-
1
-
-
0032551829
-
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
-
Agrawal, A., Eastman, Q.M., Schatz, D.G., Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394 (1998), 744–751.
-
(1998)
Nature
, vol.394
, pp. 744-751
-
-
Agrawal, A.1
Eastman, Q.M.2
Schatz, D.G.3
-
2
-
-
0031712128
-
The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis
-
Callebaut, I., Mornon, J.P., The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell. Mol. Life Sci. 54 (1998), 880–891.
-
(1998)
Cell. Mol. Life Sci.
, vol.54
, pp. 880-891
-
-
Callebaut, I.1
Mornon, J.P.2
-
3
-
-
32044434448
-
Mobilization of RAG-generated signal ends by transposition and insertion in vivo
-
Chatterji, M., Tsai, C.L., Schatz, D.G., Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol. Cell. Biol. 26 (2006), 1558–1568.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 1558-1568
-
-
Chatterji, M.1
Tsai, C.L.2
Schatz, D.G.3
-
4
-
-
0036315559
-
A short peptide at the C terminus is responsible for the nuclear localization of RAG2
-
Corneo, B., Benmerah, A., Villartay, J.P., A short peptide at the C terminus is responsible for the nuclear localization of RAG2. Eur. J. Immunol. 32 (2002), 2068–2073.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 2068-2073
-
-
Corneo, B.1
Benmerah, A.2
Villartay, J.P.3
-
5
-
-
34848843525
-
Rag mutations reveal robust alternative end joining
-
Corneo, B., Wendland, R.L., Deriano, L., Cui, X., Klein, I.A., Wong, S.Y., Arnal, S., Holub, A.J., Weller, G.R., Pancake, B.A., et al. Rag mutations reveal robust alternative end joining. Nature 449 (2007), 483–486.
-
(2007)
Nature
, vol.449
, pp. 483-486
-
-
Corneo, B.1
Wendland, R.L.2
Deriano, L.3
Cui, X.4
Klein, I.A.5
Wong, S.Y.6
Arnal, S.7
Holub, A.J.8
Weller, G.R.9
Pancake, B.A.10
-
6
-
-
0141950446
-
Mobile DNA: an introduction
-
American Society of Microbiology
-
Craig, N.L., Mobile DNA: an introduction. Mobile DNA II, 2002, American Society of Microbiology.
-
(2002)
Mobile DNA II
-
-
Craig, N.L.1
-
7
-
-
0021646330
-
A murine T cell receptor gene complex: isolation, structure and rearrangement
-
Davis, M.M., Chien, Y.H., Gascoigne, N.R., Hedrick, S.M., A murine T cell receptor gene complex: isolation, structure and rearrangement. Immunol. Rev. 81 (1984), 235–258.
-
(1984)
Immunol. Rev.
, vol.81
, pp. 235-258
-
-
Davis, M.M.1
Chien, Y.H.2
Gascoigne, N.R.3
Hedrick, S.M.4
-
8
-
-
33644536713
-
Tunicates and not cephalochordates are the closest living relatives of vertebrates
-
Delsuc, F., Brinkmann, H., Chourrout, D., Philippe, H., Tunicates and not cephalochordates are the closest living relatives of vertebrates. Nature 439 (2006), 965–968.
-
(2006)
Nature
, vol.439
, pp. 965-968
-
-
Delsuc, F.1
Brinkmann, H.2
Chourrout, D.3
Philippe, H.4
-
9
-
-
66749159635
-
Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity
-
Dreyfus, D.H., Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity. PLoS ONE, 4, 2009, e5778.
-
(2009)
PLoS ONE
, vol.4
, pp. e5778
-
-
Dreyfus, D.H.1
-
10
-
-
0029864993
-
Initiation of V(D)J recombination in vitro obeying the 12/23 rule
-
Eastman, Q.M., Leu, T.M., Schatz, D.G., Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380 (1996), 85–88.
-
(1996)
Nature
, vol.380
, pp. 85-88
-
-
Eastman, Q.M.1
Leu, T.M.2
Schatz, D.G.3
-
11
-
-
0037447338
-
The C-terminal portion of RAG2 protects against transposition in vitro
-
Elkin, S.K., Matthews, A.G., Oettinger, M.A., The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J. 22 (2003), 1931–1938.
-
(2003)
EMBO J.
