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Volumn 7, Issue JUN, 2016, Pages

Pharmacological targeting of the hepcidin/ferroportin axis

Author keywords

Anemia; Erythropoiesis; Hemochromatosis; Inflammation; Iron metabolism

Indexed keywords

FERROPORTIN; HEPCIDIN; INTERLEUKIN 6; STAT3 PROTEIN;

EID: 84977633506     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2016.00160     Document Type: Review
Times cited : (82)

References (96)
  • 2
    • 84920905125 scopus 로고    scopus 로고
    • Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus
    • Arezes, J., Jung, G., Gabayan, V., Valore, E., Ruchala, P., Gulig, P. A., et al. (2015). Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. Cell Host Microbe 17, 47-57. doi: 10.1016/j.chom.2014.12.001
    • (2015) Cell Host Microbe , vol.17 , pp. 47-57
    • Arezes, J.1    Jung, G.2    Gabayan, V.3    Valore, E.4    Ruchala, P.5    Gulig, P.A.6
  • 3
    • 78649655459 scopus 로고    scopus 로고
    • Iron-deficiency anemia in Castleman disease: implication of the interleukin 6/hepcidin pathway
    • Arlet, J. B., Hermine, O., Darnige, L., Ostland, V., Westerman, M., Badoual, C., et al. (2010). Iron-deficiency anemia in Castleman disease: implication of the interleukin 6/hepcidin pathway. Pediatrics 126, e1608-e1612. doi: 10.1542/peds.2010-1123
    • (2010) Pediatrics , vol.126 , pp. e1608-e1612
    • Arlet, J.B.1    Hermine, O.2    Darnige, L.3    Ostland, V.4    Westerman, M.5    Badoual, C.6
  • 4
    • 84962034386 scopus 로고    scopus 로고
    • High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin
    • Asperti, M., Naggi, A., Esposito, E., Ruzzenenti, P., Di Somma, M., Gryzik, M., et al. (2016). High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin. Front. Pharmacol. 6:316. doi: 10.3389/fphar.2015.00316
    • (2016) Front. Pharmacol , vol.6 , pp. 316
    • Asperti, M.1    Naggi, A.2    Esposito, E.3    Ruzzenenti, P.4    Di Somma, M.5    Gryzik, M.6
  • 5
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., et al. (2006). Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38, 531-539. doi: 10.1038/ng1777
    • (2006) Nat. Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5    Samad, T.A.6
  • 7
    • 84957842438 scopus 로고    scopus 로고
    • Modulation of hepcidin to treat iron deregulation: potential clinical applications
    • Blanchette, N. L., Manz, D. H., Torti, F. M., and Torti, S. V. (2016). Modulation of hepcidin to treat iron deregulation: potential clinical applications. Expert Rev. Hematol. 9, 169-186. doi: 10.1586/17474086.2016.1124757
    • (2016) Expert Rev. Hematol , vol.9 , pp. 169-186
    • Blanchette, N.L.1    Manz, D.H.2    Torti, F.M.3    Torti, S.V.4
  • 8
    • 77957255073 scopus 로고    scopus 로고
    • Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells
    • Boergermann, J. H., Kopf, J., Yu, P. B., and Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Int. J. Biochem. Cell Biol. 42, 1802-1807. doi: 10.1016/j.biocel.2010.07.018
    • (2010) Int. J. Biochem. Cell Biol , vol.42 , pp. 1802-1807
    • Boergermann, J.H.1    Kopf, J.2    Yu, P.B.3    Knaus, P.4
  • 9
    • 84931564592 scopus 로고    scopus 로고
    • Anti-repulsive guidance molecule C (RGMc) antibodies increases serum iron in rats and cynomolgus monkeys by hepcidin downregulation
    • Böser, P., Seemann, D., Liguori, M. J., Fan, L., Huang, L., Hafner, M., et al. (2015). Anti-repulsive guidance molecule C (RGMc) antibodies increases serum iron in rats and cynomolgus monkeys by hepcidin downregulation. AAPS J. 17, 930-938. doi: 10.1208/s12248-015-9770-4
    • (2015) AAPS J , vol.17 , pp. 930-938
    • Böser, P.1    Seemann, D.2    Liguori, M.J.3    Fan, L.4    Huang, L.5    Hafner, M.6
  • 10
    • 84956923279 scopus 로고    scopus 로고
    • Ineffective erythropoiesis and regulation of iron status in iron loading anaemias
    • Camaschella, C., and Nai, A. (2016). Ineffective erythropoiesis and regulation of iron status in iron loading anaemias. Br. J. Haematol. 172, 512-523. doi: 10.1111/bjh.13820
    • (2016) Br. J. Haematol , vol.172 , pp. 512-523
    • Camaschella, C.1    Nai, A.2
  • 11
    • 84945536472 scopus 로고    scopus 로고
    • Analysis of inflammatory and anemia-related biomarkers in a randomized, double-blind, placebo-controlled study of siltuximab (Anti-IL6 Monoclonal Antibody) in patients with multicentric castleman disease
    • Casper, C., Chaturvedi, S., Munshi, N., Wong, R., Qi, M., Schaffer, M., et al. (2015). Analysis of inflammatory and anemia-related biomarkers in a randomized, double-blind, placebo-controlled study of siltuximab (Anti-IL6 Monoclonal Antibody) in patients with multicentric castleman disease. Clin. Cancer Res. 21, 4294-4304. doi: 10.1158/1078-0432.CCR-15-0134
    • (2015) Clin. Cancer Res , vol.21 , pp. 4294-4304
    • Casper, C.1    Chaturvedi, S.2    Munshi, N.3    Wong, R.4    Qi, M.5    Schaffer, M.6
  • 12
    • 84978370086 scopus 로고    scopus 로고
    • Minihepcidin peptides as disease modifiers in mice affected by beta-thalassemia and polycythemia vera
    • [Epub ahead of print]
    • Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., et al. (2016). Minihepcidin peptides as disease modifiers in mice affected by beta-thalassemia and polycythemia vera. Blood. doi: 10.1182/blood-2015-10-676742. [Epub ahead of print].
