids: metabolites versus parent compounds: a review. Food Chem. 73, 501-513 (2015).
27. Pei K, Ou J, Huang C et al. Derivatives of ferulic acid: structure, preparation and biological activities. Annu. Res. Rev. Biol. 5(6), 512 (2015).
28. Seo MD, Won HS, Kim JH et al. Antimicrobial peptides for therapeutic applications: a review. Molecules 17(10), 12276-12286 (2012).
29. Li WR, Xie XB, Shi QS et al. Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli. Appl. Microbiol. Biotechnol. 85 (4), 1115-1122 (2010).
30. Radheshkumar C, Munstedt H. Morphology and mechanical properties of antimicrobial polyamide/silver composites. Mater. Lett. 59 (14), 1949-1953 (2005).
31. + release measured by anode stripping voltammetry. React. Funct. Polym. 66(7), 780-788 (2006).
32. Sanchez-Valdes S, Ortega-Ortiz H, Ramos-De Valle LF et al. Mechanical and antimicrobial properties of multilayer flms with a polyethylene/silver nanocomposite layer. J. Appl. Polym. Sci. 111(2), 953-962 (2009).
33. Kong H, Song J, Jang J. One-step preparation of antimicrobial polyrhodanine nanotubes with silver nanoparticles. Macromol. Rapid Comm. 30(15), 1350-1355 (2009).
34. Palza H, Gutierrez S, Delgado K et al. Toward tailored made biocide materials based on poly (propylene)/copper nanoparticles. Macromol. Rapid Comm. 31(6), 563-567 (2010).
35. Zhang W, Zhang Y, Ji J et al. Antimicrobial polyethylene with controlled copper release. J. Biomed. Mater. Res. Part A 83(3), 838-844 (2007).
36. Visai L, De Nardo L, Punta C et al. Titanium oxide antibacterial surfaces in biomedical devices. Int. J. Artif. Organs 34(9), 929-946 (2011).
37. Silvestre C, Cimmino S, Pezzuto M et al. Preparation and characterization of isotactic polypropylene/zinc oxide microcomposites with antibacterial activity. Polym. J. 45(9), 938-945 (2013).
38. Meng N, Zhou NL, Zhang SQ et al. Synthesis and antimicrobial activities of polymer/montmorillonite-chlorhexidine acetate nanocomposite flms. Appl. Clay Sci. 42(3), 667-670 (2009).
39. Nigmatullin R, Gao F, Konovalova V. Polymer-layered silicate nanocomposites in the design of antimicrobial materials. J. Mat. Sci. 43(17), 5728-5733 (2008).
40. Li Y, Xiang Q, Zhang Q et al. Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application. Peptides 37(2), 207-215 (2012).
41. Brandenburg LO, Merres J, Albrecht LJ et al. Antimicrobial peptides: multifunctional drugs for different applications. Polymers 4(1), 539-560 (2012).
42. Fjell CD, Hiss JA, Hancock REW et al. Designing antimicrobial peptides: form follows function. Nat. Rev. Drug Discov. 11(1), 37-51 (2011).
43. The Antimicrobial Peptide Database (APD). http://aps.unmc.edu/AP/main.php
44. Database of Antimicrobial Activity and Structure of Peptides. www.biomedicine.org.ge/dbaasp
45. Gogoladze G, Grigolava M, Vishnepolsky B et al. DBAASP: database of antimicrobial activity and structure of peptides. FEMS Microbial. Lett. 357(1), 63-68 (2014).
46. Afacan N, Yeung A, Pena O et al. Therapeutic potential of host defense peptides in antibiotic-resistant infections. Curr. Pharm. Design 18(6), 807-819 (2012).
47. Maisetta G, Batoni G, Esin S et al. Activity of human p-defensin 3 alone or combined with other antimicrobial agents against oral bacteria. Antimicrob. Ag Chemother. 47(10), 3349-3351 (2003).
