Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

Cell

Volumn 166, Issue 1, 2016, Pages 102-114

  Huang, Shengfeng ^a   Tao, Xin ^a   Yuan, Shaochun ^a   Zhang, Yuhang ^c   Li, Peiyi ^a   Beilinson, Helen A ^c   Zhang, Ya ^a   Yu, Wenjuan ^a   Pontarotti, Pierre ^e   Escriva, Hector ^f   Le Petillon, Yann ^f   Liu, Xiaolong ^g   Chen, Shangwu ^a   Schatz, David G ^c,d   Xu, Anlong ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e AIX MARSEILLE UNIVERSITÉ   (France)

^f CNRS   (France)

^g INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIVALENT CATION; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEIC ACID BINDING PROTEIN; PROTORAG PROTEIN; RAG1 PROTEIN; RAG2 PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; RAG-1 PROTEIN; TRANSPOSON; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ADAPTIVE IMMUNITY; ANTIBIOTIC RESISTANCE; ARTICLE; BRANCHIOSTOMA; CELLULAR DISTRIBUTION; DNA CLEAVAGE; DNA END JOINING REPAIR; DNA FLANKING REGION; DNA RECOMBINATION; DNA STRAND; DNA TRANSPOSITION; EX VIVO STUDY; GENE DUPLICATION; GENE LOCUS; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRON; INVERTED REPEAT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEA URCHIN; SPECIES DIFFERENCE; T LYMPHOCYTE RECEPTOR GENE; TRANSPOSON; VDJ RECOMBINATION; ANIMAL; GENETICS; LONG TERMINAL REPEAT; MOLECULAR EVOLUTION;

ANIMALS; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; HOMEODOMAIN PROTEINS; LANCELETS; TERMINAL REPEAT SEQUENCES; V(D)J RECOMBINATION;

EID: 84976871257     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.05.032     Document Type: Article

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