    • (2016) Blood
    • Casu, C.1    Oikonomidou, P.R.2    Chen, H.3    Nandi, V.4    Ginzburg, Y.5    Prasad, P.6
  • 13
    • 84926421904 scopus 로고    scopus 로고
    • A holistic approach to targeting disease with polymeric nanoparticles
    • Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., and Saltzman, W. M. (2015). A holistic approach to targeting disease with polymeric nanoparticles. Nat. Rev. Drug Discov. 14, 239-247. doi: 10.1038/nrd4503
    • (2015) Nat. Rev. Drug Discov , vol.14 , pp. 239-247
    • Cheng, C.J.1    Tietjen, G.T.2    Saucier-Sawyer, J.K.3    Saltzman, W.M.4
  • 15
    • 84888219710 scopus 로고    scopus 로고
    • A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates
    • Cooke, K. S., Hinkle, B., Salimi-Moosavi, H., Foltz, I., King, C., Rathanaswami, P., et al. (2013). A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates. Blood 122, 3054-3061. doi: 10.1182/blood-2013-06-505792
    • (2013) Blood , vol.122 , pp. 3054-3061
    • Cooke, K.S.1    Hinkle, B.2    Salimi-Moosavi, H.3    Foltz, I.4    King, C.5    Rathanaswami, P.6
  • 16
    • 78049463632 scopus 로고    scopus 로고
    • BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
    • Corradini, E., Schmidt, P. J., Meynard, D., Garuti, C., Montosi, G., Chen, S., et al. (2010). BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology 139, 1721-1729. doi: 10.1053/j.gastro.2010.07.044
    • (2010) Gastroenterology , vol.139 , pp. 1721-1729
    • Corradini, E.1    Schmidt, P.J.2    Meynard, D.3    Garuti, C.4    Montosi, G.5    Chen, S.6
  • 17
    • 84879829832 scopus 로고    scopus 로고
    • Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: results of a phase 1, randomized, open-label trial
    • Doyle, M. K., Rahman, M. U., Frederick, B., Birbara, C. A., De Vries, D., Toedter, G., et al. (2013). Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: results of a phase 1, randomized, open-label trial. Rheumatology 52, 1214-1219. doi: 10.1093/rheumatology/kes381
    • (2013) Rheumatology , vol.52 , pp. 1214-1219
    • Doyle, M.K.1    Rahman, M.U.2    Frederick, B.3    Birbara, C.A.4    De Vries, D.5    Toedter, G.6
  • 18
    • 84948566965 scopus 로고    scopus 로고
    • Ironing out Ferroportin
    • Drakesmith, H., Nemeth, E., and Ganz, T. (2015). Ironing out Ferroportin. Cell Metab. 22, 777-787. doi: 10.1016/j.cmet.2015.09.006
    • (2015) Cell Metab , vol.22 , pp. 777-787
    • Drakesmith, H.1    Nemeth, E.2    Ganz, T.3
  • 19
    • 77954563247 scopus 로고    scopus 로고
    • Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form
    • Fatih, N., Camberlein, E., Island, M. L., Corlu, A., Abgueguen, E., Detivaud, L., et al. (2010). Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J. Mol. Med. 88, 477-486. doi: 10.1007/s00109-009-0588-3
    • (2010) J. Mol. Med , vol.88 , pp. 477-486
    • Fatih, N.1    Camberlein, E.2    Island, M.L.3    Corlu, A.4    Abgueguen, E.5    Detivaud, L.6
  • 20
    • 79955956398 scopus 로고    scopus 로고
    • Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice
    • Finberg, K. E., Whittlesey, R. L., and Andrews, N. C. (2011). Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Blood 117, 4590-4599. doi: 10.1182/blood-2010-10-315507
    • (2011) Blood , vol.117 , pp. 4590-4599
    • Finberg, K.E.1    Whittlesey, R.L.2    Andrews, N.C.3
  • 21
    • 79959789099 scopus 로고    scopus 로고
    • Investigation of a researcher's death due to septicemic plague
    • Frank, K. M., Schneewind, O., and Shieh, W. J. (2011). Investigation of a researcher's death due to septicemic plague. N. Engl. J. Med. 364, 2563-2564. doi: 10.1056/NEJMc1010939
    • (2011) N. Engl. J. Med , vol.364 , pp. 2563-2564
    • Frank, K.M.1    Schneewind, O.2    Shieh, W.J.3
  • 22
    • 84874302553 scopus 로고    scopus 로고
    • High-throughput screening of small molecules identifies hepcidin antagonists
    • Fung, E., Sugianto, P., Hsu, J., Damoiseaux, R., Ganz, T., and Nemeth, E. (2013). High-throughput screening of small molecules identifies hepcidin antagonists. Mol. Pharmacol. 83, 681-690. doi: 10.1124/mol.112.083428
    • (2013) Mol. Pharmacol , vol.83 , pp. 681-690
    • Fung, E.1    Sugianto, P.2    Hsu, J.3    Damoiseaux, R.4    Ganz, T.5    Nemeth, E.6
  • 23
    • 84885768132 scopus 로고    scopus 로고
    • Systemic iron homeostasis
    • Ganz, T. (2013). Systemic iron homeostasis. Physiol. Rev. 93, 1721-1741. doi: 10.1152/physrev.00008.2013
    • (2013) Physiol. Rev , vol.93 , pp. 1721-1741
    • Ganz, T.1
  • 24
    • 84937979159 scopus 로고    scopus 로고
    • Iron homeostasis in host defence and inflammation
    • Ganz, T., and Nemeth, E. (2015). Iron homeostasis in host defence and inflammation. Nat. Rev. Immunol. 15, 500-510. doi: 10.1038/nri3863
