메뉴 건너뛰기




Volumn 83, Issue 3, 2013, Pages 681-690

High-throughput screening of small molecules identifies hepcidin antagonistss

Author keywords

[No Author keywords available]

Indexed keywords

BENFOTIAMINE; FERROPORTIN; FURSULTIAMINE;

EID: 84874302553     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.083428     Document Type: Article
Times cited : (63)

References (33)
  • 1
    • 84864053080 scopus 로고    scopus 로고
    • Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling
    • Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, and Coppin H (2012) Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 120: 431-439.
    • (2012) Blood , vol.120 , pp. 431-439
    • Besson-Fournier, C.1    Latour, C.2    Kautz, L.3    Bertrand, J.4    Ganz, T.5    Roth, M.P.6    Coppin, H.7
  • 2
    • 0013954846 scopus 로고
    • The anemia of chronic disorders
    • Cartwright GE (1966) The anemia of chronic disorders. Semin Hematol 3:351-375.
    • (1966) Semin Hematol , vol.3 , pp. 351-375
    • Cartwright, G.E.1
  • 3
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • DOI 10.1016/j.cmet.2005.01.003, PII S1550413105000306
    • Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, and Andrews NC (2005) The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1:191-200. (Pubitemid 43960600)
    • (2005) Cell Metabolism , vol.1 , Issue.3 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3    Pinkus, G.S.4    Zon, L.I.5    Robine, S.6    Andrews, N.C.7
  • 4
    • 79959893643 scopus 로고    scopus 로고
    • Digoxin: Clinical highlights: A review of digoxin and its use in contemporary medicine
    • Ehle M, Patel C, and Giugliano RP (2011) Digoxin: Clinical highlights: A review of digoxin and its use in contemporary medicine. Crit Pathw Cardiol 10:93-98.
    • (2011) Crit Pathw Cardiol , vol.10 , pp. 93-98
    • Ehle, M.1    Patel, C.2    Giugliano, R.P.3
  • 7
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T and Nemeth E (2011) Hepcidin and disorders of iron metabolism. Annu Rev Med 62:347-360.
    • (2011) Annu Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 8
    • 84861837657 scopus 로고    scopus 로고
    • Update on safety of ESAs in cancer-induced anemia
    • Glaspy J (2012) Update on safety of ESAs in cancer-induced anemia. J Natl Compr Canc Netw 10:659-666.
    • (2012) J Natl Compr Canc Netw , vol.10 , pp. 659-666
    • Glaspy, J.1
  • 9
    • 78649753411 scopus 로고    scopus 로고
    • Detection, evaluation, and management of iron-restricted erythropoiesis
    • Goodnough LT, Nemeth E, and Ganz T (2010) Detection, evaluation, and management of iron-restricted erythropoiesis. Blood 116:4754-4761.
    • (2010) Blood , vol.116 , pp. 4754-4761
    • Goodnough, L.T.1    Nemeth, E.2    Ganz, T.3
  • 10
    • 34547657479 scopus 로고    scopus 로고
    • Cytoprotective agents used in the treatment of patients with cancer
    • Hogle WP (2007) Cytoprotective agents used in the treatment of patients with cancer. Semin Oncol Nurs 23:213-224.
    • (2007) Semin Oncol Nurs , vol.23 , pp. 213-224
    • Hogle, W.P.1
  • 11
    • 0027490469 scopus 로고
    • Pharmacokinetics of thiamin after oral administration of thiamin tetrahydrofurfuryl disulfide to humans
    • Kitamori N and Itokawa Y (1993) Pharmacokinetics of thiamin after oral administration of thiamin tetrahydrofurfuryl disulfide to humans. J Nutr Sci Vitaminol (Tokyo) 39:465-472. (Pubitemid 23357506)
    • (1993) Journal of Nutritional Science and Vitaminology , vol.39 , Issue.5 , pp. 465-472
    • Kitamori, N.1    Itokawa, Y.2
  • 12
    • 4644371377 scopus 로고    scopus 로고
    • Thiamine tetrahydrofurfuryl disulfide: A little known therapeutic agent
    • Lonsdale D (2004) Thiamine tetrahydrofurfuryl disulfide: A little known therapeutic agent. Med Sci Monit 10:RA199-RA203. (Pubitemid 39278571)
    • (2004) Medical Science Monitor , vol.10 , Issue.9
    • Lonsdale, D.1
  • 14
    • 69149098551 scopus 로고    scopus 로고
    • N-acetylcysteine: Multiple clinical applications
    • Millea PJ (2009) N-acetylcysteine: Multiple clinical applications. Am Fam Physician 80:265-269.
    • (2009) Am Fam Physician , vol.80 , pp. 265-269
    • Millea, P.J.1
  • 15
    • 30144432585 scopus 로고    scopus 로고
    • The N-terminus of hepcidin is essential for its interaction with ferroportin: Structure-function study
    • DOI 10.1182/blood-2005-05-2049
    • Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, and Ganz T (2006) The Nterminus of hepcidin is essential for its interaction with ferroportin: Structurefunction study. Blood 107:328-333. (Pubitemid 43053559)
    • (2006) Blood , vol.107 , Issue.1 , pp. 328-333
    • Nemeth, E.1    Preza, G.C.2    Jung, C.-L.3    Kaplan, J.4    Waring, A.J.5    Ganz, T.6
  • 16
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • DOI 10.1172/JCI200420945
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, and Ganz T (2004a) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113:1271-1276. (Pubitemid 39069926)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.9 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 17
