Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative/nitrosative stress and suppression of inflammation and apoptosis in rats

Experimental and Toxicologic Pathology

Volumn 67, Issue 2, 2015, Pages 133-141

  Hagar, Hanan ^a,c   El Medany, Azza ^a   Salam, Reem ^a,d   El Medany, Gamila ^b   Nayal, Omina A ^a  

^a KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c Zagazig University   (Egypt)

^d Ain Shams University   (Egypt)

Author keywords

Acute renal injury; Betaine; Caspase 3; Cisplatin; Nuclear factor kappa; Oxidative stress

Indexed keywords

BETAINE; CASPASE 3; CATALASE; CISPLATIN; CREATININE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRITE; NITROGEN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; UREA; ANTINEOPLASTIC AGENT; NITRIC ACID DERIVATIVE;

ADULT; ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY INJURY; KIDNEY PARENCHYMA; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; UPREGULATION; UREA NITROGEN BLOOD LEVEL; ANIMAL; CHEMICALLY INDUCED; DIET SUPPLEMENTATION; DRUG EFFECTS; IMMUNOLOGY; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TEST; METABOLISM; NITROSATION; PATHOLOGY; WISTAR RAT;

RATTUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BETAINE; CISPLATIN; DIETARY SUPPLEMENTS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALE; NITRATES; NITRITES; NITROSATION; OXIDATIVE STRESS; RATS, WISTAR;

EID: 84977784322     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2014.11.001     Document Type: Article

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