    • (2015) Nat. Rev. Immunol , vol.15 , pp. 500-510
    • Ganz, T.1    Nemeth, E.2
  • 25
    • 78649813036 scopus 로고    scopus 로고
    • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice
    • Gardenghi, S., Ramos, P., Marongiu, M. F., Melchiori, L., Breda, L., Guy, E., et al. (2010). Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice. J. Clin. Invest. 120, 4466-4477. doi: 10.1172/JCI41717
    • (2010) J. Clin. Invest , vol.120 , pp. 4466-4477
    • Gardenghi, S.1    Ramos, P.2    Marongiu, M.F.3    Melchiori, L.4    Breda, L.5    Guy, E.6
  • 26
    • 84908083483 scopus 로고    scopus 로고
    • A chemical screen identifies small molecules that regulate hepcidin expression
    • Gaun, V., Patchen, B., Volovetz, J., Zhen, A. W., Andreev, A., Pollastri, M. P., et al. (2014). A chemical screen identifies small molecules that regulate hepcidin expression. Blood Cells Mol. Dis. 53, 231-240. doi: 10.1016/j.bcmd.2014.06.002
    • (2014) Blood Cells Mol. Dis , vol.53 , pp. 231-240
    • Gaun, V.1    Patchen, B.2    Volovetz, J.3    Zhen, A.W.4    Andreev, A.5    Pollastri, M.P.6
  • 27
    • 80054838641 scopus 로고    scopus 로고
    • beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
    • Ginzburg, Y., and Rivella, S. (2011). beta-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 118, 4321-4330. doi: 10.1182/blood-2011-03-283614
    • (2011) Blood , vol.118 , pp. 4321-4330
    • Ginzburg, Y.1    Rivella, S.2
  • 28
    • 84857363315 scopus 로고    scopus 로고
    • Regulation of iron transport and the role of transferrin
    • Gkouvatsos, K., Papanikolaou, G., and Pantopoulos, K. (2012). Regulation of iron transport and the role of transferrin. Biochim. Biophys. Acta 1820, 188-202. doi: 10.1016/j.bbagen.2011.10.013
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 188-202
    • Gkouvatsos, K.1    Papanikolaou, G.2    Pantopoulos, K.3
  • 29
    • 84926660351 scopus 로고    scopus 로고
    • A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia
    • Guida, C., Altamura, S., Klein, F. A., Galy, B., Boutros, M., Ulmer, A. J., et al. (2015). A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood 125, 2265-2275. doi: 10.1182/blood-2014-08-595256
    • (2015) Blood , vol.125 , pp. 2265-2275
    • Guida, C.1    Altamura, S.2    Klein, F.A.3    Galy, B.4    Boutros, M.5    Ulmer, A.J.6
  • 30
    • 84875849962 scopus 로고    scopus 로고
    • Reducing TMPRSS6 ameliorates hemochromatosis and beta-thalassemia in mice
    • Guo, S., Casu, C., Gardenghi, S., Booten, S., Aghajan, M., Peralta, R., et al. (2013a). Reducing TMPRSS6 ameliorates hemochromatosis and beta-thalassemia in mice. J. Clin. Invest. 123, 1531-1541. doi: 10.1172/JCI66969
    • (2013) J. Clin. Invest , vol.123 , pp. 1531-1541
    • Guo, S.1    Casu, C.2    Gardenghi, S.3    Booten, S.4    Aghajan, M.5    Peralta, R.6
  • 31
    • 84878914192 scopus 로고    scopus 로고
    • Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells
    • Guo, W., Bachman, E., Li, M., Roy, C. N., Blusztajn, J., Wong, S., et al. (2013b). Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell 12, 280-291. doi: 10.1111/acel.12052
    • (2013) Aging Cell , vol.12 , pp. 280-291
    • Guo, W.1    Bachman, E.2    Li, M.3    Roy, C.N.4    Blusztajn, J.5    Wong, S.6
  • 32
    • 77955092647 scopus 로고    scopus 로고
    • Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production
    • Hashizume, M., Uchiyama, Y., Horai, N., Tomosugi, N., and Mihara, M. (2010). Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Rheumatol. Int. 30, 917-923. doi: 10.1007/s00296-009-1075-4
    • (2010) Rheumatol. Int , vol.30 , pp. 917-923
    • Hashizume, M.1    Uchiyama, Y.2    Horai, N.3    Tomosugi, N.4    Mihara, M.5
  • 33
    • 84904723183 scopus 로고    scopus 로고
    • Iron-Refractory Iron Deficiency Anemia (IRIDA)
    • Heeney, M. M., and Finberg, K. E. (2014). Iron-Refractory Iron Deficiency Anemia (IRIDA). Hematol. Oncol. Clin. North Am. 28, 637-652. doi: 10.1016/j.hoc.2014.04.009
    • (2014) Hematol. Oncol. Clin. North Am , vol.28 , pp. 637-652
    • Heeney, M.M.1    Finberg, K.E.2
  • 34
    • 84878425491 scopus 로고    scopus 로고
    • 'Discovery and preclinical characterization of a novel hepcidin antagonist with tunable PK/PD properties for the treatment of anemia in different patient populations, '
    • ASH) (San Diego, CA
    • Hohlbaum, A. M., Trentman, S., Gille, H., Allesdorfer, A., Belaiba, R. S., Huelsmeyer, M., et al. (2011). "Discovery and preclinical characterization of a novel hepcidin antagonist with tunable PK/PD properties for the treatment of anemia in different patient populations, "in 53th Annual Meeting of the American Society for Hematology (ASH) (San Diego, CA), Abstract 687.