48. Fjell CD, Hiss J A, Hancock REW et al. Designing antimicrobial peptides: form follows function. Nat. Rev. Drug Discov. 11(1), 37-51 (2012).
49. Tavanti A, Maisetta G, Del Gaudio G et al. Fungicidal activity of the human peptide hepcidin 20 alone or in combination with other antifungals against Candida glabrata isolates. Peptides 32(12), 2484-2487 (2011).
50. Maisetta G, Mangoni ML, Esin S et al. In vitro bactericidal activity of the N-terminal fragment of the frog peptide esculentin-1b (Esc 1-18) in combination with conventional antibiotics against Stenotrophomonas maltophilia. Peptides 30 (9), 1622-1626 (2009).
51. Mansour SC, Pena OM, Hancock RE. Host defense peptides: front-line immunomodulators. Trends Immunol. 35, 443-450 (2014).
52. Otvos LIR, Ostorhazi E. Therapeutic utility of antibacterial peptides in wound healing. Expert. Rev. Anti. Infect. Ther. 13(7), 871-881 (2015).
53. Mendez-Samperio P. Peptidomimetics as new generation of antimicrobial agents: current progress. Infect. Drug. Resist. 30(7), 229-237 (2014).
54. Yeung ATY, Gellatly SL, Hancock REW. Multifunctional cationic host defence peptides and their clinical applications. Cell. Mol. Life Sci. 68(13), 2161-2176 (2011).
55. Maisetta G, Di Luca M, Esin S et al. Evaluation of the inhibitory effects of human serum components on bactericidal activity of human beta defensins 3. Peptides 29(1), 1-6 (2008).
56. Maisetta G, Brancatisano F, Esin S et al. Gingipains produced by Porphyromonas gingivalis ATCC49417 degrade human-p-defensin 3 and affect peptide's antibacterial activity in vitro. Peptides 32(5), 1073-1077 (2011).
57. Nishikawa T, Nakagami H, Maeda A et al. Development of a novel antimicrobial peptide, AG-30, with with angiogenic properties. J. Cell Mol. Med. 13(3), 535-546 (2009).
58. Marr AK, Gooderham WJ, Hancock REW. Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr. Opin. Pharmacol. 6(5), 468-472 (2006).
59. Hancock REW, Sahl HG. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol. 24(12), 1551-1557 (2006).
60. Ashby M, Petkova A, Hilpert K. Cationic antimicrobial peptides as potential new therapeutic agents in neonates and children: a review. Curr. Opin. Infect. Dis. 27(3), 258-267 (2014).
61. Cruz J, Ortiz C, Guzman F et al. Antimicrobial peptides: promising compounds against pathogenic microorganisms. Curr. Med. Chem. 21(20), 2299-2321 (2014).
62. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/home
63. Ong ZY, Wiradharma N, Yang YY. Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials. Adv. Drug Deliv. Rev. 78, 28-45 (2014).
64. Piras AM, Maisetta G, Sandreschi S et al. Preparation, physical-chemical and biological characterization of chitosan nanoparticles loaded with lysozyme. Int. J. Biol. Macromol. 67, 124-131 (2014).
65. Brandelli A. Nanostructures as promising tools for delivery of antimicrobial peptides. Mini Rev. Med. Chem. 12(8), 731-741 (2012).
66. Yadav SC, Kumari A, Yadav R. Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation. Peptides 32(1), 173-187 (2011).
67. Chiellini F, Piras AM, Errico C, Chiellini E. Micro/nanostructured polymeric systems for biomedical and pharmaceutical applications. Nanomedicine 3(3), 367-393 (2008).
68. Pachioni-Vasconcelos JDA, Lopes AM, Apolinário AC et al. Nanostructures for protein drug delivery. Biomater. Sci. 4(2), 205-218 (2016).
69. Malheiros PS, Daroit DJ, Brandelli A. Food applications of liposome-encapsulated antimicrobial peptides. Trends Food Sci. Technol. 21, 284-292 (2010).
