In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide

Journal of Pharmaceutical Sciences

Volumn 90, Issue 10, 2001, Pages 1647-1657

  Lange, Carlos F ^a   Hancock, Robert E W ^b   Samuel, John ^a   Finlay, Warren H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cationic peptide; Liposome encapsulation; Lung deposition simulation; Nebulization efficiency

Indexed keywords

DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLGLYCEROL; ANTIBIOTIC AGENT; CATIONIC PEPTIDE; DILAUROYLPHOSPHATIDYLCHOLINE; LIPOSOME; PROTEIN CM3; UNCLASSIFIED DRUG;

ADULT; AEROSOL; ANTIMICROBIAL ACTIVITY; ARTICLE; CASE REPORT; CHILD; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; ENCAPSULATION; HUMAN; LUNG ALVEOLUS SURFACE TENSION; LUNG MODEL; NEBULIZATION; NEBULIZER;

EID: 0034758170     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1115     Document Type: Article

References (55)

1. Peptide antibiotics
2. Peptide antibiotics
3. Biological properties of structurally related a-helical cationic antimicrobial peptides
4. Antiendotoxic potential of cationic peptide antimicrobials
5. Liberation of endotoxin from Escherichia coli by antibiotics
6. The therapeutic potential of cationic peptides
7. Aerosol delivery of liposomal all-trans-retinoic acid to the lungs
8. The stability of liposomes to nebulisation
9. Nebulization of liposomes. I. Effects of lipid composition
10. Nebulization of liposomes. II. The effects of size and modeling of solute release profiles
11. Nebulisers for the generation of liposomal aerosols
12. Nebulization of liposomes. III. The effects of operating conditions and local environment
13. An investigation of some of the factors influencing the jet nebulisation of liposomes
14. Nebulized glucocorticoids in liposomes: Aerosol characteristics and human dose estimates
15. Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol
16. 99m-Technetium as a marker of liposomal deposition and clearance in the human lung
17. 99m technetium-labelled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers
18. Airway surface liquid: Concepts and measurements
19. Regional lung deposition of nebulized liposome-encapsulated ciprofloxacin
20. Lung delivery of aerosolized dextran
21. Factors affecting microencapsulation of drugs in liposomes
22. Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
23. Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles
24. Liposomes as pharmaceuticals
25. Undersizing of droplets from a vented nebulizer caused by aerosol heating during transit through an Anderson impactor
26. Predicting regional lung dosages of a nebulized suspension: Pulmicort (budesonide)
27. Liposome aerosols
28. Respiratory and abdominal muscle responses to expiratory threshold loading in cystic fibrosis
29. Breathing patterns in adult patients
30. RhDNase I aerosol deposition and related factors in cystic fibrosis
31. Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age
32. Regional deposition of inhaled hygroscopic aerosols: In vivo SPECT compared with mathematical deposition modelling
33. Can models be trusted to subdivide lung deposition into alveolar and tracheobronchial fractions?
34. A diameter-based reconstruction of the branching pattern of the human bronchial tree. Part I. Description and application
35. Morphometry of the human pulmonary acinus
36. Postnatal enlargement of human tracheobronchial airways and implications for particle deposition
37. Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans
38. Theory of gravitational deposition of particles from laminar flows in channels
39. Gravitational deposition of particles from laminar aerosol flow through inclined circular tubes
40. Diffusion from a stream flowing through a cylindrical tube
41. Modelling and algebraic formulation of regional deposition in man
42. Estimating the type of hygroscopic behaviour exhibited by aqueous droplets
43. Coordinated clearance of periciliary liquid and mucus from airway surfaces
44. Length and distribution of cilia in human and canine airways
45. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract
46. Goblet cells: Physiology and pharmacology
47. Tracheobronchial epithelium in the adult rhesus monkey: A quantitative histochemical and ultrastructural study
48. Mucociliary transport in trachea of patients with cystic fibrosis
49. Forced expirations against a variable resistance: A new chest physiotherapy method in cystic fibrosis
50. Chest physiotherapy in hospitalized patients with cystic fibrosis: A study of lung function effects and sputum production
51. Liposomal formulations of synthetic MUC1 peptides: Effects of encapsulation versus surface display of peptides on immune responses
52. Sputum pharmacodynamics and pharmacokinetics of recombinant human DNase I in cystic fibrosis