    • (2011) 53th Annual Meeting of the American Society for Hematology
    • Hohlbaum, A.M.1    Trentman, S.2    Gille, H.3    Allesdorfer, A.4    Belaiba, R.S.5    Huelsmeyer, M.6
  • 35
    • 84888590842 scopus 로고    scopus 로고
    • Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis
    • Isaacs, J. D., Harari, O., Kobold, U., Lee, J. S., and Bernasconi, C. (2013). Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis. Arthritis Res. Ther. 15, R204. doi: 10.1186/ar4397
    • (2013) Arthritis Res. Ther , vol.15 , pp. R204
    • Isaacs, J.D.1    Harari, O.2    Kobold, U.3    Lee, J.S.4    Bernasconi, C.5
  • 36
    • 58849102674 scopus 로고    scopus 로고
    • Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
    • Jiao, Y., Wilkinson, J. T., Di, X., Wang, W., Hatcher, H., Kock, N. D., et al. (2009). Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 113, 462-469. doi: 10.1182/blood-2008-05-155952
    • (2009) Blood , vol.113 , pp. 462-469
    • Jiao, Y.1    Wilkinson, J.T.2    Di, X.3    Wang, W.4    Hatcher, H.5    Kock, N.D.6
  • 37
    • 84928476752 scopus 로고    scopus 로고
    • New insights into iron regulation and erythropoiesis
    • Kim, A., and Nemeth, E. (2015). New insights into iron regulation and erythropoiesis. Curr. Opin. Hematol. 22, 199-205. doi: 10.1097/MOH.0000000000000132
    • (2015) Curr. Opin. Hematol , vol.22 , pp. 199-205
    • Kim, A.1    Nemeth, E.2
  • 38
    • 84964788505 scopus 로고    scopus 로고
    • Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels
    • Kovac, S., Boser, P., Cui, Y., Ferring-Appel, D., Casarrubea, D., Huang, L., et al. (2016). Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels. Haematologica 101, e173. doi: 10.3324/haematol.2015.140772
    • (2016) Haematologica , vol.101
    • Kovac, S.1    Boser, P.2    Cui, Y.3    Ferring-Appel, D.4    Casarrubea, D.5    Huang, L.6
  • 39
    • 84924299913 scopus 로고    scopus 로고
    • Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function
    • Lakhal-Littleton, S., Wolna, M., Carr, C. A., Miller, J. J., Christian, H. C., Ball, V., et al. (2015). Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc. Natl. Acad. Sci. U.S.A. 112, 3164-3169. doi: 10.1073/pnas.1422373112
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. 3164-3169
    • Lakhal-Littleton, S.1    Wolna, M.2    Carr, C.A.3    Miller, J.J.4    Christian, H.C.5    Ball, V.6
  • 40
    • 84893655780 scopus 로고    scopus 로고
    • Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin
    • Latour, C., Kautz, L., Besson-Fournier, C., Island, M. L., Canonne-Hergaux, F., Loreal, O., et al. (2014). Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology 59, 683-694. doi: 10.1002/hep.26648
    • (2014) Hepatology , vol.59 , pp. 683-694
    • Latour, C.1    Kautz, L.2    Besson-Fournier, C.3    Island, M.L.4    Canonne-Hergaux, F.5    Loreal, O.6
  • 41
    • 84956666572 scopus 로고    scopus 로고
    • Progesterone receptor membrane component-1 regulates hepcidin biosynthesis
    • Li, X., Rhee, D. K., Malhotra, R., Mayeur, C., Hurst, L. A., Ager, E., et al. (2016). Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J. Clin. Invest. 126, 389-401. doi: 10.1172/JCI83831
    • (2016) J. Clin. Invest , vol.126 , pp. 389-401
    • Li, X.1    Rhee, D.K.2    Malhotra, R.3    Mayeur, C.4    Hurst, L.A.5    Ager, E.6
  • 42
    • 27144459908 scopus 로고    scopus 로고
    • Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
    • Lin, L., Goldberg, Y. P., and Ganz, T. (2005). Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 106, 2884-2889. doi: 10.1182/blood-2005-05-1845
    • (2005) Blood , vol.106 , pp. 2884-2889
    • Lin, L.1    Goldberg, Y.P.2    Ganz, T.3
  • 43
    • 84964587124 scopus 로고    scopus 로고
    • Hepcidin: a promising therapeutic target for iron disorders: a systematic review
    • Liu, J., Sun, B., Yin, H., and Liu, S. (2016). Hepcidin: a promising therapeutic target for iron disorders: a systematic review. Medicine 95, e3150. doi: 10.1097/MD.0000000000003150
    • (2016) Medicine , vol.95
    • Liu, J.1    Sun, B.2    Yin, H.3    Liu, S.4
  • 44
    • 0037926880 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of iron transport in human monocytic cells
    • Ludwiczek, S., Aigner, E., Theurl, I., and Weiss, G. (2003). Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 101, 4148-4154. doi: 10.1182/blood-2002-08-2459
    • (2003) Blood , vol.101 , pp. 4148-4154
    • Ludwiczek, S.1    Aigner, E.2    Theurl, I.3    Weiss, G.4
  • 45
    • 84922191755 scopus 로고    scopus 로고
    • Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation
    • Mayeur, C., Kolodziej, S. A., Wang, A., Xu, X., Lee, A., Yu, P. B., et al. (2015). Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica 100, e68-e71. doi: 10.3324/haematol.2014.111484
    • (2015) Haematologica , vol.100 , pp. e68-e71
    • Mayeur, C.1    Kolodziej, S.A.2    Wang, A.3    Xu, X.4    Lee, A.5    Yu, P.B.6
  • 46
    • 77957340866 scopus 로고    scopus 로고
    • Ferroportin disease: a systematic meta-analysis of clinical and molecular findings
    • Mayr, R., Janecke, A. R., Schranz, M., Griffiths, W. J., Vogel, W., Pietrangelo, A., et al. (2010). Ferroportin disease: a systematic meta-analysis of clinical and molecular findings. J. Hepatol. 53, 941-949. doi: 10.1016/j.jhep.2010.05.016
    • (2010) J. Hepatol , vol.53 , pp. 941-949
    • Mayr, R.1    Janecke, A.R.2    Schranz, M.3    Griffiths, W.J.4    Vogel, W.5    Pietrangelo, A.6
  • 47
    • 34250850987 scopus 로고    scopus 로고
    • The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation
    • Merle, U., Fein, E., Gehrke, S. G., Stremmel, W., and Kulaksiz, H. (2007). The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology 148, 2663-2668. doi: 10.1210/en.2006-1331
    • (2007) Endocrinology , vol.148 , pp. 2663-2668
    • Merle, U.1    Fein, E.2    Gehrke, S.G.3    Stremmel, W.4    Kulaksiz, H.5
  • 48
    • 84897568295 scopus 로고    scopus 로고
    • Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling
    • Mleczko-Sanecka, K., Roche, F., Da Silva, A. R., Call, D., D'Alessio, F., Ragab, A., et al. (2014). Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood 123, 1574-1585. doi: 10.1182/blood-2013-07-515957
    • (2014) Blood , vol.123 , pp. 1574-1585
    • Mleczko-Sanecka, K.1    Roche, F.2    Da Silva, A.R.3    Call, D.4    D'Alessio, F.5    Ragab, A.6
  • 49
    • 84977639278 scopus 로고    scopus 로고
    • 'A phase I study investigating the safety, tolerability, pharmacokinetics and pharmacodynamic activity of the hepcidin antagonist PRS-080#022. Results from a randomized, placebo controlled, double-blind study following single administration to healthy subjects, '
    • ASH) (Orlando, FL
    • Moebius, U., Feuerer, W., Fenzl, E., Van Swelm, R., Swinkels, D. W., and Hohlbaum, A. (2015). "A phase I study investigating the safety, tolerability, pharmacokinetics and pharmacodynamic activity of the hepcidin antagonist PRS-080#022. Results from a randomized, placebo controlled, double-blind study following single administration to healthy subjects, "in 57th Annual Meeting of the American Society for Hematology (ASH) (Orlando, FL), Abstract 536.