70. Imran M, Revol-Junelles AM, Paris C et al. Liposomal nanodelivery systems using soy and marine lecithin to encapsulate food biopreservative nisin. LW T-Food Sci. Technol. 62(1), 341-349 (2015).
71. Garcia-Orue I, Gainza G, Girbau C et al. LL37 loaded nanostructured lipid carriers (NLC): a new strategy for the topical treatment of chronic wounds. Eur. J. Pharm. Biopharm. doi:10.1016/j.ejpb.2016.04.006 (2016) (Epub ahead of print).
72. Ron-Doitch S, Sawodny B, Kühbacher A et al. Reduced cytotoxicity and enhanced bioactivity of cationic antimicrobial peptides liposomes in cell cultures and 3D epidermis model against HSV. J. Control. Release 229, 163-171 (2016).
73. Lange CF, Hancock REW, Samuel J et al. In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide. J. Pharm. Sci. 90 (10), 1647-1657 (2001).
74. Puppi D, Zhang X, Yang L et al. Nano/microfbrous polymeric constructs loaded with bioactive agents and designed for tissue engineering applications: a review. J. Biomed. Mater. Res. B Appl. Biomater. 102 (7), 1562-1579 (2014).
75. Puppi D, Piras AM, Pirosa A et al. Levofoxacin-loaded star poly(ϵ-caprolactone) scaffolds by additive manufacturing. J. Mater. Sci. Mater. Med. 27 (3), 1-11 (2016).
76. Jiang SS, Wang H, Chu C et al. Synthesis of antimicrobial Nisin-phosphorylated soybean protein isolate/poly(l-lactic acid)/ZrO2 membranes. Int. J. Biol. Macromol. 72, 502-509 (2015).
77. Wang X, Yue T, Lee TC. Development of Pleurocidin-poly(vinyl alcohol) electrospun antimicrobial nanofbers to retain antimicrobial activity in food system application. Food Control 54, 150-157 (2015).
78. Heunis TDJ, Botes M, Dicks LMT. Encapsulation of Lactobacillus plantarum 423 and its bacteriocin in nanofbers. Probiotics Antimicrob. Proteins 2(1), 46-51 (2010).
79. Yüksel E, Karakeçili A. Antibacterial activity on electrospun poly(lactide-co-glycolide) based membranes via Magainin II grafting. Mater. Sci. Eng. C 45, 510-518 (2014).
80. Yüksel E, AKarakeçili A, DemirtaS TT et al. Preparation of bioactive and antimicrobial PLGA membranes by magainin II/EGF functionalization. Int. J. Biol. Macromol 86, 162-168 (2016).
81. Gomes AP, Mano JF, Queiroz JA et al. Incorporation of antimicrobial peptides on functionalized cotton gauzes for medical applications, Carbohydr. Polym. 127(20), 451-461 (2015).
82. Dizaj SM, Lotfpour F, Barzegar-Jalali M et al. Antimicrobial activity of the metals and metal oxide nanoparticles. Mater. Sci. Eng. C 44, 278-284 (2014).
83. Barani H, Montazer M, Samadi N et al. In situ synthesis of nano silver/lecithin on wool: enhancing nanoparticles diffusion. Colloids Surfaces B 92, 9-15 (2012).
84. Soenen SJ, Rivera-Gil P, Montenegro JM et al. Cellular toxicity of inorganic nanoparticles: common aspects and guidelines for improved nanotoxicity evaluation. Nano Today 6(5), 446-465 (2011).
85. Chen G, Zhou M, Chen S et al. Nanolayer bioflm coated on magnetic nanoparticles by using a dielectric barrier discharge glow plasma fuidized bed for immobilizing an antimicrobial peptide. Nanotechnology 20(46), 465706 (2009).
86. Chen L, Patrone N, Liang JF. Peptide self-assembly on cell membranes to induce cell lysis. Biomacromolecules 13(10), 3327-3333 (2012).