, vol.22
, pp. 1931-1938
-
-
Elkin, S.K.1
Matthews, A.G.2
Oettinger, M.A.3
-
12
-
-
72849115174
-
Origin and evolution of the adaptive immune system: genetic events and selective pressures
-
Flajnik, M.F., Kasahara, M., Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat. Rev. Genet. 11 (2010), 47–59.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 47-59
-
-
Flajnik, M.F.1
Kasahara, M.2
-
13
-
-
77949269476
-
The origins of the Rag genes–from transposition to V(D)J recombination
-
Fugmann, S.D., The origins of the Rag genes–from transposition to V(D)J recombination. Semin. Immunol. 22 (2010), 10–16.
-
(2010)
Semin. Immunol.
, vol.22
, pp. 10-16
-
-
Fugmann, S.D.1
-
14
-
-
33644856255
-
An ancient evolutionary origin of the Rag1/2 gene locus
-
Fugmann, S.D., Messier, C., Novack, L.A., Cameron, R.A., Rast, J.P., An ancient evolutionary origin of the Rag1/2 gene locus. Proc. Natl. Acad. Sci. USA 103 (2006), 3728–3733.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 3728-3733
-
-
Fugmann, S.D.1
Messier, C.2
Novack, L.A.3
Cameron, R.A.4
Rast, J.P.5
-
15
-
-
0035997348
-
V(D)J recombination: RAG proteins, repair factors, and regulation
-
Gellert, M., V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71 (2002), 101–132.
-
(2002)
Annu. Rev. Biochem.
, vol.71
, pp. 101-132
-
-
Gellert, M.1
-
16
-
-
84864710938
-
Functional characterization of an active Rag-like transposase
-
Hencken, C.G., Li, X., Craig, N.L., Functional characterization of an active Rag-like transposase. Nat. Struct. Mol. Biol. 19 (2012), 834–836.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 834-836
-
-
Hencken, C.G.1
Li, X.2
Craig, N.L.3
-
17
-
-
0023659483
-
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals
-
Hesse, J.E., Lieber, M.R., Gellert, M., Mizuuchi, K., Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell 49 (1987), 775–783.
-
(1987)
Cell
, vol.49
, pp. 775-783
-
-
Hesse, J.E.1
Lieber, M.R.2
Gellert, M.3
Mizuuchi, K.4
-
18
-
-
0024691453
-
V(D)J recombination: a functional definition of the joining signals
-
Hesse, J.E., Lieber, M.R., Mizuuchi, K., Gellert, M., V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3 (1989), 1053–1061.
-
(1989)
Genes Dev.
, vol.3
, pp. 1053-1061
-
-
Hesse, J.E.1
Lieber, M.R.2
Mizuuchi, K.3
Gellert, M.4
-
19
-
-
0032555758
-
DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations
-
Hiom, K., Melek, M., Gellert, M., DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 94 (1998), 463–470.
-
(1998)
Cell
, vol.94
, pp. 463-470
-
-
Hiom, K.1
Melek, M.2
Gellert, M.3
-
20
-
-
84964313946
-
Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes
-
Huang, S., Chen, Z., Yan, X., Yu, T., Huang, G., Yan, Q., Pontarotti, P.A., Zhao, H., Li, J., Yang, P., et al. Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes. Nat. Commun., 5, 2014, 5896.
-
(2014)
Nat. Commun.
, vol.5
, pp. 5896
-
-
Huang, S.1
Chen, Z.2
Yan, X.3
Yu, T.4
Huang, G.5
Yan, Q.6
Pontarotti, P.A.7
Zhao, H.8
Li, J.9
Yang, P.10
-
21
-
-
77951893700
-
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci
-
Ji, Y., Resch, W., Corbett, E., Yamane, A., Casellas, R., Schatz, D.G., The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 141 (2010), 419–431.
-
(2010)
Cell
, vol.141
, pp. 419-431
-
-
Ji, Y.1
Resch, W.2
Corbett, E.3
Yamane, A.4
Casellas, R.5
Schatz, D.G.6
-
22
-
-
22744445703
-
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons
-
Kapitonov, V.V., Jurka, J., RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons. PLoS Biol., 3, 2005, e181.
-
(2005)
PLoS Biol.
, vol.3
, pp. e181
-
-
Kapitonov, V.V.1
Jurka, J.2
-
23
-
-
84928580279
-
Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon
-
Kapitonov, V.V., Koonin, E.V., Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon. Biol. Direct, 10, 2015, 20.