    • (2015) 57th Annual Meeting of the American Society for Hematology
    • Moebius, U.1    Feuerer, W.2    Fenzl, E.3    Van Swelm, R.4    Swinkels, D.W.5    Hohlbaum, A.6
  • 50
    • 84861525631 scopus 로고    scopus 로고
    • Deletion of TMPRSS6 attenuates the phenotype in a mouse model of beta-thalassemia
    • Nai, A., Pagani, A., Mandelli, G., Lidonnici, M. R., Silvestri, L., Ferrari, G., et al. (2012). Deletion of TMPRSS6 attenuates the phenotype in a mouse model of beta-thalassemia. Blood 119, 5021-5029. doi: 10.1182/blood-2012-01-401885
    • (2012) Blood , vol.119 , pp. 5021-5029
    • Nai, A.1    Pagani, A.2    Mandelli, G.3    Lidonnici, M.R.4    Silvestri, L.5    Ferrari, G.6
  • 51
    • 84969201260 scopus 로고    scopus 로고
    • Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice
    • Nai, A., Rubio, A., Campanella, A., Gourbeyre, O., Artuso, I., Bordini, J., et al. (2016). Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice. Blood 127, 2327-2336. doi: 10.1182/blood-2015-11-681494
    • (2016) Blood , vol.127 , pp. 2327-2336
    • Nai, A.1    Rubio, A.2    Campanella, A.3    Gourbeyre, O.4    Artuso, I.5    Bordini, J.6
  • 52
    • 0037847496 scopus 로고    scopus 로고
    • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
    • Nicolas, G., Viatte, L., Lou, D. Q., Bennoun, M., Beaumont, C., Kahn, A., et al. (2003). Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat. Genet. 34, 97-101. doi: 10.1038/ng1150
    • (2003) Nat. Genet , vol.34 , pp. 97-101
    • Nicolas, G.1    Viatte, L.2    Lou, D.Q.3    Bennoun, M.4    Beaumont, C.5    Kahn, A.6
  • 53
  • 54
    • 79953092772 scopus 로고    scopus 로고
    • Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation
    • Perlstein, T. S., Pande, R., Berliner, N., and Vanasse, G. J. (2011). Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 117, 2800-2806. doi: 10.1182/blood-2010-09-309708
    • (2011) Blood , vol.117 , pp. 2800-2806
    • Perlstein, T.S.1    Pande, R.2    Berliner, N.3    Vanasse, G.J.4
  • 55
    • 84977629965 scopus 로고    scopus 로고
    • 'ALK2 Inhibition via TP-0184 abrogates inflammation-induced hepcidin expression and is a potential therapeutic for anemia of chronic disease, '
    • ASH, (Orlando, FL)
    • Peterson, P. A., Soh, K. K., Lee, Y. S., Kim, W., Whatcott, C. J., Siddiqui-Jain, A., et al. (2015). "ALK2 Inhibition via TP-0184 abrogates inflammation-induced hepcidin expression and is a potential therapeutic for anemia of chronic disease, "in 57th Annual Meeting of the American Society for Hematology (ASH), (Orlando, FL), Abstract 273.
    • (2015) 57th Annual Meeting of the American Society for Hematology
    • Peterson, P.A.1    Soh, K.K.2    Lee, Y.S.3    Kim, W.4    Whatcott, C.J.5    Siddiqui-Jain, A.6
  • 56
    • 84942340966 scopus 로고    scopus 로고
    • Genetics, genetic testing, and management of hemochromatosis: 15 years since hepcidin
    • Pietrangelo, A. (2015). Genetics, genetic testing, and management of hemochromatosis: 15 years since hepcidin. Gastroenterology 149, 1240-1251. doi: 10.1053/j.gastro.2015.06.045
    • (2015) Gastroenterology , vol.149 , pp. 1240-1251
    • Pietrangelo, A.1
  • 57
    • 84952802841 scopus 로고    scopus 로고
    • Iron and the liver
    • Pietrangelo, A. (2016). Iron and the liver. Liver Int. 36(Suppl. 1), 116-123. doi: 10.1111/liv.13020
    • (2016) Liver Int , vol.36 , pp. 116-123
    • Pietrangelo, A.1
  • 58
    • 77955607931 scopus 로고    scopus 로고
    • Ferroportin and iron regulation in breast cancer progression and prognosis
    • Pinnix, Z. K., Miller, L. D., Wang, W., D'agostino, R. Jr., Kute, T., Willingham, M. C., et al. (2010). Ferroportin and iron regulation in breast cancer progression and prognosis. Sci. Transl. Med. 2, 43ra56. doi: 10.1126/scitranslmed.3001127
    • (2010) Sci. Transl. Med , vol.2
    • Pinnix, Z.K.1    Miller, L.D.2    Wang, W.3    D'agostino, R.4    Kute, T.5    Willingham, M.C.6
  • 59
    • 84897504790 scopus 로고    scopus 로고
    • Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo
    • Poli, M., Asperti, M., Naggi, A., Campostrini, N., Girelli, D., Corbella, M., et al. (2014a). Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo. Blood 123, 1564-1573. doi: 10.1182/blood-2013-07-515221
    • (2014) Blood , vol.123 , pp. 1564-1573
    • Poli, M.1    Asperti, M.2    Naggi, A.3    Campostrini, N.4    Girelli, D.5    Corbella, M.6
  • 60
    • 84910652964 scopus 로고    scopus 로고
    • Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo
    • Poli, M., Asperti, M., Ruzzenenti, P., Mandelli, L., Campostrini, N., Martini, G., et al. (2014b). Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo. Biochem. Pharmacol. 92, 467-475. doi: 10.1016/j.bcp.2014.09.007
    • (2014) Biochem. Pharmacol , vol.92 , pp. 467-475
    • Poli, M.1    Asperti, M.2    Ruzzenenti, P.3    Mandelli, L.4    Campostrini, N.5    Martini, G.6
  • 61
    • 84901046083 scopus 로고    scopus 로고
    • Hepcidin antagonists for potential treatments of disorders with hepcidin excess
    • Poli, M., Asperti, M., Ruzzenenti, P., Regoni, M., and Arosio, P. (2014c). Hepcidin antagonists for potential treatments of disorders with hepcidin excess. Front. Pharmacol. 5:86. doi: 10.3389/fphar.2014.00086
    • (2014) Front. Pharmacol , vol.5 , pp. 86
    • Poli, M.1    Asperti, M.2    Ruzzenenti, P.3    Regoni, M.4    Arosio, P.5
  • 62
    • 78751696745 scopus 로고    scopus 로고
    • Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo
    • Poli, M., Girelli, D., Campostrini, N., Maccarinelli, F., Finazzi, D., Luscieti, S., et al. (2011). Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo. Blood 117, 997-1004. doi: 10.1182/blood-2010-06-289082
    • (2011) Blood , vol.117 , pp. 997-1004
    • Poli, M.1    Girelli, D.2    Campostrini, N.3    Maccarinelli, F.4    Finazzi, D.5    Luscieti, S.6
  • 64
    • 84960411269 scopus 로고    scopus 로고
    • Haemochromatosis
    • [Epub ahead of print]
    • Powell, L. W., Seckington, R. C., and Deugnier, Y. (2016). Haemochromatosis. Lancet. doi: 10.1016/S0140-6736(15)01315-X. [Epub ahead of print].