87. Eby DM, Farrington KE, Johnson GR. Synthesis of bioinorganic antimicrobial peptide nanoparticles with potential therapeutic properties. Biomacromolecules 9(9), 2487-2494 (2008).
88. Liu L, Xu K, Wang H et al. Self-assembled cationic peptide nanoparticles as an effcient antimicrobial agent. Nat. Nanotechnol. 4(7), 457-463 (2009).
89. Hakansson J, Bjorn C, Lindgren K et al. Effcacy of the novel topical antimicrobial agent PXL150 in a mouse model of surgical site infections. Antimicrob. Agents Ch. 58(5), 2982-2984 (2014).
90. Danhier F, Ansorena E, Silva JM et al. PLGA-based nanoparticles: an overview of biomedical applications. J. Control. Release 161(2), 505-522 (2012).
91. Chereddy KK, Her CH, Comune M et al. PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. J. Control. Release 194, 138-147 (2014).
92. DAngelo I, Casciaro B, Miro A et al. Overcoming barriers in Pseudomonas aeruginosa lung infections: engineered nanoparticles for local delivery of a cationic antimicrobial peptide. Colloids Surfaces B 135, 717-725 (2015).
93. Salmaso S, Elvassore N, Bertucco A et al. Nisin-loaded poly-L-lactide nano-particles produced by CO2 anti-solvent precipitation for sustained antimicrobial activity. Int. J. Pharm. 287(1), 163-173 (2004).
94. Niece KL, Vaughan AD, Devore DI. Graft copolymer polyelectrolyte complexes for delivery of cationic antimicrobial peptides. J. Biomed. Mater. Res. A 101(9), 2548-2558 (2013).
95. Elzoghby AO. Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. J. Control. Release 172(3), 1075-1091 (2013).
96. Bi L, Yang L, Narsimhan G et al. Designing carbohydrate nanoparticles for prolonged effcacy of antimicrobial peptide. J. Control. Release 150(2), 150-156 (2011).
97. Piras AM, Sandreschi S, Maisetta G et al. Chitosan nanoparticles for the linear release of model cationic peptide. Pharm. Res. 32(7), 2259-2265 (2015).
98. Landriscina A, Rosen J, Friedman AJ. Biodegradable chitosan nanoparticles in drug delivery for infectious disease. Nanomedicine 10(10), 1609-1619 (2015).
99. Piras AM, Maisetta G, Sandreschi S et al. Chitosan nanoparticles loaded with the antimicrobial peptide temporin B exert a long-term antibacterial activity in vitro against clinical isolates of Staphylococcus epidermidis. Front. Microbiol. 6(372), 1-10 (2015).
100. Strempel N, Strehmel J, Overhage J. Potential application of antimicrobial peptides in the treatment of bacterial bioflm infections. Curr. Pharm. Design 21(1), 67-84 (2015).
101. Eckert R, Qi F, Yarbrough DK et al. Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp. Antimicrob. Ag Chemother. 50(4), 1480-1488 (2006).
102. Murugesh J, Sameera A, Aysha S. STAMPs" smart therapy against Streptococcus mutans-review article. Oral Med. Oral Surg. Oral Pathol. Oral Radiol. 1(1), 19-23 (2015).
103. Esteban E, Ferrer R, Alsina L et al. Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge. Mediators Infamm. 2013, 507539 (2013).
104. Iba T, Nagaoka I, Yamada A et al. Effect of hemoperfusion using polymyxin B-immobilized fbers on acute lung injury in a rat sepsis model. Int. J. Med. Sci. 11(3), 255 (2014).
105. Zweytick D, Deutsch G, Andra J et al. Studies on lactoferricin-derived Escherichia coli membrane-active peptides reveal differences in the mechanism of N-acylated versus nonacylated peptides. J. Biol. Chem. 286(24), 21266-21276 (2011).
106. Weghuber J, Aichinger MC, Brameshuber M et al. Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells. Biochim. Biophys. Acta 1808(10), 2581-2590 (2011).