-
(2015)
Biol. Direct
, vol.10
, pp. 20
-
-
Kapitonov, V.V.1
Koonin, E.V.2
-
24
-
-
84924052353
-
Crystal structure of the V(D)J recombinase RAG1-RAG2
-
Kim, M.S., Lapkouski, M., Yang, W., Gellert, M., Crystal structure of the V(D)J recombinase RAG1-RAG2. Nature 518 (2015), 507–511.
-
(2015)
Nature
, vol.518
, pp. 507-511
-
-
Kim, M.S.1
Lapkouski, M.2
Yang, W.3
Gellert, M.4
-
25
-
-
1942421722
-
RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination
-
Lee, G.S., Neiditch, M.B., Salus, S.S., Roth, D.B., RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination. Cell 117 (2004), 171–184.
-
(2004)
Cell
, vol.117
, pp. 171-184
-
-
Lee, G.S.1
Neiditch, M.B.2
Salus, S.S.3
Roth, D.B.4
-
26
-
-
0028048275
-
The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses
-
Lewis, S.M., The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56 (1994), 27–150.
-
(1994)
Adv. Immunol.
, vol.56
, pp. 27-150
-
-
Lewis, S.M.1
-
27
-
-
3242879122
-
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
-
Lieber, M.R., Ma, Y., Pannicke, U., Schwarz, K., The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst.) 3 (2004), 817–826.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 817-826
-
-
Lieber, M.R.1
Ma, Y.2
Pannicke, U.3
Schwarz, K.4
-
28
-
-
84942108408
-
The mechanism of V(D)J recombination A2
-
T. Honjo M. Reth A. Radbruch F.W. Alt Second Edition Academic Press
-
Little, A.J., Matthews, A., Oettinger, M., Roth, D.B., Schatz, D.G., The mechanism of V(D)J recombination A2. Honjo, T., Reth, M., Radbruch, A., Alt, F.W., (eds.) Molecular Biology of B Cells, Second Edition, 2015, Academic Press, 13–34.
-
(2015)
Molecular Biology of B Cells
, pp. 13-34
-
-
Little, A.J.1
Matthews, A.2
Oettinger, M.3
Roth, D.B.4
Schatz, D.G.5
-
29
-
-
35349024178
-
A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
-
Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R., Desiderio, S., A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity 27 (2007), 561–571.
-
(2007)
Immunity
, vol.27
, pp. 561-571
-
-
Liu, Y.1
Subrahmanyam, R.2
Chakraborty, T.3
Sen, R.4
Desiderio, S.5
-
30
-
-
37249041657
-
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
-
Matthews, A.G., Kuo, A.J., Ramón-Maiques, S., Han, S., Champagne, K.S., Ivanov, D., Gallardo, M., Carney, D., Cheung, P., Ciccone, D.N., et al. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 450 (2007), 1106–1110.
-
(2007)
Nature
, vol.450
, pp. 1106-1110
-
-
Matthews, A.G.1
Kuo, A.J.2
Ramón-Maiques, S.3
Han, S.4
Champagne, K.S.5
Ivanov, D.6
Gallardo, M.7
Carney, D.8
Cheung, P.9
Ciccone, D.N.10
-
31
-
-
0028805853
-
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
-
McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., Oettinger, M.A., Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83 (1995), 387–395.
-
(1995)
Cell
, vol.83
, pp. 387-395
-
-
McBlane, J.F.1
van Gent, D.C.2
Ramsden, D.A.3
Romeo, C.4
Cuomo, C.A.5
Gellert, M.6
Oettinger, M.A.7
-
32
-
-
0025301095
-
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
-
Oettinger, M.A., Schatz, D.G., Gorka, C., Baltimore, D., RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248 (1990), 1517–1523.
-
(1990)
Science
, vol.248
, pp. 1517-1523
-
-
Oettinger, M.A.1
Schatz, D.G.2
Gorka, C.3
Baltimore, D.4
-
33
-
-
41149163571
-
Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes
-
Panchin, Y., Moroz, L.L., Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes. Biochem. Biophys. Res. Commun. 369 (2008), 818–823.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.369
, pp. 818-823
-
-
Panchin, Y.1
Moroz, L.L.2
-
34
-
-
0028291092
-
Conservation of sequence in recombination signal sequence spacers
-
Ramsden, D.A., Baetz, K., Wu, G.E., Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res. 22 (1994), 1785–1796.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1785-1796
-
-
Ramsden, D.A.1
Baetz, K.2
Wu, G.E.3
-
35
-
-
33745132455
-
Genomic instability due to V(D)J recombination-associated transposition
-
Reddy, Y.V., Perkins, E.J., Ramsden, D.A., Genomic instability due to V(D)J recombination-associated transposition. Genes Dev. 20 (2006), 1575–1582.