    • (2016) Lancet
    • Powell, L.W.1    Seckington, R.C.2    Deugnier, Y.3
  • 65
    • 84055190801 scopus 로고    scopus 로고
    • Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
    • Preza, G. C., Ruchala, P., Pinon, R., Ramos, E., Qiao, B., Peralta, M. A., et al. (2011). Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J. Clin. Invest. 121, 4880-4888. doi: 10.1172/JCI57693
    • (2011) J. Clin. Invest , vol.121 , pp. 4880-4888
    • Preza, G.C.1    Ruchala, P.2    Pinon, R.3    Ramos, E.4    Qiao, B.5    Peralta, M.A.6
  • 66
    • 84868545645 scopus 로고    scopus 로고
    • Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
    • Ramos, E., Ruchala, P., Goodnough, J. B., Kautz, L., Preza, G. C., Nemeth, E., et al. (2012). Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood 120, 3829-3836. doi: 10.1182/blood-2012-07-440743
    • (2012) Blood , vol.120 , pp. 3829-3836
    • Ramos, E.1    Ruchala, P.2    Goodnough, J.B.3    Kautz, L.4    Preza, G.C.5    Nemeth, E.6
  • 67
    • 84921265843 scopus 로고    scopus 로고
    • The iron-regulatory hormone hepcidin: a possible therapeutic target?
    • Rochette, L., Gudjoncik, A., Guenancia, C., Zeller, M., Cottin, Y., and Vergely, C. (2015). The iron-regulatory hormone hepcidin: a possible therapeutic target? Pharmacol. Ther. 146, 35-52. doi: 10.1016/j.pharmthera.2014.09.004
    • (2015) Pharmacol. Ther , vol.146 , pp. 35-52
    • Rochette, L.1    Gudjoncik, A.2    Guenancia, C.3    Zeller, M.4    Cottin, Y.5    Vergely, C.6
  • 68
    • 84896736426 scopus 로고    scopus 로고
    • The pathophysiology and pharmacology of hepcidin
    • Ruchala, P., and Nemeth, E. (2014). The pathophysiology and pharmacology of hepcidin. Trends Pharmacol. Sci. 35, 155-161. doi: 10.1016/j.tips.2014.01.004
    • (2014) Trends Pharmacol. Sci , vol.35 , pp. 155-161
    • Ruchala, P.1    Nemeth, E.2
  • 69
    • 84856225143 scopus 로고    scopus 로고
    • Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis
    • Saeed, O., Otsuka, F., Polavarapu, R., Karmali, V., Weiss, D., Davis, T., et al. (2012). Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 32, 299-307. doi: 10.1161/ATVBAHA.111.240101
    • (2012) Arterioscler. Thromb. Vasc. Biol , vol.32 , pp. 299-307
    • Saeed, O.1    Otsuka, F.2    Polavarapu, R.3    Karmali, V.4    Weiss, D.5    Davis, T.6
  • 70
    • 77951745552 scopus 로고    scopus 로고
    • Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
    • Sasu, B. J., Cooke, K. S., Arvedson, T. L., Plewa, C., Ellison, A. R., Sheng, J., et al. (2010). Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood 115, 3616-3624. doi: 10.1182/blood-2009-09-245977
    • (2010) Blood , vol.115 , pp. 3616-3624
    • Sasu, B.J.1    Cooke, K.S.2    Arvedson, T.L.3    Plewa, C.4    Ellison, A.R.5    Sheng, J.6
  • 71
    • 84896734636 scopus 로고    scopus 로고
    • Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches
    • Schmidt, P. J., and Fleming, M. D. (2014). Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches. Hematol. Oncol. Clin. North Am. 28, 387-401. doi: 10.1016/j.hoc.2013.11.004
    • (2014) Hematol. Oncol. Clin. North Am , vol.28 , pp. 387-401
    • Schmidt, P.J.1    Fleming, M.D.2
  • 72
    • 84874066920 scopus 로고    scopus 로고
    • An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia
    • Schmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., et al. (2013). An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia. Blood 121, 1200-1208. doi: 10.1182/blood-2012-09-453977
    • (2013) Blood , vol.121 , pp. 1200-1208
    • Schmidt, P.J.1    Toudjarska, I.2    Sendamarai, A.K.3    Racie, T.4    Milstein, S.5    Bettencourt, B.R.6
  • 73
    • 84877930663 scopus 로고    scopus 로고
    • The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys
    • Schwoebel, F., Van Eijk, L. T., Zboralski, D., Sell, S., Buchner, K., Maasch, C., et al. (2013). The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood 121, 2311-2315. doi: 10.1182/blood-2012-09-456756
    • (2013) Blood , vol.121 , pp. 2311-2315
    • Schwoebel, F.1    Van Eijk, L.T.2    Zboralski, D.3    Sell, S.4    Buchner, K.5    Maasch, C.6
  • 74
    • 80053615986 scopus 로고    scopus 로고
    • Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice
    • Sebastiani, G., and Pantopoulos, K. (2011). Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice. Metallomics 3, 971-986. doi: 10.1039/c1mt00082a
    • (2011) Metallomics , vol.3 , pp. 971-986
    • Sebastiani, G.1    Pantopoulos, K.2
  • 75
    • 84888002594 scopus 로고    scopus 로고
    • Liver as a target for oligonucleotide therapeutics
    • Sehgal, A., Vaishnaw, A., and Fitzgerald, K. (2013). Liver as a target for oligonucleotide therapeutics. J. Hepatol. 59, 1354-1359. doi: 10.1016/j.jhep.2013.05.045
