Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury

Toxicology and Applied Pharmacology

Volumn 234, Issue 2, 2009, Pages 236-246

  Jung, Michaela ^a   Hotter, Georgina ^a,b   Viñas, Jose Luis ^a,b   Sola, Anna ^a,b  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

Apoptosis; Cisplatin nephrotoxicity; Cytoskeleton; Mitochondrial nitric oxide synthase; Peroxynitrite

Indexed keywords

CASPASE 3; CISPLATIN; CYTOCHROME C; F ACTIN; LINSIDOMINE; N(G) PROPYLARGININE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PHALLOIDIN; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; KIDNEY CELL CULTURE; KIDNEY INJURY; MALE; MITOCHONDRION; NEPHROTOXICITY; NONHUMAN; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CISPLATIN; COLORING AGENTS; CYTOCHROMES C; CYTOSKELETON; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; MALE; MITOCHONDRIA; MOLSIDOMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PEROXYNITROUS ACID; PHALLOIDINE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 58149260218     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.10.014     Document Type: Article

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