-
(2006)
Genes Dev.
, vol.20
, pp. 1575-1582
-
-
Reddy, Y.V.1
Perkins, E.J.2
Ramsden, D.A.3
-
36
-
-
84947910288
-
Molecular mechanism of V(D)J recombination from synaptic RAG1-RAG2 complex structures
-
Ru, H., Chambers, M.G., Fu, T.M., Tong, A.B., Liao, M., Wu, H., Molecular mechanism of V(D)J recombination from synaptic RAG1-RAG2 complex structures. Cell 163 (2015), 1138–1152.
-
(2015)
Cell
, vol.163
, pp. 1138-1152
-
-
Ru, H.1
Chambers, M.G.2
Fu, T.M.3
Tong, A.B.4
Liao, M.5
Wu, H.6
-
37
-
-
0018627375
-
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
-
Sakano, H., Hüppi, K., Heinrich, G., Tonegawa, S., Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280 (1979), 288–294.
-
(1979)
Nature
, vol.280
, pp. 288-294
-
-
Sakano, H.1
Hüppi, K.2
Heinrich, G.3
Tonegawa, S.4
-
38
-
-
80355122714
-
V(D)J recombination: mechanisms of initiation
-
Schatz, D.G., Swanson, P.C., V(D)J recombination: mechanisms of initiation. Annu. Rev. Genet. 45 (2011), 167–202.
-
(2011)
Annu. Rev. Genet.
, vol.45
, pp. 167-202
-
-
Schatz, D.G.1
Swanson, P.C.2
-
39
-
-
0024846088
-
The V(D)J recombination activating gene, RAG-1
-
Schatz, D.G., Oettinger, M.A., Baltimore, D., The V(D)J recombination activating gene, RAG-1. Cell 59 (1989), 1035–1048.
-
(1989)
Cell
, vol.59
, pp. 1035-1048
-
-
Schatz, D.G.1
Oettinger, M.A.2
Baltimore, D.3
-
40
-
-
84939167512
-
RAG represents a widespread threat to the lymphocyte genome
-
Teng, G., Maman, Y., Resch, W., Kim, M., Yamane, A., Qian, J., Kieffer-Kwon, K.R., Mandal, M., Ji, Y., Meffre, E., et al. RAG represents a widespread threat to the lymphocyte genome. Cell 162 (2015), 751–765.
-
(2015)
Cell
, vol.162
, pp. 751-765
-
-
Teng, G.1
Maman, Y.2
Resch, W.3
Kim, M.4
Yamane, A.5
Qian, J.6
Kieffer-Kwon, K.R.7
Mandal, M.8
Ji, Y.9
Meffre, E.10
-
41
-
-
0028867419
-
New insights into V(D)J recombination and its role in the evolution of the immune system
-
Thompson, C.B., New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3 (1995), 531–539.
-
(1995)
Immunity
, vol.3
, pp. 531-539
-
-
Thompson, C.B.1
-
42
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa, S., Somatic generation of antibody diversity. Nature 302 (1983), 575–581.
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
43
-
-
0037447298
-
Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2
-
Tsai, C.L., Schatz, D.G., Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2. EMBO J. 22 (2003), 1922–1930.
-
(2003)
EMBO J.
, vol.22
, pp. 1922-1930
-
-
Tsai, C.L.1
Schatz, D.G.2
-
44
-
-
0344874233
-
DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase
-
Tsai, C.L., Chatterji, M., Schatz, D.G., DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase. Nucleic Acids Res. 31 (2003), 6180–6190.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 6180-6190
-
-
Tsai, C.L.1
Chatterji, M.2
Schatz, D.G.3
-
45
-
-
66149096706
-
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis
-
Yin, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., Schatz, D.G., Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat. Struct. Mol. Biol. 16 (2009), 499–508.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 499-508
-
-
Yin, F.F.1
Bailey, S.2
Innis, C.A.3
Ciubotaru, M.4
Kamtekar, S.5
Steitz, T.A.6
Schatz, D.G.7
-
46
-
-
84891948853
-
An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1
-
Zhang, Y., Xu, K., Deng, A., Fu, X., Xu, A., Liu, X., An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1. Proc. Natl. Acad. Sci. USA 111 (2014), 397–402.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 397-402
-
-
Zhang, Y.1
Xu, K.2
Deng, A.3
Fu, X.4
Xu, A.5
Liu, X.6
|