    • (2013) J. Hepatol , vol.59 , pp. 1354-1359
    • Sehgal, A.1    Vaishnaw, A.2    Fitzgerald, K.3
  • 76
    • 84961258762 scopus 로고    scopus 로고
    • Management of human factors engineering-associated hemochromatosis: a 2015 update
    • Sivakumar, M., and Powell, L. W. (2016). Management of human factors engineering-associated hemochromatosis: a 2015 update. World J. Hepatol. 8, 395-400. doi: 10.4254/wjh.v8.i8.395
    • (2016) World J. Hepatol , vol.8 , pp. 395-400
    • Sivakumar, M.1    Powell, L.W.2
  • 77
    • 84884791621 scopus 로고    scopus 로고
    • Comparative evaluation of the effects of treatment with tocilizumab and TNF-alpha inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients
    • Song, S. N., Iwahashi, M., Tomosugi, N., Uno, K., Yamana, J., Yamana, S., et al. (2013). Comparative evaluation of the effects of treatment with tocilizumab and TNF-alpha inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients. Arthritis Res. Ther. 15, R141. doi: 10.1186/ar4323
    • (2013) Arthritis Res. Ther , vol.15 , pp. R141
    • Song, S.N.1    Iwahashi, M.2    Tomosugi, N.3    Uno, K.4    Yamana, J.5    Yamana, S.6
  • 78
    • 78149324897 scopus 로고    scopus 로고
    • Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
    • Song, S. N., Tomosugi, N., Kawabata, H., Ishikawa, T., Nishikawa, T., and Yoshizaki, K. (2010). Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease. Blood 116, 3627-3634. doi: 10.1182/blood-2010-03-271791
    • (2010) Blood , vol.116 , pp. 3627-3634
    • Song, S.N.1    Tomosugi, N.2    Kawabata, H.3    Ishikawa, T.4    Nishikawa, T.5    Yoshizaki, K.6
  • 79
    • 79955980950 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    • Steinbicker, A. U., Sachidanandan, C., Vonner, A. J., Yusuf, R. Z., Deng, D. Y., Lai, C. S., et al. (2011). Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 117, 4915-4923. doi: 10.1182/blood-2010-10-313064
    • (2011) Blood , vol.117 , pp. 4915-4923
    • Steinbicker, A.U.1    Sachidanandan, C.2    Vonner, A.J.3    Yusuf, R.Z.4    Deng, D.Y.5    Lai, C.S.6
  • 80
    • 84884512943 scopus 로고    scopus 로고
    • A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats
    • Sun, C. C., Vaja, V., Chen, S., Theurl, I., Stepanek, A., Brown, D. E., et al. (2013). A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrol. Dial. Transplant. 28, 1733-1743. doi: 10.1093/ndt/gfs584
    • (2013) Nephrol. Dial. Transplant , vol.28 , pp. 1733-1743
    • Sun, C.C.1    Vaja, V.2    Chen, S.3    Theurl, I.4    Stepanek, A.5    Brown, D.E.6
  • 81
    • 84942888188 scopus 로고    scopus 로고
    • Hepcidin regulation in prostate and its disruption in prostate cancer
    • Tesfay, L., Clausen, K. A., Kim, J. W., Hegde, P., Wang, X., Miller, L. D., et al. (2015). Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 75, 2254-2263. doi: 10.1158/0008-5472.CAN-14-2465
    • (2015) Cancer Res , vol.75 , pp. 2254-2263
    • Tesfay, L.1    Clausen, K.A.2    Kim, J.W.3    Hegde, P.4    Wang, X.5    Miller, L.D.6
  • 82
    • 80052647221 scopus 로고    scopus 로고
    • Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
    • Theurl, I., Schroll, A., Sonnweber, T., Nairz, M., Theurl, M., Willenbacher, W., et al. (2011). Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood 118, 4977-4984. doi: 10.1182/blood-2011-03-345066
    • (2011) Blood , vol.118 , pp. 4977-4984
    • Theurl, I.1    Schroll, A.2    Sonnweber, T.3    Nairz, M.4    Theurl, M.5    Willenbacher, W.6
  • 83
    • 84873467895 scopus 로고    scopus 로고
    • Hepcidin is a potential regulator of iron status in chronic kidney disease
    • Tsuchiya, K., and Nitta, K. (2013). Hepcidin is a potential regulator of iron status in chronic kidney disease. Ther. Apher. Dial. 17, 1-8. doi: 10.1111/1744-9987.12001
    • (2013) Ther. Apher. Dial , vol.17 , pp. 1-8
    • Tsuchiya, K.1    Nitta, K.2
  • 84
    • 84885953717 scopus 로고    scopus 로고
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
    • Urrutia, P., Aguirre, P., Esparza, A., Tapia, V., Mena, N. P., Arredondo, M., et al. (2013). Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J. Neurochem. 126, 541-549. doi: 10.1111/jnc.12244
    • (2013) J. Neurochem , vol.126 , pp. 541-549
    • Urrutia, P.1    Aguirre, P.2    Esparza, A.3    Tapia, V.4    Mena, N.P.5    Arredondo, M.6
  • 86
    • 84908233244 scopus 로고    scopus 로고
    • Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans
    • Van Eijk, L. T., John, A. S., Schwoebel, F., Summo, L., Vauleon, S., Zollner, S., et al. (2014). Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans. Blood 124, 2643-2646. doi: 10.1182/blood-2014-03-559484
    • (2014) Blood , vol.124 , pp. 2643-2646
    • Van Eijk, L.T.1    John, A.S.2    Schwoebel, F.3    Summo, L.4    Vauleon, S.5    Zollner, S.6
  • 87
