The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1

Nature Communications

Volumn 7, Issue , 2016, Pages

  Boada Romero, Emilio ^a   Serramito Gómez, Inmaculada ^a   Sacristán, María P ^a   Boone, David L ^b   Xavier, Ramnik J ^c,d   Pimentel Muiños, Felipe X ^a  

^a CSIC   (Spain)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; MEMBRANE PROTEIN; TMEM59 PROTEIN; UNCLASSIFIED DRUG; ATG16L1 PROTEIN, HUMAN; ATG16L1 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN; CARRIER PROTEIN; CASPASE 3; DCF1 PROTEIN, HUMAN; NERVE PROTEIN; PEPTIDE; PROTEIN BINDING;

ALLELE; AMINO ACID; BACTERIUM; ENZYME ACTIVITY; GASTROENTERITIS; HOMINID; MEMBRANE; POLYMORPHISM; PROTEIN;

ALLELE; ARTICLE; ATG16L1 A300 GENE; AUTOPHAGY; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONTROLLED STUDY; CROHN DISEASE; GENE; GENETIC POLYMORPHISM; GENETIC RISK; HCT116 CELL LINE; HEK293 CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN MOTIF; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; ANIMAL; CHEMISTRY; GENETIC PREDISPOSITION; GENETICS; HCT 116 CELL LINE; INTRACELLULAR SPACE; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TRANSPORT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; WD REPEAT;

BACTERIA (MICROORGANISMS);

ALLELES; AMINO ACID MOTIFS; ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEINS; CARRIER PROTEINS; CASPASE 3; CROHN DISEASE; GENETIC PREDISPOSITION TO DISEASE; HCT116 CELLS; HEK293 CELLS; HUMANS; INTRACELLULAR SPACE; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; PEPTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN TRANSPORT; RISK FACTORS; STAPHYLOCOCCUS AUREUS; WD40 REPEATS;

EID: 84976416752     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11821     Document Type: Article

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