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • DOI 10.1126/science.1104742
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, and Kaplan J (2004b) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093. (Pubitemid 40007660)
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.D.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 18
    • 0014703513 scopus 로고
    • The metabolic fate of methyl tetrahydrofurfuryl sulfide and its related compounds in rats
    • Nishikawa K, Kikuchi S, and Suzuoki Z (1970) The metabolic fate of methyl tetrahydrofurfuryl sulfide and its related compounds in rats. Eur J Pharmacol 9:111-115.
    • (1970) Eur J Pharmacol , vol.9 , pp. 111-115
    • Nishikawa, K.1    Kikuchi, S.2    Suzuoki, Z.3
  • 19
    • 77951909056 scopus 로고    scopus 로고
    • Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice
    • Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, Sun X, Zhao L, Yu M, and Xu Z et al. (2010) Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 133:1342-1351.
    • (2010) Brain , vol.133 , pp. 1342-1351
    • Pan, X.1    Gong, N.2    Zhao, J.3    Yu, Z.4    Gu, F.5    Chen, J.6    Sun, X.7    Zhao, L.8    Yu, M.9    Xu, Z.10
  • 20
    • 84055190801 scopus 로고    scopus 로고
    • Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
    • Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, and Nemeth E (2011) Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest 121:4880-4888.
    • (2011) J Clin Invest , vol.121 , pp. 4880-4888
    • Preza, G.C.1    Ruchala, P.2    Pinon, R.3    Ramos, E.4    Qiao, B.5    Peralta, M.A.6    Sharma, S.7    Waring, A.8    Ganz, T.9    Nemeth, E.10
  • 23
    • 24744458603 scopus 로고    scopus 로고
    • Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    • DOI 10.1182/blood-2005-04-1766
    • Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, and Ganz T (2005) Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 106:2196-2199. (Pubitemid 41291740)
    • (2005) Blood , vol.106 , Issue.6 , pp. 2196-2199
    • Rivera, S.1    Nemeth, E.2    Gabayan, V.3    Lopez, M.A.4    Farshidi, D.5    Ganz, T.6
  • 24
    • 34247366783 scopus 로고    scopus 로고
    • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
    • DOI 10.1182/blood-2006-10-051755
    • Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, and Andrews NC (2007) Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 109:4038-4044. (Pubitemid 46641759)
    • (2007) Blood , vol.109 , Issue.9 , pp. 4038-4044
    • Roy, C.N.1    Mak, H.H.2    Akpan, I.3    Losyev, G.4    Zurakowski, D.5    Andrews, N.C.6
  • 25
    • 77951745552 scopus 로고    scopus 로고
    • Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
    • Sasu BJ, Cooke KS, Arvedson TL, Plewa C, Ellison AR, Sheng J, Winters A, Juan T, Li H, and Begley CG et al. (2010) Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood 115:3616-3624.
    • (2010) Blood , vol.115 , pp. 3616-3624
    • Sasu, B.J.1    Cooke, K.S.2    Arvedson, T.L.3    Plewa, C.4    Ellison, A.R.5    Sheng, J.6    Winters, A.7    Juan, T.8    Li, H.9    Begley, C.G.10
  • 26
    • 13844270538 scopus 로고    scopus 로고
    • Autosomal dominant hereditary hemochromatosis associated with a novel ferroportin mutation and unique clinical features
    • DOI 10.1016/j.bcmd.2004.12.002
    • Sham RL, Phatak PD, West C, Lee P, Andrews C, and Beutler E (2005) Autosomal dominant hereditary hemochromatosis associated with a novel ferroportin mutation and unique clinical features. Blood Cells Mol Dis 34:157-161. (Pubitemid 40250491)
    • (2005) Blood Cells, Molecules, and Diseases , vol.34 , Issue.2 , pp. 157-161
    • Sham, R.L.1    Phatak, P.D.2    West, C.3    Lee, P.4    Andrews, C.5    Beutler, E.6
  • 29
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G and Goodnough LT (2005) Anemia of chronic disease. N Engl J Med 352: 1011-1023.
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 31
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    • Zelcer N, Hong C, Boyadjian R, and Tontonoz P (2009) LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325:100-104.
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3    Tontonoz, P.4
  • 32
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • DOI 10.1177/108705719900400206
    • Zhang JH, Chung TD, and Oldenburg KR (1999) A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen 4:67-73. (Pubitemid 29278954)
    • (1999) Journal of Biomolecular Screening , vol.4 , Issue.2 , pp. 67-73
    • Zhang, J.-H.1    Chung, T.D.Y.2    Oldenburg, K.R.3
  • 33
    • 84865565820 scopus 로고    scopus 로고
    • Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice
    • Zhang Z, Zhang F, Guo X, An P, Tao Y, and Wang F (2012) Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice. Hepatology 56:961-971.
    • (2012) Hepatology , vol.56 , pp. 961-971
    • Zhang, Z.1    Zhang, F.2    Guo, X.3    An, P.4    Tao, Y.5    Wang, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.