    • 84958780878 scopus 로고    scopus 로고
    • Hepcidin regulation in the anemia of inflammation
    • Wang, C. Y., and Babitt, J. L. (2016). Hepcidin regulation in the anemia of inflammation. Curr. Opin. Hematol. 23, 189-197. doi: 10.1097/MOH.0000000000000236
    • (2016) Curr. Opin. Hematol , vol.23 , pp. 189-197
    • Wang, C.Y.1    Babitt, J.L.2
  • 88
    • 84941912205 scopus 로고    scopus 로고
    • Anemia of chronic disorders: new diagnostic tools and new treatment strategies
    • Weiss, G. (2015). Anemia of chronic disorders: new diagnostic tools and new treatment strategies. Semin. Hematol. 52, 313-320. doi: 10.1053/j.seminhematol.2015.07.004
    • (2015) Semin. Hematol , vol.52 , pp. 313-320
    • Weiss, G.1
  • 89
    • 84977606067 scopus 로고    scopus 로고
    • 'LY2928057, an antibody targeting ferroportin, is a potent inhibitor of hepcidin activity and increases iron mobilization in normal cynomolgus monkeys, '
    • ASH) (New Orleans, LA
    • Witcher, D. R., Leung, D., Hill, K. A., De Rosa, D. C., Xu, J., Manetta, J., et al. (2013). "LY2928057, an antibody targeting ferroportin, is a potent inhibitor of hepcidin activity and increases iron mobilization in normal cynomolgus monkeys, "in 55th Annual Meeting of the American Society for Hematology (ASH) (New Orleans, LA), Abstract 3433.
    • (2013) 55th Annual Meeting of the American Society for Hematology
    • Witcher, D.R.1    Leung, D.2    Hill, K.A.3    De Rosa, D.C.4    Xu, J.5    Manetta, J.6
  • 90
    • 84862736353 scopus 로고    scopus 로고
    • 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site
    • Yang, Q., Jian, J., Katz, S., Abramson, S. B., and Huang, X. (2012). 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology 153, 3170-3178. doi: 10.1210/en.2011-2045
    • (2012) Endocrinology , vol.153 , pp. 3170-3178
    • Yang, Q.1    Jian, J.2    Katz, S.3    Abramson, S.B.4    Huang, X.5
  • 91
    • 37249010753 scopus 로고    scopus 로고
    • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu, P. B., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., et al. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4, 33-41. doi: 10.1038/nchembio.2007.54
    • (2008) Nat. Chem. Biol , vol.4 , pp. 33-41
    • Yu, P.B.1    Hong, C.C.2    Sachidanandan, C.3    Babitt, J.L.4    Deng, D.Y.5    Hoyng, S.A.6
  • 92
    • 84922069986 scopus 로고    scopus 로고
    • Hepatic hepcidin protects against polymicrobial sepsis in mice by regulating host iron status
    • Zeng, C., Chen, Q., Zhang, K., Chen, Q., Song, S., and Fang, X. (2015). Hepatic hepcidin protects against polymicrobial sepsis in mice by regulating host iron status. Anesthesiology 122, 374-386. doi: 10.1097/ALN.0000000000000466
    • (2015) Anesthesiology , vol.122 , pp. 374-386
    • Zeng, C.1    Chen, Q.2    Zhang, K.3    Chen, Q.4    Song, S.5    Fang, X.6
  • 93
    • 83155177082 scopus 로고    scopus 로고
    • AG490: an inhibitor of hepcidin expression in vivo
    • Zhang, S. P., Wang, Z., Wang, L. X., and Liu, S. J. (2011). AG490: an inhibitor of hepcidin expression in vivo. World J. Gastroenterol. 17, 5032-5034. doi: 10.3748/wjg.v17.i45.5032
    • (2011) World J. Gastroenterol , vol.17 , pp. 5032-5034
    • Zhang, S.P.1    Wang, Z.2    Wang, L.X.3    Liu, S.J.4
  • 94
    • 84884982933 scopus 로고    scopus 로고
    • The small molecule, genistein, increases hepcidin expression in human hepatocytes
    • Zhen, A. W., Nguyen, N. H., Gibert, Y., Motola, S., Buckett, P., Wessling-Resnick, M., et al. (2013). The small molecule, genistein, increases hepcidin expression in human hepatocytes. Hepatology 58, 1315-1325. doi: 10.1002/hep.26490
    • (2013) Hepatology , vol.58 , pp. 1315-1325
    • Zhen, A.W.1    Nguyen, N.H.2    Gibert, Y.3    Motola, S.4    Buckett, P.5    Wessling-Resnick, M.6
  • 95
    • 84956871250 scopus 로고    scopus 로고
    • Advances in hepatitis C therapy: what is the current state-what come's next?
    • Zopf, S., Kremer, A. E., Neurath, M. F., and Siebler, J. (2016). Advances in hepatitis C therapy: what is the current state-what come's next? World J. Hepatol. 8, 139-147. doi: 10.4254/wjh.v8.i3.139
    • (2016) World J. Hepatol , vol.8 , pp. 139-147
    • Zopf, S.1    Kremer, A.E.2    Neurath, M.F.3    Siebler, J.4
  • 96
    • 84901468319 scopus 로고    scopus 로고
    • The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes
    • Zughaier, S. M., Alvarez, J. A., Sloan, J. H., Konrad, R. J., and Tangpricha, V. (2014). The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes. J. Clin. Transl. Endocrinol. 1, 19-25. doi: 10.1016/j.jcte.2014.01.003
    • (2014) J. Clin. Transl. Endocrinol , vol.1 , pp. 19-25
    • Zughaier, S.M.1    Alvarez, J.A.2    Sloan, J.H.3    Konrad, R.J.4    Tangpricha, V.5


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